Abstract: Systems and methods for generating and processing modeling workflows are disclosed. In some examples, a reference distribution of scores generated by a model is determined. The reference distribution of scores is recorded in a structured database. One or more unexpected scores are detected during execution of the model. To detect the one or more unexpected scores, a production distribution of scores is compared with the reference distribution of scores recorded in the structured database. The production distribution of scores is generated by the model for a production input data set. An alert is then provided to an external system, when an alert condition is determined to be satisfied based on the comparison. The alert indicates detection of the one or more unexpected scores.

Abstract: A microelectronic device includes a stack structure comprising blocks separated from one another by dielectric slot structures and each including a vertically alternating sequence of conductive structures and insulative structures arranged in tiers. At least one of the blocks comprising a stadium structure comprising opposing staircase structures each having steps comprising edges of the tiers; and a filled trench vertically overlying and within horizontal boundaries of the stadium structure of the at least one of the blocks. The filled trench includes a dielectric liner material on the opposing staircase structures of the stadium structure and on inner sidewalls of the two bridge regions and at least one dielectric structure doped with one or more of carbon and boron on the dielectric liner material, the at least one dielectric structure horizontally overlapping the steps of the stadium structure.

Abstract: Processes for depositing silicon-containing films (e.g., silicon, amorphous silicon, silicon oxide, silicon nitride, silicon carbide, silicon oxynitride, silicon carbonitride, doped silicon films, and metal-doped silicon nitride films) are performed using halidosilane precursors. Examples of halidosilane precursor compounds described herein, include, but are not limited to, monochlorodisilane (MCDS), monobromodisilane (MBDS), monoiododisilane (MIDS), monochlorotrisilane (MCTS), and monobromotrisilane (MBTS), monoiodotrisilane (MITS).

Abstract: Methods and systems for explaining an output from a machine learning model. The methods include receiving from a machine learning model a probability score, a plurality of features, and a contribution value for each feature; transforming the plurality of features to a reduced number of features; generating at least one cluster of a portion of a population; grouping the patient in the generated cluster; and visually presenting to a user a comparison of the reduced number of features of the profile with the plurality of features associated with the portion of the population to explain the probability score.

Abstract: An apparatus comprises a processing device that is configured to obtain information about driver installations of a given driver on a plurality of computing devices and to obtain information about system failures from the plurality of computing devices. The processing device is further configured to determine a correlation between the driver installations and the system failures and to determine that the given driver is likely to cause a system failure based at least in part on the determined correlation between the driver installations and the system failures. The processing device is further configured to provide an indication that the given driver is likely to cause a system failure to a given computing device. The indication is configured to cause the given computing device to inhibit a presentation of a recommendation to install the given driver to a user of the given computing device.

Abstract: Quad photodiode microlens arrangements, and associated systems and methods. In one embodiment, a plurality of pixels are arranged in rows and columns of a pixel array disposed in a semiconductor material. The plurality of pixels includes green (G) pixels, red (R) pixels, blue (B) pixels and clear (C) pixels. Each pixel comprises a plurality of photodiodes that are configured to receive incoming light through an illuminated surface of the semiconductor material. A plurality of small microlenses are distributed over individual photodiodes of clear (C) pixels. A plurality of large microlenses are distributed over individual green (G) pixels. A diameter of the small microlenses is smaller than a diameter of the large microlenses.

Abstract: The present invention relates to a recombinant fusion protein comprising a fragment of the cardioprotective protein neuregulin-1 (NRG-1) fused to a monoclonal antibody (mAb) backbone and to a method of treating a disease or condition in a subject in need thereof comprising administering a therapeutically effective amount of the recombinant fusion protein or the pharmaceutical composition comprising the recombinant fusion protein disclosed herein.

Abstract: The present invention relates to a recombinant fusion protein comprising a fragment of the cardioprotective protein neuregulin-1 (NRG-1) fused to a monoclonal antibody (mAb) backbone and to a method of treating a disease or condition in a subject in need thereof comprising administering a therapeutically effective amount of the recombinant fusion protein or the pharmaceutical composition comprising the recombinant fusion protein disclosed herein.

Abstract: Virus and microbe-killing, self-sterilizing resistive heated air filters and methods of making and using same methods. The air filter is includes laser-induced graphene (LIG), a porous conductive graphene foam formed through photothermal conversion of a polyimide film (or another source or source of polymer or other LIG precursor material) by a laser source. The LIG in the air filter can capture particulates and bacteria. The bacteria cannot proliferate even when submerged in culture medium. Through a periodic Joule-heating mechanism, the filter easily reaches greater than 300° C.

Abstract: A wearable device includes a housing to encompass a portion of a body part, biometric sensors coupled to the housing, a controller coupled to the housing and biometric sensors, a communication channel for communicating with external devices and a temperature regulator to controllably adjust a temperature of the housing. The wearable device is configured to provide remote controlled heating and cooling of the body part. The wearable device may include an evaporative heat exchanger and a thermoelectric heat pump. The wearable device may provide means for dissipating heat through vaporization of a substance or using an advective flux and phase transition.

Abstract: An apparatus comprises a processing device that is configured to obtain information about driver installations of a given driver on a plurality of computing devices and to obtain information about system failures from the plurality of computing devices. The processing device is further configured to determine a correlation between the driver installations and the system failures and to determine that the given driver is likely to cause a system failure based at least in part on the determined correlation between the driver installations and the system failures. The processing device is further configured to provide an indication that the given driver is likely to cause a system failure to a given computing device. The indication is configured to cause the given computing device to inhibit a presentation of a recommendation to install the given driver to a user of the given computing device.

Abstract: A method for detecting and quantifying allergen components of a substance is described herein. A method can include obtaining an Ig sample derived from two or more individuals, and one or more capillaries comprising allergenic biologics adhered thereto. The Ig sample can be applied to the one or more capillaries and allergen component and molecules that has bound with the Ig sample, can be detected in the one or more capillaries. A molecular weight and/or frequency of appearance, an isoelectric charge and/or frequency of appearance, a molecular functional group and/or frequency of appearance or a combination thereof, of the allergen component can be recorded. Furthermore, methods for determining the minimum and maximum concentrations of the detected allergen components for pre-determined platforms, formulating an allergen product using the determined concentration ranges and applying the allergen product to result an effective assay are described.

Abstract: The present invention relates to a recombinant fusion protein comprising a fragment of the cardioprotective protein neuregulin-1 (NRG-1) fused to a monoclonal antibody (mAb) backbone and to a method of treating a disease or condition in a subject in need thereof comprising administering a therapeutically effective amount of the recombinant fusion protein or the pharmaceutical composition comprising the recombinant fusion protein disclosed herein.

Abstract: The present invention relates to a recombinant fusion protein comprising a fragment of the cardioprotective protein neuregulin-1 (NRG-1) fused to a monoclonal antibody (mAb) backbone and to a method of treating a disease or condition in a subject in need thereof comprising administering a therapeutically effective amount of the recombinant fusion protein or the pharmaceutical composition comprising the recombinant fusion protein disclosed herein.

Abstract: An isolated monoclonal antibody or an antigen-binding fragment that specifically binds human PD-1. A nucleic acid molecule encoding the antibody or the antigen-binding fragment, an expression vector, a host cell and a method for expressing the antibody or the antigen-binding fragment are also provided. The present invention further provides an immunoconjugate, a bispecific molecule, a chimeric antigen receptor, an oncolytic virus and a pharmaceutical composition comprising the antibody or the antigen-binding fragment, as well as a treatment method using an anti-PD-1 antibody of the invention.

Abstract: The present invention provides an isolated monoclonal antibody, or an antigen-binding portion thereof, specifically binding to CD40. The present invention further provides a pharmaceutical composition comprising the antibody, or the antigen-binding portion thereof, as well as a treatment method using the antibody or the antigen-binding portion thereof, or the pharmaceutical composition.

Abstract: Embodiments of the systems, methods, and computer readable medium devices disclosed herein provide a sentiment analysis system that can determine sentiment from an input of a user received from a device. Once the input is received, parsing and analysis can be performed to determine a particular sentiment corresponding to the input. The system can determine an overall sentiment of some or all of the users or viewers watching a particular video stream, such as a live video stream. The determined overall sentiment can represent a metric indicating what users generally feel about a portion of the video stream, and the system can use the determination to cause modification of the video stream or a future video stream to enhance the user experience.

Abstract: Intramedullary nails are provided for the fixation of epiphyseal fragments in a long bone of a patient in need thereof. The intramedullary nails have a cap portion that allows for fixation of the epiphyseal bone fragments thereto, and an intramedullary shaft for insertion into the medullary canal of the long bone. The intramedullary nails can provide for fixation of comminuted fractures that are difficult to treat with conventional methods. In some aspects, the patient is a human patient and the fracture is a Mason type II radial head fracture or a Mason type III radial head fracture. Methods of fixation of epiphyseal fractures using the intramedullary nails of the present disclosure are also described.

Abstract: The present invention relates to a recombinant fusion protein comprising a fragment of the cardioprotective protein neuregulin-1 (NRG-1) fused to a monoclonal antibody (mAb) backbone and to a method of treating a disease or condition in a subject in need thereof comprising administering a therapeutically effective amount of the recombinant fusion protein or the pharmaceutical composition comprising the recombinant fusion protein disclosed herein.