Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

Abstract: Methods for forming optical articles with antireflective nanostructured (ARN) surfaces. An aluminum layer is deposited or otherwise applied to the cavity of an injection mold tool. Sequential chemical treatments such as anodization and etching steps form an ARN mold texture on the interior surface of the cavity. The ARN mold texture is a negative of a desired surface texture of the article. During injection molding, the desired ARN surface is thereby produced in the optical article.

Abstract: An optical system, such as may be used in directional luminaires. Engineered diffusion and tailoring of the components of the system corrects undesirable artifacts in the projected beam.

Abstract: A luminaire module includes a light source located in a first plane and a truncated optical system having an optical axis. The truncated optical system is configured to focus and aim light from the light source to form an output beam. The module also controls a tilt angle of the output beam over a range of tilt angles by adjusting a position of the optical system relative to a position of the light source in a plane perpendicular to the optical axis. The spatial extent of the optical system is constrained to the minimum dimensions required in order to focus and aim substantially all of the light from the light source over a predetermined range of tilt angles for the output beam. A pan angle of the output beam can also be adjusted, such as by rotating the luminaire module. Tilt and/or pan may be manual or motorized and controlled by a control system. Multiple such luminaire modules may be combined.

Abstract: Methods for forming optical articles with antireflective nanostructured (ARN) surfaces. An aluminum layer is deposited or otherwise applied to the cavity of an injection mold tool. Sequential chemical treatments such as anodization and etching steps form an ARN mold texture on the interior surface of the cavity. The ARN mold texture is a negative of a desired surface texture of the article. During injection molding, the desired ARN surface is thereby produced in the optical article.

Abstract: A device for pumping fluid such as paints, sealants, caulks, and polymers made of a rotor assembly and a pump body. The rotor assembly contains at least one laminar flow element arranged in such a manner as to conduct the fluid from inlet to outlet as the rotor spins. The rotor may vary its distance from the pump body. This arrangement provides a rotor with exceptional capacity to pump without damage to the fluid media and to measure the fluid rate at low or high rotational speed with viscosity that can vary. The device also may provide a spray nozzle or nozzles that produce a multiplicity of spray patterns.

Abstract: The present application relates to processes for preparing (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatment of hyperkinetic movement disorders such as tardive dyskinesia (TD).

Abstract: Helmets and methods for manufacturing a helmet are described. An example helmet includes a shell and a shock absorbing liner attached to the shell. The shock absorbing liner includes a cavity. The helmet a shock absorbing insert formed of a material different than the material of the shock absorbing liner. The cavity is configured to retain the shock absorbing insert.

Abstract: Various examples are directed to apparatus and methods for providing a sign post flasher assembly. An apparatus includes an elongated assembly having one or more channels, and one or more light sources configured to be placed within the one or more channels. The apparatus also includes an electrically conductive material configured to electrically connect the one or more light sources, and a covering material configured to cover the electrically conductive material to provide a waterproof seal. The elongated assembly is configured to be affixed to and align with a front of a sign post along a length of the sign post, and the electrically conductive material is configured to be connected to a controller to control flashing of the one or more light sources.

Abstract: An intraoperative tissue oximetry device includes a tissue marker that includes one or more pens or one or more similar ink sources, such that the tissue marker can mark tissue according to oxygen saturation measurements made by the tissue oximetry device, thereby visually delineating regions of potentially viable tissue from regions of potentially nonviable tissue.

Abstract: A system includes an enclosure having a processor and a memory coupled to the processor. The enclosure includes a display coupled to the processor where the display is visible from an exterior of the enclosure; and a battery within the enclosure coupled to the processor and the display. The enclosure includes a probe tip coupled to an exterior of the enclosure. The probe tip includes first, second, and third sensor openings. A first distance between the first and second sensor openings is different than a second distance between the first and third sensor openings. The enclosure includes code stored in the memory where the code is executable by the processor, and includes code to receive first data associated with the first and second sensor openings, code to receive second data associated with the first and second sensor openings, and code to perform SRS using the first and the second data.

Abstract: Helmets and methods for manufacturing a helmet are described. An example helmet includes a shell and a shock absorbing liner attached to the shell. The shock absorbing liner includes a cavity. The helmet a shock absorbing insert formed of a material different than the material of the shock absorbing liner. The cavity is configured to retain the shock absorbing insert.

Abstract: A device for pumping fluid such as paints, sealants, caulks, and polymers made of a rotor assembly and a pump body. The rotor assembly contains at least one laminar flow element arranged in such a manner as to conduct the fluid from inlet to outlet as the rotor spins. The rotor may vary its distance from the pump body. This arrangement provides a rotor with exceptional capacity to pump without damage to the fluid media and to measure the fluid rate at low or high rotational speed with viscosity that can vary. The device also may provide a spray nozzle or nozzles that produce a multiplicity of spray patterns.

Abstract: Helmets and methods for manufacturing a helmet are described. An example helmet includes a shell and a shock absorbing liner attached to the shell. The shock absorbing liner includes a cavity. The helmet a shock absorbing insert formed of a material different than the material of the shock absorbing liner. The cavity is configured to retain the shock absorbing insert.

Abstract: An intraoperative tissue oximetry device includes a tissue marker that includes one or more pens or one or more similar ink sources, such that the tissue marker can mark tissue according to oxygen saturation measurements made by the tissue oximetry device, thereby visually delineating regions of potentially viable tissue from regions of potentially nonviable tissue.

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

Abstract: A steerable illumination fixture includes an emitting source and a refractive optical system that steers an emitted beam by relative translation of the emitting source against the optical system. The light emitting source may be placed along an optical axis of one or more lenses to produce an output beam along that axis, or translated in-plane (orthogonal to the optical axis) relative to the lenses to produce a steered beam. The optical system may include refractive lenses or mixing channels and/or one or more baffles with apertures. A round, uniform beam results that retains approximately the same power level and beam width as it is steered. A second lens having a diameter equal to or larger than a first lens may be provided and configured with an effective focal plane of the two lenses located approximately at the plane of the light emitting source.

Abstract: A system includes an enclosure having a processor and a memory coupled to the processor. The enclosure includes a display coupled to the processor where the display is visible from an exterior of the enclosure; and a battery within the enclosure coupled to the processor and the display. The enclosure includes a probe tip coupled to an exterior of the enclosure. The probe tip includes first, second, and third sensor openings. A first distance between the first and second sensor openings is different than a second distance between the first and third sensor openings. The enclosure includes code stored in the memory where the code is executable by the processor, and includes code to receive first data associated with the first and second sensor openings, code to receive second data associated with the first and second sensor openings, and code to perform SRS using the first and the second data.

Abstract: A device for pumping fluid such as paints, sealants, caulks, and polymers made of a rotor assembly and a pump body. The rotor assembly contains at least one laminar flow element arranged in such a manner as to conduct the fluid from inlet to outlet as the rotor spins. The rotor may vary its distance from the pump body. This arrangement provides a rotor with exceptional capacity to pump without damage to the fluid media and to measure the fluid rate at low or high rotational speed with viscosity that can vary.