Abstract: An elongated catheter includes a tissue-engaging device configured to be urged to move and contact a first surface of the first biological wall. The tissue-engaging device extends from the distal catheter section. The tissue-engaging device is configured to be urged to puncture through the first biological wall. The tissue-engaging device is also configured to be urged to contact the first biological wall without impinging the second biological wall, after the tissue-engaging device has punctured through the first biological wall.

Abstract: Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.

Abstract: Systems and methods are disclosed for use with Implantable Medical Devices (IMD) such as Implantable Stimulator Devices. The system includes a permanent magnet which can be used to reset the IMD (such as during an emergency) and to place the IMD in a pairing mode to establish communications with an external device. An external device paired to the IMD can be used to place the IMD in an MRI mode that renders the IMD safe during a Magnetic Resonance Imaging (MRI) scan. In the event that the external device is unavailable to cause the IMD to exit the MRI mode, the bar magnet can also be used in the MRI mode to pair the IMD with another external device.

Abstract: Compositions and methods for development of potent siRNA therapeutics for prevention and treatment of Corona Virus (2019-nCoV; COVID-19) infections are provided. The compositions include a pharmaceutical composition comprising siRNA cocktails that target critical viral genes and pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers. Administration methods for prevention and treatment are provided, including airway instillation, subcutaneous injections and nebulizer aerosolization.

Abstract: A method for contextual data visualization includes receiving data selected by a user and meta-data associated with the data. The data is analyzed, using a processor of a computing device, to determine content and structure attributes of the data that are relevant to visualization of the data. The meta-data is analyzed, using a processor of the computing device, to determine a context in which the visualization of the data will be used. A database comprising an aggregation of visualization records from a plurality of users is accessed and at least one template from the data visualization records that matches the data attributes and context is selected. A data visualization is created by applying at least one template to the data.

Abstract: A method of, and equipment for gathering fibres entrained a gas stream, for example by melt blowing, comprises an enclosure having an inlet, through which a gas stream carrying entrained fibres may be directed into the enclosure, a fibre outlet from which an assembly of gathered fibres may be withdrawn from the enclosure and an exhaust outlet through which gas may pass out of the enclosure. The enclosure is constructed to provide a pathway for the fibres from the inlet to the fibre outlet in which surplus gas in the gas stream is separated from the entrained fibres and directed to the exhaust outlet, thereby reducing turbulence in the fibres in the enclosure which may affect the quality of the finished assembly.

Abstract: A computer system including a server having a processor and a memory, the memory having a video database and a music database, the video database storing at least one video file having a plurality of video file markers, and the music database storing at least one music file having a plurality of music file markers, wherein the server receives and decodes encoded data from computer readable code, identifies and retrieves from the music database a music file based on the decoded data, synchronizes the retrieved music file with one of the video files by aligning the video file markers of the video file with the music file markers for the retrieved music file to produce a synchronized video-music file, and transmits the synchronized video-music file to a display, wherein the video file markers are generated for each video file and the music file markers are generated for each music file.

Abstract: The present disclosure provides heterodimeric polypeptides comprising: 1) a variant hepatitis C virus (HCV) E2 polypeptide and an HCV E1 polypeptide; 2) a variant HCV E1 polypeptide and an HCV E2 polypeptide; or 3) a variant HCV E1 polypeptide and a variant HCV E2 polypeptide, where the variant HCV E2 polypeptide and/or the HCV E1 polypeptide comprises one or more T cell epitopes, present in an HCV polypeptide other than an HCV E1 polypeptide or an HCV E2 polypeptide. The present disclosure provides nucleic acids encoding a polyprotein that includes E1 and variant E2, E2 and variant E1, or variant E2 and variant E1. The present disclosure provides a method of producing an E1/E2 heterodimer of the present disclosure. The present disclosure provides a method of inducing an immune response in an individual. The present disclosure provides variant E2 polypeptides and variant E1 polypeptides; and nucleic acids encoding same.

Abstract: A data analysis system presents a user interface to allow a user to provide a natural language query pertaining to a dataset, wherein the dataset is associated with a data object model comprising a plurality of objects and receives, via the user interface, user input specifying the natural language query. The data analysis system further modifies, in the user interface, the user input to visually indicate one or more portions of the natural language query that each represent one of the plurality of objects and presents, in the user interface, a response to the natural language query, the response being based on data from the dataset, the data corresponding to the one of the plurality of objects.

Abstract: Polyacrylamide-based copolymers act as stabilizing excipients in formulations of antibody biopharmaceutical agents without interacting directly with the antibody or altering its pharmacokinetic properties. The polyacrylamide-based copolymers confer a substantial stability benefit to high concentration compositions of a variety of antibodies by precluding adsorption of the antibody to the interfaces of the composition, preventing undesirable aggregation events and maintaining the binding activity of the antibody. Such antibody compositions are useful in methods of administering the composition to a subject.

Abstract: A system and method for receiving one or more non-fungible tokens (NFTs) that are associated with links to digital assets, ownership information, NFT metadata, media content metadata, or other media content information. The system may associate the one or more NFTs with other NFTs to create a collection of NFTs that form a song, album, video, or other collection/combination of media content. The system may provide a NFT collectible player to interact with the combination of NFTs in a particular order or for a particular duration.

Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions, or disorders.

Abstract: Methods and systems for protecting a secure computing system. Aspects include connecting a pluggable security card to a motherboard of the secure computing system. Aspects also include activating a detection circuit to monitor a physical connection between the pluggable security card and the motherboard. Based on detecting that the physical connection between the pluggable security card and the motherboard has been interrupted, aspects include setting a tamper event flag, wherein the secure computing system is prevented from being operated when the tamper event flag is set.

Abstract: Filtering device for filtering cerebrospinal fluid are disclosed. An example filtering device may include a filter housing having an inlet for receiving cerebrospinal fluid from a patient and an outlet for returning filtered cerebrospinal fluid to the patient. The filter housing may include a plurality of layers coupled together and defining a fluid pathway therein between the inlet and the outlet. A filtering section may be defined within the filter housing along the fluid pathway. The filtering section may include a widened region of the fluid pathway that is configured to slow the passage of fluid therethrough.

Abstract: A method, computer program product, and computer system for full allocation volume to deduplication volume migration in a storage system. The method includes moving a physical allocation of stored data associated with a full allocation volume into a virtual address range in a deduplication domain and setting up the deduplication metadata to be a passthrough. The method then performs a background deduplication process on the virtual address range once populated with the physical allocations using a drive query hash interface to perform hash calculations on physical drives at which the data is stored.