Patents by Inventor John Mills

John Mills has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11992535
    Abstract: Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: May 28, 2024
    Assignee: CHDI Foundation, Inc.
    Inventors: Longbin Liu, Matthew Lee, Celia Dominguez, Peter David Johnson, Christopher John Brown, Sarah Hayes, Adrian Kotey, Matthew Robert Mills, Michael Edward Prime
  • Publication number: 20240148642
    Abstract: The present disclosure provides a cell housing device and a method of manufacturing such a device that has an array of channels to increase the ratio of surface area to volume.
    Type: Application
    Filed: January 18, 2024
    Publication date: May 9, 2024
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: CHRISTOPHER THANOS, Danya M. Lavin, Briannan E. Bintz, Divya Bhatnagar, John Mills, Megan Billings
  • Publication number: 20240142312
    Abstract: Described are techniques for quality analysis using thermographic imaging. In one example, a system including a test chamber for receiving an unpowered component. The system further includes an external heat source for heating the unpowered component for a predetermined period of time. The system further includes a thermographic imaging system for collecting thermographic images of the unpowered component during the predetermined period of time. The system further includes a computer communicatively coupled to the thermographic imaging system and configured to classify a quality of the unpowered component based on the thermographic images of the unpowered component.
    Type: Application
    Filed: October 28, 2022
    Publication date: May 2, 2024
    Inventors: John R. Dangler, Tory Johnson, GUNNAR MILLS, AUSTIN CARTER, Susan Zichittella, Colin Edward MASTERSON
  • Patent number: 11954995
    Abstract: Methods and systems for asset tagging bedding components and accessories in a sleep environment or manufacturing environment.
    Type: Grant
    Filed: March 30, 2022
    Date of Patent: April 9, 2024
    Assignee: DREAMWELL, LTD.
    Inventors: John-David Velilla, Tyler Marino, Garrison Mills
  • Patent number: 11951206
    Abstract: The present disclosure provides a cell housing device and a method of manufacturing such a device that has an array of channels to increase the ratio of surface area to volume.
    Type: Grant
    Filed: September 29, 2018
    Date of Patent: April 9, 2024
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Christopher Thanos, Danya M. Lavin, Briannan E. Bintz, Divya Bhatnagar, John Mills, Megan Billings
  • Publication number: 20240087547
    Abstract: A system for platform-independent visualization of audio content, in particular audio tracks utilizing a central computer system in communication with user devices via a computer network. The central system utilizes various algorithms to identify spoken content from audio tracks and identifies “great moments” and/or selects visual assets associated with the identified content. Audio tracks, for example Podcasts, may be segmented into topical audio segments based upon themes or topics, with segments from disparate podcasts combined into a single listening experience, based upon certain criteria, e.g., topics, themes, keywords, and the like.
    Type: Application
    Filed: November 3, 2023
    Publication date: March 14, 2024
    Inventors: John Ivers, Theo Rosendorf, Kevin Carlson, Michael Kakoyiannis, Sherry Mills
  • Publication number: 20240051985
    Abstract: Provided are compounds of Formula (I?) or (I) below, or pharmaceutically acceptable salts thereof, and methods for their use and production.
    Type: Application
    Filed: October 13, 2021
    Publication date: February 15, 2024
    Inventors: Matthew H. Daniels, Thomas Andrew Wynn, Brian Andrew Sparling, Ernest Allen Sickmier, Andrew Stewart Tasker, James Edward John Mills
  • Publication number: 20240033216
    Abstract: The present disclosure provides a cell housing device and a method of manufacturing such a device that has an array of chemicals to increase the ratio of surface area to volume.
    Type: Application
    Filed: September 21, 2023
    Publication date: February 1, 2024
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Christopher Thanos, Danya M. Lavin, Briannan E. Bintz, Divya Bhatnagar, John Mills, Megan Billings
  • Publication number: 20230101819
    Abstract: The present disclosure provides carboxamides and sulfonamides having Formula (I); and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
    Type: Application
    Filed: November 22, 2021
    Publication date: March 30, 2023
    Inventors: Megan Alene Cloonan FOLEY, Kevin Wayne KUNTZ, James Edward John MILLS, Lorna Helen MITCHELL, Michael John MUNCHHOF, Darren Martin HARVEY
  • Publication number: 20230027361
    Abstract: Provided are compounds of Formula (I?) or (II?), or pharmaceutically acceptable salts thereof, and methods for their use and production.
    Type: Application
    Filed: October 20, 2020
    Publication date: January 26, 2023
    Applicant: Accent Therapeutics, Inc.
    Inventors: Thomas Andrew Wynn, Brian Lewis Hodous, Paula Ann Boriack-Sjodin, Ernest Allen Sickmier, James Edward John Mills, Robert A. Copeland, Andrew Stewart Tasker, Matthew H. Daniels, Kenneth W. Duncan, Brian Andrew Sparling
  • Publication number: 20220372040
    Abstract: Provided are compounds of Formula (I?) or (I) below, or pharmaceutically acceptable salts thereof, and methods for their use and production.
    Type: Application
    Filed: October 22, 2020
    Publication date: November 24, 2022
    Applicants: Accent Therapeutics, Inc., Accent Therapeutics, Inc.
    Inventors: Thomas Andrew Wynn, Brian Lewis Hodous, Paula Ann Boriack-Sjodin, Ernest Allen Sickmier, James Edward John Mills, Andrew Stewart Tasker, Robert A. Copeland
  • Publication number: 20220324851
    Abstract: The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.
    Type: Application
    Filed: March 24, 2022
    Publication date: October 13, 2022
    Inventors: John Emmerson CAMPBELL, Kenneth William DUNCAN, James Edward John MILLS, Michael John MUNCHHOF
  • Publication number: 20220175511
    Abstract: The present disclosure relates to macroencapsulation devices and related methods of manufacture where the membranes of a device may be mounted to an associated frame in a relaxed, or slack, configuration prior to filling with a desired material.
    Type: Application
    Filed: April 2, 2020
    Publication date: June 9, 2022
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Christopher Thanos, Danya M. Lavin, John Mills, Megan Billings
  • Publication number: 20220143374
    Abstract: Macroencapsulation devices and their methods of use are disclosed. In one embodiment, a macroencapsulation device may include a first outer membrane, a second outer membrane, and at least one semipermeable membrane disposed there between to form at least a primary compartment configured to house a first population of cells and a secondary compartment in fluid communication with the primary compartment through the first semipermeable membrane. In some embodiments, the flow of material into and out of the compartments of the macroencapsulation device and/or the application of an appropriate pressure differential between the compartments may be used to control the flow of filtrates, ancillary agents, and other materials between the compartments of the device when positioned in vivo.
    Type: Application
    Filed: April 2, 2020
    Publication date: May 12, 2022
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Christopher Thanos, John Mills, Megan Billings
  • Publication number: 20220071183
    Abstract: The current invention describes a laboratory animal model for dirofilarial nematodes wherein said laboratory animal is fed a dietary admixture of laboratory feed containing an immunosuppressing agent, for example, a glucocorticoid. The invention also describes the use of the laboratory animal model for screening endoparasiticides for the treatment and/or prevention of filarial nematode infections in animals.
    Type: Application
    Filed: January 7, 2020
    Publication date: March 10, 2022
    Inventors: Brian John Mills, Tom L. McTier, Christopher S. Knauer, Debra Jean Woods
  • Publication number: 20220065639
    Abstract: One or more techniques and/or systems are provided for road segment ranking. Incident data associated with a first road segment is evaluated to determine an incident trend for the first road segment. Factors for the first road segment are identified. A first danger rating is assigned to the first road segment based upon the incident trend and the factors. The first danger rating is displayed on a display of a device.
    Type: Application
    Filed: September 3, 2020
    Publication date: March 3, 2022
    Inventors: Stephen Henry MISTELE, Kevin Tom ROONEY, Aidan James John MACKEY, Nicholas Anders TALLIS, Bryn John MILLS, Jeffrey Adam SUMMERSON
  • Publication number: 20210198252
    Abstract: The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such a SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
    Type: Application
    Filed: May 1, 2020
    Publication date: July 1, 2021
    Inventors: Megan Alene Cloonan Foley, Kevin Wayne KUNTZ, James Edward John MILLS, Lorna Helen MITCHELL, Michael John MUNCHHOF, Darren Martin HARVEY
  • Publication number: 20210198277
    Abstract: The present disclosure relates to amine-substituted aryl or heteroaryl compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., sickle cell anemia) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted aryl or heteroaryl compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.
    Type: Application
    Filed: November 20, 2020
    Publication date: July 1, 2021
    Inventors: John Emmerson CAMPBELL, Kenneth William DUNCAN, Megan Alene FOLEY, Darren Martin HARVEY, Kevin Wayne KUNTZ, James Edward John MILLS, Michael John MUNCHHOF
  • Patent number: 11035851
    Abstract: Methods of identifying potential skin moisturizing actives for the treatment of dry skin and method of formulating a moisturizing skin care composition using actives identified by the method. Moisturizing agents can be identified by comparing the transcriptional profile of a skin tissue sample contacted by a test agent to a negative or positive control to determine if the regulation of certain genes corresponds to the appropriate direction of regulation indicated by the control. Agents identified as skin moisturizing agents can then be incorporated into a skin moisturizing composition.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: June 15, 2021
    Assignee: The Procter & Gamble Company
    Inventors: Qing Stella, Michael Keith Robinson, Kevin John Mills
  • Publication number: 20210016073
    Abstract: Provided herein are devices, systems, and methods for subcutaneous membrane, encapsulation chamber, or reservoir implantation comprising or employing an implantation device configured to insert a membrane, encapsulation chamber, or reservoir into a subject.
    Type: Application
    Filed: March 12, 2019
    Publication date: January 21, 2021
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Christopher Thanos, Moses Goddard, Moses Sandrof, John Mills, Megan Billings