Patents by Inventor Jonathan Braun

Jonathan Braun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200313326
    Abstract: An electrical cable assembly is presented herein. The electrical cable assembly includes a multiconductor flat cable including a first and second electrically conductive wire arranged in a coplanar fashion with each other and encased within a planar dielectric structure. A slot is defined in the planar dielectric structure intermediate the first and second wires, thereby forming first wing features in the dielectric structure extending from the first wire and second wing features extending from the second wire. Exposed portions of the first and second wires extend beyond the first and second wing features. A method of forming the electrical cable assembly, an apparatus for forming the electrical cable assembly, and an electrical terminal configured for use in the electrical cable assembly is also presented.
    Type: Application
    Filed: March 25, 2019
    Publication date: October 1, 2020
    Inventors: David R. Peterson, Jared Bilas, Joseph Sudik, JR., Jonathan D. Weidner, Sean P. Krompegel, Jesse Braun
  • Publication number: 20200117979
    Abstract: Example methods, apparatus, systems and articles of manufacture (e.g., physical storage media) to implement neural network processing of set-top box return path data to estimate household demographics are disclosed. Example demographic estimation systems disclosed herein include a feature generator to generate features from return path data reported from set-top boxes associated with return path data households. Disclosed example demographic estimation systems also include a neural network to process the features generated from the return path data to predict demographic classification probabilities for the return path data households, the neural network to be trained based on panel data reported from meters that monitor media devices associated with panelist household.
    Type: Application
    Filed: December 21, 2018
    Publication date: April 16, 2020
    Inventors: Jonathan Sullivan, Joshua Ivan Friedman, Elise Braun, Paul Chimenti, Juan Guillermo Llanos, Ludo Daemen, Freddy Boulton
  • Publication number: 20200030302
    Abstract: Combination therapy regimens including liposomal irinotecan, oxaliplatin and 5-fluorouracil are useful in the treatment of gastric cancer, including treatment of patients diagnosed with previously untreated gastric cancer. The combination therapy can include the administration of liposomal irinotecan, oxaliplatin, leucovorin and 5-fluorouracil once every two weeks.
    Type: Application
    Filed: November 1, 2017
    Publication date: January 30, 2020
    Applicant: Ipsen Biopharm Ltd.
    Inventors: Jonathan Basil Fitzgerald, Ashish Kalra, Shannon Leonard, Stephan Braun, Bin Zhang
  • Publication number: 20200017965
    Abstract: A substrate carrier structure wherein the substrate may be a wafer and its use in nanoscale processes, such as deposition and/or growth processes. The carrier structure comprises grooves on its frontside and or backside.
    Type: Application
    Filed: February 28, 2018
    Publication date: January 16, 2020
    Inventors: Shane BRAUN, Jonathan KUNTZ, Joshua AUMAN, Joseph WENDEL, Austin MOHNEY, Tom GOETZ
  • Publication number: 20190352399
    Abstract: Provided herein are compositions and methods for the treatment of a cancer in a subject having such a cancer (e.g., a breast cancer). In particular, the compositions provided herein include an anti-EMP2 antibody and a PD-1/PD-L1 pathway antagonist.
    Type: Application
    Filed: January 22, 2018
    Publication date: November 21, 2019
    Inventors: Madhuri WADEHRA, Jonathan BRAUN, Lynn K. GORDON
  • Patent number: 10413577
    Abstract: Inoculation of ATM-deficient mice with probiotic microorganisms, such as L. johnsonii, changed immune parameters, decreased a marker of DNA damage and increased the lifespan of the mice. Compositions and methods described herein are useful for the treatment and prevention of Ataxia telangiectasia and other cancer-prone disease, such as p53 deficiency-associated cancers. Compositions and methods of the present invention are also useful for treating and preventing radiation-induced toxicity to normal tissue in a subject being exposed to radiation. Compositions and methods of the invention can increase lifespans in a simple, non-invasive manner.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: September 17, 2019
    Assignee: The Regents of the University of California
    Inventors: Mitsuko L. Yamamoto, Robert H. Schiestl, Ramune Reliene, James Borneman, Laura L. Presley, Jonathan Braun
  • Patent number: 10385395
    Abstract: NK cell licensing predisposes patients to chronic inflammatory disease. Methods and kits to diagnose and treat chronic inflammatory disease based on genetic haplotype and cytokine profile are described herein.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: August 20, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jonathan Braun, Lin Lin
  • Publication number: 20190077852
    Abstract: Reduction of EMP2 expression and/or anti-EMP2 therapy reduces cancer stem cells in multiple types of cancer. For example, breast cancers stem cells were defined by the presence of HIF-1?, CD44 and ALDH. It is found that anti-EMP2 IgG1 can be used to reduce the numbers of cancer stem cells.
    Type: Application
    Filed: February 28, 2018
    Publication date: March 14, 2019
    Inventors: Madhuri WADEHRA, Jonathan BRAUN, Lynn K. GORDON, Gary S. LAZAR
  • Publication number: 20190040127
    Abstract: Provided herein are novel anti-EMP2 antibodies useful for the treatment and diagnosis of cancers that express or overexpress EMP2. In one aspect, provided herein is an isolated antibody that binds to Epithelial Membrane Protein 2 (EMP2), that includes heavy chain variable region and a light chain variable region. The heavy chain variable region includes three heavy chain complementary determining regions (HCDRs) and the light chain variable region includes three light chain variable regions (LCDRs). In some embodiments, the sequence of HCDR1 is SEQ ID NO: 11, the sequence of HCDR2 is SEQ ID NO: 12, the sequence of HCDR3 is SEQ ID NO: 13, the sequence of LCDR1 is SEQ ID NO:14, the sequence of LCDR2 is SEQ ID NO: 15, and the sequence of LCDR3 is SEQ ID NO: 16.
    Type: Application
    Filed: December 5, 2016
    Publication date: February 7, 2019
    Inventors: Madhuri WADEHRA, Jonathan BRAUN
  • Patent number: 10028983
    Abstract: Inoculation of ATM-deficient mice with probiotic microorganisms, such as L. johnsonii, changed immune parameters, decreased a marker of DNA damage and increased the lifespan of the mice. Compositions and methods described herein are useful for the treatment and prevention of Ataxia telangiectasia and other cancer-prone diseases, such as p53 deficiency-associated cancers. Compositions and methods of the present invention are also useful for treating and preventing radiation-induced toxicity to normal tissue in a subject being exposed to radiation. Compositions and methods of the invention can increase lifespan in a simple, non-invasive manner.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: July 24, 2018
    Assignee: The Regents of the University of California
    Inventors: Mitsuko L. Yamamoto, Robert H. Schiestl, Ramune Reliene, James Borneman, Laura L. Presley, Jonathan Braun
  • Publication number: 20180000876
    Abstract: Inoculation of ATM-deficient mice with probiotic microorganisms, such as L. johnsonii, changed immune parameters, decreased a marker of DNA damage and increased the lifespan of the mice. Compositions and methods described herein are useful for the treatment and prevention of Ataxia telangiectasia and other cancer-prone disease, such as p53 deficiency-associated cancers. Compositions and methods of the present invention are also useful for treating and preventing radiation-induced toxicity to normal tissue in a subject being exposed to radiation, Compositions and methods of the invention can increase lifespans in a simple, non-invasive manner.
    Type: Application
    Filed: April 27, 2017
    Publication date: January 4, 2018
    Inventors: Mitsuko L. Yamamoto, Robert H. Schiestl, Ramune Reliene, James Borneman, Laura L Presley, Jonathan Braun
  • Patent number: 9624304
    Abstract: The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The methods and compositions target cancers which express or overexpress EMP2 nucleic acids and polypeptides by targeting EMP2.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: April 18, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jonathan Braun, Lynn K. Gordon, Kaori Shimazaki Dadgostar, Madhuri Wadehra, Kathy A. Kelly, Anna M. Wu
  • Patent number: 9464135
    Abstract: Methods of preventing retinal detachment associated with proliferative vitreoretinopathy are provided by administering agents which antagonize the activity or function of EMP2 to subjects at risk of the detachment.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: October 11, 2016
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNITED STATES OF AMERICA DEPARTMENT OF VETERAN AFFAIRS
    Inventors: Lynn K. Gordon, Shawn A. Morales, David Telander, Jonathan Braun
  • Publication number: 20160000841
    Abstract: Inoculation of ATM-deficient mice with probiotic microorganisms, such as L. johnsonii, changed immune parameters, decreased a marker of DNA damage and increased the lifespan of the mice. Compositions and methods described herein are useful for the treatment and prevention of Ataxia telangiectasia and other cancer-prone diseases, such as p53 deficiency-associated cancers. Compositions and methods of the present invention are also useful for treating and preventing radiation-induced toxicity to normal tissue in a subject being exposed to radiation. Compositions and methods of the invention can increase lifespan in a simple, non-invasive manner.
    Type: Application
    Filed: February 19, 2014
    Publication date: January 7, 2016
    Inventors: Mitsuko L. Yamamoto, Robert H. Schiestl, Ramune Reliene, James Bomeman, Laura L. Presley, Jonathan Braun
  • Publication number: 20150329621
    Abstract: Reduction of EMP2 expression and/or anti-EMP2 therapy reduces cancer stem cells in multiple types of cancer. For example, breast cancers stem cells were defined by the presence of HIF-1?, CD44 and ALDH. It is found that anti-EMP2 IgG1 can be used to reduce the numbers of cancer stem cells.
    Type: Application
    Filed: March 14, 2013
    Publication date: November 19, 2015
    Inventors: Madhuri WADEHRA, Jonathan BRAUN, Lynn K. GORDON, Gary S. LAZAR
  • Publication number: 20150329641
    Abstract: The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The methods and compositions target cancers which express or overexpress EMP2 nucleic acids and polypeptides by targeting EMP2.
    Type: Application
    Filed: March 23, 2015
    Publication date: November 19, 2015
    Inventors: Jonathan BRAUN, Lynn K. Gordon, Kaori Shimazaki Dadgostar, Madhuri Wadehra, Kathy A. Kelly, Anna M. Wu
  • Patent number: 9110064
    Abstract: The present invention discloses methods of using epithelial membrane protein 2 (EMP2) as a biomarker for stratification of endometrial premalignancy, diagnosing, staging and imaging of endometrial neoplasia. Further, methods for identifying pharmaceutical/therapeutic modalities are described, including compositions which modulate glycolipid-enriched lipid raft microdomains (GEMs).
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: August 18, 2015
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: Jonathan Braun, Madhuri Wadehra, Sathima Natarajan, Robert Soslow
  • Patent number: 9011857
    Abstract: The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The methods and compositions target cancers which express or overexpress EMP2 nucleic acids and polypeptides by targeting EMP2.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: April 21, 2015
    Assignee: The Regents of The University of California
    Inventors: Jonathan Braun, Lynn K. Gordon, Kaori Shimazaki, Madhuri Wadehra, Kathy A. Kelly, Anna M. Wu
  • Publication number: 20150079116
    Abstract: NK cell licensing predisposes patients to chronic inflammatory disease. Methods and kits to diagnose and treat chronic inflammatory disease based on genetic haplotype and cytokine profile are described herein.
    Type: Application
    Filed: April 11, 2013
    Publication date: March 19, 2015
    Inventors: Jonathan Braun, Lin Lin
  • Publication number: 20150079089
    Abstract: Disclosed herein are methods and compositions for modulating neovascularization. The disclosed compositions find particular use in the treatment of uterine cancers, specifically endometrial cancers.
    Type: Application
    Filed: February 6, 2013
    Publication date: March 19, 2015
    Inventors: Madhuri Wadehra, Jonathan Braun, Lynn K. Gordon