Abstract: Provided herein are methods for the treatment of polycystic kidney disease, including autosomal dominant polycystic kidney disease, using modified oligonucleotides targeted to miR-17.

Abstract: A resilient coin sorting pad for imparting motion to a plurality of coins is provided, the resilient coin sorting pad designed to be coupled to a rotatable disc of a coin sorter, the resilient coin sorting pad being generally circular and having an outer periphery edge. The resilient coin sorting pad comprises a lower foam layer having a top surface, an upper skin layer coupled to the top surface of the foam layer, and a layer of mesh material. According to some embodiments, the upper skin layer comprises at least one layer of nitrile rubber and the layer of mesh material is nylon fiber mesh. According to some embodiments, the upper skin layer comprises at least two layers of nitrile rubber and the layer of mesh material is positioned between the at least two layers of nitrile rubber.

Abstract: A music analysis and recommendation system (“the system”) is configured to receive and analyzing data associated with a song performed by a performer. The system also accesses a current contextual information repository to identify a current cultural paradigm and maps the current cultural paradigm to a historical contextual information repository to identify one or more historical periods that have a cultural paradigm matching the current cultural paradigm. The system then identifies one or more hit songs during the one or more historical periods and retrieves data associated with the one or more hit songs. The data associated with the song performed by the performer is compared with data associated with each of the hit songs to determine a similarity. Based upon the determined similarities, the system determines a likelihood of the song becoming a hit song and/or a likelihood of the performer becoming a hit song performer.

Abstract: Stimulation and recording electrode assemblies that are particularly useful for Automatic Period Stimulation (APS). Such embodiments are compatible with nerve monitoring systems to provide continuous stimulation of a nerve during surgery. Certain embodiments include an electrode assembly having cuff including a body and two ears extending from the body. Within the body, at least one electrode is supported and connected to a lead wire assembly. The ears can be brought together to enlarge a gap in the body so that the electrode assembly can be fixated around a nerve. Other embodiments include an electrode assembly including first and second needle electrodes that each have a tip. A body is provided to interconnect the needle electrodes and can be manipulated to move the tips either toward or away from one another. Disclosed embodiments provide nerve monitoring and stimulation in cases where the nerve is only partially dissected.

Abstract: A coated urinary catheter or urinary stent device includes a urinary catheter or stent which, in a deployed position, includes or defines a protective surface area and a protected surface area and a coating upon at least a portion of the protective surface area. The coating includes a lubricant and an antimicrobial and/or pH buffering material. The device is configured such that, upon application of negative pressure to the catheter or stent, tissue of a urinary tract of a patient conforms or collapses onto the protective surface area and is thereby prevented or inhibited from occluding one or more protected drainage holes, ports or perforations of the catheter or stent.

Abstract: Currency processing systems, coin processing machines, coin sorting and recycling assemblies, and methods of making and methods of using the same are presented herein. A currency processing system is disclosed which includes a housing with a coin input area for receiving coins and coin receptacles for stowing processed coins. A disk-type coin processing unit includes a rotatable disk for imparting motion to input coins, and a sorting head for separating and discharging coins from exit stations. An automated coin chute receives coins from one of the exit stations. The automated coin chute includes a movable diverter plate that selectively transitions between a first position, whereby coins received from the exit station of the disk-type coin processing unit are redirected through a coin-recycling output passage to a coin-recycling receptacle, and a second position, whereby coins received from the exit station are redirected through a coin-depositing output passage to a coin-depositing receptacle.

Abstract: The present invention provides a disposal splash guard that enables water flowing into the disposal splash guard to be directed through peripheral openings in the disposal splash guard. The disposal splash guard comprises a body and a baffle. A size of the peripheral openings is operable to direct water flowing into the disposal splash guard through the peripheral openings in the baffle. At least one of a shape of the body and a shape of the baffle is operable to direct water flowing into the disposal splash guard through the peripheral openings in the baffle. At least one of a size of the peripheral openings, a shape of the body, and a shape of the baffle is operable to direct at least ten percent of water flowing into the disposal splash guard through the peripheral openings in the baffle.

Abstract: A tissue retractor comprising an outer ring, an inner ring, and a flexible, metal sheath extending therebetween is described. Embodiments of the inner ring comprise a flat or wedge-shaped conformation useful for insertion between muscle layers. Other embodiments of the inner ring include variable diameter inner rings, where the diameter can be adjusted as required and optionally locked into place, and reshapeable inner rings that permit a user to conform the inner ring to the anatomy of the patient when placing the inner ring.

Abstract: In some embodiments, an arrow comprises a shaft, a nock and a structural asymmetry orienting a weak bending axis of the arrow.

Abstract: A patient data management platform, e.g., a community paramedicine platform, which may also be referred to as a mobile integrative health platform or system, may include a web-based, cloud-based, and/or software-based system for tracking patients and patient visits by health care providers, paramedics or other emergency medical services (“EMS”) professionals in an out of hospital, mobile, and/or non-emergency context. Such a platform performs functions and data input, visit logging, and reporting tasks that are distinct from that of a traditional EMS electronic patient care reporting system.

Abstract: The present disclosure relates to a golf tee, comprising: (a) a top portion connected to a bottom portion through a stem portion, wherein the top portion comprises one or more ball positioning elements that extend outwardly from the top portion, and wherein the top portion is configured to receive a golf ball with the one or more ball positioning elements; (b) the stem portion having an elongated body and comprising a first end connected to the top portion and a second end connected to the bottom portion; and (c) wherein the bottom portion has a blade shape that is thickest at a point where the bottom portion connects to the stem portion and narrows as the bottom portion extends further away from the top portion, wherein the bottom portion is configured to position the golf tee into the ground.

Abstract: A tissue specimen removal device comprises a specimen bag; a flexible ring, the flexible ring configured to form a top opening of the specimen bag; a cannula assembly comprising: an inner tube portion and an outer tube portion. The device may further comprise a connector carrier, the connector carrier configured to retain at least one connector housing, the at least one connector housing comprising one or more connector portions and reside within an interior of the connector carrier, and wherein the connector carrier can be moved from a position within the cannula assembly to outside the cannula assembly.

Abstract: A roll for an agricultural baler includes an interior tube and an exterior tube surrounding and connected to the interior tube. The exterior tube has an exterior surface and a plurality of loops extending from the exterior surface of the exterior tube.

Abstract: Ethylene-based polymers are generally characterized by a high load melt index of less than 12 g/10 min, a weight-average molecular weight from 200,000 to 550,000 g/mol, a number-average molecular weight from 18,000 to 48,000 g/mol, a CY-a parameter of less than 0.12, a tan ? at 0.1 sec?1 from 0.5 to 0.9 degrees, a tan ? at 100 sec?1 from 0.5 to 0.75 degrees, and a viscosity at 0.001 sec?1 from 1.3×106 to 1×107 Pa-sec. These ethylene polymers can be produced by peroxide-treating a bimodal molecular weight distribution dual metallocene-catalyzed resin, and can be used to produce blow molded bottles and other blow molded products.

Abstract: A laser alignment system for adjusting a mounting bracket of a lamp is disclosed. The laser alignment system includes an alignment bracket including a body portion defining one or more target features and a plurality of index features. The one or more target features include a target that is configured to align with a laser beam and the plurality of index features that are configured to position the alignment bracket along a surface. The laser alignment system also includes a laser alignment tool including a base, a mount, and a laser device. The mount holds the laser device in place and the laser device is configured to emit the laser beam, and the base of the laser alignment tool is shaped to fit within the mounting bracket for the lamp and the laser device directs the laser beam towards a corresponding one of target features of the alignment bracket.

Abstract: A filter arrangement for threadably securing to a filter head includes a housing having a surrounding wall defining an interior volume, an open mouth providing access to the interior volume and an end opposite of the open mouth. The surrounding wall has an exterior and an interior. A filter media construction is operably held within the interior volume. A sleeve, distinct from the housing, is secured to the exterior of the surrounding wall adjacent to the housing mouth and extending partially along the surrounding wall. The sleeve has an exterior and an interior. The exterior of the sleeve defines mounting threads constructed and arranged to removably mount with the filter head, when the filter arrangement is secured to the filter head. The interior of the sleeve is against the exterior of the surrounding wall. A first seal member is oriented against the sleeve to create a seal with a filter head, when the filter arrangement is secured to the filter head.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: A percutaneous urinary catheter configured to be deployed in a urinary tract, including: (a) a proximal portion; and (b) a distal portion including a retention portion configured to be deployed in a kidney and/or a renal pelvis, the retention portion including one or more drainage holes leading to one or more lumen(s) within the proximal portion, wherein the retention portion, when deployed, defines a three-dimensional shape sized and positioned to maintain patency of fluid flow between the kidney and/or renal pelvis and a proximal end of the catheter by inhibiting mucosal tissue from appreciably occluding the one or more drainage holes when negative pressure is applied through the catheter.

Abstract: Disclosed embodiments include nuclear fission reactor cores, nuclear fission reactors, methods of operating a nuclear fission reactor, and methods of managing excess reactivity in a nuclear fission reactor.

Abstract: Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.