Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.

Abstract: An orientation independent delivery device. The delivery device includes a gas chamber, a delivery chamber, a gas cell, and a delivery aperture. The gas chamber includes a gas-side rigid portion and a gas-side flexible barrier. The gas-side flexible barrier is sealed to the gas-side rigid portion. The delivery chamber includes a delivery-side rigid portion and a delivery-side flexible barrier. The delivery-side flexible barrier is sealed to the delivery-side rigid portion and is oriented adjacent to the gas-side flexible barrier. The gas cell is coupled to the gas-side rigid portion of the gas chamber. The gas cell increases a gas pressure within the gas chamber to expand the gas-side flexible barrier. Expansion of the gas-side flexible barrier applies a compressive force to the delivery-side flexible barrier allowing a delivery material to escape from the delivery chamber.

Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: A smoking article may include a cigarette incorporated within an electrically powered aerosol generating device that acts as a holder for that cigarette. The smoking article possesses at least one form of tobacco. The smoking article also possesses a mouth-end piece that is used by the smoker to inhale components of tobacco that are generated by the action of heat upon components of the cigarette. A representative smoking article possesses an outer housing incorporating a source of electrical power (e.g., a battery), a sensing mechanism for powering the device at least during periods of draw, and a heating device (e.g., at least one electrical resistance heating element) for forming a thermally generated aerosol that incorporates components of tobacco. During use, the cigarette is positioned within the device, and after use, the used cigarette is removed from the device and replaced with another cigarette.

Abstract: A smoking article may include a cigarette incorporated within an electrically powered aerosol generating device that acts as a holder for that cigarette. The smoking article possesses at least one form of tobacco. The smoking article also possesses a mouth-end piece that is used by the smoker to inhale components of tobacco that are generated by the action of heat upon components of the cigarette. A representative smoking article possesses an outer housing incorporating a source of electrical power (e.g., a battery), a sensing mechanism for powering the device at least during periods of draw, and a heating device (e.g., at least one electrical resistance heating element) for forming a thermally generated aerosol that incorporates components of tobacco. During use, the cigarette is positioned within the device, and after use, the used cigarette is removed from the device and replaced with another cigarette.

Abstract: A multi-polarized scanning phased array antenna is provided, which includes a first element, second element, first feed line, second feed line, first 180 degree phase shifter, second 180 degree phase shifter, third 180 degree phase shifter, fourth 180 degree phase shifter, ?1 degree phase shifter, and ?2 degree phase shifter. The first element is fed with a first polarization signal at a first feed point and a third feed point, and a second polarization signal at a second feed point and a fourth feed point. The second element is fed with the first polarization signal at a fifth feed point and a seventh feed point, and the second polarization signal at a sixth feed point and an eighth feed point. The first feed line is coupled to the elements and associated with the first polarization. The second feed line is coupled to the plurality of elements and associated with the second polarization.

Abstract: A wound therapy device is disclosed. The wound therapy device may include a housing for covering at least a portion of a wound and for sealing to a body surface of a patient. The housing may also include a liquid collector for retaining liquid therein and a vacuum connection for coupling to a vacuum source. The vacuum connection may be in gaseous communication with the liquid collector. The vacuum connection may be separated from the liquid collector by a liquid barrier.

Abstract: Systems, computer program products, and methods are described herein for a model framework and system for cyber security services. The present invention is configured to determine one or more access paths to the internal computing device from an external computing device; determine one or more controls associated with each access path; determine one or more types of access that may be made via one or more of the access paths by the external computing device to access the internal computing device; determine whether the one or more controls associated with the at least one of the one or more access paths is capable of detecting the access; determine one or more tools configured to regulate the one or more controls; and incorporate the one or more tools within the network to regulate the one or more controls to detect and monitor the access.

Abstract: An air cooling system for an unmanned aerial vehicle including a propeller (14) driven by an engine (12) has at least one cooling air duct (22) to direct cooling air to cool a vehicle component e.g. a cylinder head. The duct has at least one air inlet and at least one air outlet. Operation of the propeller causes a pressure differential between the air outlet (24,124) and the air inlet (23,123) which draws air through said cooling air duct (22). A cowling (16) can cover at least part of the engine, and can form a plenum and have the supply of cooling air through a front face aperture (164) or side walls (17) of the engine cowl (16).

Abstract: Systems and methods for managing territory assignment for a CRM system. Customer data may be loaded from the CRM system to a memory device and mapped to data fields of the memory device. Rides may be received and executed to process customer data to determine territory of each account in the customer data. The territory information may then be stored in a territory management database and synchronized to the CRM system and other CRM systems.

Abstract: In this application is described a method for preparing nano-VLP composition, thereby permitting purification using chromatography and filtration. The nano-VLP composition has a more uniform size range of filovirus particles, roughly 230 nm diameter, allowing ease of manipulation of the composition, while retaining GP conformational integrity and the antigenic effectiveness of the vaccine. Additionally, the nano-VLP can be lyophilized without loss of nano-VLP structure, or GP immunogenicity. Lyophilized nano-VLP have greatly enhanced thermostability, allowing the creation of a filovirus nano-VLP vaccine without a cold chain requirement.

Abstract: Alkali metals and sulfur may be recovered from alkali monosulfide and polysulfides in an electrolytic process that utilizes an electrolytic cell having an alkali ion conductive membrane. An anolyte includes an alkali monosulfide, an alkali polysulfide, or a mixture thereof and a solvent that dissolves elemental sulfur. A catholyte includes molten alkali metal. Applying an electric current oxidizes sulfide and polysulfide in the anolyte compartment, causes alkali metal ions to pass through the alkali ion conductive membrane to the catholyte compartment, and reduces the alkali metal ions in the catholyte compartment. Liquid sulfur separates from the anolyte and may be recovered. The electrolytic cell is operated at a temperature where the formed alkali metal and sulfur are molten.

Abstract: This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.

Abstract: A linac-based X-ray system for cargo scanning and imaging applications uses linac design, RF power control, beam current control, and beam current pulse duration control to provide stable sequences of pulses having different energy levels or different doses.

Abstract: A substrate having one or more shaped effusion cooling holes formed therein. Each shaped cooling hole has a bore angled relative to an exit surface of the combustor liner. One end of the bore is an inlet formed in an inlet surface of the combustor liner. The other end of the bore is an outlet formed in the exit surface of the combustor liner. The outlet has a shaped portion that expands in only one dimension. Also methods for making the shaped cooling holes.

Abstract: A method for removing alkali metal from a hydrocarbon feedstock comprising alkali metal, non-alkali metal and sulfur. The method includes separating out at least a portion of any alkali metal sulfide and a portion of any non-alkali metal from the hydrocarbon feedstock. Hydrogen sulfide can be added to the remaining hydrocarbon feedstock to form alkali hydrosulfide from any alkali metal remaining in the hydrocarbon feedstock. The alkali hydrosulfide is then separated from the hydrocarbon feedstock. Alkali metal may be removed from the alkali metal sulfide separated out from the hydrocarbon feedstock. Alkali hydrosulfide may be treated to form alkali metal sulfide, and alkali metal may also be removed from the formed alkali metal sulfide.

Abstract: An electrical connector includes a housing having contact channels with electrical contacts received therein each having a poke-in spring beam configured to engage an electrical wire when poked-in to the housing. The electrical contact is movable between a resting position when no wire is present in the wire channel and a clearance position where the electrical contact allows the electrical wire to be removed from the wire channel. Pivot levers are held by the housing and are coupled to corresponding electrical contacts with a pivot end pivotably coupled to the housing and a push button end having a push button pressed to move the corresponding electrical contact to the clearance position. When the electrical wire is loaded into the wire channel, the electrical contact is positioned in a pinching position in which the spring beam pinches against the electrical wire in physical contact with the electrical wire.

Abstract: The present disclosure relates to substrates for use in microwave plasma reactors. Certain substrates include a cylindrical disc of a carbide forming refractory metal having a flat growth surface on which CVD diamond is to be grown and a flat supporting surface opposed to said growth surface. The cylindrical disc may have a diameter of 80 mm or more. The growth surface may have a flatness variation no more than 100 mm The supporting surface may have a flatness variation no more than 100 mm.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: An apparatus for managing input/output (I/O) data may include a streaming I/O controller to receive data from a load/store domain component and output the data as first streaming data of a first data type comprising a first data movement type and first data format type. The apparatus may also include at least one accelerator coupled to the streaming I/O controller to receive the first streaming data, transform the first streaming data to second streaming data having a second data type different than the first data type, and output the second streaming data. In addition, the apparatus may include a streaming interconnect to conduct the second data to a peer device configured to receive data of the second data type.