Abstract: The present disclosure provides a cell housing device and a method of manufacturing such a device that has an array of channels to increase the ratio of surface area to volume.

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Abstract: The present disclosure relates to inserts for use with sandwich panels, such as composite panels, and related methods. Presently disclosed inserts may include a retention feature and/or an anti-rotation feature that may be configured to retain the insert in place within a bore formed in the sandwich panel. In this manner, presently disclosed inserts may be secured without the use of adhesive compounds, which may increase efficiency and/or reduce costs in manufacturing apparatus that include one or more sandwich panels having one or more inserts placed therein. Presently disclosed methods of installing an insert into a sandwich panel may include rotating the insert with respect to the sandwich panel as the insert is installed, such that a portion of the insert may be positioned under the skin of the sandwich panel (e.g., a portion of the insert may be positioned between the skin and the core of the sandwich panel).

Abstract: The present disclosure provides substituted isoxazole carboxamide compounds having Formula (1) and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, A, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2 Compounds of the present disclosure are especially useful for treating cancer.

Abstract: The present disclosure provides substituted piperidine compounds having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

Abstract: The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmacentically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

Abstract: The present disclosure provides substituted isoxazole carboxamide compounds having Formula (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, A, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

Abstract: An apparatus for eliciting a blood sample comprises a housing, an aperture in a wall of the housing, an aperture cover moveable between a first position in which the aperture is covered and a second position in which the aperture is uncovered, the aperture cover comprising a sealing member configured to seal the aperture on a first side of the wall when the aperture cover is in the first position and a user-contactable part extending from the sealing member through the aperture to the second side of the wall and configured to allow a user to move the aperture cover between the first and second positions.

Abstract: The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

Abstract: An apparatus for eliciting a blood sample comprises a housing, an aperture in a wall of the housing, an aperture cover moveable between a first position in which the aperture is covered and a second position in which the aperture is uncovered, the aperture cover comprising a sealing member configured to seal the aperture on a first side of the wall when the aperture cover is in the first position and a user-contactable part extending from the sealing member through the aperture to the second side of the wall and configured to allow a user to move the aperture cover between the first and second positions.

Abstract: An anti-immunoglobulin specific antibody (or fragment thereof), characterised that the antibody or fragment thereof comprises one or more non-disulphide cross-links between at least one heavy chain or fragment thereof and at least one light chain or fragment thereof of the antibody or fragment thereof. A method purifying an anti-immunoglobulin specific antibody (or fragment thereof), characterised that the antibody or fragment thereof comprises one or more non-disulphide cross-links between at least one heavy chain or fragment thereof and at least one light chain or fragment thereof of the antibody or fragment thereof.

Abstract: An apparatus comprises a housing, a testing member rotatably mounted in the housing, a lancet protruding from an edge of the testing member and having a piercing end, and a cover configured to cover at least the piercing end of the lancet and to be displaced from the piercing end of the lancet during actuation of the testing member.

Abstract: A method for providing adaptive control of the flow of a plurality of ejector valves arranged in close proximity to each other in a sorting machine is described. The method comprises measuring a temporal response curve for each ejector valve, comparing the measured temporal response curve for each ejector valve to a library set of previously stored temporal response curves, determining from the comparison a predicted flow for each ejector valve, and adapting a drive signal for each ejector valve in dependence on the predicted flow. Temporal response curves may be measured and compared in a calibration (non-sorting) mode, and real-time feedback of the measured temporal responses in a sorting mode may be used to indicate health of a valve and to further adapt the drive signal to provide conformal performance. The number of neighboring ejector valves may also be taken into account.

Abstract: The present disclosure relates to inserts for use with sandwich panels, such as composite panels, and related methods. Presently disclosed inserts may include a retention feature and/or an anti-rotation feature that may be configured to retain the insert in place within a bore formed in the sandwich panel. In this manner, presently disclosed inserts may be secured without the use of adhesive compounds, which may increase efficiency and/or reduce costs in manufacturing apparatus that include one or more sandwich panels having one or more inserts placed therein. Presently disclosed methods of installing an insert into a sandwich panel may include rotating the insert with respect to the sandwich panel as the insert is installed, such that a portion of the insert may be positioned under the skin of the sandwich panel (e.g., a portion of the insert may be positioned between the skin and the core of the sandwich panel).

Abstract: A flight procedure criteria prototyping system and method is described herein. According to embodiments, the system is configured to generate a prototype, generate a dependency tree based on the prototype, wherein the dependency tree is comprised of one or more dependency tree nodes, translate the dependency tree into one or more construction steps, wherein there is a mapping between the one or more dependency tree nodes and the one or more construction steps, maintain an ordered list of the one or more construction steps, and generate one or more software specifications based on the one or more construction steps.

Abstract: The present disclosure relates to inserts for use with sandwich panels, such as composite panels, and related methods. Presently disclosed inserts may include a retention feature and/or an anti-rotation feature that may be configured to retain the insert in place within a bore formed in the sandwich panel. In this manner, presently disclosed inserts may be secured without the use of adhesive compounds, which may increase efficiency and/or reduce costs in manufacturing apparatus that include one or more sandwich panels having one or more inserts placed therein. Presently disclosed methods of installing an insert into a sandwich panel may include rotating the insert with respect to the sandwich panel as the insert is installed, such that a portion of the insert may be positioned under the skin of the sandwich panel (e.g., a portion of the insert may be positioned between the skin and the core of the sandwich panel).

Abstract: Methods and systems for determining functional relationships between a skin-active agent and a skin condition of interest, and methods and systems for identifying cosmetic agents effective for treatment of dandruff, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both are provided. Methods for developing in vitro models of skin disease and models for specific skin diseases are also provided.

Abstract: Methods and systems for constructing a gene expression signature representative of a number of biological conditions, systems and methods for determining functional relationships between a skin-active agent and skin conditions of interest, and methods and systems for identifying skin-active agents with broad spectrum activity are provided.

Abstract: A method of treating a skin condition including applying a rinse-off multi-phase cleansing composition including a cleansing phase including an anionic surfactant and zinc pyrithione and a benefit phase including a benefit agent.

Abstract: A meter configured to perform a blood analysis is presented where the meter has a housing, the housing having an aperture configured to receive a body part of a user. The meter also having a plurality of light sources supported by the housing and a controller configured to control the plurality of light sources to indicate an operational status of the apparatus.