Abstract: A blade for a turbine engine with a wall separating a cooling fluid flow and a hot gas fluid flow and having a heated surface along which the hot gas fluid flow flows and a cooled surface facing the cooling fluid flow. A plurality of cooling holes each having a passage extending between an inlet at the cooled surface and an outlet at the heated surface. The outlet extending between an upstream end and a downstream end with respect to the hot gas fluid flow to define a distance, the passage defining a centerline forming a first angle (?) with the heated surface.

Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: A transparent wearable data display having a source of collimated light, a deflector for deflecting the collimated light into a scanned beam, and a first of switchable grating elements sandwiched between first and second parallel transparent substrates, which together functioning as a first light guide. A first coupling is provided for directing the scanned beam into a first total internal reflection (TIR) light path of the first light guide along the first array column. The grating elements having diffracting and non-diffracting states, in their diffracting state deflecting light out of said light guide. The grating elements are switchable into their diffracting states one group of elements at a time.

Abstract: A diffuser for use with a wound retractor and configured to deliver gases includes an interface tube for connecting to a gases supply and a diffuser interface positioned at a proximal end of the interface tube, the diffuser interface configured for delivering gases received from the gases supply through the interface tube, and the diffuser interface comprising a diffusion mechanism configured to deliver gases in a diffusion direction. A wound retractor with an integrated diffuser is also disclosed. The wound retractor includes an upper ring, a lower ring, a sleeve extending between and connecting the upper ring to the lower ring, and an integrated diffuser interface having a gases inlet and a diffusion mechanism.

Abstract: In one aspect of the present disclosure, a disc brake rotor assembly is provided that includes a disc brake rotor and a wheel hub. One of the disc brake rotor and the wheel hub includes a plurality of pairs of partial keyways and the other of the disc brake rotor and the wheel hub includes intermediate partial keyways configured to fit intermediate the pairs of partial keyways to form keyways. The disc brake rotor assembly further includes a plurality of fasteners configured to be received in the keyways to secure the disc brake rotor and the wheel hub together.

Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.

Abstract: Medical devices configured for in vivo assays of one or more analytes can sometimes be problematic if left inserted in a tissue, such as skin, for an extended time. Certain medical device surface profiles may aid in alleviating this issue. Accordingly, medical devices may comprise a base surface having a tissue-facing surface profile defined thereon, and a sensor extending through the base surface and at least a portion of the tissue-facing surface profile. The tissue-facing surface profile deviates from the base surface, and the tissue-facing surface profile is also configured to undergo a change in shape, hardness, or a combination thereof after contacting a tissue for a length of time. A dynamic material may be present in at least a portion of the tissue-facing surface profile.

Abstract: An apparatus for a heart of a patient having a cardiac assist device adapted to be implanted into the patient to assist the heart with pumping blood. The apparatus has a sensor adapted to be implanted into the patient. The sensor in communication with the cardiac assist device and the heart which measures native volume of the heart. Alternatively, the sensor monitors the heart based on admittance while the cardiac assist device. Alternatively, the sensor monitors the heart based on impedance.

Abstract: A method for monitoring and controlling neutron beams includes performing a calibration process for a monitoring dosimeter at a first set of conditions for directing a neutron beam towards an object location, the neutron beam being emitted from a neutron-generating target in response to an incident charged particle beam, the process comprising: obtaining data indicating a first neutron flux measured by the monitoring dosimeter between the monitoring dosimeter and the object location, the monitoring dosimeter offset from the axis by a distance equal to or greater than the beam radius; obtaining data indicating a second neutron flux measured by a reference dosimeter between the target and the object location; storing calibration data including a correlation between the first neutron flux and the second neutron flux; and based on the calibration data, using the monitoring dosimeter to monitor neutron flux incident on a patient during boron neutron capture therapy treatment.

Abstract: A method for detecting and responding to damage in a rotor blade of a wind turbine includes monitoring at least one signal of a pitch actuator of a pitch system of the rotor blade of the wind turbine. The signal(s) is a proxy for a pitch driving torque of the pitch actuator of the pitch system. Thus, the method includes defining a metric that captures certain behavior of the proxy for the pitch driving torque of the pitch actuator of the pitch system. The method further includes comparing the metric to a corresponding metric associated with a reference rotor blade representing a healthy rotor blade. Moreover, the method includes implementing a control action when the metric is outside of a predetermined range defined by the healthy rotor blade.

Abstract: Breathing assistance apparatus includes a gases supply unit adapted to, in use, deliver a stream of pressurised gases from an outlet. The gases supply unit is adapted to vary the pressure of the stream of pressurised gases. A supply path includes a flexible self-supporting gases transportation pathway having a first end connected to the outlet so that the gases transportation pathway receives the stream of gases and conveys the gases to a patient. A patient interface is connected to the second end of the gases transportation pathway receives a stream of gases. At least one sensor measures at least one information parameter of the supply path. A control system associated with the gases supply unit receives the information parameter. The control system contains reference data, and compares the received data to reference data, and determines a supply path based on the comparison.

Abstract: Compounds of general formula (I) wherein R1, R2, R3, R4, R5 and X are as defined herein are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions, skin conditions and ocular conditions.

Abstract: An apparatus for a heart of a patient having a cardiac assist device adapted to be implanted into the patient to assist the heart with pumping blood. The apparatus has a sensor adapted to be implanted into the patient. The sensor in communication with the cardiac assist device and the heart which measures native volume of the heart. Alternatively, the sensor monitors the heart based on admittance while the cardiac assist device. Alternatively, the sensor monitors the heart based on impedance.

Abstract: Embodiments herein describe spectroscopy systems that use an unmodulated reference optical signal to mitigate noise, or for other advantages. In one embodiment, the unmodulated reference optical signal is transmitted through the same vapor cell as a modulated pump optical signal. As such, the unmodulated reference optical signal experiences absorption by the vapor, which converts laser phase noise to amplitude noise like the other optical signals passing through the vapor cell. In one embodiment, the unmodulated reference optical signal has an optical path in the gas cell that is offset (or non-crossing) from the optical path of the modulated pump optical signal. The unmodulated reference optical signal allows removal or mitigation of the noise on the other optical signal.

Abstract: The present invention provides lyophilized formulations of active agents, particularly of TAT-NR2B9c, as chloride salts. TAT-NR2B9c has shown promise for treating stroke, aneurysm, subarachnoid hemorrhage and other neurological or neurotraumatic conditions. The chloride salt of TAT-NR2B9c shows improved stability compared with the acetate salt form of prior formulations. Formulations of the chloride salt of TAT-NR2B9c are stable at ambient temperature thus facilitating maintenance of supplies of such a formulation in ambulances for administration at the scene of illness or accident or in transit to a hospital.

Abstract: Approaches described herein can capture an audio signal using at least one microphone while a user of an electronic device is determined to be asleep. At least one audio frame can be determined from the audio signal. The at least one audio frame represents a spectrum of frequencies detected by the at least one microphone over some period of time. One or more sounds associated with the at least one audio frame can be determined. Sleep-related information can be generated. The information identifies the one or more sounds as potential sources of sleep disruption.

Abstract: The described technology is generally directed towards coordinating the generation, validation and enabling of content selection graphs in an in-memory content selection graph data store. When a set of content selection graphs is requested, a coordinator starts the generation of the relevant graphs. Upon successful generation, the coordinator starts a validation of the generated graphs against rules for the nodes/response data in the graphs. If the generated graphs pass validation, the coordinator enables the graph set for use in an in-memory cache, whereby when a request to return content selection data is received, an active graph that corresponds to the request and the current time is accessed to obtain and return the response data as the requested content selection data.

Abstract: An energy efficient heat pump for a heating, ventilation, and air conditioning (HVAC) system includes a compressor system configured to direct a working fluid flow along a working fluid circuit of the energy efficient heat pump. The compressor system includes a first compressor configured to direct the working fluid flow in a first direction along the working fluid circuit and a second compressor configured to direct the working fluid flow in a second direction along the working fluid circuit, opposite the first direction. The energy efficient heat pump also includes a controller communicatively coupled to the first compressor and the second compressor, where the controller is configured to operate the first compressor and suspend operation of the second compressor in a cooling mode of the energy efficient heat pump and to operate the second compressor and suspend operation of the first compressor in a heating mode of the energy efficient heat pump.

Abstract: A machine learning system is provided to enhance various aspects of machine learning models. In some aspects, a substantially photorealistic three-dimensional (3D) graphical model of an object is accessed and a set of training images of the 3D graphical mode are generated, the set of training images generated to add imperfections and degrade photorealistic quality of the training images. The set of training images are provided as training data to train an artificial neural network.