Abstract: Herein provided are methods and systems for method for transmitting data from an aircraft. A communication module for transmitting data from an aircraft comprises: a physical interface for removably coupling the communication module to an aircraft communication system which obtains the data; a data interface for obtaining at least one message for transmission from the aircraft communication system, the at least one message based on the data; and at least one radio for transmitting the at least one message via at least one antenna.

Abstract: Provided herein is a method for sequencing a polynucleotide molecules. The method includes the steps of providing a plurality of polynucleotide molecules attached to a surface, wherein a first portion of each polynucleotide molecule is attached to a first location of the surface and a second portion of each polynucleotide molecule is attached to a second location of the surface, the relative proximity of the first and second locations being correlated with the probability that the first and second portions are paired, separating the first and second portions of the polynucleotide molecules on the surface, determining the sequences of the first and second portions of the polynucleotide molecules and comparing the relative proximities and the sequences to determine which first and second portions are paired and to determine the sequence of the target polynucleotide molecules.

Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: A patient interface can have a frame supporting a sealing member. Various features of the sealing member can improve comfort and sealing performance in the context of forming seals with the nares of a user, as well as contact with other facial surfaces. The sealing member can include convex portions, concave portions and thickness variations for providing various sealing, comfort, and deformability effects.

Abstract: Soft cooked egg products having a runny yolk are prepared by removing the eggs from their shells; cooking so that the egg white has a temperature of no more than about 175° F. and the egg yolk has a temperature of no more than about 150° F.; cooling the egg to an internal temperature of 75° F. or less; sealing the egg in a package; and pasteurizing. Alternatively the shell-less eggs are packaged sealed in a package and cooked so that the egg white has a temperature of no more than about 175° F. and the egg yolk has an internal temperature of no more than about 150° F. The processes are carried out under processing conditions such that the pasteurized, cooked, packaged eggs have runny yolks. Products made by this process are also described.

Abstract: A method including (a) providing an amplification reagent including an array of sites, and a solution having different target nucleic acids; and (b) reacting the amplification reagent to produce amplification sites each having a clonal population of amplicons from a target nucleic acid from the solution. The reacting can include simultaneously transporting the nucleic acids to the sites at an average transport rate, and amplifying the nucleic acids that transport to the sites at an average amplification rate, wherein the average amplification rate exceeds the average transport rate. The reacting can include producing a first amplicon from a nucleic acid that transports to each of the sites, and producing subsequent amplicons from the nucleic acid or from the first amplicon, wherein the average rate at which the subsequent amplicons are generated exceeds the average rate at which the first amplicon is generated.

Abstract: A switchable glazing unit comprising a glazing panel spaced apart from a pane of glazing material by a perimeter seal is described. The glazing panel comprises first and second glass sheets. A first electrode layer is on a first major surface of the first glass sheet and a second electrode layer is on a first major surface of the second glass sheet. A layer of liquid crystal material is between the first electrode layer and the second electrode layer. When no voltage is applied to the first and second electrode layers, the liquid crystal layer has a first opacity, and upon applying a suitable voltage between the first and second electrode layers, the liquid crystal layer has a second opacity different to the first opacity. Methods of making such a switchable glazing unit are also described.

Abstract: A tracker for a navigation system. A tracker body defines an opening, and a lens is positionable to seal the opening. A plug is configured to be coupled to the tracker body to secure the lens. A tracking element may be disposed between the lens and the plug so as to be visible through the lens. The tracking element may be disposed within a sealed enclosure defined by the lens and the plug. The plug may define a counterbore in fluid communication with the opening, and the plug may be at least partially disposed within the counterbore. The plug may further define a groove, and the tracker may include a sealing element disposed within the groove. The plug may include a shoulder configured to in sealing engagement with the tracker body. Methods of assembling the tracker for use with the navigation system are also disclosed.

Abstract: Disclosed are methods, systems, and non-transitory computer-readable medium for optimizing user experience with respect to sequences of electronic messages to drive user engagement. For example, a method may include determining a set of messages including at least a first message and a second message; transmitting the first and second messages as an initial message to a first plurality of devices and a second plurality of devices, respectively; determining a first and second performance indicator at least based on one or more responses to the first and second messages transmitted as the initial message, respectively; comparing the first performance indicator and the second performance indicator; and sorting a sequence of the set of messages based on the comparison of the first performance indicator to the second performance indicator.

Abstract: The present disclosure provides methods and systems for determining and/or characterizing one or more haplotypes and/or phasing of haplotypes in a nucleic acid sample. In particular, the disclosure provides methods for determining a haplotype and/or phasing of haplotypes in a nucleic acid sample by incorporating synthetic polymorphisms into fragments of a nucleic acid sample and utilizing the synthetic polymorphisms in determining one or more haplotypes and/or phasing of haplotypes.

Abstract: The present disclosure provides methods and systems for determining and/or characterizing one or more haplotypes and/or phasing of haplotypes in a nucleic acid sample. In particular, the disclosure provides methods for determining a haplotype and/or phasing of haplotypes in a nucleic acid sample by incorporating synthetic polymorphisms into fragments of a nucleic acid sample and utilizing the synthetic polymorphisms in determining one or more haplotypes and/or phasing of haplotypes.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: Systems and techniques are provided for forecasting for time series with limited data. A computing device may determine a distance between the long-term time series or section and a short-term time series may be determined for each long-term time series and section in a repository. The computing device may determine which of the long-term time series and sections from the repository has the shortest distance between that long-term series or section and the short-term time series. The computing device may generate forecasted data points for the short-term time series based on the long-term time series or section determined to have the shortest distance between that long-term time series or section and the short-term time series. The computing device may store the forecasted data points for the short-term time series with the short-term time series.

Abstract: This invention relates to a breath indicator for providing an indication of an inhalation and/or exhalation state of a user. Said breath indicator comprising a body comprising a gas sampling portion configured for receipt of a user's inhalation and/or exhalation gases, and an indicator portion. Said gas sampling portion in fluid communication with said indicator portion. Said indicator portion comprising at least a first region and at least a second region, the first region comprising a gas parameter detecting material capable of changing between an initial visual state and a subsequent visual state indicative of detection of a gas parameter of inhalation and/or exhalation gases of said user; and wherein said initial visual state and/or said subsequent visual state of the first region visually contrasts with a visual state of at least said second region.

Abstract: A system for generating a graphical user interface in a client device. The system may include a processor in communication with the client device and a database. The processor may execute: receiving a request for occupancy information of a specified merchant; obtaining a plurality of credit card authorizations associated with the merchant; generating a posted transaction array based on the credit card authorizations; removing outlier members of the posted transaction array by applying a threshold filter; generating a transaction frequency array based on the posted transaction array, the transaction frequency array comprising weekdays and aggregated transactions associated with the weekdays; modifying the transaction frequency array by applying a transformation to the aggregated transactions; generating a smoothed array by applying a kernel density estimate to the transaction frequency array; and generating a graphical user interface displaying information in the smoothed array.

Abstract: Provided herein is a method for sequencing a polynucleotide molecules. The method includes the steps of providing a plurality of polynucleotide molecules attached to a surface, wherein a first portion of each polynucleotide molecule is attached to a first location of the surface and a second portion of each polynucleotide molecule is attached to a second location of the surface, the relative proximity of the first and second locations being correlated with the probability that the first and second portions are paired, separating the first and second portions of the polynucleotide molecules on the surface, determining the sequences of the first and second portions of the polynucleotide molecules and comparing the relative proximities and the sequences to determine which first and second portions are paired and to determine the sequence of the target polynucleotide molecules.