Abstract: An adhesive patch is secured to an infusion set, patch pump or other on-body medical device by an overmolding process during manufacture of the medical device, or during manufacture of a portion of the medical device, without the need for a separate adhesive. This provides a more secure connection between the patch and the medical device, and reduces the required number of adhesive layers from two (skin attachment side and device attachment side) to one (skin attachment side only), thereby simplifying the design and manufacture of the patch.

Abstract: An adhesive patch is secured to an infusion set, patch pump or other on-body medical device by an overmolding process during manufacture of the medical device, or during manufacture of a portion of the medical device, without the need for a separate adhesive. This provides a more secure connection between the patch and the medical device, and reduces the required number of adhesive layers from two (skin attachment side and device attachment side) to one (skin attachment side only), thereby simplifying the design and manufacture of the patch.

Abstract: The disclosure provides methods of treating a patient having primary hyperoxaluria or idiopathic hyperoxaluria comprising administering a therapeutically effective amound of compound of the formula and pharmaceutically acceptable salts, solvates, and hydrates thereof to the patient. The variables, e.g. ring A, n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful inhibiting the conversion of glyoxylate to oxalate. When administered to a patient having a disease or disorder associated with elevated oxalate levels, such as PH type 1, type 2, or type 3 or idiopathic hyperoxaluria the compounds prevent or substantially reduce the amount and buildup of oxalate the patient's kidneys, bladder, urinary tract and other parts of the patient's body.

Abstract: A system comprises an imaging device that includes a two dimensional array of pixels. Each pixel of the array includes a first optical filter having a first pass band arranged to filter excitation light reflected by a moving object and a first detector configured to detect light transmitted through the first optical filter and to generate a first electrical signal. Each pixel of the array also includes a second optical filter having a second pass band arranged to filter excitation light reflected by a moving object and a second detector configured to detect light transmitted through the second optical filter and to generate a second electrical signal. The imaging device further includes circuitry that generates output signals from each of the pixels based on the first electrical signal and the second electrical signal of the pixel. The output signal includes information about the speed and direction of the moving object.

Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the LDHA gene, as well as methods of inhibiting expression of LDHA, methods of inhibiting LDHA and HAO1, and methods of treating subjects that would benefit from reduction in expression of LDHA, such as subjects having an oxalate pathway-associated disease, disorder, or condition, using such dsRNA compositions.

Abstract: A method of manufacturing a medical device, including forming a flexible base portion to have a plurality of through-holes therethrough, placing the flexible base portion on a non-patient side of an adhesive patch with the through-holes in communication with the adhesive patch, dispensing an adhesive into the through-holes onto the adhesive patch and walls of the flexible base portion surrounding the through-holes; and curing the adhesive to form an adhesive plug mechanically bonding the flexible base portion to the adhesive patch.

Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the LDHA gene, as well as methods of inhibiting expression of LDHA, methods of inhibiting LDHA and HAO1, and methods of treating subjects that would benefit from reduction in expression of LDHA, such as subjects having an oxalate pathway-associated disease, disorder, or condition, using such dsRNA compositions.

Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the LDHA gene, as well as methods of inhibiting epression of LDHA, methods of inhibiting LDHA and HAO1, and methods of treating subjects that would benefit from reduction in expression of LDHA, such as subjects having an oxalate pathway-associated disease, disorder, or condition, using such dsRNA compositions.

Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.

Abstract: Methods, systems and computer-readable medium are provided for implementing commands by a collaboration system on behalf of participants of an event utilizing such collaboration system. A method includes identifying participants associated with an event conducted using an online collaboration system; generating a per-participant metric for each one of the participants to generate a plurality of metrics; populating each of the plurality of metrics for a corresponding participant using data received from multiple data sources, each data source providing a particular type of data for the corresponding participant and in association with participation of the corresponding participant in the event; determining a command to be performed on behalf of one or more of the participants; determining, using the plurality of metrics, at least one target associated with the command to yield at least one identified target; and performing the command for the at least one target.

Abstract: A method for managing ice accretion on a gas turbine engine component comprises providing an ice management system comprising a de-icing promoter applied to only portions of a gas turbine engine component. The method further comprises operating the ice management system in icing conditions to promote the shedding of ice accreted on the gas turbine engine component on those portions where the de-icing promoter is applied.

Abstract: A medical device, such as a catheter, for use in medical applications includes an elongated body (26) with a tip having an opening (32) at one end. The catheter tip is configured to inhibit occluding and to permit outflow of fluid medication from the catheter to ensure proper delivery of the medication to an intended target area. The tip of the catheter is constructed to have at least one beveled end surface (42) to assist insertion into the patient and a radial thickness (49) at a critical bend point substantially equal to the radius (41) of the fluid path (36) and at a location spaced from the end a distance substantially equal to the radius of the fluid path to inhibit folding and occluding the catheter during use.

Abstract: An adhesive patch is secured to an infusion set, patch pump or other on-body medical device by an overmolding process during manufacture of the medical device, or during manufacture of a portion of the medical device, without the need for a separate adhesive. This provides a more secure connection between the patch and the medical device, and reduces the required number of adhesive layers from two (skin attachment side and device attachment side) to one (skin attachment side only), thereby simplifying the design and manufacture of the patch.

Abstract: Methods and apparatus to provision cloud computing network elements are disclosed. A disclosed example method includes receiving a selection of a cloud networking template from a client, wherein the cloud networking template includes a data center connector type and a wide area network connector type, configuring a virtual machine on a host server based on the cloud networking template, configuring a data center connector based on the data center connector type, configuring a wide area network connector based on the wide area network connector type, and coupling the wide area network connector to the data center connector and coupling the data center connector to the virtual machine within the host server to enable the client to access the virtual machine.

Abstract: A system and method for removing acetic acid and other short chain fatty acids described as organic acid from a rich mono-ethylene glycol (“MEG”) solution does so by stripping the organic acid from the rich MEG solution by contacting the solution with a gas, the gas being nitrogen or a fuel gas such as methane; and stripping the organic acid from the gas by contacting the gas with a caustic solution such as a dilute sodium hydroxide solution. The stripping steps take place in respective stripping columns. A portion of the gas exiting the gas/organic acid stripping column can be recycled to the MEG/organic acid stripping column to reduce total gas usage. A portion of the waste stream exiting the gas/organic acid stripping column can be recycled back to the gas/organic acid stripping column to reduce the amount of caustic solution used as well as the amount of waste.

Abstract: In one embodiment, upon detection of a mobile device within a proximity of a video conference endpoint and authentication of the mobile device at a server managing the video conference endpoint, the server may receive information regarding a camera of the mobile device. The server may then receive the output of the camera from the mobile device. Finally, after receiving the output of the camera, the server may send the output of the camera to the video conference endpoint as part of media to be presented by the video conference endpoint. The server may also send the output of the camera to one or more other endpoints participating in a video conference managed by the server.

Abstract: A jacket assembly for a separable connector includes multiple pieces joined by an overlapping or interference fit. The multiple pieces include a body segment between a cable entrance segment and a bushing interface segment. The cable entrance segment includes a bore that extends axially through the cable entrance segment and is sized to receive an insulated power cable. The bushing interface segment includes a lug portion with another bore that is sized to receive a portion of an insulative inner housing and a portion of a conductive insert for accepting a compression lug. The bushing may also be configured to receive another portion of the insulative inner housing and another portion of a conductive insert for accepting a probe or bushing insert from another device. The body segment includes still another bore extending axially from a first end of the body segment to a second end of the body segment.

Abstract: Digital content, such as movies, television productions, and the like are processed and delivered based upon digital masters. The masters may be produced as the initial content, or any other content may be digitized to create the masters. An HD full aperture version is used to create a reduced set of masters that can be used to fill orders having a wide range of features and options. The HD full aperture version is combined with pan and scanned instructions parsed from original pan and scan files to permit automatic creation of the basic masters used to fill the orders, such as a letter box version, a 16:9 FF version, and a 4:3 FF version. The derived masters may be HD versions or SD versions. Upon receipt of orders, the proper version is selected and assembled with any other components that may be ordered by the customer. Ingestion of the masters may be delayed until order reception, and transcoding of the original master may also be delayed until order reception.

Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.

Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.