Abstract: A method of treating a skin condition including applying a rinse-off multi-phase cleansing composition including a cleansing phase including an anionic surfactant and zinc pyrithione and a benefit phase including a benefit agent.

Abstract: The present disclosure provides substituted piperidine compounds having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

Abstract: The present disclosure relates to amine-substituted aryl or heteroaryl compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., sickle cell anemia) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted aryl or heteroaryl compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Abstract: The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

Abstract: Methods and systems for constructing a gene expression signature representative of a number of biological conditions, systems and methods for determining functional relationships between a skin-active agent and skin conditions of interest, and methods and systems for identifying skin-active agents with broad spectrum activity are provided.

Abstract: Methods of identifying potential skin moisturizing actives for the treatment of dry skin and method of formulating a moisturizing skin care composition using actives identified by the method. Moisturizing agents can be identified by comparing the transcriptional profile of a skin tissue sample contacted by a test agent to a negative or positive control to determine if the regulation of certain genes corresponds to the appropriate direction of regulation indicated by the control. Agents identified as skin moisturizing agents can then be incorporated into a skin moisturizing composition.

Abstract: Provided are methods and systems for determining functional relationships between ex vivo skin models and an inflammatory skin condition. Also provided are methods and systems for identifying modulators of inflammation of skin, as well as the use of modulators identified by such methods or systems for the preparation of cosmetic compositions, personal care products, or both.

Abstract: The methods apparatuses described herein involve recovering of glycol from an aqueous phase to form a stream of recovered glycol and a glycol recovery system. The aqueous phase is fed to the top of a lower theoretical stage in a distillation column. An overhead vapor stream is drawn from the distillation column overhead of an upper theoretical stage, and a bottom stream comprising a stream of regenerated glycol is drawn from the distillation column via a bottom outlet configured below the lower theoretical stage. The stream of recovered glycol comprises the regenerated glycol. In addition, a first middle theoretical stage is situated within the distillation column gravitationally above the lower theoretical stage and below the upper theoretical stage. A side stream of liquid water is drawn from the bottom of the upper theoretical stage in the distillation column.

Abstract: The present disclosure provides substituted isoxazole carboxamide compounds having Formula (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, A, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

Abstract: Disclosed is a removable seat divider for placement in a seat. The removable seat divider includes a vertical structure configured to be placed on the seat along an approximate center of the seat. The vertical structure includes a first outer surface, second outer surface, top, and back portion, where the back portion of the vertical structure is configured to be placed adjacent to a back portion of the seat. The removable seat divider also includes a cavity located adjacent to the back portion, where the cavity connects the first outer surface to the second outer surface, and the cavity is configured to pass a seat belt through the cavity. The base back portion is configured to produce a restraining force against the seat that is proportional to a tension on the seat belt that passes through the cavity.

Abstract: The present disclosure relates to inserts for use with sandwich panels, such as composite panels, and related methods. Presently disclosed inserts may include a retention feature and/or an anti-rotation feature that may be configured to retain the insert in place within a bore formed in the sandwich panel. In this manner, presently disclosed inserts may be secured without the use of adhesive compounds, which may increase efficiency and/or reduce costs in manufacturing apparatus that include one or more sandwich panels having one or more inserts placed therein. Presently disclosed methods of installing an insert into a sandwich panel may include rotating the insert with respect to the sandwich panel as the insert is installed, such that a portion of the insert may be positioned under the skin of the sandwich panel (e.g., a portion of the insert may be positioned between the skin and the core of the sandwich panel).

Abstract: A method of treating a skin condition including applying a rinse-off multi-phase cleansing composition including a cleansing phase including an anionic surfactant and zinc pyrithione and a benefit phase including a benefit agent.

Abstract: A system and method of targeted tuning of a speech recognition system are disclosed. A particular method includes detecting that a frequency of occurrence of a particular type of utterance satisfies a threshold. The method further includes tuning a speech recognition system with respect to the particular type of utterance.

Abstract: The specification describes a cartridge for insertion into a meter, the interior of the meter comprising a boss having a main body and a protrusion extending from the main body. The cartridge comprises an orientation member provided at one end of the cartridge, the orientation member comprising a recess having a cross-sectional shape corresponding to that of the boss and configured to receive the boss therein, the orientation member further comprising a ramp surrounding at least part of the portion of the recess corresponding to the main body, the portion of the recess which corresponds to the protrusion adjoining the lower end of the ramp via a step.

Abstract: Systems and methods for processing audio are provided. The system may include a processor to convert an audio input received via a call to text. The processor may perform a comparison between a portion of the text to one or more phrases included in a table. The processor may also make a selection of at least one of a first object or a first action based on the comparison. The processor may further route the call based on the at least one of the first object or the first action.

Abstract: A cartridge for insertion into a meter comprises: a plurality of cartridge brackets disposed on an inner wall of the cartridge; a spindle mounted so as to be rotatable within the cartridge and movable longitudinally in first and second directions within the cartridge; and a plurality of testing members each arranged to be supported temporarily by at least one of the plurality of cartridge brackets, each of the testing members including a hole through which the spindle is located, the spindle having a plurality of spindle brackets disposed on an outer surface thereof, each spindle bracket being movable between first and second positions wherein in the first position the spindle bracket's distal end is at a first distance radially from the longitudinal axis of the spindle and wherein in the second position the spindle bracket's distal end is at a greater distance radially from the longitudinal axis of the spindle, and wherein when a given one of the spindle brackets is in the second position its distal end is l

Abstract: The present invention relates to the field of microbiological testing of food. It relates to a kit comprising a reaction medium containing at least one inhibitor of Gram-negative bacteria and a fluorescent substrate specific for PC-PLC. It further relates to a diagnostic kit for identifying bacteria of the Bacillus cereus group comprising a container of a selective or nonselective reaction medium with a pH between 6.8 and 8.0, the medium comprising at least one inhibitor of Gram-negative bacteria and a fluorescent phosphatidylcholine phospholipase C (PC-PLC) substrate.

Abstract: A cartridge (700) for insertion into a meter comprises: a plurality of cartridge brackets (704) disposed on an inner wall (703) of the cartridge; a spindle (702) mounted so as to be rotatable within the cartridge and movable longitudinally in first and second directions within the cartridge; and a plurality of testing members (708) each arranged to be supported temporarily by at least one of the plurality of cartridge brackets, each of the testing members including) a hole (306) through which the spindle is located, the spindle having a plurality of spindle brackets (706) disposed on an outer surface thereof, each spindle bracket being movable between first and second positions.

Abstract: The present application relates to an apparatus for eliciting a blood sample. The apparatus has a housing having an aperture. A shaft extends in the housing and a testing member is mounted on the shaft which rotates with the shaft. A lancing member is pivotably mounted to the testing member and a lancet protrudes from the lancing member. The lancing member is arranged to pivot relative to the testing member from a retracted position to a skin penetrating position in which the lancet extends into or through the aperture when the testing member is rotated so that the lancing member is coincident with the aperture.

Abstract: Systems and methods for processing audio are provided. The system may include a processor to convert an audio input received via a call to text. The processor may perform a comparison between a portion of the text to one or more phrases included in a table. The processor may also make a selection of at least one of a first object or a first action based on the comparison.