Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the LDHA gene, as well as methods of inhibiting expression of LDHA, methods of inhibiting LDHA and HAO1, and methods of treating subjects that would benefit from reduction in expression of LDHA, such as subjects having an oxalate pathway-associated disease, disorder, or condition, using such dsRNA compositions.

Abstract: Systems and methods for image generation are described. Embodiments of the present disclosure receive a text phrase that describes a target image to be generated; generate text features based on the text phrase; retrieve a search image based on the text phrase; and generate the target image using an image generation network based on the text features and the search image.

Abstract: Disclosed herein are glass-ceramic articles including a crystalline phase comprising a jeffbenite crystalline structure. The glass-ceramic articles may include a first surface, a second surface opposite the first surface, and a perimeter defining a shape of the glass-ceramic article. The glass-ceramic articles may further include a phase assemblage comprising one or more crystalline phases and a glass phase. The one or more crystalline phases may include a crystalline phase having the jeffbenite crystalline structure.

Abstract: The concepts and technologies disclosed herein are directed to time-aware blockchain staged regulatory control of Internet of Things (“IoT”) data. A federation platform can receive a registration request from an enterprise edge platform to register a blockchain identifier for publication of public data on a public blockchain. The federation platform can determine if the registration request contains any restricted data parameters. In response to determining that the registration request does not contain any restricted data parameters, the federation platform can query a security module to obtain an encryption key. The federation platform can receive the encryption key from the security module. The federation platform can store the encryption key in association with the blockchain identifier and an enterprise edge platform ID that uniquely identifies the enterprise edge platform.

Abstract: Methods for treating a neuropsychiatric disorder by administering an iboga alkaloid and a cardioprotective agent in conjunction with analysis of brain image data is described. Also described are methods to improve brain health and to slow or reverse brain aging by disorder by administering an iboga alkaloid and a cardioprotective agent, where analysis of brain image data is used to monitor and/or evaluate treatment effectiveness.

Abstract: Digital content layout encoding techniques for search are described. In these techniques, a layout representation is generated (using machine learning automatically and without user intervention) that describes a layout of elements included within the digital content. In an implementation, the layout representation includes a description of both spatial and structural aspects of the elements in relation to each other. To do so, a two-pathway pipeline that is configured to model layout from both spatial and structural aspects using a spatial pathway, and a structural pathway, respectively. In one example, this is also performed through use of multi-level encoding and fusion to generate a layout representation.

Abstract: Disclosed embodiments relate to apparatuses and methods for wound treatment. In certain embodiments, a negative pressure wound therapy apparatus includes one or more electronic components configured to be incorporated into layers of the wound dressing or integrated on top of the wound dressing. In some embodiments, a negative pressure source is incorporated into the wound dressing. The negative pressure source can be sealed between two moisture vapor permeable cover layers or enclosed in a moisture vapor permeable pouch, and may be received in a recess of an absorbent layer or spacer layer of a wound dressing apparatus.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for securely publishing and accessing a media's premium content. Methods include a media that comprises premium content encrypted with a first cryptographic key. The media also comprises data structures that include this key and the access entitlements. These data structures are encrypted using the key for each entity that can authorize user access to the media. Methods further include verifying user access to the media and then providing the decrypted premium content. Methods include decrypting the data structure using the authorizing entity's key and providing the first cryptographic key in the decrypted data structure to the client device, after verifying that the user has the appropriate access entitlements for the media. Methods include decrypting the premium content using the first cryptographic key and then displaying the media, including the decrypted premium content, on the client device.

Abstract: A glass composition includes greater than or equal to 45 mol % to less than or equal to 60 mol % SiO2; greater than or equal to 15 mol % to less than or equal to 25 mol % Al2O3; greater than or equal to 10 mol % to less than or equal to 20 mol % Li2O; greater than or equal to 0 mol % to less than or equal to 7.5 mol % Na2O; greater than or equal to 0 mol % to less than or equal to 5 mol % K2O; greater than or equal to 7 mol % to less than or equal to 13 mol % P2O5, and greater than or equal to 0 mol % to less than or equal to 4 mol % TiO2. The glass composition may have a liquidus temperature of less than or equal to 1300° C. and an inter-diffusion coefficient greater than or equal to 4000 ?m2/hour. The glass composition is chemically strengthenable. The glass composition may be used in a glass-based article or a consumer electronic product.

Abstract: A visual search system facilitates retrieval of provenance information using a machine learning model to generate content fingerprints that are invariant to benign transformations while being sensitive to manipulations. The machine learning model is trained on a training image dataset that includes original images, benign transformed variants of the original images, and manipulated variants of the original images. A loss function is used to train the machine learning model to minimize distances in an embedding space between benign transformed variants and their corresponding original images and increase distances between the manipulated variants and their corresponding original images.

Abstract: Battery cell monitoring systems comprising a flexible substrate and components integrated onto the flexible substrate, and methods of operating the same are disclosed. The components comprise a computing device and at least one sensor, where the at least one sensor is configured to generate sensor signals indicative of a physical state of the battery cell. The computing device is configured to hold characteristic data values which have been generated based on prior sensor signals. The computing device is configured to receive the sensor signals from the at least one sensor and to generate battery cell status data in dependence on the sensor signals and the characteristic data values.

Abstract: Disclosed embodiments relate to apparatuses and methods for wound treatment. In some embodiments, a negative pressure source is incorporated into a wound dressing apparatus so that the wound dressing and the negative pressure source are part of an integral or integrated wound dressing structure that applies the wound dressing and the negative pressure source simultaneously to a patient's wound. The negative pressure source and/or electronic components may be positioned between a wound contact layer and a cover layer of the wound dressing. A component may be used to prevent wound exudate from contacting the inlet of the negative pressure source.

Abstract: Digital content layout encoding techniques for search are described. In these techniques, a layout representation is generated (using machine learning automatically and without user intervention) that describes a layout of elements included within the digital content. In an implementation, the layout representation includes a description of both spatial and structural aspects of the elements in relation to each other. To do so, a two-pathway pipeline that is configured to model layout from both spatial and structural aspects using a spatial pathway, and a structural pathway, respectively. In one example, this is also performed through use of multi-level encoding and fusion to generate a layout representation.

Abstract: Methods of performing post-manufacturing adaptation of a data processing apparatus manufactured in accordance with a processor design and corresponding data processing apparatus configurations are provided. Post-manufacturing testing of the data processing apparatus determines any dysfunctional instructions by comparison between component usage profiles for each instruction and a component fault-detection procedure applied to the data processing apparatus. The data processing apparatus can be determined nevertheless to be operationally viable when any dysfunctional instructions can be substituted for by emulation using other functional instructions. The data processing apparatus can be provided with dysfunctional instruction handling circuitry configured to identify occurrence of a program instruction instance of a dysfunctional instruction and to invoke an interrupt handling routine associated with the dysfunctional instruction to emulate the instance of a dysfunctional instruction.

Abstract: A method of planning a coverage path to cover an area. The method includes a computing arrangement iteratively receiving, generating and displaying. The computing arrangement is configured to receive a range acceptable user-inputs. The receiving includes receiving user-input within the range of acceptable user-inputs. The generating includes generating a feasible coverage path based on the user-input. The displaying includes displaying at least some detail of the feasible coverage path.

Abstract: A glass-ceramic article includes a crystalline phase comprising stuffed ?-quartz and gahnite and a residual glass phase. The glass-ceramic has a composition comprising: greater than or equal to 69.5 mol % and less than or equal to 85 mol % SiO2; greater than or equal to 7 mol % and less than or equal to 20 mol % Al2O3; greater than or equal to 4.5 mol % and less than or equal to 12 mol % ZnO: greater than or equal to 1 mol % and less than or equal to 8 mol % LizO; and greater than or equal to 0.5 mol % and less than or equal to 4 mol % ZrO2.

Abstract: A glass composition includes: greater than or equal to 45 mol % and less than or equal to 70 mol % SiO2; greater than or equal to 5 mol % and less than or equal to 15 mol % Al2O3; greater than or equal to 5 mol % and less than or equal to 15 mol % B2O3; greater than or equal to 5.5 mol % and less than or equal to 15 mol % Li2O; and greater than or equal to 0.5 mol % and less than or equal to 12 mol % MgO. RO may be greater than or equal 5.5 mol % and less than or equal to 14 mol %, wherein RO is the sum of MgO, CaO, BaO, and SrO. The glass composition may be free of at least one of La2O3 and Yb2O3. The glass composition may be phase separable.

Abstract: Apparatuses and methods of operating such apparatuses are disclosed. An apparatus comprises feature dataset input circuitry to receive a feature dataset comprising multiple feature data values indicative of a set of features, wherein each feature data value is represented by a set of bits. Class retrieval circuitry is responsive to reception of the feature dataset from the feature dataset input circuitry to retrieve from class indications storage a class indication for each feature data value received in the feature dataset, wherein class indications are predetermined and stored in the class indications storage for each permutation of the set of bits for each feature. Classification output circuitry is responsive to reception of class indications from the class retrieval circuitry to determine a classification in dependence on the class indications. A predicated class may thus be accurately generated from a simple apparatus.

Abstract: A negative pressure wound therapy system can include a source of negative pressure negative pressure configured to aspirate fluid from a wound covered by a wound dressing and electronic circuitry with a power source, boost converter circuitry configured to receive power at a first level from the power source and supply power at a second level to the source of negative pressure, the second level being higher than the first level, and a controller configured to, in response to a determination that a capacity of the power source is being depleted, cause the boost converter circuitry to supply power to the source of negative pressure at a third level lower than the second level. The controller can further lower a target negative pressure level associated with negative pressure provided by the source of negative pressure.

Abstract: Disclosed embodiments relate to apparatuses for wound treatment. In certain embodiments, a negative pressure wound therapy apparatus includes one or more electronic components configured to be incorporated into layers of the wound dressing or integrated on top of the wound dressing. In some embodiments, a negative pressure source is incorporated into the wound dressing. The negative pressure source can be sealed between two moisture vapor permeable cover layers or enclosed in a moisture vapor permeable pouch, and may be received in a recess of an absorbent layer or spacer layer of a wound dressing apparatus.