Abstract: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.

Abstract: A method of manufacturing a steering rack bar (6) by forging, the method comprising the steps of pacing a heated cylindrical rack bar (6) in a first forging die (15) and forging a first toothed protion (37) at one end thereof; removing the rack bar; heating the rack bar at or near the other end of said rack; and placing the other end of the rack bar in a second forging die and forging a second toothed portion (39) wherein, prior to forging the second toothed portion, the rack bar is axially and angularly aligned to a predetermined axial location and angularly orientated utilising the first toothed portion or features at or near the one end of the rack bar as a datum, and placed and held in the predetermined axial location and angular orientation prior to forging of the second toothed portion.

Abstract: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.

Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

Abstract: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.

Abstract: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.

Abstract: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.

Abstract: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.

Abstract: A simple, relatively low-cost direct injection high efficiency nebulizer (DIHEN) is suitable for argon inductively coupled plasma (Ar ICP) spectrometry. The DIHEN may be operated at solution uptake rates of 1-100 .mu.L/min. Analytical performance indices for the DIHEN and fundamental characteristics of the aerosol produced are obtained using an ICP mass spectrometer (ICPMS) and a 2-dimensional phase Doppler particle analyzer (2D PDPA), respectively. Results are compared to those obtained with a conventional crossflow pneumatic nebulizer (PN), equipped with a Scott-type spray chamber. Droplet sizes and velocities produced with the DIHEN are smaller than those reported for the direct injection nebulizer (DIN). The DIHEN offers optimal sensitivity at low injector gas flow rates (approx. 0.25 L/min) and high RF power (approx. 1.5 kW). For the 17 elements tested, detection limits (ppt) and sensitivities achieved with the DIHEN (at 85 .mu.

Abstract: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.

Abstract: A forging die for forming a steering rack portion having teeth and two longitudinally extending guide faces from a blank. The die comprising first (18) and second (19) die members and four forming elements (52, 53, 54, 55) to converge on the blank. The first forming element (52) being on the second die member (19) for forming the teeth, the second (53) and third (54) forming elements being on the first die member (18) for forming the guide faces. The fourth forming element (55) slidable relative to the first die member (18) for forming a surface of the portion and connected to a first bias means (83, 84) allowing movement of the fourth forming element (55) during forging.

Abstract: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.

Abstract: An imaging lidar system for underwater applications is presented which is well suited for imaging and detecting underwater targets suspended above and on the bottom in shallow and coastal water. The present invention provides the capability for rapid and reliable search, detection, classification and localization of objects in the surf zone which may present hazards to navigation and utilization of coastal areas as well as undesirable effluents and biological fouling of underwater objects. The present invention provides an improved bottom tracker, improved ability to deal with brightness variation and surface glint, and computerized real time detection algorithms.

Abstract: An intrauterine device providing a membrane to cover substantially the entire surface of the uterine cavity, said device having a Y- and or V-shaped resilient member with two diverging arms, a membrane covering the entire area between the diverging arms and, in addition, extending above an imaginary line passing through the terminal ends of the arms, and a flexible tail or string connected to the intersection of the arms for aiding in the removal of the device from the uterus when desired. Optionally, the arms may having a plurality of flexible spurs extending therefrom for maintaining the intrauterine device in position within the uterus.

Abstract: An intrauterine device providing a membrane to cover substantially the entire surface of the uterine cavity, said device having a Y- or V-shaped resilient member with two diverging arms, a membrane covering the entire area between the diverging arms and, in addition, extending above an imaginary line passing through the terminal ends of the arms, and a flexible tail or string connected to the intersection of the arms for aiding in the removal of the device from the uterus when desired. The ends of the diverging arms have enlarged end portions and the arms are of unequal length so that the arms may be resiliently collapsed and placed in a tubular inserter with the enlarged end portions longitudinally spaced in the inserter.