Abstract: Compounds of general formula (I): (I) wherein R1, R2, R3, R4, R5, Y and Z are as defined herein are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

Abstract: One embodiment provides an apparatus for displaying an image comprising: a first optical substrate comprising at least one waveguide layer configured to propagate light in a first direction, wherein the at least one waveguide layer of the first optical substrate comprises at least one grating lamina configured to extract the light from the first substrate along the first direction; and a second optical substrate comprising at least one waveguide layer configured to propagate the light in a second direction, wherein the at least one waveguide layer of the second optical substrate comprises at least one grating lamina configured to extract light from the second substrate along the second direction; wherein the at least one grating lamina of at least one of the first and second optical substrates comprises an SBG in a passive mode.

Abstract: Institutional sprinkler assemblies are provided that includes a sprinkler housing and protective cap arrangement to protect a thermally responsive shielding trigger. The sprinkler housing and trigger arrangement provide for an annular buffer to protect the trigger. The institutional sprinkler assemblies include configurations for installation in pendent and horizontal and orientations.

Abstract: A system includes a plurality of roofing shingles installed on a roof deck. Each of the roofing shingles includes first and second ends, first and second edges, a head lap, a reveal portion, a first side lap at the first end, and a second side lap at the second end. The second side lap includes a first surface, which has an adhesive. The first side lap of a first one of the roofing shingles overlays and is attached to the second side lap of a second one of the roofing shingles to form a sealed portion between the head lap of the first one of the roofing shingles and the head lap of the second one of the roofing shingles.

Abstract: A technique for neurostimulation therapy is disclosed, particularly for patients suffering from Restless Legs Syndrome (RLS) or Periodic Limb Movement Disorder (PLMD). The technique can involve initiating a high-frequency electrostimulation signal during a specific time period associated with the patient's transition from sleep to wakefulness. The signal can be delivered to a target location on the patient at a frequency ranging from 500 Hz to 15,000 Hz and can be controlled toward parameters below the threshold that would wake the patient, while effectively mitigating the symptoms of RLS or PLMD.

Abstract: An example of an apparatus to connect a power distribution network with an energy storage unit. The apparatus includes a mobile platform. In addition, the apparatus includes a connection system to connect with an energy storage unit and to receive a current from the energy storage unit. Furthermore, the apparatus includes a transformer mounted on the mobile platform to convert the voltage from the connection system to the voltage of a power distribution network. The apparatus also includes an output cable to connect with the power distribution network.

Abstract: A technique for neurostimulation therapy is disclosed, particularly for patients suffering from Restless Legs Syndrome (RLS) or Periodic Limb Movement Disorder (PLMD). The technique can involve initiating a high-frequency electrostimulation signal during a specific time period associated with the patient's transition from sleep to wakefulness. The signal can be delivered to a target location on the patient at a frequency ranging from 500 Hz to 15,000 Hz and can be controlled toward parameters below the threshold that would wake the patient, while effectively mitigating the symptoms of RLS or PLMD.

Abstract: An example of a system to provide energy storage capacity moveable between multiple locations is provided. The system includes a plurality of docking stations, wherein each docking station is connected to a power distribution network. In addition, the system includes an energy storage unit to connect to a first docking station selected from the plurality of docking stations. Furthermore, the system includes a transporter onto which the energy storage unit is mounted to transport the energy storage unit from the first docking station to a second docking station.

Abstract: Embodiments herein describe a path length adjuster for, e.g., adjusting the length of an optical cavity of a laser. In one embodiment, the path length adjuster includes a circulator element for ensuring unidirectional lasing. The path length adjuster may also include one or more focusing elements such as a focusing lens and/or a collimator which directs received laser light at a mirror. The mirror is mounted on an actuator that moves the mirror in a direction parallel with the propagation of the laser light, thereby increasing or reducing the length of the ring cavity.

Abstract: A respiratory mask can have a frame supporting a sealing arrangement. Various features of the frame and sealing arrangement can improve comfort and reduce the occurrence of pressure sores. The frame can include cheek supports that have a large surface area configured to spread loads over a greater area of the patient's face and therefore reduce the forces applied to the face and the occurrence of point loads. The seal can have a main body that includes a spring with a silicone skin, wherein the spring applies a substantially constant force to the face and/or nares of the patient.

Abstract: An ophthalmic device includes an optic including an optic axis and a closed-loop haptic structure coupled to the optic via a frame surrounding the optic, the closed-loop haptic structure including a closed loop extending from first and second attachment points to the frame. The closed loop includes a first hinge and a second hinge. The first hinge has a first section having a first component extending in a first angular direction, a second section having a second component extending in a second angular direction opposite to the first angular direction, and a first connecting section between the first section and the second section. The second hinge has a third section having a third component extending in the second angular direction, a fourth section having a fourth component extending in the first angular direction, the fourth section being connected to the second section to form the closed loop.

Abstract: An apparatus can include a first tube. The apparatus can include a manifold coupled to the first tube. The manifold can have an opening. The apparatus can include a second tube at least partially disposed in the first tube. The second tube can enter the first tube via the opening of the manifold.

Abstract: An aircraft includes external structures, and one or more thermal emitters integrated with one or more of the external structures. The one or more thermal emitters are configured to generate heat to deice the one or more external structures. The one or more thermal emitters are configured to receive electrical power from one or more of an auxiliary power unit of the aircraft, a power distribution system of the aircraft, one or more engines of the aircraft, or an external power cart that is separate and distinct from the aircraft.

Abstract: There is disclosed system for oxygenating a patient in relation to anaesthesia using high flow gas delivery. The system has a flow source, and a controller for determining oxygenation requirements of the patient before or during anaesthesia. A method of oxygenating a patient in relation to anaesthesia using high flow gas delivery is also disclosed. The method determines oxygenation requirements of the patient before or during anaesthesia.

Abstract: Content is organized for brands by selecting a plurality of brand templates. After each selection, a set of properties is generated by applying a portion of settings of the respective brand template, with the remaining settings being overridden with settings for a channel communicating one of a plurality of presentations to a node of a network involved in the communication. The plurality of presentations may include different renditions of the same content. The properties may include sections configured for different focus areas and/or types of content associated with at tags to enable brand-level-targeting. Filters may be identified in the properties. Based on each of the identifications, a property from among the generated sets of properties may be selected based on comparisons with the associated tags.

Abstract: A system and method are provided for analyzing and reacting to interactions between entities using electronic communication channels. The method includes receiving, via the communications module, data captured from a conversational exchange between a first entity communicating with a second entity using an electronic communication channel. The method also includes analyzing the captured data to detect an indication that the first entity is or was distracted during the conversational exchange, is or was disinterested in a portion of the conversational exchange or missed the portion of the conversational exchange. The method also includes determining based on the indication an action to address the distraction during, disinterest in, or missing of, the portion of the conversational exchange; and providing, via the communications module, an automated message to at least one of the first entity and the second entity for executing the action.

Abstract: A company may implement automated workflows for convenience of users or to reduce support costs. For example, allowing a user to change an address using an automated workflow may be faster or less expensive than with a human agent. In some instances, a first communications session may be started between a first user and a second user. During the first communications session, one or more communications may be processed to select an intent of the first user and a value of an information item communicated by the first user. An automated workflow may be selected to continue assisting the first user, and the first user may be transferred to a second communications session with the automated workflow. The automated workflow may be initialized with the value of the information item that was provided during the first communications session so that the first user does not need to repeat information.

Abstract: A wing lock and deployment apparatus for an air launched vehicle includes a ball screw and driver acted on by a single actuation event. The disclosed wing lock and deployment apparatus is capable of unlocking deployable wings of an air launched vehicle, deploying deployable wings of the air launched vehicle from a stored position, and locking deployable wings of the air launched vehicle in a deployed position in sequential order with the one single actuation event.

Abstract: A marine pump may have a nozzle interface and a detachable strainer base. The nozzle interface may have an aperture for removably receiving a nozzle, and a detent channel defined therein. The detent channel may be configured to receive portion of a detent, which may be configured to contact the nozzle and hold the nozzle in place when inserted into the nozzle interface. The detachable strainer base may have a plurality of slots and a plurality of holes configured to interact with and stop particulates in a fluid passing through the strainer base.