Abstract: The present invention provides a method for treating alopecia using certain pharmaceutically active pyrrolo[2,3-d]pyrimidinyl acrylamides having the structure: or a pharmaceutically acceptable salt thereof, as set forth in the Description.

Abstract: Institutional sprinkler assemblies are provided that includes a sprinkler housing and protective cap arrangement to protect a thermally responsive shielding trigger. The sprinkler housing and trigger arrangement provide for an annular buffer to protect the trigger. The institutional sprinkler assemblies include configurations for installation in pendent and horizontal and orientations.

Abstract: Breathing assistance apparatus includes a gases supply unit adapted to, in use, deliver a stream of pressurised gases from an outlet. The gases supply unit is adapted to vary the pressure of the stream of pressurised gases. A supply path includes a flexible self-supporting gases transportation pathway having a first end connected to the outlet so that the gases transportation pathway receives the stream of gases and conveys the gases to a patient. A patient interface is connected to the second end of the gases transportation pathway receives a stream of gases. At least one sensor measures at least one information parameter of the supply path. A control system associated with the gases supply unit receives the information parameter. The control system contains reference data, and compares the received data to reference data, and determines a supply path based on the comparison.

Abstract: The present disclosure provides lipolytic enzyme variants having one or more modifications as compared to a parent lipolytic enzyme. Specifically, the present disclosure provides one or more lipolytic enzyme variants that has at least one improved performance when compared to one or more reference lipolytic enzymes. In addition, the present disclosure provides compositions comprising a lipolytic enzyme variant of the disclosure. The present disclosure also provides methods of cleaning using compositions comprising a lipolytic enzyme variant of the disclosure.

Abstract: There is disclosed a computer-implemented system and method A computer-implemented method for rating wireless networks, including crowd-sourcing, from a plurality of end users, WiFi access point (WAP) reputation data for a plurality of WAPs, wherein the WAP reputation data comprise WAP records including an identifier for a WAP, a geographic location of the WAP, and a user-supplied rating for the WAP; receiving, from an end user device, a device geolocation; and supplying, to the end user device, one or more WAP records for one or more WAPs near the device geolocation.

Abstract: Patient interfaces for respiratory therapy in the form of nasal interfaces or nasal masks include features that enhance or provide lateral stability of the interface. At least some of the embodiments provide multiple facial contact points or areas located in the general areas of the user's cheeks and/or upper lip. Some embodiments of the nasal interfaces provide advantageous sealing characteristics. The nasal interfaces may provide a controlled expiratory flow to reduce noise. Some embodiments include nasal pillows instead of or in addition to nasal prongs. The nasal pillows can have exhaust vents or can change in length in response to a pressure level within the nasal pillow.

Abstract: High flow therapy is used to treat Cheyne-Stokes respiration and other types of periodic respiration disorders by periodic application of high flow therapy, adjustment of high flow therapy flow rates and/or periodic additions of CO2 or O2 into the air flow provided to the patient.

Abstract: A breach detection engine detects and mitigates the effects of breaches across one or more data sources. An index is generated based on one or more data sources and the index is queried using keywords indicative of potential breaches. A database of potential breaches is populated based on the query of the index. The potential breach database is queried using keywords associated with a system identity (e.g., a third party). A likelihood of a candidate breach is identified based on a set of breach criteria weights. A network node associated with a candidate breach determined to be an actual breach is identified for isolation or for the performance of one or more additional security actions.

Abstract: A composite tank for a reusable launch vehicle comprises a composite wall, having a first coefficient of thermal expansion. The composite wall comprises a first end, a second end, a central axis, which passes through the first end and through the second end, and a cylindrical interior surface. The composite tank also comprises slosh baffles, formed from a second material, having a second coefficient of thermal expansion that is different from the first coefficient of thermal expansion. Each of the slosh baffles is attached to the cylindrical interior surface of the composite wall. Each of the slosh baffles is annular and is separated from the cylindrical interior surface of the composite wall by a radial gap, selected, in part, based on a difference between the first coefficient of thermal expansion and the second coefficient of thermal expansion. The radial gap is configured to change responsive to changes in temperature of the composite tank.

Abstract: Methods and systems for thermal management are disclosed. The thermal management method and systems may reduce the likelihood of a data processing system exceeding thermal limits even in cases of highly customizable and modifiable data processing system. To reduce the likelihood of the data processing system failing to meet thermal limits, the data processing system may implement a distributed thermal management system. The distributed thermal management system may include multiple components that are responsible for granular and/or global thermal management of the data processing system.

Abstract: An optical display comprises: a first waveguide comprising a first surface and a second surface, an input coupler, a fold grating, and an output grating. The input coupler receives collimated first wavelength light from an Input Image Node causes the light to travel within the first waveguide via total internal reflection between the first surface and the second surface to the fold grating. The fold grating provides pupil expansion in a first direction directs the light to the output grating via total internal reflection between the first surface and the second surface. The output grating provides pupil expansion in a second direction different than the first direction and causes the light to exit the first waveguide from the first surface or the second surface. At least one of the input coupler, fold grating and output grating is a rolled k-vector grating, and the fold grating is a dual interaction grating.

Abstract: Various aspects of the subject technology relate to systems, methods, and machine-readable media for encrypting data. The method includes adding a new encryption key for encrypting and/or decrypting data of a database, the data previously encrypted by an old encryption key. The method also includes hashing the new encryption key to generate a new hash. The method also includes comparing the new hash and an old hash with values in an encryption log, the old hash generated by hashing an old encryption key. The method also includes in response to the comparing, decrypting the data with the old encryption key when the new hash and old hash match the values in the encryption log. The method also includes encrypting the data with the new encryption key. The method also includes adding a new entry into the encryption log, the new entry comprising the new hash.

Abstract: A method and apparatus for generating a Value Bearing Indicium (VBI) for on-line ticketing applications. A VBI may be generated by hashing user information to create a message digest that is used to create a digital signature. The digital signature is combined with the user information to create a VBI that can be validated by a variety of stand-alone or on-line methods. An on-line ticketing application using the VBI is described.

Abstract: Systems and methods for optimization-based travel itinerary planning utilizing a multiattribute travel booking platform are described herein. The system has a database, a scheduler, a parser, and a processor. The database stores a travel lexicon having attribute names, a travel taxonomy having look-up tables, and user preferences for a user related to travel attributes. The scheduler instantiates the travel attributes in terms of the travel lexicon and indexes them, searches for feasible travel itineraries, and transmits an optimal travel itinerary. The parser parses the travel-related query and ascertains a relevant attribute set, which produces attribute values. The processor receives a travel-related query from a user device, receives the user preferences from the database, ranks and weights the attribute values, associates values to the feasible travel itineraries, scores the feasible travel itineraries, and selects the optimal travel itinerary.

Abstract: An apparatus can include a fluid access assembly. The fluid access assembly can include a first fluid access configured to pass first fluid with a first fluid pressure. The fluid access assembly can include a second fluid access configured to pass second fluid with a second fluid pressure. The first fluid pressure can be greater than the second fluid pressure. The first fluid access can be concentric with the second a fluid ir access.

Abstract: A waveguide display is provided comprising: an input image generator providing image light projected over a field of view; a waveguide having first and second external surfaces; and at least one grating optically coupled to the waveguide for extracting light towards a viewer. The waveguide has a lateral refractive index variation between said external surfaces that prevents any ray propagated within the waveguide from optically interacting with at least one of the external surfaces.

Abstract: Some embodiments may provide a method for improving a vehicle's accessibility. A digital tag may be associated with the vehicle. Signals from the digital tag may be received. Based on the signals, information about a person and an animal may be inferred. The person may have a driver profile associated with the vehicle. The animal may be bearing the digital tag. Based on inferring from the information that the person may intend for the animal to occupy the vehicle, a setting of the vehicle may be modified.