Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: Systems and methods for training models to improve fairness.

Abstract: Power switch assemblies are provided herein each having a power switch enclosure including a box portion and a cover portion removably attachable to the box portion, a power switch installed in a box cavity and having a plurality of terminals, a handle shaft extending through a wall of the cover, and a monitor circuit including a circuit board attached to the cover, monitor circuitry formed on the circuit board, and a plurality of connectors installed on the circuit board, wherein the connectors are configured, upon attachment of the cover to the box, without manual disconnection or reconnection of wires, to electrically interact with a terminal of the power switch for electrical communication between the power switch and the monitor circuitry, and wherein the connectors are configured, without manual disconnection or reconnection of wires, to terminate the electrical interactions upon removal of the cover from the box.

Abstract: Virus and microbe-killing, self-sterilizing resistive heated air filters and methods of making and using same methods. The air filter is includes laser-induced graphene (LIG), a porous conductive graphene foam formed through photothermal conversion of a polyimide film (or another source or source of polymer or other LIG precursor material) by a laser source. The LIG in the air filter can capture particulates and bacteria. The bacteria cannot proliferate even when submerged in culture medium. Through a periodic Joule-heating mechanism, the filter easily reaches greater than 300° C. This destroys any microorganisms including bacteria, along with molecules that can cause adverse biological reactions and diseases such as viruses, pyrogens, allergens, exotoxins, endotoxins, teichoic acids, mycotoxins, nucleic acids, and prions.

Abstract: The disclosure herein describes deploying a Virtual Secure Enclave (VSE) using a universal enclave binary and a Trusted Runtime (TR). A universal enclave binary is generated that includes a set of binaries of Instruction Set Architectures (ISAs) associated with Trusted Execution Environment (TEE) hardware backends. A TEE hardware backend is identified in association with a VSE-compatible device. A VSE that is compatible with the identified TEE hardware backend is generated on the VSE-compatible device and an ISA binary that matches the TEE hardware backend is selected from the universal enclave binary. The selected binary is linked to a runtime library of the TR and loads the linked binary into memory of the generated VSE. The execution of a trusted application is initiated in the generated VSE using a set of interfaces of the TR. The trusted application depends on the TR interfaces rather than the selected ISA binary.

Abstract: Methods and systems for displaying a healthcare condition. The methods include receiving at an interface a plurality of inputs of healthcare data associated with a patient, mapping the plurality of inputs of healthcare data to a phenotype using a first ontology system, determining at least one body portion associated with the phenotype using a second ontology system representative of body portions, and generating a first interactive display of the at least one body portion associated with the phenotype.

Abstract: Peroxyformic acid compositions for removal of biofilm growth and other contaminants and impurities from industrial processing hard surfaces are disclosed. In particular, peroxyformic acid compositions may be dosed on site and/or generated in situ for the reduction and prevention of biofilms on the hard surfaces. Methods of employing the peroxyformic acid compositions for removal of biofilm growth and other impurities such as aldehydes and alcohols from industrial CO2 effluent are also disclosed which beneficially provide ambient biofilm control and break down more rapidly than other peracids, allowing for extended runs between CIP cleaning, including a reduction and/or elimination of cleaning of the scrubbers and other industrial surfaces.

Abstract: Among other things, the present disclosure provides various agents. In some embodiments, provided agents can bind to beta-catenin. In some embodiments, the present disclosure provides technologies for modulating beta-catenin functions. In some embodiments, the present disclosure provides technologies for preventing and/or treating conditions, disorders or diseases associated with beta-catenin. In some embodiments, the present disclosure provides designed amino acids which can provide improved properties and/or activities. In some embodiments, the present disclosure provides agents comprising such amino acids.

Abstract: An embodiment of the present disclosure a system and method for extracting items of information, such as wine from a wine list of a commercial establishment.

Abstract: Techniques are provided for single sided beam management in a millimeter wave (mmW) communication system for use in bistatic radio frequency (RF) sensing. An example method of tracking targets with bistatic radio frequency sensing includes receiving a scanning reference signal, generating a scanning signal report indicating one or more target groups associated with the scanning reference signal, transmitting the scanning signal report, receiving tracking signal configuration information indicating a tracking reference signal associated with the one or more target groups, receiving the tracking reference signal identified in the tracking signal configuration information, and tracking the one or more target groups associated with the tracking reference signal.

Abstract: A hydrogen-plasma rotary kiln furnace reactor and a method of reducing iron ore to iron using the same are disclosed. The hydrogen-plasma rotary kiln furnace includes a rotary kiln furnace and a hydrogen-plasma generator.

Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Abstract: Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural and/or functional features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.

Abstract: A wearable device includes an elastically compliant body having a side for attaching to skin of a patient, a plurality of accelerometers for receiving acoustic wave data from acoustic waves transmitted by a transducer, a short-range radio transmitter for transmitting the acoustic wave data to a computing device, a processor for receiving the acoustic wave data from the plurality of accelerometers and providing the acoustic wave data to the short-range radio transmitter, and a battery for providing power to the processor, the plurality of accelerometers, and the short-range radio transmitter. A distance between each accelerometer of the plurality of accelerometers is predetermined. The processor, the plurality of accelerometers, the short-range radio transmitter, and the battery are embedded within the elastically compliant body.

Abstract: Methods and systems for structuring, storing and displaying time series data in a user interface. One system includes processors executing instructions to determine, from time series data from a first sensor, a first subset of time series data for the first batch from the first start time and the first end time, determine, from the time series data from the first sensor, a second subset of time series data for the second batch from the second start time and the second end time, generate a time series user interface comprising a chart, the chart including a first plot for the first subset of time series data and a second plot for the second subset of time series data, the first plot being aligned to the second plot, and cause presentation of the time series user interface.

Abstract: Technologies for a field effect transistor (FET) with a ferroelectric gate dielectric are disclosed. In an illustrative embodiment, a perovskite stack is grown on a buffer layer as part of manufacturing a transistor. The perovskite stack includes one or more doped semiconductor layers alternating with other lattice-matched layers, such as undoped semiconductor layers. Growing the doped semiconductor layers on lattice-matched layers can improve the quality of the doped semiconductor layers. The lattice-matched layers can be preferentially etched away, leaving the doped semiconductor layers as fins for a ribbon FET. In another embodiment, an interlayer can be deposited on top of a semiconductor layer, and a ferroelectric layer can be deposited on the interlayer. The interlayer can bridge a gap in lattice parameters between the semiconductor layer and the ferroelectric layer.

Abstract: This disclosure relates to the cross carrier scheduling of sidelink carrier aggregation, and includes a method and apparatus for determining a component carrier (CC) index for at least one of a first sidelink transmission with a second UE and a Uu transmission with a network entity, the CC index indicating one or more CCs among which at least one of the first sidelink transmission and the Uu transmission occur; and communicating at least one of the first sidelink transmission to the second UE and the Uu transmission to the network entity based on the CC index.

Abstract: A bipolar electrosurgical device including an outer shaft, an inner shaft, first and second electrode surfaces, and an irrigation channel. The outer shaft defines a lumen, a proximal end and a distal end forming a cutting window. The inner shaft is rotatably disposed within the outer shaft, and defines a distal portion forming a cutting tip. The cutting tip and the cutting window combine to define a cutting implement. The first and second electrode surfaces are electrically isolated, and are formed at the cutting implement. The irrigation channel extends parallel to the outer shaft, and terminates in at least one outlet port. The outlet port is proximally spaced from the cutting window and is located radially outside of the outer shaft. Fluid (e.g., saline) is emitted at the exterior surface of the device near the cutting window and is readily present for interacting with the electrode surfaces.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: This disclosure describes a system, method, and non-transitory computer readable media for an ultrasound probe configured to capture ultrasound images of an examination region. The system includes a first set of one or more sensors coupled to the ultrasound probe and configured to estimate a first positional information associated with the ultrasound probe. The system includes a second set of one or more sensors coupled to the ultrasound probe and configured to capture electromagnetic force (EMF) measurements in the examination region to estimate a second positional information associated with the ultrasound probe. The second positional information is used to calibrate the first set of one or more sensors. The system includes a controller configured to use at least one of (i) the first positional information, or (ii) the second positional information to generate a reconstruction of the examination region based on ultrasound images captured by the ultrasound probe.