Patents by Inventor John S. Foster
John S. Foster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240117806Abstract: A fluid routing plug for use with a fluid end section. The fluid end section being one of a plurality of fluid end sections making up a fluid end side of a high pressure pump. The fluid routing plug is installed within a horizontal bore formed in a fluid end section and is configured to route fluid between an intake and discharge bore. The fluid routing plug comprises a plurality of first and second fluid passages. The first and second passages do not intersect and are offset from one another. The first fluid passages are configured to direct fluid delivered to the horizontal bore from intake bores towards a reciprocating plunger. The second fluid passages are configured to direct fluid pressurized by the plunger towards a discharge bore.Type: ApplicationFiled: December 19, 2023Publication date: April 11, 2024Inventors: Micheal Cole Thomas, Christopher Todd Barnett, Kelcy Jake Foster, Nicholas Son, John Keith, Mark S. Nowell
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Patent number: 11930267Abstract: An electronic device may be provided with control circuitry, wireless transceiver circuitry, and a display. The electronic device may be used to provide information to a user in response to being pointed at a particular object. The control circuitry may determine when the electronic device is pointed at a particular object using wireless control circuitry and/or motion sensor circuitry. In response to determining that the electronic device is pointed at a particular object, the control circuitry may take suitable action. This may include, for example, displaying information about an object when the electronic device is pointed at the object, displaying control icons for electronic equipment when the electronic device is pointed at the electronic equipment, and/or displaying a virtual object when the electronic device is pointed at real world object.Type: GrantFiled: June 18, 2021Date of Patent: March 12, 2024Assignee: Apple Inc.Inventors: Adam S. Meyer, Peter C. Tsoi, Duncan Robert Kerr, Martha Evans Hankey, John B. Morrell, James H. Foster
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Publication number: 20240077076Abstract: A high pressure pump comprising a fluid end mechanically coupled to a power end. The power end is modular and comprises a crankshaft section, a crosshead section, and a connector section coupled together by a first set of stay rods. The fluid end comprises a plurality of fluid end sections positioned in a side-by-side relationship. Each of the plurality of fluid end sections are attached to the power end using a plurality of second set of stay rods.Type: ApplicationFiled: November 14, 2023Publication date: March 7, 2024Inventors: Mark S. Nowell, Kelcy Jake Foster, Micheal Cole Thomas, Christopher Todd Barnett, Nicholas Son, John Keith, Guy J. Lapointe, Michael Eugene May
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Patent number: 11920587Abstract: A fluid routing plug for use with a fluid end section. The fluid end section being one of a plurality of fluid end sections making up a fluid end side of a high pressure pump. The fluid routing plug is installed within a horizontal bore formed in a fluid end section and is configured to route fluid between an intake and discharge bore. The fluid routing plug comprises a plurality of first and second fluid passages. The first and second passages do not intersect and are offset from one another. The first fluid passages are configured to direct fluid delivered to the horizontal bore from intake bores towards a reciprocating plunger. The second fluid passages are configured to direct fluid pressurized by the plunger towards a discharge bore.Type: GrantFiled: February 13, 2023Date of Patent: March 5, 2024Assignee: Kerr Machine Co.Inventors: Micheal Cole Thomas, Christopher Todd Barnett, Kelcy Jake Foster, Nicholas Son, John Keith, Mark S. Nowell
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Patent number: 11898954Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. Deep learning techniques are brought to bear on the camera output to increase speed, accuracy and reliability.Type: GrantFiled: June 22, 2019Date of Patent: February 13, 2024Assignee: Owl biomedical, Inc.Inventors: John S. Foster, Mark A. Naivar, Kevin E. Shields, Daryl W. Grummitt, Lily Li, Yareeve Zemel
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Patent number: 11850592Abstract: A cell sorting device is disclosed, wherein the device includes a sorting magnet and at least one particle manipulation device, wherein the particle manipulation device is formed on a surface of a fabrication substrate. The device may include at least one fluid channel, wherein the sorting magnet and the particle manipulation device are in fluid communication with one another through at least one fluid channel. A method of sorting cells from a first cell suspension is also disclosed, The method may include a) magnetic labeling of first target cells and removal of the non-target cells by applying magnetic fields to obtain a second cell suspension; b) fluorescence-activated labeling of second target cells present in the second cell suspension and separating the fluorescence-activated second target cells from the not labeled cells to obtain a third cell suspension.Type: GrantFiled: February 11, 2020Date of Patent: December 26, 2023Assignee: Owl biomedical, Inc.Inventors: John S. Foster, Kevin Shields, Mehran Hoonejani
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Publication number: 20220362778Abstract: A microfabricated droplet dispensing structure is described, which may include a MEMS microfluidic fluidic valve, configured to open and close a microfluidic channel. The opening and closing of the valve may separate a target biological particle containing genomic material, and a bead from a sample stream, and direct these two particle into a single droplet formed at the edge of the substrate. The droplet may then be encased in a sheath flow of an immiscible fluid, and provided to a downstream workflow.Type: ApplicationFiled: July 26, 2022Publication date: November 17, 2022Applicant: Owl biomedical, Inc.Inventors: John S. Foster, Mehran Hoonejani, Kevin Shields, Hansueli Meyer, Robert Pinard, Matthias Wahl, Sasa Lazevski, John Harley
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Publication number: 20220288590Abstract: A microfabricated particle manipulation system, wherein a target particle is pierced by a microfabricated actuator or by a microfabricated knife edge. In either case, the particle membrane is altered, so as to allow material to traverse the membrane. The device may be used to extract cellular material from inside a cell, or to transfect a cell with foreign material.Type: ApplicationFiled: June 3, 2022Publication date: September 15, 2022Applicant: Owl biomedical, Inc.Inventors: John S. FOSTER, Mehran Hoonejani, Kevin SHIELDS, Lily Li
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Publication number: 20220260480Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. Deep learning techniques are brought to bear on the camera output to increase speed, accuracy and reliability.Type: ApplicationFiled: April 8, 2022Publication date: August 18, 2022Inventors: John S. Foster, Mark A. Naivar, Kevin E. Shields, Daryl W. Grummitt, Timothy J. Wilt, Yareeve Zemel, Lily Li
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Publication number: 20210268506Abstract: A microfabricated droplet dispensing structure is described, which may include a MEMS microfluidic fluidic valve, configured to open and close a microfluidic channel. The opening and closing of the valve may separate a target biological particle containing genomic material, and a bead from a sample stream, and direct these two particle into a single droplet formed at the edge of the substrate. The droplet may then be encased in a sheath flow of an immiscible fluid, and provided to a sequencing module. The sequencing module may sequence the genomic material and/or an identifying barcode attached to the bead.Type: ApplicationFiled: May 19, 2021Publication date: September 2, 2021Applicant: Owl biomedical, Inc.Inventors: John S FOSTER, Mehran Hoonejani, Kevin SHIELDS, Hansueli Meyer, Robert Pinard, Matthias Wahl
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Patent number: 11040347Abstract: A microfabricated droplet dispensing structure is described, which may include a MEMS microfluidic fluidic valve, configured to open and close a microfluidic channel. The opening and closing of the valve may separate a target particle and a bead from a sample stream, and direct these two particle into a single droplet formed at the edge of the substrate. The droplet may then be encased in a sheath flow of an immiscible fluid.Type: GrantFiled: June 14, 2018Date of Patent: June 22, 2021Assignee: Owl biomedical, Inc.Inventors: John S Foster, Mehran Hoonejani, Kevin Shields
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Patent number: 10737269Abstract: A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device which has a sample inlet channel, output channels, and a movable member formed on a substrate. The device may be used to separate a target particle from non-target material in a sample stream. In order to improve the sorter speed, accuracy or yield, the particle manipulation system may also include a microfluidic structure which focuses the target particles in a particular portion of the sample inlet channel. The particle manipulation device may have two separate sort output channels, wherein the sort channel used depends on the characteristics of the sort pulse delivered to the micromechanical particle manipulation device.Type: GrantFiled: November 13, 2017Date of Patent: August 11, 2020Assignee: Owl biomedical, Inc.Inventors: John S. Foster, Kevin Shields, Mehran Hoonejani
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Publication number: 20200222275Abstract: A device is described for delivering a therapeutic vibration to a body. The device may include at least two motors in a housing with unbalanced masses coupled to their axles, such that vibration of the masses causes the two motors and housing to vibrate at a beat frequency. The motors and housing may be coupled to the body via a platform which places the motors and housings at or near a resonant structure in the body, creating a coupled oscillation between the platform and the body. The device may also include at least one sensor which senses at least one piece of bioinformation the vibration may be based on the at least one piece of bioinformation.Type: ApplicationFiled: January 11, 2020Publication date: July 16, 2020Applicant: Cofactor Systems, Inc.Inventors: John S FOSTER, Michael Northen, Alan J. Macy, Anton SELZER
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Publication number: 20200179931Abstract: A cell sorting device is disclosed, wherein the device includes a sorting magnet and at least one particle manipulation device, wherein the particle manipulation device is formed on a surface of a fabrication substrate. The device may include at least one fluid channel, wherein the sorting magnet and the particle manipulation device are in fluid communication with one another through at least one fluid channel. A method of sorting cells from a first cell suspension is also disclosed, The method may include a) magnetic labeling of first target cells and removal of the non-target cells by applying magnetic fields to obtain a second cell suspension; b) fluorescence-activated labeling of second target cells present in the second cell suspension and separating the fluorescence-activated second target cells from the not labeled cells to obtain a third cell suspension.Type: ApplicationFiled: February 11, 2020Publication date: June 11, 2020Applicant: Owl biomedical, Inc.Inventors: John S. FOSTER, Kevin SHIELDS, Mehran Hoonejani
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Publication number: 20190381506Abstract: A microfabricated droplet dispensing structure is described, which may include a MEMS microfluidic fluidic valve, configured to open and close a microfluidic channel. The opening and closing of the valve may separate a target particle and a bead from a sample stream, and direct these two particle into a single droplet formed at the edge of the substrate. The droplet may then be encased in a sheath flow of an immiscible fluid.Type: ApplicationFiled: June 14, 2018Publication date: December 19, 2019Applicant: Owl biomedical, Inc.Inventors: John S FOSTER, Mehran Hoonejani, Kevin SHIELDS
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Publication number: 20190360915Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. Deep learning techniques are brought to bear on the camera output to increase speed, accuracy and reliability.Type: ApplicationFiled: June 22, 2019Publication date: November 28, 2019Applicant: Owl biomedical, Inc.Inventors: John S. FOSTER, Mark A. NAIVAR, Kevin E. SHIELDS, Daryl W. GRUMMITT, Lily LI, Daryl W. GRUMMITT, Yareeve ZEMEL
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Publication number: 20190292511Abstract: A microfabricated particle manipulation system, wherein a target particle is pierced by a microfabricated actuator or by a microfabricated knife edge. In either case, the particle membrane is altered, so as to allow material to traverse the membrane. The device may be used to extract cellular material from inside a cell, or to transfect a cell with foreign material.Type: ApplicationFiled: May 25, 2018Publication date: September 26, 2019Applicant: Owl biomedical, Inc.Inventors: John S. FOSTER, Mehran Hoonejani, Kevin SHIELDS, Lily Li
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Patent number: 10379030Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process.Type: GrantFiled: August 22, 2016Date of Patent: August 13, 2019Assignee: Owl biomedical, Inc.Inventors: John S Foster, Kevin E. Shields, Mehran R. Hoonejani, Mark A. Naivar, Yareeve Zemel
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Publication number: 20190143329Abstract: A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device which may be used to separate a target particle from non-target material in a sample stream. In order to improve the sorter speed, accuracy or yield, the particle manipulation system may also include a microfluidic structure which focuses the target particles in a particular portion of the sample inlet channel. The particle manipulation device may have two separate sort output channels, wherein the sort channel used depends on the characteristics of the sort pulse delivered to the micromechanical particle manipulation device. Because of the improved focusing and pulse details, a droplet may be formed which contains a single particle, which may also be barcoded with an identifiable signature bead.Type: ApplicationFiled: January 4, 2019Publication date: May 16, 2019Applicant: Owl biomedical, Inc.Inventors: John S. FOSTER, Kevin E. SHIELDS, Mehran R. HOONEJANI
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Patent number: 10272431Abstract: Described here is a microfabricated particle sorting device that uses a transient pulse of fluidic pressure to deflect the target particle. The transient pulse may be generated by a microfabricated (MEMS) actuator, which pushes a volume of fluid into a channel, or sucks a volume of fluid from the channel. The transient pressure pulse may divert a target particle into a sort channel.Type: GrantFiled: February 18, 2017Date of Patent: April 30, 2019Assignee: Owl biomedical, Inc.Inventors: John S Foster, Stefan Miltenyi, Kevin Shields, Mehran Hoonejani