Abstract: The disclosure provides methods of treating a malignancy comprising administering an effective dose of a chimeric antigen receptor genetically modified T cell immunotherapy and methods for manufacturing such immunotherapy. Some aspects of the disclosure relate to methods of determining objective response of a patient to a T cell immunotherapy based on the levels of attributes prior to and after administration of the immunotherapy to the patient.

Abstract: Provided herein are methods for preparing, producing, processing, culturing, isolating, or making cells suitable for immune or cell therapy, and for their use in cell therapy.

Abstract: Disclosed herein are conditional siRNAs activatable by pro-hypertrophic RNA sequences and use thereof for treating conditions such as cardiac hypertrophy. The conditional siRNAs target calcineurin or HDAC2.

Abstract: A system and method for building and assembling parts of or entire modular structures such as dwelling units, marine structures or watercraft from recycled PET material panels. Each assembly is made from panels of recycled PET material having a core and a rigid skin on both faces of the panel. The panels are joined together with splines of the same type of panel material. The splines may be glued and or fastened in place. The panels provide the necessary rigidity and insulative qualities for construction and watercraft manufacture and may be painted. The panels are impervious to environmental elements as well as to insects.

Abstract: A fluid ejection controller interface includes input logic to receive control data packets and a first clock signal, each control data packet including a set of primitive data bits and a set of random bits, wherein the input logic identifies the random bits in the received control data packets to facilitate the creation of modified control data packets. The fluid ejection controller interface includes a clock signal generator to generate a second clock signal that is different than the first clock signal, and output logic to receive the modified control data packets, and output the modified control data packets to a fluid ejection controller of a fluid ejection device based on the second clock signal.

Abstract: An integrated circuit to drive a plurality of fluid actuation devices includes a strain gauge sensor, an amplifier, and a voltage bias generator. The strain gauge sensor generates a strain gauge signal. The amplifier amplifies the strain gauge signal. The voltage bias generator offsets the amplified strain gauge signal.

Abstract: A fluid ejection controller interface includes input logic to receive control data packets and a first clock signal, each control data packet including a set of primitive data bits and a set of random bits, wherein the input logic identifies the random bits in the received control data packets to facilitate the creation of modified control data packets. The fluid ejection controller interface includes a clock signal generator to generate a second clock signal that is different than the first clock signal, and output logic to receive the modified control data packets, and output the modified control data packets to a fluid ejection controller of a fluid ejection device based on the second clock signal.

Abstract: A print component includes an array of fluidic actuation structures including a first column of fluidic actuating structures addressable by a set of actuation addresses, each fluidic actuating structure having a different one of the actuation addresses and having a fluidic architecture type, and a second column of fluidic actuating structures addressable by the set of actuation addresses. Each fluidic actuating structure of the second column has a different one of the actuation addresses and has a same fluidic architecture type as the fluidic actuating structure of the first column having the same address. An address bus communicates the set of addresses to the array of fluidic actuating structures, and a fire signal line communicates a plurality of fire pulse signal types to the array of fluidic actuating structures, the fire pulse signal type depending on the actuation address on the address bus.

Abstract: The present invention relates to compositions comprising TWIST signaling inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.

Abstract: In some examples, a controller includes an interface to receive an indication based on an electrical current through a device, and a processor to send control data to the device to operate the device, detect a measurement based on the indication that is responsive to an operation of the device according to the control data, and determine whether an issue exists in the device responsive to determining whether the measurement satisfies an expected property based on the control data.

Abstract: A print component includes an array of fluidic actuation structures including a first column of fluidic actuating structures addressable by a set of actuation addresses, each fluidic actuating structure having a different one of the actuation addresses and having a fluidic architecture type, and a second column of fluidic actuating structures addressable by the set of actuation addresses. Each fluidic actuating structure of the second column has a different one of the actuation addresses and has a same fluidic architecture type as the fluidic actuating structure of the first column having the same address. An address bus communicates the set of addresses to the array of fluidic actuating structures, and a fire signal line communicates a plurality of fire pulse signal types to the array of fluidic actuating structures, the fire pulse signal type depending on the actuation address on the address bus.

Abstract: Disclosed herein are conditional siRNAs activatable by CBF?-MYH11 oncogenic gene and use thereof for treating conditions such as acute myeloid leukemia (AML). The conditional siRNAs target MCL-1 or HDAC8.

Abstract: An integrated circuit includes thermal tracking logic, control logic, and an output interface. The thermal tracking logic determines a temperature of a fluid ejection die. The control logic defines an emulated parameter of the fluid ejection die as a function of the temperature of the fluid ejection die. The output interface outputs the emulated parameter to a printer system based on the function and the temperature of the fluid ejection die.

Abstract: A communicating print component a print head comprising a number of memory bits and a single lane analog bus conductively coupling the number of memory bits to a pad located on the exterior of the print head. The pad is to transmit an electrical signal from the number of memory bits, wherein the electrical signal indicates a combination of all selected bits of the number of memory bits.

Abstract: A communicating print component a print head comprising a number of memory bits and a single lane analog bus conductively coupling the number of memory bits to a pad located on the exterior of the print head. The pad is to transmit an electrical signal from the number of memory bits, wherein the electrical signal indicates a combination of all selected bits of the number of memory bits.

Abstract: An integrated circuit to drive a plurality of fluid actuation devices includes a plurality of contact pads, a plurality of pulldown devices, and control logic. The plurality of contact pads include a first contact pad and a second contact pad. Each of the pulldown devices is electrically coupled to a corresponding contact pad. The control logic enables at least a portion of the pulldown devices in response to both a logic low signal on the first contact pad and a logic low signal on the second contact pad.

Abstract: A print component includes an array of fluidic actuation structures including a first column of fluidic actuating structures addressable by a set of actuation addresses, each fluidic actuating structure having a different one of the actuation addresses and having a fluidic architecture type, and a second column of fluidic actuating structures addressable by the set of actuation addresses. Each fluidic actuating structure of the second column has a different one of the actuation addresses and has a same fluidic architecture type as the fluidic actuating structure of the first column having the same address. An address bus communicates the set of addresses to the array of fluidic actuating structures, and a fire signal line communicates a plurality of fire pulse signal types to the array of fluidic actuating structures, the fire pulse signal type depending on the actuation address on the address bus.

Abstract: Disclosed herein are conditional siRNAs activatable by CBF?-MYH11 oncogenic gene and use thereof for treating conditions such as acute myeloid leukemia (AML). The conditional siRNAs target MCL-1 or HDAC8.

Abstract: Disclosed herein are conditional siRNAs activatable by pro-hypertrophic RNA sequences and use thereof for treating conditions such as cardiac hypertrophy. The conditional siRNAs target calcineurin or HDAC2.

Abstract: The present invention relates to compositions comprising TWIST signaling inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.