Abstract: A dispensing package for a floor treatment composition. The dispensing package includes a coupling shell and a container. The coupling shell is engaged with the container by a neck fitment projecting from the coupling shell. The coupling shell is provided with a dispensing opening and at least two support zones. The container includes a membrane seal engaged with a sealing surface of the container. The coupling shell can provide for a connection between a container and a dispensing system.

Abstract: A coupling shell including a top wall, a shell wall, a front aperture in the top wall, a dispensing opening in the top wall, and a neck fitment projecting into the shell interior of the shell wall. The coupling shell can provide for a connection between a container and a dispensing system.

Abstract: A dispensing system for a floor treatment composition. The dispensing system includes a housing partially enclosing a cavity and a cradle moveable within the housing along a z-axis from a first position to a second position. The dispensing system further includes a chassis and a sliding lock that includes an open frame. An inlet canula projects through the open frame. When the cradle is in the second position, the inlet canula entrance projects through the open frame and through a liquid transport aperture in the cradle. Latches extending from the open frame also project through engagement apertures in the cradle when the cradle is in the second position. The dispensing system further includes a pump in fluid communication with the inlet canula and a mop head in fluid communication with the pump.

Abstract: A dispensing package for a floor treatment composition. The dispensing package includes a coupling shell and a container. The coupling shell is provided with a dispensing opening and at least one front aperture. The container includes a membrane seal engaged with a sealing surface of the container. The coupling shell can provide for a connection between a container and a dispensing system.

Abstract: The invention relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: A removable hot box is disclosed that includes a lower hot box portion, comprising: a lower housing comprising a plurality of lower clamping structures to clamp the lower housing to a press and locating structures to provide repeatable placing in the press; and a lower heating platen, received within the lower housing, wherein the lower housing or the lower heating platen comprises lower electrical connectors to provide a lower electrical connection to a heating system and lower cooling connectors to provide a lower cooling connection to a cooling system; and an upper hot box portion, positionable above the lower hot box portion and comprising: an upper housing comprising a plurality of upper clamping structures to clamp the upper housing to the press; an upper heating platen, received within the upper housing.

Abstract: A device including a speaker and a housing, in which the speaker is configured to generate sound and includes a diaphragm and the housing encloses the speaker and includes a plurality of openings within one portion of the housing. The speaker is positioned within the housing to define a front chamber between the diaphragm and the one portion, and the plurality of openings are sized to collectively generate, with the front chamber, an increased output of the device within a frequency range of an output of the speaker corresponding to an alarm tone. Also provided are methods for assembling a device including a speaker and a housing.

Abstract: Systems and methods for effecting bariatric procedures are disclosed. Each system includes an instrument, a control valve and, optionally, a suction controller. The instrument is in the form of an elongated, flexible sizing tube having a distal end portion including a plurality of apertures. The control valve enables suction to be applied to the patient's stomach via the apertures to drain gastric fluids and to bring adjacent portions of the patient's stomach into engagement with the sizing tube to provide a visually perceptible delineation line along which a portion of the stomach may be resected, sealed and tested.

Abstract: Helmets and methods for manufacturing a helmet are described. An example helmet includes a shell and a shock absorbing liner attached to the shell. The shock absorbing liner includes a cavity. The helmet a shock absorbing insert formed of a material different than the material of the shock absorbing liner. The cavity is configured to retain the shock absorbing insert.

Abstract: Various examples are directed to apparatus and methods for providing a sign post flasher assembly. An apparatus includes an elongated assembly having one or more channels, and one or more light sources configured to be placed within the one or more channels. The apparatus also includes an electrically conductive material configured to electrically connect the one or more light sources, and a covering material configured to cover the electrically conductive material to provide a waterproof seal. The elongated assembly is configured to be affixed to and align with a front of a sign post along a length of the sign post, and the electrically conductive material is configured to be connected to a controller to control flashing of the one or more light sources.

Abstract: An intraoperative tissue oximetry device includes a tissue marker that includes one or more pens or one or more similar ink sources, such that the tissue marker can mark tissue according to oxygen saturation measurements made by the tissue oximetry device, thereby visually delineating regions of potentially viable tissue from regions of potentially nonviable tissue.

Abstract: A system includes an enclosure having a processor and a memory coupled to the processor. The enclosure includes a display coupled to the processor where the display is visible from an exterior of the enclosure; and a battery within the enclosure coupled to the processor and the display. The enclosure includes a probe tip coupled to an exterior of the enclosure. The probe tip includes first, second, and third sensor openings. A first distance between the first and second sensor openings is different than a second distance between the first and third sensor openings. The enclosure includes code stored in the memory where the code is executable by the processor, and includes code to receive first data associated with the first and second sensor openings, code to receive second data associated with the first and second sensor openings, and code to perform SRS using the first and the second data.

Abstract: Helmets and methods for manufacturing a helmet are described. An example helmet includes a shell and a shock absorbing liner attached to the shell. The shock absorbing liner includes a cavity. The helmet a shock absorbing insert formed of a material different than the material of the shock absorbing liner. The cavity is configured to retain the shock absorbing insert.

Abstract: A device for pumping fluid such as paints, sealants, caulks, and polymers made of a rotor assembly and a pump body. The rotor assembly contains at least one laminar flow element arranged in such a manner as to conduct the fluid from inlet to outlet as the rotor spins. The rotor may vary its distance from the pump body. This arrangement provides a rotor with exceptional capacity to pump without damage to the fluid media and to measure the fluid rate at low or high rotational speed with viscosity that can vary. The device also may provide a spray nozzle or nozzles that produce a multiplicity of spray patterns.

Abstract: Helmets and methods for manufacturing a helmet are described. An example helmet includes a shell and a shock absorbing liner attached to the shell. The shock absorbing liner includes a cavity. The helmet a shock absorbing insert formed of a material different than the material of the shock absorbing liner. The cavity is configured to retain the shock absorbing insert.

Abstract: An intraoperative tissue oximetry device includes a tissue marker that includes one or more pens or one or more similar ink sources, such that the tissue marker can mark tissue according to oxygen saturation measurements made by the tissue oximetry device, thereby visually delineating regions of potentially viable tissue from regions of potentially nonviable tissue.

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

Abstract: A steerable illumination fixture includes an emitting source and a refractive optical system that steers an emitted beam by relative translation of the emitting source against the optical system. The light emitting source may be placed along an optical axis of one or more lenses to produce an output beam along that axis, or translated in-plane (orthogonal to the optical axis) relative to the lenses to produce a steered beam. The optical system may include refractive lenses or mixing channels and/or one or more baffles with apertures. A round, uniform beam results that retains approximately the same power level and beam width as it is steered. A second lens having a diameter equal to or larger than a first lens may be provided and configured with an effective focal plane of the two lenses located approximately at the plane of the light emitting source.