Abstract: Embodiments of the invention include devices, systems, methods and software applications that automatically detect measured blood alcohol content (BAC). In aspects, a blood alcohol content sensor detects blood alcohol content by measuring an amount of sweat via a wearable device. The systems and methods can also predict the future BAC of a subject by considering the present BAC along with physiological events and/or historical data. The results can be reported to a server to applying a protocol in response to the reported results.

Abstract: In some embodiments, the present invention provides for a computer system which includes at least the following components: a plurality of computing devices associated with a plurality of users associated with a plurality of users; where each computing device of the plurality of computing devices is configured to: electronically receive software which, when being executed, cause such computing device to display a plurality of instances of a specifically programmed graphical user interface (GUI); where each instance of the GUI is configured to display a real-time updatable meeting information representative of a direct electronic proximity-based communication between at least two computing devices associated with at least two users who desire to meet at a particular location to engage in a transaction of at least one good, at least one service, or both, whose marketable value lasts for a period of 30 seconds to 60 minutes.

Abstract: In some embodiments, the present invention provides for a computer system which includes at least the following components: a plurality of computing devices associated with a plurality of users associated with a plurality of users; where each computing device of the plurality of computing devices is configured to: electronically receive software which, when being executed, cause such computing device to display a plurality of instances of a specifically programmed graphical user interface (GUI); where each instance of the GUI is configured to display a real-time updatable meeting information representative of a direct electronic proximity-based communication between at least two computing devices associated with at least two users who desire to meet at a particular location to engage in a transaction of at least one good, at least one service, or both, whose marketable value lasts for a period of 30 seconds to 60 minutes.

Abstract: This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of human cancer and methods of their use.

Abstract: The disclosure provides for pathogenic biomarkers and serum extracellular vesicular biomarkers that are associated with vascular anomalies and malformation of endothelial cells, and uses thereof, including for diagnosis, prognosis and therapy.

Abstract: An apparatus and method for monitoring body temperature includes a temperature sensor configured to detect a body temperature of a user wearing a wearable device and produce a temperature signal representative of the detected body temperature. A transmitter is configured to send and receive signals including the temperature signal produced by the temperature sensor. When those instructions are executed by the circuitry, the wearable device receives a plurality of temperature signals from the temperature sensor over a predetermined period of time and transmits the plurality of temperature signals to a server to determine a baseline temperature pattern for the user. A user alert signal is received from the server when the current temperature signal differs from the baseline temperature pattern by a predetermined threshold, the user alert signal indicating a potential illness of the user.

Abstract: A system and method of storing and reading digital data, including providing a nanopore polymer memory (NPM) device having at least one memory cell comprising at least two addition chambers each arranged to add a unique chemical construct (or codes) to a polymer (or DNA) string when the polymer enters the respective addition chamber, the data comprising a series of codes; successively steering the polymer from deblock chambers through the nanopore into the addition chambers to add codes to the polymer to create the digital data pattern on the polymer; and accurately controlling the bit rate of the polymer using a servo controller. The device may have loading chamber(s) to load (or remove) the polymer into/from the deblock chambers through at least one “micro-hole”. The cell may be part of a memory system that stores and retrieves “raw” data and allows for remote retrieval and conversion. The cell may store multi-bit data having a plurality of states for the codes.

Abstract: A system and method for order fulfillment includes receiving an order for a plurality of items, initiating collection of the plurality of items for the order, detecting presence of a user at a selected one of a plurality of delivery locations when the plurality of items are ready for delivery, and initiating delivery of the items to the user at the selected delivery location.

Abstract: This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of human cancer and methods of their use.

Abstract: A frame for retaining one or more masonry slips is provided. The one or more masonry slips each have at least two slots formed on at least two sides thereof. The frame includes a supporting structure including a back plate, and is configured to house two or more masonry slips, and two or more face rails positioned on the back plate of the supporting structure. Each face rail is configured to house at least one masonry sup, and includes a projection directed away from the back plate of the supporting structure, and a retaining element positioned at the end of the projection so that the retaining element is approximately parallel to the back plate of the supporting structure, and the retaining element is configured to be positioned within one of the two slots formed on the sides of the masonry slip.

Abstract: A system and method of storing and reading digital data, including providing a nanopore polymer memory (NPM) device having at least one memory cell comprising at least two addition chambers each arranged to add a unique chemical construct (or codes) to a polymer (or DNA) string when the polymer enters the respective addition chamber, the data comprising a series of codes; successively steering the polymer from deblock chambers through the nanopore into the addition chambers to add codes to the polymer to create the digital data pattern on the polymer; and accurately controlling the bit rate of the polymer using a servo controller. The device may have loading chamber(s) to load (or remove) the polymer into/from the deblock chambers through at least one “micro-hole”. The cell may be part of a memory system that stores and retrieves “raw” data and allows for remote retrieval and conversion. The cell may store multi-bit data having a plurality of states for the codes.

Abstract: In some embodiments, the present invention provides for a computer system which includes at least the following components: a plurality of computing devices associated with a plurality of users associated with a plurality of users; where each computing device of the plurality of computing devices is configured to: electronically receive software which, when being executed, cause such computing device to display a plurality of instances of a specifically programmed graphical user interface (GUI); where each instance of the GUI is configured to display a real-time updatable meeting information representative of a direct electronic proximity-based communication between at least two computing devices associated with at least two users who desire to meet at a particular location to engage in a transaction of at least one good, at least one service, or both, whose marketable value lasts for a period of 30 seconds to 60 minutes.

Abstract: In some embodiments, the present invention provides for a computer system which includes at least the following components: a plurality of computing devices associated with a plurality of users associated with a plurality of users; where each computing device of the plurality of computing devices is configured to: electronically receive software which, when being executed, cause such computing device to display a plurality of instances of a specifically programmed graphical user interface (GUI); where each instance of the GUI is configured to display a real-time updatable meeting information representative of a direct electronic proximity-based communication between at least two computing devices associated with at least two users who desire to meet at a particular location to engage in a transaction of at least one good, at least one service, or both, whose marketable value lasts for a period of 30 seconds to 60 minutes.

Abstract: A system and method of storing and reading digital data, including providing a nanopore polymer memory (NPM) device having at least one memory cell comprising at least two addition chambers each arranged to add a unique chemical construct (or codes) to a polymer (or DNA) string when the polymer enters the respective addition chamber, the data comprising a series of codes; successively steering the polymer from deblock chambers through the nanopore into the addition chambers to add codes to the polymer to create the digital data pattern on the polymer; and accurately controlling the bit rate of the polymer using a servo controller. The device may have loading chamber(s) to load (or remove) the polymer into/from the deblock chambers through at least one “micro-hole”. The cell may be part of a memory system that stores and retrieves “raw” data and allows for remote retrieval and conversion. The cell may store multi-bit data having a plurality of states for the codes.

Abstract: A system and method for order fulfillment includes receiving an order for a plurality of items, initiating collection of the plurality of items for the order, detecting presence of a user at a selected one of a plurality of delivery locations when the plurality of items are ready for delivery, and initiating delivery of the items to the user at the selected delivery location.

Abstract: A method of characterising tremor stability in a subject is described for a subject having an involuntary tremor symptomatic of a neurological disorder. The method comprising: identifying a series of tremor cycles from measured tremor data of the subject, said tremor cycles measuring periodic variation in movement of the subject due to the tremor; determining an instantaneous frequency for each tremor cycle and collating the instantaneous frequencies; determining an instantaneous variation between the instantaneous frequencies of each pair of adjacent tremor cycles within the series; comparing the instantaneous variation to the collation of determined instantaneous frequencies to determine a distribution of instantaneous variations; and determining an index value of the distribution of the instantaneous variations, said index value defining the stability of the tremor.

Abstract: Provided are methods and compositions to target delivery of cells to a tissue lesion, thereby treating the lesion. For example, biotinylated antibodies with affinity to a lesion epitope are administered at the lesion. Reparative cells including avidin and biotin are then administered at the lesion. The reparative cells are targeted to the lesion via avidin-biotin bridges to the antibodies, with additional cells recruited to the lesion via cell-to-cell avidin-biotin bridges. In certain examples, antibody-reparative cell complexes are formed by mixing the biotinylated antibodies with the reparative cells including avidin and biotin. The complexes are then administered at the lesion. In other examples, multivalent antibodies are used to target reparative cells to the lesion, such as by binding an epitope at the lesion and an epitope present on the reparative cell. In other examples, the antibodies are chemically linked to a reparative cell or to a nanosome containing a therapeutic agent.

Abstract: An example method comprises identifying a plurality of zones of a spectrogram of an audio sample associated with an operation cycle of an imaging device, generating a set of audio models by transforming the audio sample to a power spectrum and identifying a plurality of audio features within the power spectrum and for the plurality of zones, generating a plurality of simulated audio samples using the set of audio models by adjusting an audio feature of the plurality of audio features, and outputting a set of training data including the audio sample and the plurality of simulated audio samples to train a predictive model indicative of a predicted failure of the imaging device.

Abstract: In some embodiments, the present invention provides for a computer system which includes at least the following components: a plurality of computing devices associated with a plurality of users associated with a plurality of users; where each computing device of the plurality of computing devices is configured to: electronically receive software which, when being executed, cause such computing device to display a plurality of instances of a specifically programmed graphical user interface (GUI); where each instance of the GUI is configured to display a real-time updatable meeting information representative of a direct electronic proximity-based communication between at least two computing devices associated with at least two users who desire to meet at a particular location to engage in a transaction of at least one good, at least one service, or both, whose marketable value lasts for a period of 30 seconds to 60 minutes.

Abstract: In some embodiments, the present invention provides for a computer system which includes at least the following components: a plurality of computing devices associated with a plurality of users associated with a plurality of users; where each computing device of the plurality of computing devices is configured to: electronically receive software which, when being executed, cause such computing device to display a plurality of instances of a specifically programmed graphical user interface (GUI); where each instance of the GUI is configured to display a real-time updatable meeting information representative of a direct electronic proximity-based communication between at least two computing devices associated with at least two users who desire to meet at a particular location to engage in a transaction of at least one good, at least one service, or both, whose marketable value lasts for a period of 30 seconds to 60 minutes.