Abstract: This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of human cancer and methods of their use.

Abstract: A recirculation system for a gas turbine engine includes a mixing chamber including an inlet end that receives exhaust gases containing unburnt fuel and an outlet end, and at least one recirculation conduit including an inlet opening in fluid communication with the mixing chamber proximate to the outlet end and an outlet opening in fluid communication with the mixing chamber proximate to the inlet end. The recirculation system further includes a fan. The fan is operable to receive at least one of a stream of substantially fuel-free exhaust gases present and a stream of fresh air within the at least one recirculation conduit and direct at least one of a portion of the stream of substantially fuel-free exhaust gases and a portion of the stream of fresh air into the mixing chamber to reduce an amount of unburnt fuel in the exhaust gases.

Abstract: In some embodiments, the present invention provides for a computer system which includes at least the following components: a plurality of computing devices associated with a plurality of users associated with a plurality of users; where each computing device of the plurality of computing devices is configured to: electronically receive software which, when being executed, cause such computing device to display a plurality of instances of a specifically programmed graphical user interface (GUI); where each instance of the GUI is configured to display a real-time updatable meeting information representative of a direct electronic proximity-based communication between at least two computing devices associated with at least two users who desire to meet at a particular location to engage in a transaction of at least one good, at least one service, or both, whose marketable value lasts for a period of 30 seconds to 60 minutes.

Abstract: The invention relates to a loading head arrangement (1, 5, 15), including a telescopic loading head (5) for loading pourable bulk materials (6) onto railway cars (20), wherein the loading head (5) sealingly rests on a filling opening (11) arranged at the railway car (20) by way of at least one seal (25, 26), and wherein the seal (25, 26) is designed as a double seal and has a first upper sealing ring (25), which rests on a horizontal flange (11a) of the filling opening (11), and a second lower sealing ring (26), which sealingly conforms to a vertical flange (11b) of the filling opening (11).

Abstract: In some embodiments, the present invention provides for a computer system which includes at least the following components: a plurality of computing devices associated with a plurality of users associated with a plurality of users; where each computing device of the plurality of computing devices is configured to: electronically receive software which, when being executed, cause such computing device to display a plurality of instances of a specifically programmed graphical user interface (GUI); where each instance of the GUI is configured to display a real-time updatable meeting information representative of a direct electronic proximity-based communication between at least two computing devices associated with at least two users who desire to meet at a particular location to engage in a transaction of at least one good, at least one service, or both, whose marketable value lasts for a period of 30 seconds to 60 minutes.

Abstract: In some embodiments, the present invention provides for a computer system which includes at least the following components: a plurality of computing devices associated with a plurality of users associated with a plurality of users; where each computing device of the plurality of computing devices is configured to: electronically receive software which, when being executed, cause such computing device to display a plurality of instances of a specifically programmed graphical user interface (GUI); where each instance of the GUI is configured to display a real-time updatable meeting information representative of a direct electronic proximity-based communication between at least two computing devices associated with at least two users who desire to meet at a particular location to engage in a transaction of at least one good, at least one service, or both, whose marketable value lasts for a period of 30 seconds to 60 minutes.

Abstract: The invention relates to a loading head arrangement (1, 5, 15), including a telescopic loading head (5) for loading pourable bulk materials (6) onto railway cars (20), wherein the loading head (5) sealingly rests on a filling opening (11) arranged at the railway car (20) by way of at least one seal (25, 26), and wherein the seal (25, 26) is designed as a double seal and has a first upper sealing ring (25), which rests on a horizontal flange (11a) of the filling opening (11), and a second lower sealing ring (26), which sealingly conforms to a vertical flange (11b) of the filling opening (11).

Abstract: Systems and methods for power converters are described. A digital to analog converter (DAC) can be configured to receive a digital representation of a maximum current value of a power conversion system. The DAC can be further configured to convert the digital representation of the maximum current value into an analog current signal. An analog to digital converter (ADC) can be configured to generate, based on the analog current signal, a digital signal representing a sensed current of the power conversion system as a function of the maximum current value.

Abstract: System and methods for a power converter are described. A controller can generate first clock signals and generate pulse width modulation (PWM) signals using the first clock signals to operate a first number of active phases in a power converter to supply power to a load. The controller can determine the load demands a second number, greater than the first number, of active phases to supply the power. The controller can generate pulse signals and combine the pulse signals with the first clock signals to generate second clock signals having a higher frequency than the first clock signals. The controller can generate the PWM signals using the second clock signals to operate the second number of active phases in the power converter to supply power to the load.

Abstract: A voltage regulator feedback circuit includes a first comparator, a second comparator and a logic circuit. The first comparator is configured to generate an overshoot signal based on a comparison of a voltage regulation target signal to a feedback voltage signal. The second comparator is configured to generate a forward current signal based on a comparison of the current sense amplifier voltage to a reference voltage. The logic circuit is configured to generate a breaking signal based on the overshoot signal and the forward current signal. A gate signal of a transistor connected between a second end of the inductor and a reference ground is generated based at least in part on the breaking signal and is configured to cause the transistor to open based at least in part on the breaking signal having a true value.

Abstract: Embodiments of the invention include devices, systems, methods and software applications that automatically detect measured blood alcohol content (BAC). In aspects, a blood alcohol content sensor detects blood alcohol content by measuring an amount of sweat via a wearable device. The systems and methods can also predict the future BAC of a subject by considering the present BAC along with physiological events and/or historical data. The results can be reported to a server to applying a protocol in response to the reported results.

Abstract: In some embodiments, the present invention provides for a computer system which includes at least the following components: a plurality of computing devices associated with a plurality of users associated with a plurality of users; where each computing device of the plurality of computing devices is configured to: electronically receive software which, when being executed, cause such computing device to display a plurality of instances of a specifically programmed graphical user interface (GUI); where each instance of the GUI is configured to display a real-time updatable meeting information representative of a direct electronic proximity-based communication between at least two computing devices associated with at least two users who desire to meet at a particular location to engage in a transaction of at least one good, at least one service, or both, whose marketable value lasts for a period of 30 seconds to 60 minutes.

Abstract: In some embodiments, the present invention provides for a computer system which includes at least the following components: a plurality of computing devices associated with a plurality of users associated with a plurality of users; where each computing device of the plurality of computing devices is configured to: electronically receive software which, when being executed, cause such computing device to display a plurality of instances of a specifically programmed graphical user interface (GUI); where each instance of the GUI is configured to display a real-time updatable meeting information representative of a direct electronic proximity-based communication between at least two computing devices associated with at least two users who desire to meet at a particular location to engage in a transaction of at least one good, at least one service, or both, whose marketable value lasts for a period of 30 seconds to 60 minutes.

Abstract: This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of human cancer and methods of their use.

Abstract: The disclosure provides for pathogenic biomarkers and serum extracellular vesicular biomarkers that are associated with vascular anomalies and malformation of endothelial cells, and uses thereof, including for diagnosis, prognosis and therapy.

Abstract: An apparatus and method for monitoring body temperature includes a temperature sensor configured to detect a body temperature of a user wearing a wearable device and produce a temperature signal representative of the detected body temperature. A transmitter is configured to send and receive signals including the temperature signal produced by the temperature sensor. When those instructions are executed by the circuitry, the wearable device receives a plurality of temperature signals from the temperature sensor over a predetermined period of time and transmits the plurality of temperature signals to a server to determine a baseline temperature pattern for the user. A user alert signal is received from the server when the current temperature signal differs from the baseline temperature pattern by a predetermined threshold, the user alert signal indicating a potential illness of the user.

Abstract: A system and method of storing and reading digital data, including providing a nanopore polymer memory (NPM) device having at least one memory cell comprising at least two addition chambers each arranged to add a unique chemical construct (or codes) to a polymer (or DNA) string when the polymer enters the respective addition chamber, the data comprising a series of codes; successively steering the polymer from deblock chambers through the nanopore into the addition chambers to add codes to the polymer to create the digital data pattern on the polymer; and accurately controlling the bit rate of the polymer using a servo controller. The device may have loading chamber(s) to load (or remove) the polymer into/from the deblock chambers through at least one “micro-hole”. The cell may be part of a memory system that stores and retrieves “raw” data and allows for remote retrieval and conversion. The cell may store multi-bit data having a plurality of states for the codes.

Abstract: A system and method for order fulfillment includes receiving an order for a plurality of items, initiating collection of the plurality of items for the order, detecting presence of a user at a selected one of a plurality of delivery locations when the plurality of items are ready for delivery, and initiating delivery of the items to the user at the selected delivery location.

Abstract: This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of human cancer and methods of their use.

Abstract: A frame for retaining one or more masonry slips is provided. The one or more masonry slips each have at least two slots formed on at least two sides thereof. The frame includes a supporting structure including a back plate, and is configured to house two or more masonry slips, and two or more face rails positioned on the back plate of the supporting structure. Each face rail is configured to house at least one masonry sup, and includes a projection directed away from the back plate of the supporting structure, and a retaining element positioned at the end of the projection so that the retaining element is approximately parallel to the back plate of the supporting structure, and the retaining element is configured to be positioned within one of the two slots formed on the sides of the masonry slip.