Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

Abstract: A steerable illumination fixture includes an emitting source and a refractive optical system that steers an emitted beam by relative translation of the emitting source against the optical system. The light emitting source may be placed along an optical axis of one or more lenses to produce an output beam along that axis, or translated in-plane (orthogonal to the optical axis) relative to the lenses to produce a steered beam. The optical system may include refractive lenses or mixing channels and/or one or more baffles with apertures. A round, uniform beam results that retains approximately the same power level and beam width as it is steered. A second lens having a diameter equal to or larger than a first lens may be provided and configured with an effective focal plane of the two lenses located approximately at the plane of the light emitting source.

Abstract: A system includes an enclosure having a processor and a memory coupled to the processor. The enclosure includes a display coupled to the processor where the display is visible from an exterior of the enclosure; and a battery within the enclosure coupled to the processor and the display. The enclosure includes a probe tip coupled to an exterior of the enclosure. The probe tip includes first, second, and third sensor openings. A first distance between the first and second sensor openings is different than a second distance between the first and third sensor openings. The enclosure includes code stored in the memory where the code is executable by the processor, and includes code to receive first data associated with the first and second sensor openings, code to receive second data associated with the first and second sensor openings, and code to perform SRS using the first and the second data.

Abstract: A device for pumping fluid such as paints, sealants, caulks, and polymers made of a rotor assembly and a pump body. The rotor assembly contains at least one laminar flow element arranged in such a manner as to conduct the fluid from inlet to outlet as the rotor spins. The rotor may vary its distance from the pump body. This arrangement provides a rotor with exceptional capacity to pump without damage to the fluid media and to measure the fluid rate at low or high rotational speed with viscosity that can vary.

Abstract: A device for pumping fluid such as paints, sealants, caulks, and polymers made of a rotor assembly and a pump body. The rotor assembly contains at least one laminar flow element arranged in such a manner as to conduct the fluid from inlet to outlet as the rotor spins. The rotor may vary its distance from the pump body. This arrangement provides a rotor with exceptional capacity to pump without damage to the fluid media and to measure the fluid rate at low or high rotational speed with viscosity that can vary. The device also may provide a spray nozzle or nozzles that produce a multiplicity of spray patterns.

Abstract: Compounds are provided herein that antagonize corticotropin-releasing factor (CRF) receptors, in particular CRF receptor 1 (CRF1), as well as related preparations, compositions and methods for treating diseases and/or disorders that would benefit from the same such as congenital adrenal hyperplasia (CAH).

Abstract: A tissue oximetry device utilizes at least three or at least four different wavelengths of light for collection of reflectance data where the different wavelengths are longer than 730 nanometers. The three or four wavelengths are utilized to generate a range of reflectance data suited for accurate determination of oxygenated hemoglobin and deoxygenated hemoglobin concentrations. The relatively long wavelengths decrease optical interference from certain dyes, particularly methylene blue and PVPI, which may be present on tissue being analyzed for viability and further enhance the generation of accurate reflectance data. The wavelengths are 760 nanometers, 810 nanometers, and 850 nanometers, or 760 nanometers, 810 nanometers, 850 nanometers, and 900 nanometers.

Abstract: Systems and methods for a wireless controller are provided. The wireless controller includes an enclosure having a top and a bottom, each having a substantially circular perimeter, and a side having a height circumferentially around the perimeter of the top and the bottom. A first sensor is configured to detect movement of the enclosure. A processor is coupled to the first sensor and configured to process signals from the first sensor and to send command signals via a wireless interface based at least upon the signals from the first sensor.

Abstract: Methods of treating diseases and disorders characterized by elevated levels of cortisol using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the disease or disorder is Cushing's syndrome.

Abstract: Electrode array assembly (10) including a carrier assembly (12) and a connector assembly (14). The carrier assembly (12) includes an array of first electrical contacts (20) coupled to a plurality of electrodes (18), and a first housing (22) canying the array of first contacts (20) and configured to allow access to the first contacts (20). The connector assembly (14) includes an array of second electrical contacts (26), and a second housing (28) canying the second contacts (26) and configured to allow access to the second contacts (26). Each of the carrier assembly (12) and the connector assembly (14) include complementary retention elements (30) and complementary locating formations (32), whereby engaging the complementary locating formations (32) allows the complementary retention elements (30) to secure the first housing (22) to the second housing (28), and allows the first contacts (20) to couple with the second contacts (26).

Abstract: A steerable illumination fixture includes an emitting source and a refractive optical system that steers an emitted beam by relative translation of the emitting source against the optical system. The light emitting source may be placed along an optical axis of one or more lenses to produce an output beam along that axis, or translated in-plane (orthogonal to the optical axis) relative to the lenses to produce a steered beam. The optical system may include refractive lenses or mixing channels and/or one or more baffles with apertures. A round, uniform beam results that retains approximately the same power level and beam width as it is steered. A second lens having a diameter equal to or larger than a first lens may be provided and configured with an effective focal plane of the two lenses located approximately at the plane of the light emitting source.

Abstract: A tissue oximetry device utilizes at least three or at least four different wavelengths of light for collection of reflectance data where the different wavelengths are longer than 730 nanometers. The three or four wavelengths are utilized to generate a range of reflectance data suited for accurate determination of oxygenated hemoglobin and deoxygenated hemoglobin concentrations. The relatively long wavelengths decrease optical interference from certain dyes, particularly methylene blue and PVPI, which may be present on tissue being analyzed for viability and further enhance the generation of accurate reflectance data. The wavelengths are 760 nanometers, 810 nanometers, and 850 nanometers, or 760 nanometers, 810 nanometers, 850 nanometers, and 900 nanometers.

Abstract: A method of scanning an industrial chemical vessel to monitor a chemical process within the industrial chemical vessel, the method comprising: positioning a first unmanned aerial vehicle (UAV) carrying a gamma radiation source on one side of the vessel, positioning a second UAV carrying a gamma radiation detector on an opposite side of the vessel, moving the first and second UAVs to scan the vessel by passing gamma radiation through the vessel from the radiation source carried by the first UAV to the radiation detector carried by the second UAV thereby measuring a density profile, identifying a location of one or more fluid layers within the industrial chemical vessel, and determining if a chemical process within the industrial chemical vessel is operating correctly based on the location of the one or more fluid layers within the industrial chemical vessel identified using the first and second UAVs.

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

Abstract: A steerable illumination fixtures include an emitting source and a refractive optical system that steers an emitted beam by relative translation of the emitting source against the optical system. The light emitting source may be placed along an optical axis of one or more lenses to produce an output beam along that axis, or translated in-plane (orthogonal to the optical axis) relative to the lenses to produce a steered beam. The optical system may include refractive lenses and in some embodiments mixing channels and/or one or more baffles with apertures. The design is typically optimized to produce a round, uniform beam that retains approximately the same power level and beam width as it is steered. It is beneficial, but not required, that a second lens have a diameter equal to or larger than a first lens. The lenses may be configured so that the effective focal plane of the two lenses together is located approximately at the plane of the light emitting source.

Abstract: Helmets and methods for manufacturing a helmet are described. An example helmet includes a shell and a shock absorbing liner attached to the shell. The shock absorbing liner includes a cavity. The helmet a shock absorbing insert formed of a material different than the material of the shock absorbing liner. The cavity is configured to retain the shock absorbing insert.

Abstract: A backfiring optical system, such as may be used in directional luminaires. Engineered diffusion and tailoring of the beam corrects undesirable artifacts in the projected beam.

Abstract: Methods for forming optical articles with antireflective nanostructured (ARN) surfaces. An aluminum layer is deposited or otherwise applied to the cavity of an injection mold tool. Sequential chemical treatments such as anodization and etching steps form an ARN mold texture on the interior surface of the cavity. The ARN mold texture is a negative of a desired surface texture of the article. During injection molding, the desired ARN surface is thereby produced in the optical article.

Abstract: Various examples are directed to apparatus and methods for providing a sign post flasher assembly. An apparatus includes an elongated assembly having one or more channels, and one or more light sources configured to be placed within the one or more channels. The apparatus also includes an electrically conductive material configured to electrically connect the one or more light sources, and a covering material configured to cover the electrically conductive material to provide a waterproof seal. The elongated assembly is configured to be affixed to and align with a front of a sign post along a length of the sign post, and the electrically conductive material is configured to be connected to a controller to control flashing of the one or more light sources.

Abstract: Systems and methods include providing an aircraft with a flight control system, a hybrid electrical or hybrid hydraulic propulsion system, and three ducted fan configuration. Each of two ducted fore fans include a single rotor system having multiple rotor blades, and a single ducted aft fan includes dual, coaxial, counter-rotating rotor systems each having multiple rotor blades. The aircraft is a vertical takeoff and landing (VTOL) aircraft that is capable of operation in an airplane mode and a helicopter mode and designed to provide an urban air-taxi that would relieve ground traffic congestion, reduce carbon emissions, and increase productivity, thereby providing a faster, more efficient means of transportation.