Patents by Inventor John M. Schaus

John M. Schaus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes
    Patent number: 5466709
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at the serotonin 1A receptor.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: November 14, 1995
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Craig S. Hoechstetter, Diane Huser, Charles J. Paget, Robert D. Titus
  • Method of inhibiting gastric acid secretion with 4- amino-1, 3, 4, 5 tetrahydrobenzo [c,d]indoles
    Patent number: 5457120
    Abstract: The present invention provides a method of inhibiting gastric acid secretion in mammals by administering a 5-HT1A agonist compound or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 29, 1994
    Date of Patent: October 10, 1995
    Assignee: Eli Lilly and Company
    Inventors: Jaswant S. Gidda, John M. Schaus
  • Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c> pyrroles as inhibitors of serotonin reuptake
    Patent number: 5457121
    Abstract: This invention provides ring-substituted cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles which are selective inhibitors of serotonin reuptake.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: October 10, 1995
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Robert D. Titus
  • Isoxazole derivatives for the treatment of irritable bowel syndrome
    Patent number: 5434174
    Abstract: Methods of treating Irritable Bowel Syndrome (IBS) using a series of isoxazole derivatives that have both 5-HT1A agonist and M1 muscarinic activities, and formulations adapted for the treatment of IBS comprising those derivatives.
    Type: Grant
    Filed: April 20, 1993
    Date of Patent: July 18, 1995
    Assignee: Eli Lilly and Company
    Inventors: Jaswant S. Gidda, John M. Schaus
  • Intermediates for making ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes
    Patent number: 5426226
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes which exhibit binding activity at the serotonin 1A receptor. An intermediate for preparing the novel compounds have the following formula: ##STR1## wherein R, R.sub.1 and R.sub.9, are as defined in the specification.
    Type: Grant
    Filed: October 21, 1993
    Date of Patent: June 20, 1995
    Inventors: Craig S. Hoechstetter, Diane L. Huser, John M. Schaus, Robert D. Titus
  • Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes
    Patent number: 5426229
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at the serotonin 1A receptor.
    Type: Grant
    Filed: December 16, 1993
    Date of Patent: June 20, 1995
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Craig S. Hoechstetter, Diane Huser, Charles J. Paget, Robert D. Titus
  • Method of treating inflammation
    Patent number: 5416090
    Abstract: The present invention relates to the use of certain ergoline analogues and BCD tricyclic ergoline part-structure analogues as defined herein as anti-inflammatory agents.
    Type: Grant
    Filed: December 8, 1992
    Date of Patent: May 16, 1995
    Assignee: Eli Lilly and Company
    Inventors: Alison M. Bendele, Henry U. Bryant, John M. Schaus
  • Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes
    Patent number: 5389687
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes which exhibit binding activity at the serotonin 1A receptor.
    Type: Grant
    Filed: April 11, 1991
    Date of Patent: February 14, 1995
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Robert D. Titus
  • 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
    Patent number: 5364856
    Abstract: 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: September 30, 1992
    Date of Patent: November 15, 1994
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Charles J. Paget, Jr., John M. Schaus
  • 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
    Patent number: 5347013
    Abstract: 6-Heterocyclic-4-amino-l,2,2a,3,4,5-hexahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: September 30, 1992
    Date of Patent: September 13, 1994
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, Michael E. Flaugh, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines
    Patent number: 5340838
    Abstract: The present invention provides a method of inhibiting gastric acid secretion in mammals by administering a 5-HT1A agonist compound or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 26, 1993
    Date of Patent: August 23, 1994
    Assignee: Eli Lilly and Company
    Inventors: Jaswant S. Gidda, John M. Schaus
  • Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes and pharmaceutical compositions thereof
    Patent number: 5286753
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at the serotonin 1A receptor.
    Type: Grant
    Filed: April 16, 1993
    Date of Patent: February 15, 1994
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Craig S. Hoechstetter, Diane Huser, Charles J. Paget, Robert D. Titus
  • Method of inhibiting gastric acid secretion with n-arylpiperazines
    Patent number: 5258379
    Abstract: The present invention provides a method of inhibiting gastric acid secretion in mammals by administering a 5-HT1A agonist compound or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 15, 1992
    Date of Patent: November 2, 1993
    Assignee: Eli Lilly and Company
    Inventors: Jaswant S. Gidda, John M. Schaus
  • 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof
    Patent number: 5244912
    Abstract: 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: September 14, 1993
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Charles J. Paget, Jr., John M. Schaus
  • 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz(cd)indoles and pharmaceutical use thereof
    Patent number: 5244911
    Abstract: 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: September 14, 1993
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • 6-substituted-hexahydrobenz[cd]indoles
    Patent number: 5229410
    Abstract: The present invention provides 4-amino-6-substituted-hexahydrobenz[cd]indoles which are useful in treating disease states which can be benefited by an alteration of 5-HT.sub.1A receptors.
    Type: Grant
    Filed: July 3, 1991
    Date of Patent: July 20, 1993
    Assignee: Eli Lilly and Company
    Inventors: Michael E. Flaugh, Michael J. Martinelli, John M. Schaus
  • 6-substituted-tetrahydrobenz[cd]indoles
    Patent number: 5229409
    Abstract: The present invention involves certain 4-amino-6-substituted-tetrahydrobenz[cd]indoles and their use in treating disorders which can be benefited by modifying 5-HT A receptor function.
    Type: Grant
    Filed: July 3, 1991
    Date of Patent: July 20, 1993
    Assignee: Eli Lilly and Company
    Inventors: Michael E. Flaugh, Michael J. Martinelli, John M. Schaus
  • Method of inhibiting gastric acid secretion with benzodioxanes
    Patent number: 5158956
    Abstract: The present invention provides a method of inhibiting gastric acid secretion in mammals by administering a 5-HT1A agonist compound or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 29, 1991
    Date of Patent: October 27, 1992
    Assignee: Eli Lilly and Company
    Inventors: Jaswant S. Gidda, John M. Schaus
  • BCD tricyclic ergoline part-structure analogues
    Patent number: 5134143
    Abstract: 7- or 8-Substituted, partially hydrogenated pyrazolo[3,4-g]quinoline, thiazolo[4,5-g]quinoline, oxazolo[4,5-g]quinoline, and pyrrolo[3,4-g]quinoline derivatives, and 8- or 9-substituted, partially hydrogenated pyrido[2,3-g]quinazoline derivatives are D-2 dopamine agonists. 6-Oxo-1-substituted-octahydroquinolines and 6-oxo-1-substituted-decahydroquinolines which are additionally substituted in the 3- or 4-position are intermediates useful in preparation of the dopamine agonists. Acetals of 4,6-dioxo-1-substituted-decahydroquinoline 3-carboxylic acid esters enable synthesis of the foregoing compounds.
    Type: Grant
    Filed: October 5, 1990
    Date of Patent: July 28, 1992
    Assignee: Eli Lilly and Company
    Inventors: Diane L. Huser, John M. Schaus
  • Method of inhibiting gastric acid secretion
    Patent number: 5096908
    Abstract: The present invention provides a method of inhibiting gastric acid secretion in mammals by administering a 5-HT1A agonist compound or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 4, 1990
    Date of Patent: March 17, 1992
    Assignee: Eli Lilly and Company
    Inventors: Jaswant S. Gidda, John M. Schaus