Patents by Inventor Jonathan M. Rothberg

Jonathan M. Rothberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210047686
    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in the concentration of inorganic pyrophosphate (PPi), hydrogen ions, and nucleotide triphosphates.
    Type: Application
    Filed: May 22, 2020
    Publication date: February 18, 2021
    Inventors: Jonathan M. Rothberg, Wolfgang Hinz, Kim L. Johnson, James Bustillo, John Leamon, Jonathan Schultz
  • Patent number: 10921404
    Abstract: According to some aspects, a low-field magnetic resonance imaging system is provided. The low-field magnetic resonance imaging system comprises a magnetics system having a plurality of magnetics components configured to produce magnetic fields for performing magnetic resonance imaging, the magnetics system comprising, a B0 magnet, a plurality of gradient coils, and at least one radio frequency coil, a power system comprising one or more power components configured to provide power to the magnetics system to operate the magnetic resonance imaging system to perform image acquisition, and a power connection configured to connect to a single-phase outlet to receive mains electricity and deliver the mains electricity to the power system to provide power needed to operate the magnetic resonance imaging system.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: February 16, 2021
    Assignee: Hyperfine Research, Inc.
    Inventors: Michael Stephen Poole, Cedric Hugon, Hadrien A. Dyvorne, Laura Sacolick, William J. Mileski, Jeremy Christopher Jordan, Alan B. Katze, Jr., Jonathan M. Rothberg, Todd Rearick, Christopher Thomas McNulty
  • Patent number: 10912517
    Abstract: Aspects relate to providing radio frequency components responsive to magnetic resonance signals. According to some aspects, a radio frequency component comprises at least one coil having a conductor arranged in a plurality of turns oriented about a region of interest to respond to corresponding magnetic resonant signal components. According to some aspects, the radio frequency component comprises a plurality of coils oriented to respond to corresponding magnetic resonant signal components. According to some aspects, an optimization is used to determine a configuration for at least one radio frequency coil.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: February 9, 2021
    Assignee: Hyperfine Research, Inc.
    Inventors: Michael Stephen Poole, Gregory L. Charvat, Todd Rearick, Jonathan M. Rothberg
  • Publication number: 20210030759
    Abstract: The disclosure also provides compositions and methods related to combination therapy with HSP90 inhibitors and BCL-2 pathway inhibitors for treating cancer. The disclosure also provides compositions and methods related to the use of ‘low dose’ HSP90 inhibitors in the treatment of cancer, alone and in combination with other therapeutic agents.
    Type: Application
    Filed: September 23, 2020
    Publication date: February 4, 2021
    Inventors: Neil Beeharry, Marylens Hernandez, Sean Landrette, Tian Xu, Jonathan M. Rothberg, Henri Lichenstein
  • Publication number: 20210025823
    Abstract: An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit also includes at least one charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers into the at least one charge carrier storage region based upon times at which the charge carriers are produced.
    Type: Application
    Filed: August 4, 2020
    Publication date: January 28, 2021
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Keith G. Fife, David M. Boisvert
  • Publication number: 20210025824
    Abstract: An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit includes at least one charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers directly into the at least one charge carrier storage region based upon times at which the charge carriers are produced.
    Type: Application
    Filed: October 15, 2020
    Publication date: January 28, 2021
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Keith G. Fife, David M. Boisvert
  • Publication number: 20200397289
    Abstract: Aspects of the present disclosure provide improved techniques for imaging a subject's retina fundus. Some aspects relate to an imaging apparatus that may be substantially binocular shaped and/or may house multiple imaging devices configured to provide multiple corresponding modes of imaging the subject's retina fundus. Some aspects relate to techniques for imaging a subject's eye using white light, fluorescence, infrared (IR), optical coherence tomography (OCT), and/or other imaging modalities that may be employed by a single imaging apparatus. Some aspects relate to improvements in white light, fluorescence, IR, OCT, and/or other imaging technologies that may be employed alone or in combination with other techniques. Some aspects relate to multi-modal imaging techniques that enable determination of a subject's health status.
    Type: Application
    Filed: June 19, 2020
    Publication date: December 24, 2020
    Applicant: Tesseract Health, Inc.
    Inventors: Tyler S. Ralston, Maurizio Arienzo, Owen Kaye-Kauderer, Benjamin Rosenbluth, Jonathan M. Rothberg, Lawrence C. West, Paul E. Glenn
  • Publication number: 20200397286
    Abstract: Aspects of the present disclosure provide improved techniques for imaging a subject's retina fundus. Some aspects relate to an imaging apparatus that may be substantially binocular shaped and/or may house multiple imaging devices configured to provide multiple corresponding modes of imaging the subject's retina fundus. Some aspects relate to techniques for imaging a subject's eye using white light, fluorescence, infrared (IR), optical coherence tomography (OCT), and/or other imaging modalities that may be employed by a single imaging apparatus. Some aspects relate to improvements in white light, fluorescence, IR, OCT, and/or other imaging technologies that may be employed alone or in combination with other techniques. Some aspects relate to multi-modal imaging techniques that enable determination of a subject's health status.
    Type: Application
    Filed: June 19, 2020
    Publication date: December 24, 2020
    Applicant: Tesseract Health, Inc.
    Inventors: Tyler S. Ralston, Maurizio Arienzo, Owen Kaye-Kauderer, Benjamin Rosenbluth, Jonathan M. Rothberg, Lawrence C. West, Paul E. Glenn
  • Publication number: 20200400620
    Abstract: Micromachined ultrasonic transducers integrated with complementary metal oxide semiconductor (CMOS) substrates are described, as well as methods of fabricating such devices. Fabrication may involve two separate wafer bonding steps. Wafer bonding may be used to fabricate sealed cavities in a substrate. Wafer bonding may also be used to bond the substrate to another substrate, such as a CMOS wafer. At least the second wafer bonding may be performed at a low temperature.
    Type: Application
    Filed: August 5, 2020
    Publication date: December 24, 2020
    Applicant: Butterfly Network, Inc.
    Inventors: Jonathan M. Rothberg, Susan A. Alie, Keith G. Fife, Nevada J. Sanchez, Tyler S. Ralston
  • Publication number: 20200397287
    Abstract: Aspects of the present disclosure provide improved techniques for imaging a subject's retina fundus. Some aspects relate to an imaging apparatus that may be substantially binocular shaped and/or may house multiple imaging devices configured to provide multiple corresponding modes of imaging the subject's retina fundus. Some aspects relate to techniques for imaging a subject's eye using white light, fluorescence, infrared (IR), optical coherence tomography (OCT), and/or other imaging modalities that may be employed by a single imaging apparatus. Some aspects relate to improvements in white light, fluorescence, IR, OCT, and/or other imaging technologies that may be employed alone or in combination with other techniques. Some aspects relate to multi-modal imaging techniques that enable determination of a subject's health status.
    Type: Application
    Filed: June 19, 2020
    Publication date: December 24, 2020
    Applicant: Tesseract Health, Inc.
    Inventors: Tyler S. Ralston, Maurizio Arienzo, Owen Kaye-Kauderer, Benjamin Rosenbluth, Jonathan M. Rothberg, Lawrence C. West, Paul E. Glenn
  • Publication number: 20200397285
    Abstract: Aspects of the present disclosure provide improved techniques for imaging a subject's retina fundus. Some aspects relate to an imaging apparatus that may be substantially binocular shaped and/or may house multiple imaging devices configured to provide multiple corresponding modes of imaging the subject's retina fundus. Some aspects relate to techniques for imaging a subject's eye using white light, fluorescence, infrared (IR), optical coherence tomography (OCT), and/or other imaging modalities that may be employed by a single imaging apparatus. Some aspects relate to improvements in white light, fluorescence, IR, OCT, and/or other imaging technologies that may be employed alone or in combination with other techniques. Some aspects relate to multi-modal imaging techniques that enable determination of a subject's health status.
    Type: Application
    Filed: June 19, 2020
    Publication date: December 24, 2020
    Applicant: Tesseract Health, Inc.
    Inventors: Tyler S. Ralston, Maurizio Arienzo, Owen Kaye-Kauderer, Benjamin Rosenbluth, Jonathan M. Rothberg, Lawrence C. West, Paul E. Glenn
  • Publication number: 20200400422
    Abstract: Aspects of the present disclosure provide improved techniques for imaging a subject's retina fundus. Some aspects relate to an imaging apparatus that may be substantially binocular shaped and/or may house multiple imaging devices configured to provide multiple corresponding modes of imaging the subject's retina fundus. Some aspects relate to techniques for imaging a subject's eye using white light, fluorescence, infrared (IR), optical coherence tomography (OCT), and/or other imaging modalities that may be employed by a single imaging apparatus. Some aspects relate to improvements in white light, fluorescence, IR, OCT, and/or other imaging technologies that may be employed alone or in combination with other techniques. Some aspects relate to multi-modal imaging techniques that enable determination of a subject's health status.
    Type: Application
    Filed: June 19, 2020
    Publication date: December 24, 2020
    Applicant: Tesseract Health, Inc.
    Inventors: Tyler S. Ralston, Maurizio Arienzo, Owen Kaye-Kauderer, Benjamin Rosenbluth, Jonathan M. Rothberg, Lawrence C. West, Paul E. Glenn
  • Publication number: 20200397290
    Abstract: Aspects of the present disclosure provide improved techniques for imaging a subject's retina fundus. Some aspects relate to an imaging apparatus that may be substantially binocular shaped and/or may house multiple imaging devices configured to provide multiple corresponding modes of imaging the subject's retina fundus. Some aspects relate to techniques for imaging a subject's eye using white light, fluorescence, infrared (IR), optical coherence tomography (OCT), and/or other imaging modalities that may be employed by a single imaging apparatus. Some aspects relate to improvements in white light, fluorescence, IR, OCT, and/or other imaging technologies that may be employed alone or in combination with other techniques. Some aspects relate to multi-modal imaging techniques that enable determination of a subject's health status.
    Type: Application
    Filed: June 19, 2020
    Publication date: December 24, 2020
    Applicant: Tesseract Health, Inc.
    Inventors: Tyler S. Ralston, Maurizio Arienzo, Owen Kaye-Kauderer, Benjamin Rosenbluth, Jonathan M. Rothberg, Lawrence C. West, Paul E. Glenn
  • Publication number: 20200383660
    Abstract: Described herein are methods and apparatuses for ultrasound coupling. Certain aspects relate to coupling bodies for acoustically coupling an ultrasound device to a subject. A coupling body may include a first surface configured to couple to an ultrasound device, a second surface configured to contact the subject, a reservoir internal to the coupling body, and a plurality of openings extending between the reservoir and one or both of the first surface and the second surface. The reservoir may contain ultrasound gel. A coupling body may include an adhesive coupled to a subpart of the surface of the coupling body. A coupling body may include a first surface configured to contact the ultrasound device and a second surface including first adhesive configured to adhere to the subject. The first surface may also include second adhesive configured to adhere to an ultrasound patch device. Certain aspects also relate to packaging coupling bodies.
    Type: Application
    Filed: June 23, 2020
    Publication date: December 10, 2020
    Applicant: Butterfly Network, Inc.
    Inventors: Jonathan M. Rothberg, Tyler S. Ralston, Christopher Thomas McNulty, Nevada J. Sanchez
  • Patent number: 10856840
    Abstract: A universal ultrasound device having an ultrasound includes a semiconductor die; a plurality of ultrasonic transducers integrated on the semiconductor die, the plurality of ultrasonic transducers configured to operate a first mode associated with a first frequency range and a second mode associated with a second frequency range, wherein the first frequency range is at least partially non-overlapping with the second frequency range; and control circuitry configured to: control the plurality of ultrasonic transducers to generate and/or detect ultrasound signals having frequencies in the first frequency range, in response to receiving an indication to operate the ultrasound probe in the first mode; and control the plurality of ultrasonic transducers to generate and/or detect ultrasound signals having frequencies in the second frequency range, in response to receiving an indication to operate the ultrasound probe in the second mode.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: December 8, 2020
    Assignee: Butterfly Network, Inc.
    Inventors: Jonathan M. Rothberg, Susan A. Alie, Nevada J. Sanchez, Tyler S. Ralston, Christopher Thomas McNulty, Jaime Scott Zahorian, Paul Francis Cristman, Matthew de Jonge, Keith G. Fife
  • Patent number: 10856847
    Abstract: To implement a single-chip ultrasonic imaging solution, on-chip signal processing may be employed in the receive signal path to reduce data bandwidth and a high-speed serial data module may be used to move data for all received channels off-chip as digital data stream. The digitization of received signals on-chip allows advanced digital signal processing to be performed on-chip, and thus permits the full integration of an entire ultrasonic imaging system on a single semiconductor substrate. Various novel waveform generation techniques, transducer configuration and biasing methodologies, etc., are likewise disclosed. HIFU methods may additionally or alternatively be employed as a component of the “ultrasound-on-a-chip” solution disclosed herein.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: December 8, 2020
    Assignee: Butterfly Network, Inc.
    Inventors: Jonathan M. Rothberg, Keith G. Fife, Tyler S. Ralston, Gregory L. Charvat, Nevada J. Sanchez
  • Patent number: 10858695
    Abstract: In some embodiments, provided are methods for nucleic acid amplification include subjecting the nucleic acid to be amplified to partially denaturing conditions. In some embodiments, methods for nucleic acid amplification include amplifying without fully denaturing the nucleic acid that is amplified. In some embodiments, the methods for nucleic acid amplification employ an enzyme that catalyzes homologous recombination and a polymerase. In some embodiments, methods for nucleic acid amplification can be conducted in a single reaction vessel. In some embodiments, methods for nucleic acid amplification can be conducted in a single continuous liquid phase of a reaction mixture, without need for compartmentalization of the reaction mixture or immobilization of reaction components. In some embodiments, methods for nucleic acid amplification comprise a amplifying at least one polynucleotide onto a surface under isothermal amplification conditions, optionally in the presence of a polymer.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: December 8, 2020
    Assignee: Life Technologies Corporation
    Inventors: Chieh-Yuan Li, David Ruff, Jennifer O'Neil, Rachel Kasinskas, Shiaw-Min Chen, Jonathan M. Rothberg, Bin Li, Kai Qin Lao
  • Publication number: 20200378919
    Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.
    Type: Application
    Filed: July 8, 2020
    Publication date: December 3, 2020
    Inventors: Mark James MILGREW, Jonathan M. Rothberg, James Bustillo
  • Patent number: 10850306
    Abstract: Processes for fabricating capacitive micromachined ultrasonic transducers (CMUTs) are described, as are CMUTs of various doping configurations. An insulating layer separating conductive layers of a CMUT may be formed by forming the layer on a lightly doped epitaxial semiconductor layer. Dopants may be diffused from a semiconductor substrate into the epitaxial semiconductor layer, without diffusing into the insulating layer. CMUTs with different configurations of N-type and P-type doping are also described.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: December 1, 2020
    Assignee: Butterfly Network, Inc.
    Inventors: Jonathan M. Rothberg, Keith G. Fife, Susan A. Alie, Joseph Lutsky, David Grosjean
  • Publication number: 20200371034
    Abstract: An active-source-pixel, integrated device capable of performing biomolecule detection and/or analysis, such as single-molecule nucleic acid sequencing, is described. An active pixel of the integrated device includes a sample well into which a sample to be analyzed may diffuse, an excitation source for providing excitation energy to the sample well, and a sensor configured to detect emission from the sample. The sensor may comprise two or more segments that produce a set of signals that are analyzed to differentiate between and identify tags that are attached to, or associated with, the sample. Tag differentiation may be spectral and/or temporal based. Identification of the tags may be used to detect, analyze, and/or sequence the biomolecule.
    Type: Application
    Filed: June 12, 2020
    Publication date: November 26, 2020
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Ali Kabiri, Jason W. Sickler, Brett J. Gyarfas, Jeremy Lackey, Gerard Schmid