Abstract: Described herein are devices and methods for irrigating and suctioning fluids from the lumens or cavities of a mammalian body. The devices include a malleable irrigation tube and a suction tube that is slidably mounted upon the irrigation tube.

Abstract: In some embodiments, a crossbow comprises a frame, a bow portion comprising a bowstring, a latch and a trigger. An arrow rest is supported by the frame at a first location. The frame is also arranged to support the arrow rest at a second location. A distance between the latch and the first location is different from a distance between the latch and the second location.

Abstract: Dynamic and self-healing optimized traffic rerouting is provided. A system and method are described for determining and implementing optimized traffic routing decision. A route orchestration system monitors network resource performance characteristics information for identifying a traffic redirection triggering event and for determining an optimized traffic control decision based on the network resource performance characteristics information. The decision may include software defined networking (SDN) instructions that may be communicated to one or more network resources (e.g., PE devices, P devices, and/or routers) that may cause traffic to be rerouted the one or more targeted servers. For example, the optimized traffic control decision may be determined to improve load balancing amongst performing servers and other network resources in the network while reducing or minimizing administrative costs.

Abstract: A monitoring system may include a processor and display system for displaying results from the monitoring. A user may be in a sterile field away from the processor and display system and selected input devices. A controller may be physically connected to the monitoring system from the sterile field to allow the user to control the monitoring system.

Abstract: Systems and methods are provided for automatically actuating preexisting water shut-off valves upon detection of leak conditions. A coupling of a valve actuator is connected to a handle of the valve, such that a motor of the valve actuator causes the selective opening and closing of the valve. A controller obtains water flow data from a non-intrusive flow sensor (e.g., an ultrasonic sensor) clamped onto a pipe attached to the valve in close proximity thereto, as well as obtaining additional sensor data from remote sensors disposed elsewhere in the water supply system (e.g., pressure levels measured by an in-line pressure sensor). When the controller determines a leak condition exists based upon the water flow data and the additional sensor data, it controls the actuator to close the valve. The controller may also test for leaks by periodically shutting the valve and measuring the pressure while the valve is shut.

Abstract: Various embodiments of the systems, methods, and devices are provided for controlled operation of an intravascular lithotripsy (“IVL”) system for breaking up calcified lesions in an anatomical conduit. More specifically, control arrangements are disclosed concerning managing and/or providing electrical energy to generate an electrical arc between a set of spaced-apart electrodes disposed within a fluid-fillable member, wherein the IVL system may be powered by an AC power source and/or a DC power source.

Abstract: Various embodiments of the systems, methods, and devices are provided for controlled operation of an intravascular lithotripsy system for breaking up calcified lesions in an anatomical conduit. More specifically, control arrangements are disclosed concerning managing and/or providing electrical energy to generate an electrical arc between a set of spaced-apart electrodes disposed within fluid-fillable member are disclosed.

Abstract: In a memory system, receiver reference voltage adjustment per path provides the capability to adjust receiver reference voltages on a per path basis. Adjustment of receiver reference voltages for the memory device to an optimal receiver reference voltage per path is accomplished with dedicated mode registers and a local receiver voltage reference adjuster circuit in the memory device for each data path. The optimal receiver reference voltage is determined during training based on selected feedback per path from the memory device. The dedicated mode registers contain adjustment values that were previously programmed during training, and include adjustments steps to add to or subtract from a global receiver reference voltage for all paths until reaching the optimal receiver reference voltage for a current path.

Abstract: Provided herein are novel anti-CD28× anti-PSMA antibodies and methods of using such antibodies for the treatment of PSMA-associated cancers. Subject anti-CD28× anti-PSMA antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and PSMA on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful in combination with other anti-cancer therapies (e.g., anti-CD3× anti-PSMA antibodies) for the treatment of prostate cancers.

Abstract: A hideable security key for a vehicle comprises a protective body which receives a fastening member configured to hold the hideable security key to an externally-accessible surface of the vehicle. A near-field communication (NFC) antenna is disposed in the protective body. An NFC controller is disposed in the protective body and is configured to drive a security key signal to the NFC antenna. A set of code entry elements are supported on the protective body adapted for manipulation by a user to input a predetermined passcode. The NFC controller is inhibited from driving the security key signal to the NFC antenna unless the user first inputs the predetermined passcode.

Abstract: A near-field communication (NFC) reader is integrated with a display panel in a passenger cabin of a vehicle by constructing a hidden antenna of the reader into a portion of the display panel. The display comprises a touchscreen display providing a display surface coincident with a touch-sensitive input detector. A trigger monitor is configured to detect a user activity by a user which is indicative of a potential for the user to attempt pairing of a mobile NFC device with the hidden antenna. A positioning messenger is configured to generate a depiction on the display surface indicating a region to be covered on the display surface by the mobile NFC device to align a mobile antenna on the mobile NFC device with the hidden antenna. The NFC device may be a smartphone, a key fob, or an NFC transponder card.

Abstract: An on-demand security inspection system is provided for dispatching an investigator to a target dwelling. The investigator (e.g., a police officer) carries a video camera (e.g., a body cam). The inspection system comprises a service management server, a requestor interface, and an investigator interface. The requestor interface is configured to link a user to the service management server in order to specify a checklist. The investigator interface is configured to link a mobile unit (e.g., a vehicle control module or a handheld mobile unit) to the service management server in order to (1) communicate a plurality of checklist prompts to the mobile unit, and (2) return video data from the video camera captured according to the checklist prompts.

Abstract: Various embodiments of the systems, methods, and devices are provided for controlled operation of IVL for breaking up calcified lesions in an anatomical conduit. More specifically, control arrangements are disclosed concerning managing and/or providing electrical energy to generate an electrical arc between a set of spaced-apart electrodes disposed within a fluid-filled balloon, creating stable and constant, or slightly increasing, pressure output over at least 300 voltage pulses. Control arrangements disclosed further determine whether an electrical arc was successfully generated.

Abstract: The present disclosure relates to pounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating DNA polymerase ? activity and may be used in the treatment of disorders in which DNA polymerase ? activity is implicated, such as cancer.

Abstract: The present disclosure generally relates to the manufacture and sealing of containers formed of metallic material or glass with metallic closures, and more specifically to an apparatus and methods used to seal containers with a Roll-on Pilfer Proof (ROPP) closure or a prethreaded closure. The closure includes a floating liner that is not attached to the closure such that the liner can move relative to a lower surface of the closure. The floating liner may comprise a polymer, a metal, a high-durometer material, and/or an elastic material. The floating liner includes an inner plug seal that seals or seats on an inner surface of a curl of the container. The floating liner can optionally include an outer alignment support configured to align with and/or be positioned adjacent to an outer surface of the curl.

Abstract: A vehicular camera includes a lens having a plurality of optical elements, a lens holder, and an imager printed circuit board. The lens is accommodated in a lens barrel. A cylindrical passageway of the lens holder accommodates at least a portion of the lens barrel. The imager printed circuit board has circuitry disposed thereat. The circuitry of the imager printed circuit board includes an imager that has an imaging array. A flexible electrical ribbon cable electrically connects the circuitry of the imager printed circuit board with additional circuitry of the vehicular camera. The lens is held in optical alignment with the imaging array of the imager via an adhesive. The adhesive may bond the lens barrel to the lens holder at its front side. The imager printed circuit board may be attached at the lens holder at its rear side.

Abstract: An aerator for a turf surface has a traction control, an OPC bail, and an aeration bail capable of single handed operation. A controller automatically lowers a tine head to begin aerating at a start location marked when the aeration bail is closed and lifts the tine head to end aeration at an end location marked when the aeration bail is released. The controller further causes the tines that enter the turf surface at the start location to penetrate to a desired hole depth. The controller also automatically adjusts ground speed to maintain a desired hole spacing during an aeration pass, but permits the operator to speed up during a turnaround between passes with a steerable front wheel freewheeling to mitigate wheel scrubbing. A handle assembly having a spring counterbalance is height adjustable and automatically engages a parking brake when placed in an upright non-operating position.

Abstract: The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.

Abstract: A sump pump system may implement adaptive learning and machine learning techniques to facilitate improved control of sump pumps. A sump pump system may implement the described techniques to generate, train, and/or implement a machine learning model that is capable of predicting or estimating one or more conditions of the sump pump system (e.g., water level in the basin, motor malfunction, stuck impeller, geyser effect, blocked outlet pipe, faulty level sensor/switch, faulty bearing, failure to engage pump at high-water mark, etc.) based on one or more detected input variables (e.g., acceleration or vibration patterns detected in water, on a pump, or on a pipe; capacitance values of water; audio signatures; electrical signatures, such as power or current draw; pump motor rotation speed; water pressure signatures or values, such as those detected at the bottom of a sump basin; etc.).

Abstract: A crane includes a lower works having one or more ground engaging elements, an upper works connected to the lower works, the upper works having a boom, and a system for determining a crane status. The system includes a sensor assembly positioned to have a line of sight along at least a portion of a length of the boom or the lower works. The sensor assembly configured to detect light transmission and output sensor information. The system further includes a computer configured to receive the sensor information and determine the crane status based on the sensor information. A method of determining the crane status is also provided.