Patents by Inventor John M. Schaus

John M. Schaus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for agonizing a dopamine receptor
    Patent number: 5057515
    Abstract: Trans-(.+-.)-2-(substituted)-6-(substituted)-5,5a,6,7,8,9,9a,10-octahydropy rido[2,3-g]quinolines are useful in treating a variety of disorders including Parkinsonism, anxiety, depression, hypertension, glaucoma, sexual dysfunction, and prolactin mediated disorders such as galactorrhea, amenorrhea, prolactinoma and the inhibition of postpartum lactation.
    Type: Grant
    Filed: January 8, 1991
    Date of Patent: October 15, 1991
    Assignee: Eli Lilly and Company
    Inventor: John M. Schaus
  • Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes
    Patent number: 5026707
    Abstract: This invention provides ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes which are selective inhibitors of serotonin reuptake.
    Type: Grant
    Filed: January 16, 1990
    Date of Patent: June 25, 1991
    Assignee: Eli Lilly and Company
    Inventors: James A. Nixon, Richard P. Pioch, John M. Schaus, Robert D. Titus
  • Dopamine agonists method
    Patent number: 5006525
    Abstract: Trans-(.+-.)-2-(substituted)-6-(substituted)-5,5a,6,7,8,9,9a,10-octahydropy rido[2,3-g]quinolines are useful in treating a variety of disorders including Parkinsonism, anxiety, depression, hypertension, glaucoma, sexual dysfunction, and prolactin mediated disorders such as galactorrhea, amenorrhea, prolactinoma and the inhibition of postpartum lactation.
    Type: Grant
    Filed: September 21, 1990
    Date of Patent: April 9, 1991
    Assignee: Eli Lilly and Company
    Inventor: John M. Schaus
  • Pyridoquinoline dopamine agonists, compositions and use
    Patent number: 4977149
    Abstract: Trans-(.+-.)-2-(substituted)-6-(substituted)-5,5a,6,7,8,9,9a,10-octahydropy rido[2,3-g]quinolines are useful in treating a variety of disorders including Parkinsonism, anxiety, depression, hypertension, glaucoma, sexual dysfunction, and prolactin mediated disorders such as galactorrhea, amenorrhea, prolactinoma and the inhibition of postpartum lactation.
    Type: Grant
    Filed: April 25, 1990
    Date of Patent: December 11, 1990
    Assignee: Eli Lilly and Company
    Inventor: John M. Schaus
  • BCD tricyclic ergoline part-structure analogues
    Patent number: 4977160
    Abstract: 7- or 8-Substituted, partially hydrogenated pyrazolo[3,4-g]quinoline, thiazolo[4,5-g]quinoline, oxazolo[4,5-g]quinoline, and pyrrolo[3,4-g]quinoline derivatives, and 8- or 9-substituted, partially hydrogenated pyrido[2,3-g]quinazoline derivatives are D-2 dopamine agonists. 6-Oxo-1-substituted-octahydroquinolines and 6-oxo-1-substituted-decahydroquinolines which are additionally substituted in the 3- or 4-position are intermediates useful in preparation of the dopamine agonists. Acetals of 4,6-dioxo-1-substituted-decahydroquinoline 3-carboxylic acid esters enable synthesis of the foregoing compounds.
    Type: Grant
    Filed: February 16, 1989
    Date of Patent: December 11, 1990
    Assignee: Eli Lilly and Company
    Inventors: Diane L. Huser, John M. Schaus
  • 2-oxo-pyrido[2,3-g]quinoline derivatives
    Patent number: 4939259
    Abstract: Trans-(.+-.)-2-(substituted)-6-(substituted)-5,5a,6,7,8,9,9a,10-octahydroph rido[2,3-g]quinolines are useful in treating a variety of disorders including Parkinsonism, anxiety, depression, hypertension, glaucoma, sexual dysfunction, and prolactin mediated disorders such as galactorrhea, amenorrhea, prolactinoma and the inhibition of postpartum lactation.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: July 3, 1990
    Assignee: Eli Lilly and Company
    Inventor: John M. Schaus
  • 6-Oxo-trans-octa- and decahydroquinolines
    Patent number: 4826986
    Abstract: 7- or 8-Substituted, partially hydrogenated pyrazolo[3,4-g]quinoline, thiazolo[4,5-g]quinoline, oxazolo[4,5-g]quinoline, and pyrrolo[3,4-g]quinoline derivatives, and 8- or 9-substituted, partially hydrogenated pyrido[2,3-g]quinazoline derivatives are D-2 dopamine agonists. 6-Oxo-1-substituted-octahydroquinolines and 6-oxo-1-substituted-decahydroquinolines which are additionally substituted in the 3- or 4-position are intermediates useful in preparation of the dopamine agonists. Acetals of 4,6-dioxo-1-substituted-decahydroquinoline 3-carboxylic acid esters enable synthesis of the foregoing compounds.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: May 2, 1989
    Assignee: Eli Lilly and Company
    Inventors: Diane L. Huser, John M. Schaus
  • 6 oxo-decahydroquinolines
    Patent number: 4778894
    Abstract: Tautomeric mixtures of trans-(.+-.)-3,5-dialkyloctahydropyrazolo[3,4-g]quinoline, of trans-(.+-.)-6-alkyloctahydropyrazolo[4,3-f]quinoline, and of trans-(.+-.)-1,6-dialkyloctahydropyrazolo[4,3-f]quinoline, individual enantiomer thereof, pharmaceutically-acceptable acid addition salts thereof, and intermediates useful in the preparation thereof, useful as hypotensive agents.
    Type: Grant
    Filed: April 23, 1986
    Date of Patent: October 18, 1988
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Diane L. Huser, Richard N. Booher
  • Octahydro-oxazolo[4,5-g]quinolines derivatives and decahydro quinoline intermediates and their use as dopamine D-2 agonists
    Patent number: 4698347
    Abstract: Trans-(.+-.)-2- and/or -5-permissibly substituted octahydro-oxazolo[4,5-g]quinolines, acid addition salts thereof and individual enantiomers thereof, useful as dopamine agonists or intermediates of the preparation of dopamine agonists.
    Type: Grant
    Filed: December 11, 1986
    Date of Patent: October 6, 1987
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Robert D. Titus
  • Process for the preparation of octahydro-oxazolo [4,5-G]quinolines
    Patent number: 4659832
    Abstract: Trans-(.+-.)-2- and/or -5-permissibly substituted octahydro-oxazolo[4,5-g]quinolines, acid addition salts thereof and individual enantiomers thereof, useful as dopamine agonists or intermediates of the preparation of dopamine agonists.
    Type: Grant
    Filed: June 10, 1985
    Date of Patent: April 21, 1987
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Robert D. Titus
  • Octa- and deca-hydroquinoline intermediates
    Patent number: 4647667
    Abstract: A 1-substituted-3-permissibly-substituted-6 (or 7)-oxodecahydroquinoline is converted to the corresponding 7 (or 6)-formyl derivative. The 6-oxo-7-formyl compound, upon treatment with hydrazine, is cyclized to a tautomeric mixture of 5-substituted-7-permissibly-substituted-4,4a,5,6,7,8,8a,9-octahydro-1H(and 2H)-pyrazolo[3,4-g]quinolines.
    Type: Grant
    Filed: September 16, 1985
    Date of Patent: March 3, 1987
    Assignee: Eli Lilly and Company
    Inventor: John M. Schaus
  • Trans-dl-1-alkyl-6-alkoxy-1,2,3,4,4a,5,8,8a octa-hydroquinolines
    Patent number: 4626591
    Abstract: A process for preparing 1-alkyl-6-oxodecahydroquinolines in 5 steps--a quaternization, hydrogenation, two organometallic reductions and hydrolysis of the thus formed enol ether--from 6-alkyloxyquinoline and intermediates useful therein.
    Type: Grant
    Filed: April 19, 1985
    Date of Patent: December 2, 1986
    Assignee: Eli Lilly and Company
    Inventor: John M. Schaus
  • Method of preparing 1-alkyl-7-oxodecahydroquinolines, and cis(.+-.) and tran(.+-.)isomers so prepared
    Patent number: 4600777
    Abstract: 1-C.sub.1-3 straight chain alkyl 7-oxodecahydroquinoline, chemical intermediates.
    Type: Grant
    Filed: August 2, 1984
    Date of Patent: July 15, 1986
    Assignee: Eli Lilly and Company
    Inventors: Diane L. Huser, John M. Schaus, Robert D. Titus, Leland O. Weigel
  • Pyrazole-ring alkylated pyrazoloquinolines
    Patent number: 4596871
    Abstract: Tautomeric mixtures of trans-(.+-.)-3,5-dialkyloctahydropyrazolo[3,4-g]quinoline, of trans-(.+-.)-6-alkyloctahydropyrazolo[4,3-f]quinoline, and of trans-(.+-.)-1,6-dialkyloctahydropyrazolo[4,3-f]quinoline, individual enantiomer thereof, pharmaceutically-acceptable acid addition salts thereof, and intermediates useful in the preparation thereof, useful as hypotensive agents.
    Type: Grant
    Filed: April 3, 1985
    Date of Patent: June 24, 1986
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Diane L. Huser, Richard N. Booher
  • Method of preparing octahydro-1H(and 2H)-pyrazolo[3,4-g]quinolines
    Patent number: 4567266
    Abstract: A 1-substituted-3-permissibly-substituted-6 (or 7)-oxodecahydroquinoline is converted to the corresponding 7 (or 6)-formyl derivative. The 6-oxo-7-formyl compound, upon treatment with hydrazine, is cyclized to a tautomeric mixture of 5-substituted-7-permissibly-substituted-4,4a,5,6,7,8,8a,9-octahydro-1H(and 2H)-pyrazolo[3,4-g]quinolines.
    Type: Grant
    Filed: August 2, 1984
    Date of Patent: January 28, 1986
    Assignee: Eli Lilly and Company
    Inventor: John M. Schaus
  • 1-Alkyl-6-pyrrolidino-octahydroquinolines
    Patent number: 4565871
    Abstract: Trans-(.+-.) or trans-(-)-2,4-permissibly-substituted-6-alkyl or allyl octahydropyrimido[4,5-g]quinolines and related compounds, ultraviolet light absorbers.
    Type: Grant
    Filed: December 11, 1984
    Date of Patent: January 21, 1986
    Assignee: Eli Lilly and Company
    Inventors: Cynthia L. Nicholas, Edmund C. Kornfeld, John M. Schaus
  • Method of preparing trans-D1-1-alkyl-6-oxodecahydroquinolines
    Patent number: 4540787
    Abstract: A process for preparing 1-alkyl-6-oxodecahydroquinolines in 5 steps--a quaternization, hydrogenation, two organometallic reductions and hydrolysis of the thus formed enol ether--from 6-alkyloxyquinoline and intermediates useful therein.
    Type: Grant
    Filed: August 10, 1983
    Date of Patent: September 10, 1985
    Assignee: Eli Lilly and Company
    Inventor: John M. Schaus
  • Method of preparing permissibly-substituted 1H(and 2H)pyrazolo[3,4-g]quinolines; pyrimido[4,5,g]quinolines; thiazolo[4,5,g]quinolines and intermediates therefore
    Patent number: 4537964
    Abstract: Trans-(.+-.)-1-permissibly-substituted-2,6-dioxodecahydroquinoline or enantiomers thereof, intermediates for preparing tautomeric trans-(.+-.)-5-permissibly substituted octahydro-1H(and 2H)pyrazolo[3,4-g]quinolines, 4aR,8aR or 4aS,8aS enantiomers thereof, for preparing trans-(.+-.)-5-permissibly substituted-octahydropyrazolo (or oxazolo)[4,5-g]quinoline, 4aR,8aR or 4aS,8aS enantiomers thereof or for preparing trans-(.+-.)-6-permissibly-substituted octahydropyrimido[4,5-g]quinolines, a 5aR,9aR or 5aS,9aS enantiomer thereof said racemic intermediates being comprised of stereoisomers of the following formulas ##STR1## wherein R is H, alkyl or C.sub.1-3 straight-chain alkyl.
    Type: Grant
    Filed: August 3, 1984
    Date of Patent: August 27, 1985
    Assignee: Eli Lilly and Company
    Inventor: John M. Schaus
  • 2-Mercaptopyrimidohexahydroquinolines and related compounds
    Patent number: 4507478
    Abstract: Trans-(.+-.) or trans-(-)-2,4-permissibly-substituted-6-alkyl or allyl octahydropyrimido[4,5-g]quinolines and related compounds, ultraviolet light absorbers.
    Type: Grant
    Filed: September 26, 1983
    Date of Patent: March 26, 1985
    Assignee: Eli Lilly and Company
    Inventors: Cynthia L. Nichols, Edmund C. Kornfeld, John M. Schaus
  • Method of resolving trans-d alpha-1-n-propyl-6-oxodecahydroquinoline and di-p-toluoyltartaric acid salts thereof
    Patent number: 4471121
    Abstract: Trans-dl-1-n-propyl-6-oxodecahydroquinoline is resolved via an optically active ditoluoyltartrate salt.
    Type: Grant
    Filed: November 3, 1982
    Date of Patent: September 11, 1984
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Richard N. Booher