Abstract: The disclosure relates to methods of diagnosis and prognosis, compositions for immunotherapies, methods of improving said compositions, and immunotherapies using the same (e.g., T cells, non-T cells, TCR-based therapies, CAR-based therapies, bispecific T-cell engagers (BiTEs), and/or immune checkpoint blockade).

Abstract: A print component includes an array of fluidic actuation structures including a first column of fluidic actuating structures addressable by a set of actuation addresses, each fluidic actuating structure having a different one of the actuation addresses and having a fluidic architecture type, and a second column of fluidic actuating structures addressable by the set of actuation addresses. Each fluidic actuating structure of the second column has a different one of the actuation addresses and has a same fluidic architecture type as the fluidic actuating structure of the first column having the same address. An address bus communicates the set of addresses to the array of fluidic actuating structures, and a fire signal line communicates a plurality of fire pulse signal types to the array of fluidic actuating structures, the fire pulse signal type depending on the actuation address on the address bus.

Abstract: An integrated circuit to drive a plurality of fluid actuation devices includes a plurality of contact pads, a plurality of pulldown devices, and control logic. The plurality of contact pads include a first contact pad and a second contact pad. Each of the pulldown devices is electrically coupled to a corresponding contact pad. The control logic enables at least a portion of the pulldown devices in response to both a logic low signal on the first contact pad and a logic low signal on the second contact pad.

Abstract: A fluid ejection controller interface includes input logic to receive control data packets and a first clock signal, each control data packet including a set of primitive data bits and a set of random bits, wherein the input logic identifies the random bits in the received control data packets to facilitate the creation of modified control data packets. The fluid ejection controller interface includes a clock signal generator to generate a second clock signal that is different than the first clock signal, and output logic to receive the modified control data packets, and output the modified control data packets to a fluid ejection controller of a fluid ejection device based on the second clock signal.

Abstract: An integrated circuit includes thermal tracking logic, control logic, and an output interface. The thermal tracking logic determines a temperature of a fluid ejection die. The control logic defines an emulated parameter of the fluid ejection die as a function of the temperature of the fluid ejection die. The output interface outputs the emulated parameter to a printer system based on the function and the temperature of the fluid ejection die.

Abstract: The disclosure provides methods of treating a malignancy comprising administering an effective dose of a chimeric antigen receptor genetically modified T cell immunotherapy and methods for manufacturing such immunotherapy. Some aspects of the disclosure relate to methods of determining objective response of a patient to a T cell immunotherapy based on the levels of attributes prior to and after administration of the immunotherapy to the patient.

Abstract: An integrated circuit to drive a plurality of fluid actuation devices includes a strain gauge sensor, an amplifier, and a voltage bias generator. The strain gauge sensor generates a strain gauge signal. The amplifier amplifies the strain gauge signal. The voltage bias generator offsets the amplified strain gauge signal.

Abstract: A fluid ejection controller interface includes output logic to receive control data packets, each control data packet including a set of primitive data bits and a set of random bits. The fluid ejection controller interface includes counter logic to cause the output logic to output modified control data packets to a fluid ejection controller of a fluid ejection device.

Abstract: In some examples, a fluid dispensing device includes a reservoir containing a fluid, fluidic actuators, and an interface to receive a data packet comprising information to control activation of the fluidic actuators, the data packet comprising a random number generated by a random number generator.

Abstract: In some examples, a controller includes an interface to receive an indication based on an electrical current through a device, and a processor to send control data to the device to operate the device, detect a measurement based on the indication that is responsive to an operation of the device according to the control data, and determine whether an issue exists in the device responsive to determining whether the measurement satisfies an expected property based on the control data.

Abstract: A communicating print component a print head comprising a number of memory bits and a single lane analog bus conductively coupling the number of memory bits to a pad located on the exterior of the print head. The pad is to transmit an electrical signal from the number of memory bits, wherein the electrical signal indicates a combination of all selected bits of the number of memory bits.

Abstract: A method for use with a series of analog delay circuits to drive a plurality of actuators with a fire signal is disclosed. A bias signal to affect a selected delay in the analog delay circuits is disabled. The fire signal is provided through the series of analog delay circuits with the bias signal disabled.

Abstract: A fluid ejection controller interface includes input logic to receive control data packets and a first clock signal, each control data packet including a set of primitive data bits and a set of random bits, wherein the input logic identifies the random bits in the received control data packets to facilitate the creation of modified control data packets. The fluid ejection controller interface includes a clock signal generator to generate a second clock signal that is different than the first clock signal, and output logic to receive the modified control data packets, and output the modified control data packets to a fluid ejection controller of a fluid ejection device based on the second clock signal.

Abstract: A fluid ejection controller interface includes output logic to receive control data packets, each control data packet including a set of primitive data bits and a set of random bits. The fluid ejection controller interface includes counter logic to cause the output logic to output modified control data packets to a fluid ejection controller of a fluid ejection device.

Abstract: An integrated circuit includes thermal tracking logic, control logic, and an output interface. The thermal tracking logic determines a temperature of a fluid ejection die. The control logic defines an emulated parameter of the fluid ejection die as a function of the temperature of the fluid ejection die. The output interface outputs the emulated parameter to a printer system based on the function and the temperature of the fluid ejection die.

Abstract: A print component includes an array of fluidic actuation structures including a first column of fluidic actuating structures addressable by a set of actuation addresses, each fluidic actuating structure having a different one of the actuation addresses and having a fluidic architecture type, and a second column of fluidic actuating structures addressable by the set of actuation addresses. Each fluidic actuating structure of the second column has a different one of the actuation addresses and has a same fluidic architecture type as the fluidic actuating structure of the first column having the same address. An address bus communicates the set of addresses to the array of fluidic actuating structures, and a fire signal line communicates a plurality of fire pulse signal types to the array of fluidic actuating structures, the fire pulse signal type depending on the actuation address on the address bus.

Abstract: Provided herein are methods for preparing, producing, processing, culturing, isolating, or making cells suitable for immune or cell therapy, and for their use in cell therapy.

Abstract: Disclosed herein are CCR7 aptamers that specifically bind to and internalize into CCR7-expressing cells. The aptamers can be used as a therapeutic agent by itself or in combination with a small molecule by forming a conjugate with the small molecule. Targeted delivery of the small molecule can be achieved by such conjugates. Also disclosed are methods of treating a subject suffering from cancer by administering an effective amount of the aptamer or the aptamer-small molecule conjugate to the subject.

Abstract: A replaceable print component is disclosed that comprises first and second electrodes, and a circuit electrically connected between the first and second electrodes to vary an electrical property of the circuit with a frequency component within a selected frequency range to indicate a parameter of a part of the circuit in response to a stimulus.

Abstract: Disclosed herein are conditional siRNAs activatable by CBF?-MYH11 oncogenic gene and use thereof for treating conditions such as acute myeloid leukemia (AML). The conditional siRNAs target MCL-1 or HDAC8.