Abstract: A control system provides automated control of gas washout of a patient interface, such as a mask or nasal prongs. A gas washout vent assembly of the system may include a variable exhaust area such as one defined by overlapping apertures of the assembly or a conduit having a variable gas passage channel. The vent assembly may be formed by nested structures, such as conic or cylindrical members, each having an opening of the overlapping apertures. The vent assembly may be attached substantially near or included with the patient interface. An actuator of the assembly, such as a solenoid or voice coil, manipulates an aperture of the vent assembly. The actuator may be configured for control by a controller to change the exhaust area of the vent assembly based on various methodologies including, for example, sleep detection, disordered breathing event detection, rebreathing volume calculation and/or leak detection.

Abstract: According to one aspect, a web optimized user device is provided. The web optimized device reduces complexity and facilitates interaction with web-based services and content. The web optimized device can be configured without a hard drive, facilitating integration of web-based services into a computing experience. The web optimized device presents a user interface that integrates video functionality into every aspect of the computer content accessed. In particular, a display manager manages the user interface presented and integrates video displays and features into the content displays in a content and/or context aware manner. These displays permit a user to intuitively interact with the video content and features while the user changes content, for example, web-based services, web-based applications, and other media content, without interruption of or interference from the video content.

Abstract: Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.

Abstract: A process and system for creating a lithium ion anolyte from lithium alloys. Metal and lithium alloys are processed to remove the metal with lithium from the alloy remaining. A lithium ion anolyte formed may be used in a process to form lithium metal. Alternatively, a process and system for recovering lithium from sources such as lithium alloys and lithium metal oxides and other feedstock such as recycled batteries into a thin lithium metal film via electrodeposition in an organic electrolyte contacting both anode (holder for lithium source) and cathode (substrate for lithium deposition) in a single-compartment electrolysis cell.

Abstract: A respiratory pressure therapy (RPT) device is disclosed for treatment of respiratory-related disorders. The RPT device includes a pressure generator, a pneumatic block, a chassis and a device outlet for delivering a supply of flow of gas to a patient interface. The RPT device also comprises an integrated humidifier including a water reservoir. An RPT device is also disclosed that includes a wireless data communication interface integrated with the housing and configured to connect to another device or a network.

Abstract: Transition metal dichalcogenide (TMDC) films and methods for conformally depositing TMDC films on a substrate surface are described. The substrate surface may have one or more features formed therein, one or more layers formed thereon, and combinations thereof. The substrate surface is exposed to a transition metal precursor and an oxidant to form a transition metal oxide film in a first phase. The transition metal oxide film is exposed to a chalcogenide precursor to convert the transition metal oxide film to the TMDC film in a second phase.

Abstract: A lithium ion conducting membrane and methods of making the same. The membrane includes a polymeric matrix and a plurality of ion-conducting particles disposed within the polymeric matrix. An inorganic coating deposited in the polymeric matrix.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: Embodiments of stents for treating congenital heart defects and related delivery systems are provided. The devices described herein are configured for insertion into a blood vessel lumen to maintain a patency of a conduit and to balance flexibility and radial resistive force for delivery through a microcatheter. The device described herein are configured to transition from a crimped configuration to an expanded configuration. In the crimped configuration, a crimped diameter of the devices is less than about 0.7 mm. In the expanded configuration, the devices are configured to have an expansion diameter of greater than about 3 mm measured at the body section. The devices described herein are configured to have a radial resistive force greater than about 0.20 N/mm at 1 mm of compression in the expanded configuration. Various devices having these features are described herein.

Abstract: Aspects of the disclosure relate to methods of promoting expression or activity of a dystrophin protein and/or methods of treating DMD in a subject. In some embodiments, the methods comprise administering to the subject a composition comprising complexes (e.g., muscle targeting complexes) comprising a phosphorodiamidate morpholino oligomer (e.g., useful for targeting DMD) covalently linked to an antibody (e.g., anti-TfR1 antibody).

Abstract: Systems and methods for privacy-preserving enablement of connections within organizations are disclosed. In one embodiment, a method may include (1) receiving, at a server comprising a computer processor, an identification of a target to contact from a requester in an organization; (2) the computer processor identifying, in a connection database, at least one user within the organization having a connection with the target; (3) the computer processor communicating anonymized information representing the at least one user having the connection and a relationship-strength score for the connection; (4) the computer processor communicating a request for introduction assistance to the at least one user; (5) the computer processor receiving acceptance of the request for introductory assistance from the at least one user; and (6) the computer processor identifying the at least one that accepted the request to the requester.

Abstract: The invention relates to an engine that generates client profile-based sales decisions. An embodiment of the present invention is directed to providing new insights to strengthen opportunities to provide additional services to clients. The system is directed to developing client profile-based recommendations for trade ideas. For example, the innovative engine may recommend opportunities, such as new trade ideas, to a particular client based upon the client's transaction history, as well as other data and factors. The system may generate an account profile based upon client data and use this profile to score a potential new trade idea.

Abstract: Techniques for recording and replay of a live conference while still attending the live conference are described. A conferencing system includes a user interface generator, a live conference processing module, and a replay processing module. The user interface generator is configured to generate a user interface that includes a replay control panel and one or more output panels. The live conference processing module is configured to extract information included in received conferencing data that is associated with one or more conferencing modalities, and to display the information in the one or more output panels in a live manner (e.g., as a live conference). The replay processing module is configured to enable information associated with the one or more conferencing modalities corresponding to a time of the conference session prior to live to be presented at a desired rate, possibly different from the real-time rate.

Abstract: The disclosure generally relates to tamper-resistant transdermal dosage forms. The dosage forms can comprise an active agent and more than one antagonist reservoir.

Abstract: The disclosure generally relates to tamper-resistant transdermal dosage forms. The dosage forms can comprise an active agent and more than one antagonist reservoir.

Abstract: Systems and methods for hierarchical dual-dynamic exception management are disclosed. In one embodiment, the system and method may provide: (1) hierarchical exception modelling, metric algorithms and aggregation; (2) node level exception metric algorithm and high-level status algorithm calculation; (3) node level investigation via “explain” of exception factors (e.g., focusing an analyst on a particular issue); (4) node level tracking workflow management through ability to add commentary, multiple-person signoff, and high-level status calculation overrides; (5) visibility, auditable compliance reporting; (6) dashboard for internal operational analysts/managers with full investigation view; (7) dashboard for external clients with sub views; (8) generic data interface to existing workflow management system; and (9) machine learning component such that the exception metric can be intelligently re-adjusted (for example, if there are too many false positives then make the thresholds more forgiving).

Abstract: The disclosure generally relates to tamper-resistant transdermal dosage forms. The dosage forms can comprise an active agent and more than one antagonist reservoir.

Abstract: Facilitating presentation of a view of the virtual space in a first view mode to users through client computing platforms and in a second view mode to users through client computing platforms. The first view mode and second view mode causing the views of the virtual space to have different view characteristics. Different inputs are effectuated when in the different view modes to facilitate interaction by the user with the virtual space in different manners.

Abstract: Techniques for recording and replay of a live conference while still attending the live conference are described. A conferencing system includes a user interface generator, a live conference processing module, and a replay processing module. The user interface generator is configured to generate a user interface that includes a replay control panel and one or more output panels. The live conference processing module is configured to extract information included in received conferencing data that is associated with one or more conferencing modalities, and to display the information in the one or more output panels in a live manner (e.g., as a live conference). The replay processing module is configured to enable information associated with the one or more conferencing modalities corresponding to a time of the conference session prior to live to be presented at a desired rate, possibly different from the real-time rate.

Abstract: The disclosure generally relates to tamper-resistant transdermal dosage forms. The dosage forms can comprise an active agent and more than one antagonist reservoir.