Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

Abstract: A cleaning solution including: a primary solvent; a secondary solvent, wherein the secondary solvent is at least partially miscible with the primary solvent; an oxidizing agent, wherein the oxidizing agent includes a peroxide; a chelating agent, wherein the chelating agent includes the structure of formula I: wherein R1-R4 are each independently selected from the group consisting of H; OH; and an alkyl, cycloalkyl, polycycloalkyl, heterocycloalkyl, aryl, alkaryl, aralkyl, alkoxy, alkanoyl, aroyl, alkenyl, alkyl-alkenyl, alcohol, ether, ketone, carboxylic acid, acid halide, acid anhydride, ester, and/or amide group containing approximately 1 to approximately 25 carbon atom(s); and wherein X1-X3 are each independently selected from the group consisting of O; S; and Se; a surfactant system, wherein the surfactant system includes a first anionic surfactant, a second anionic surfactant, a third anionic surfactant, and a fourth anionic surfactant; a pH modifier; and an optional amino acid.

Abstract: A gaseous fuel engine includes an engine housing having a cylinder block with a combustion cylinder therein, and an engine head including an intake port, an exhaust port, a fuel port, and an igniter bore, each extending to a fire deck. The gaseous fuel engine includes a fuel admission valve movable to close and open the fuel port. A non-axisymmetric clearance is defined between an inner port surface and the fuel admission valve and directionally biases a flow of gaseous fuel from the fuel port. Related methodology is also disclosed.

Abstract: Compositions, such as consumer products and/or fragrance/flavoring compositions, that include a meta-(C1-C4 alkoxy)salicylaldehyde, such as ortho-ethylvanillin. Processes of making and using such compositions.

Abstract: A building system is disclosed comprising a beam and column connection particularly suited for mass timber buildings. A first connection arrangement comprises a projection and slot arrangement with the beam being supported on an upwardly facing bearing surface. A second connection arrangement may be provided to tie the column to the beam. The system also discloses arrangements to accommodate greater tolerance at the connection and to provide an ability to accommodate limited rotation under dynamic loading.

Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in combination with mitochondrial transit peptides in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been modified or edited.

Abstract: A capacitance sensor made of a plurality of layers includes: a first layer including a first electrode; and a second layer including a second electrode and arranged to face the first layer, wherein at least one of the first layer and the second layer is an elastomer layer which is a dielectric and is made of an elastically deformable elastomer, and the elastomer layer is bonded by an adhesion layer formed by applying an elastomer in a pre-curing state that is a material identical to the first layer or the second layer and curing the elastomer.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for computing enhanced surprise metrics for autonomously driven vehicles. One of the methods includes receiving data representing a predicted state of an agent at a particular time, data representing an actual state of the agent for the particular time, and computing a surprise metric for the actual state of the agent based on a measure of the residual information between the predicted state of the agent and the actual state of the agent.

Abstract: Waveguide based displays benefit from gratings which are capable of diffracting both S and P polarized light with high efficiency. While typical surface relief gratings (SRGs) diffract P polarized light efficiently, SRGs do not typically diffract S polarized light efficiently. One class of gratings that diffracts S polarized light with high efficiency is deep SRGs. One approach to producing deep SRGs is holographic polymer dispersed liquid crystal (HPDLC) gratings. In producing HPDLC gratings, a reactive monomer mixture is exposed to light in a polymerization process. Reactive monomer mixtures may include co-initiators and photo-initiator dyes. Co-initiators which include liquid amine synergist have been demonstrated to have advantageous results. Further, photo-initiator dyes with high extinction coefficients have demonstrated advantageous results.

Abstract: A method of manufacturing a non-fibrous water soluble product comprising particles, comprising: a) providing a first continuous water soluble non-fibrous substrate comprising a first side and moving in a first direction, b) providing a discretizing unit comprising one or more pockets comprising an opening; c) providing a continuous feed of first particles to at least one of the one or more pockets of the discretizing unit through the pocket opening at least partially filling the at least one of the one or more pockets, d) delivering the first particles from the pocket through the opening onto a portion of the first side of the first continuous water soluble non-fibrous substrate, and e) at least partially covering the first side of the first continuous water soluble non-fibrous substrate.

Abstract: Precursors and methods related to a tin-based photoresist are disclosed herein. In some embodiments, a method for forming a tin-based photoresist may include exposing a tin-containing precursor and a co-reagent to a substrate to form a photoresist having tin clusters; selectively exposing the photoresist to extreme ultraviolet radiation (EUV); and exposing the photoresist to heat to form, in the region, crosslinking between the tin clusters. In some embodiments, the precursor has a formula R1R2Sn(N(CH3)2)2, and R1 and R2 are selected from the group consisting of neo-silyl, neo-pentyl, phenyl, benzyl, methyl-bis(trimethylsilyl), methyl, ethyl, isopropyl, tert-butyl, n-butyl, N,N-dimethylpropylamine, and N, N-dimethlybutylamine. In other embodiments, the precursor includes a chelating alkyl-amine or alkyl-amide ligand featuring a 5 membered or 6 membered tin-based heterocycle bound ?2-C,N with an alkyl group on the ligand backbone, wherein the alkyl group includes methyl, ethyl, vinyl, hydrogen, or tert-butyl.

Abstract: Provided herein are compounds of formula (II): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, R2, R3, R5, R6, R7, R8, R9, R10, R11a, R11b, and X are as defined elsewhere herein. Also provided herein are methods of preparing compounds of formula (II). Also provided herein are methods of inhibiting SLC6A19 and methods of treating a SLC6A19-mediated disease, disorder, or condition in an individual in need thereof.

Abstract: A toner including a parent toner particle comprising at least one resin, an optional colorant, an optional wax; and a surface additive formulation disposed on a surface of the parent toner particle; wherein the surface additive formulation comprises a silicone fluid treated aluminum oxide.

Abstract: In an example, a vehicle seat sensor system includes a vehicle seat, a flexible seat sensor, and an electronics unit. The vehicle seat includes a seat surface. The flexible seat sensor is disposed within a deformable distance from the seat surface and includes one or more signal electrodes, one or more ground electrodes, one or more dielectric layers, and one or more capacitors. Each capacitor is formed by a combination of a corresponding signal electrode and a corresponding ground electrode with a corresponding dielectric layer positioned between the corresponding signal electrode and the corresponding ground electrode. The electronics unit is connected to the flexible seat sensor and is configured to electrically communicate with the flexible seat sensor. The flexible seat sensor is configured to provide a capacitive output proportional to an amount of pressure applied to the flexible seat sensor.

Abstract: A head-mounted display comprising (1) an electronic display configured to emit light and (2) a pancake lens optically coupled to the electronic display, the pancake lens comprising a beam splitter configured to (A) transmit a spatial average fraction of the light and (B) reflect an additional spatial average fraction of the light that is less than the spatial average fraction of the light. Various other apparatuses, devices, systems, and methods are also disclosed.

Abstract: A method for controlling a device using a shape-memory alloy wire is disclosed. The method includes determining an ontime for the shape-memory alloy wire based on a target volume to be pumped by a pump plunger, determining the temperature of the shape-memory alloy wire and adjusting the ontime based on the temperature of the shape-memory alloy wire.

Abstract: Systems and methods are provided for multi-layer high-efficiency dielectric grating with improved manufacturability. An example diffraction grating based morphology includes a plurality of grating lines; a plurality of intermediate layers; and a substrate bearing both of the plurality of grating lines and the plurality of intermediate layers; where one or more of the plurality of grating lines include a plurality of grating layers; and where at least two of the plurality of grating layers include different refractive index (RI) material. The plurality of grating layers includes one or more layers having low refractive index (RI) material and one or more layers having high refractive index (RI) material. The plurality of intermediate layers includes a plurality of matching layers and a plurality of dielectric layers.

Abstract: The present invention relates to efficient processes useful in the preparation of fluorinated cyclic dinucleosides, such as [P(R)]-2?-deoxy-2?-fluoro-5?-O—[(R)-hydroxymercaptophosphinyl]-P-thio-?-D-arabino-adenylyl-(3??5?)-3?-deoxy-3?-fluoroguanosine cyclic nucleotide, which is also known as (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2, 10-bis(sulfanyl)octahydro-2H,10H, 12H-2?5,10?5-5,8-methanofuro[3,2-1][1, 3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

Abstract: A contaminant detector is capable of sending a signal or alert when a contaminant is detected within a housing of a utility meter, a meter transmission unit (MTU), or other associated equipment. Circuitry enclosed within the housing is capable of detecting utility usage, transmitting information between one or more utility meters and a utility provider, and/or otherwise monitoring or tracking utility usage. The contaminant detector includes a resistive voltage divider network having a resistance that varies when in contact with a contaminant such as a form of water or metal. The variable resistor has a serpentine structure comprising a plurality of detective fingers that are formed from conductive material and separated by a non-conductive substance.

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using lysenin.