Abstract: Provided is a gesture-recognition (GR) device that includes a printed circuit board (PCB) and a controller. The circuit board has an aspect ratio exceeding a threshold value that corresponds to at least a 70 percent difference between length and width of the PCB. The PCB includes a first unit and a second unit. The first unit corresponds to a base unit to be grasped by hand of a user. The second unit corresponds to an elongate unit that extends outward from the first unit. The second unit is characterized by a minimal wand form factor. A rigid strength of the second unit is based on at least a shape of an outer shell and a structural attribute of the second unit. The controller controls illumination of a plurality of light sources mounted on the second unit of the circuit board based on assertion signals.

Abstract: Provided is a system that includes an interactive casing and a GR device. The interactive casing receives a first signal based on activation of a masked electrical switch by release of a magnetic assertion when a lid member of an interactive casing is disengaged from a base member of the interactive casing. A first system state of the interactive casing is converted to a second system state. Audio-visual feedback is generated and a second signal is communicated to the GR device based on the conversion. Based on the received second signal, a first device state of the GR device is converted to a second device state. Power levels of a first power storage device of the interactive casing and a second power storage device of the GR device are maintained during the first system state and the first device state, respectively.

Abstract: The disclosure provides antibody molecules that bind to TCR V? regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: The present invention relates to immunoglobulins that specifically bind CD40L and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the immunoglobulins of the present invention inhibit the activity of CD40L and are safe.

Abstract: Multifunctional molecules that include i) an antigen binding domain that binds to a calreticulin protein; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule; and/or (iv) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: Multifunctional molecules that include i) an antigen binding domain that binds to a TCR variable beta chain (TCRBV) antigen; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule or cytokine inhibitor molecule; and/or (iv) a death receptor signal enhancer. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating autoimmune diseases using the aforesaid molecules.

Abstract: The disclosure provides antibody molecules that bind to TCR V? regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating an infectious disease using the aforesaid molecules.

Abstract: Multifunctional molecules that include i) an antigen binding domain that binds to a T cell receptor beta chain constant domain 1 or T cell receptor beta chain constant domain 2; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule or cytokine inhibitor molecule; (iv) a death receptor signal enhancer; and/or (v) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: A system comprises: a contactor having a first surface, a second surface, a first hole, a second hole parallel to the first hole, and a third hole parallel to the first hole; a first signal pin held in the first hole of the contactor, extending to at least the second surface of the contactor, and extending to at least the first surface of the contactor; a first short ground pin held in the second hole of the contactor, extending to at least the second surface of the contactor, and extending within the first surface of the contactor; and a ground pin held in the third hole of the contactor, extending to at least the second surface of the contactor, and extending to at least the first surface of the contactor.

Abstract: The disclosure provides antibody molecules that bind to TCR V? regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: A method for facilitating part fabrication, such as by automated toolpath generation, can include one or more of: receiving a virtual part; modifying the virtual part; and/or determining toolpaths to fabricate the target part. The toolpaths preferably define an ordered series of additive and subtractive toolpaths, more preferably wherein the additive and subtractive toolpaths are interleaved, which can function to achieve high manufacturing efficiency and/or performance. The method can additionally or alternatively include: generating machine instructions based on the toolpaths; fabricating the target part based on the machine instructions; calibrating the fabrication system; and/or any other suitable elements.

Abstract: A method for facilitating part fabrication, such as by automated toolpath generation, can include one or more of: receiving a virtual part; modifying the virtual part; and/or determining toolpaths to fabricate the target part. The toolpaths preferably define an ordered series of additive and subtractive toolpaths, more preferably wherein the additive and subtractive toolpaths are interleaved, which can function to achieve high manufacturing efficiency and/or performance. The method can additionally or alternatively include: generating machine instructions based on the toolpaths; fabricating the target part based on the machine instructions; calibrating the fabrication system; and/or any other suitable elements.

Abstract: A method for facilitating part fabrication, such as by automated toolpath generation, can include one or more of: receiving a virtual part; modifying the virtual part; and/or determining toolpaths to fabricate the target part. The toolpaths preferably define an ordered series of additive and subtractive toolpaths, more preferably wherein the additive and subtractive toolpaths are interleaved, which can function to achieve high manufacturing efficiency and/or performance. The method can additionally or alternatively include: generating machine instructions based on the toolpaths; fabricating the target part based on the machine instructions; calibrating the fabrication system; and/or any other suitable elements.

Abstract: A system comprises: a contactor having a first surface, a second surface, a first hole, a second hole parallel to the first hole, and a third hole parallel to the first hole; a first signal pin held in the first hole of the contactor, extending to at least the second surface of the contactor, and extending to at least the first surface of the contactor; a first short ground pin held in the second hole of the contactor, extending to at least the second surface of the contactor, and extending within the first surface of the contactor; and a ground pin held in the third hole of the contactor, extending to at least the second surface of the contactor, and extending to at least the first surface of the contactor.

Abstract: A controller of a non-volatile memory system may be configured to identify bits of data to be stored in memory elements of non-volatile memory that are identified as unreliable. The controller may be configured to bias at least some of these bits to a predetermined logic value at which the bits are likely to be read from the unreliable memory elements. The controller may do so using a biasing key that the controller generates based on identification of the bits. Subsequently, when the data is read, the controller may assign log likelihood ratio values for the bits to correspond to a percent likelihood of the bits being biased to the predetermined logic value. The bits may also be unbiased using the biasing key.

Abstract: The present invention relates to immunoglobulins that specifically bind CD40L and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the immunoglobulins of the present invention inhibit the activity of CD40L and are safe.

Abstract: A memory system and method for reducing read disturb errors are disclosed. In one embodiment, a memory system is provided comprising a plurality of blocks of memory and a controller. The controller is configured to detect a read disturb error in a block, identify data that caused the read disturb error, and move the data that caused the read disturb error to a block with a higher read endurance. This can be done by assigning read counters to blocks to determine frequently-read data, and storing that data in a separate block until it is less frequently read and will likely not cause additional read disturb errors.

Abstract: A data storage device includes a memory (including a single level cell (SLC) memory portion and a multilevel cell (MLC) memory portion), a plurality of data latches, and routing circuitry coupled to the plurality of data latches. The routing circuitry is configured to cause write data, received from a controller, to be stored at a data latch of the plurality of data latches. The routing circuitry is further configured to cause the write data to be copied from the data latch to a particular portion of the memory based on receiving a program mode command after the write data is stored at the data latch, where the program mode command indicates the particular portion as one of the SLC memory portion or the MLC memory portion.

Abstract: A controller of a non-volatile memory system may be configured to identify bits of data to be stored in memory elements of non-volatile memory that are identified as unreliable. The controller may be configured to bias at least some of these bits to a predetermined logic value at which the bits are likely to be read from the unreliable memory elements. The controller may do so using a biasing key that the controller generates based on identification of the bits. Subsequently, when the data is read, the controller may assign log likelihood ratio values for the bits to correspond to a percent likelihood of the bits being biased to the predetermined logic value. The bits may also be unbiased using the biasing key.

Abstract: A controller of a non-volatile memory system may be configured to identify bits of data to be stored in memory elements of non-volatile memory that are identified as unreliable. The controller may be configured to bias at least some of these bits to a predetermined logic value at which the bits are likely to be read from the unreliable memory elements. The controller may do so using a biasing key that the controller generates based on identification of the bits. Subsequently, when the data is read, the controller may assign log likelihood ratio values for the bits to correspond to a percent likelihood of the bits being biased to the predetermined logic value. The bits may also be unbiased using the biasing key.