Abstract: The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.

Abstract: A management system and method providing a flexible, iterative approach for conducting strategic consulting and planning engagements as well as application-based and custom system development projects. The system and method are intended to provide a unifying framework to both communicate planning and delivery approaches to clients and to enable collaboration among various personnel called upon to deliver a client solution. In one embodiment, said method includes creating a decision inventory and business process flow, identifying and designing models to inform decision yield and business architecture requirements; capturing baseline decision yield information; and quantifying potential improvements to the decision yield to determine a decision yield value proposition with said quantifying being based at least in part on said captured baseline decision yield information.

Abstract: An optical sensor assembly comprising a plurality of optical fibre sensor coils optically coupled by optical fibre; and an elongate support element, on which said plurality of optical fibre sensor coils and optically coupling optical fibre are mounted is disclosed. The support element has an elastic limit such that when said support element is bent from the elongate axis, the optical fibre fracture limit is reached before the elastic limit is reached. An array of these optical sensor assemblies, the mandrel on which the sensing coils are mounted and their method of manufacture are also disclosed.

Abstract: The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.

Abstract: A fibre-optic package comprises at least two fibre optic devices or components (102, 104, 106, 118, 120, 122, 124) coupled together by fused-fibre coupling. The package typically comprises two or more fibre optic accelerometers, and may be of reduced size compared to fibre-optics packages of the prior art, due to the reduced length of optical fibre required to connect the devices or components.

Abstract: System, method and computer program product for recovering from a failure of a computing device. Start up of a first component of the device is monitored and a determination is made whether the first component has started successfully. If so, a second, higher level component of the device is started. Operational data received from the second component is monitored. If the operational data falls outside of an operational boundary, an action is performed on the second component to enable the second component to operate within a preferred operational boundary. If the first component does not start up successfully, a determination is made if start up of the first component is critical to operation of the second component. If so, a corrective action is performed relative to the first component and afterwards, an attempt is made to start up the second component.

Abstract: This invention relates to N-aroyl cyclic amino derivatives and their use as pharmaceuticals.

Abstract: System, method and computer program product for recovering from a failure of a computing device. Start up of a first component of the device is monitored and a determination is made whether the first component has started successfully. If so, a second, higher level component of the device is started. Operational data received from the second component is monitored. If the operational data falls outside of an operational boundary, an action is performed on the second component to enable the second component to operate within a preferred operational boundary. If the first component does not start up successfully, a determination is made if start up of the first component is critical to operation of the second component. If so, a corrective action is performed relative to the first component and afterwards, an attempt is made to start up the second component.

Abstract: An intra-luminal device for the extraction of occlusive or partially occlusive material is disclosed. Said device comprises a novel catheter extension which minimizes cavitation of extracted fluids and also allows the better navigation of tortuous lumens or vasculature.

Abstract: Disclosed are piperazine bis-amide derivatives useful as antagonists of the orexin receptor and pharmaceutical compositions containing the same.

Abstract: A device suitable for removing material from a living being is provided, featuring at least an aspiration pump, powered by a motor. The aspiration pump and any optional infusate pump preferably feature a helical pumping mechanism, and operate at a high rate of rotation, thereby ensuring adequate pumping performance and flexibility. The helical pumping mechanism may be a helical coiled wire about a central core tube. The helical coil wire, whether together with, or independent of, the core tube, may be rotated to cause a pumping action. Additionally, a narrow crossing profile is maintained, ensuring that the device may reach more tortuous regions of the vasculature. In one embodiment, the system comprises a wire-guided mono-rail catheter with a working head mounted on a flexible portion of the catheter that can laterally displace away from the guide wire to facilitate thrombus removal.

Abstract: A system for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The method entails using an instrument to deploy the stent at occlusive material within the blood vessel to open the lumen, whereupon some debris may be produced. Operating a debris extraction system for removing debris during deployment of the stent.

Abstract: An optical sensor assembly including a coupler and an optical fibre coil. The coupler is attached to the central member of the cable at a position where outer layers of the cable been removed. A first terminal of the coupler is connected to an optical fibre traveling along the cable in a fibre conduit external to the central strength member. A second terminal of the coupler is connected to a first end of the coil and a third terminal of the coupler is connected to an optical fibre a mirrored end. The coil is supported about a tubular mandrel, which mandrel fits over the cable. The other end of the coil is attached to the fibre in the cable. The mandrel is located about the cable at a position covering the coupler and the part of the cable where the outer layers are removed.

Abstract: A vibration sensing device, package and system and a method of manufacturing a vibration sensing device are disclosed. The vibration sensing device comprises a body whose geometry is such that it exhibits flextensional properties.

Abstract: An attachment tool to facilitate the attachment of one or more catheters or similar elongated instruments to a guide-wire or other elongated guide member, without requiring access to either end of said wire or member. The tool provides repeatable and reliable alignment of components to be attached, while being operated with a single hand. The catheter systems can be used for revascularization or treatment of arteries and lumens within the body, and the associated delivery of therapies therein and can include side attachable and over-the-wire components and/or low profile combination catheters to allow for flush and extraction of debris in small or tortuous anatomic pathways.

Abstract: A system and method of use for effecting the bypass or other anastomosis, connection, or port in a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes a connector assembly and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The system includes a piercer-dilator instrument to form an opening in the wall of the vessel, duct, lumen or tubular organ into which a connector assembly may be deployed by the deployment instrument. The connector assembly may be at least partially formed of a resorbable material and includes movable members for securing it to the tissue of the vessel, duct, lumen or tubular organ contiguous with the opening. Other components may be included in the device for expediting the procedure, with or without the use of sutures.

Abstract: A device suitable for removing material from a living being is provided, featuring an infusate pump, and an aspiration pump, both powered by a motor. The aspiration pump and infusate pump preferably feature a helical pumping mechanism, and operate at a high rate of rotation, thereby ensuring adequate pumping performance and flexibility. Additionally, a narrow crossing profile is maintained, ensuring that the device may reach more tortuous regions of the vasculature. In one embodiment, the system comprises a wire-guided mono-rail catheter with a working head mounted on a flexible portion of the catheter that can laterally displace away from the guide wire to facilitate thrombus removal. The working head may be operated to separate and move away from the guide wire to come within a closer proximity of the obstructive material to more effectively remove it from the vessel.

Abstract: A vibration sensing device, an acceleration sensing system and a method of manufacturing a vibration sensing device wherein the vibration sensing device comprises a flexible disk that is mounted symmetrically about a radial plane and has a mass located on the disk substantially symmetrical about this radial plane which exerts a force that is greater towards the edge than it is towards the centre of the disk. The vibration sensing device is sensitive to on-axis signals and insensitive to cross axis signals.

Abstract: A multipurpose plate burner system is presented where a collection of components may be selected in combination to configure the system to achieve one of a selection of purposes. A combination selected from supports, pivots, pivot arms, trammel points, and wheels support a shaft over a workpiece. The cutting nozzle of a torch is supported by one of a selection of torch nozzle receptacles, providing for a range of perpendicular or angled cutting edges. The shaft supports the selected torch nozzle receptacle. Additional components may be optionally selected, such as a saddle support fitted on the shaft for supporting the torch tool and additional torch leveling supports. Depending on the combination of components selected, the plate burner system may be configured to cut circles with or without beveling, cut in obstructed locations, such as corners, cut along track lines, or perform protractor and other marking functions.

Abstract: A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being's vascular system. The system introduces an infusate liquid at a first flow rate to the occluded portion of the blood vessel, and withdraws that liquid and some blood at a second and higher flow rate. This action creates a differential flow in the occluded blood vessel portion and thereby prevent particles of occlusive material from flowing into any upstream blood vessel or downstream blood vessel in said living being's vascular system.