Abstract: A patient support apparatus includes a plurality of primary sensors adapted to measure different parameters used in the control of the patient support apparatus. One or more suites of secondary sensors are added to the patient support apparatus to provide data about the primary sensors. The secondary sensors may be used to detect errors in the primary sensors, to modify outputs from the primary sensors, and/or to provide usage and/or diagnostic data about the use of the patient support apparatus. The suite(s) of secondary sensors may measure parameters that affect the outputs of one or more of the primary sensors. In some embodiments, the suite(s) of secondary sensors include one or more dormant sensors that are not used on the patient support apparatus until a code modification is received from one or more external sources instructing the control system of the patient support apparatus to begin using the dormant sensor(s).

Abstract: The present invention relates to methods of imaging template hybridisation for estimating cluster numbers prior to solid phase amplification and sequencing. More particularly, an initial round of imaging is carried out at the single molecule template hybridisation stage which allows a general estimation of cluster numbers prior to clusters being formed. Amplification of the signal allows single molecule imaging to be carried out using standard sequencing imaging apparatus.

Abstract: Clamping device includes a clamp frame that is configured to move between an open configuration, in which the clamp frame is configured to receive at least one longitudinal element, and a closed configuration, in which the clamp frame wraps around and holds the at least one longitudinal element. The clamp frame includes a coupling end having an inner surface and a coupling base having an outer surface. The inner and outer surfaces have profiles that form a locked engagement to hold the clamp frame in the closed configuration. The clamping device also includes a secondary locking mechanism that secures the coupling end and the coupling base to each other. The secondary locking mechanism is activated after the clamp frame is held in the closed configuration by the locked engagement.

Abstract: Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from one or more scaffold DNA molecules and one or more scaffold polypeptides, the single template site for bonding a template polynucleotide to the scaffold is selected from a covalent template bonding site and a noncovalent template bonding site and the plurality of accessory sites for bonding accessory oligonucleotides to the scaffold are selected from covalent accessory oligonucleotide bonding sites and noncovalent accessory oligonucleotide bonding sites. Also provided are methods of using the nanoparticle.

Abstract: A processor that was manufactured by a manufacturer comprises privileged debug operational circuitry, a debug restriction fuse, a credential store, a credential of the manufacturer in the credential store, and debug control circuitry. The debug restriction fuse is a one-time programmable fuse. The debug control circuitry is to automatically restrict access to the privileged debug operational circuitry, based on the debug restriction fuse. The processor may also include public debug operational circuitry, a prevent-unauthorized-debug (PUD) fuse, and an undo-PUD fuse. When the PUD fuse is set and the undo-PUD fuse is clear, the debug control circuitry may respond to an attempt by a debugger to use the public debug operational circuitry by determining whether the debugger is authorized, disallowing access if the debugger is not authorized, and allowing access if the debugger is authorized. Other embodiments are described and claimed.

Abstract: A foldable shoe includes a first sole section under the ball of a wearer's foot and includes a first outsole portion and a first footbed. A second sole section is located under the heel the foot and includes a second outsole portion and a second footbed. An upper section extends from the first sole section, and a hinge is connected to the first sole section and the second sole section and is configured to fold the foldable shoe from a first position, to be worn, to a second position, for storage. The upper section includes a first upper section connected to the first sole section and a second upper section connected to the second sole section. A connector connects the first upper section to the second upper section when the foldable shoe is in the first position and is disengaged when the foldable shoe is in the second position.

Abstract: Methods and systems for adjusting timing of fuel injectors to reduce cylinder to cylinder air-fuel maldistribution are disclosed. In one example, fuel injection timing is adjusted as a function of pressure ratios that are based on fuel rail pressures observed during injection of fuel. The pressure ratio may be a ratio of a root-mean-square pressure and a scheduling fuel pressure.

Abstract: A process for preparing a composite part, the process comprising: recovering unsaturated resin prepreg scrap; combining the recovered unsaturated resin prepreg scrap with a second resinous thermosetting component; and co-molding the prepreg scrap and resinous thermosetting component together under a pressure of 25 to 4000 psi and at a temperature of 100-400° F.

Abstract: Disclosed are methods, systems, and non-transitory computer-readable medium for optimizing user experience with respect to sequences of electronic messages to drive user engagement. For example, a method may include determining a set of messages including at least a first message and a second message; transmitting the first and second messages as an initial message to a first plurality of devices and a second plurality of devices, respectively; determining a first and second performance indicator at least based on one or more responses to the first and second messages transmitted as the initial message, respectively; comparing the first performance indicator and the second performance indicator; and sorting a sequence of the set of messages based on the comparison of the first performance indicator to the second performance indicator.

Abstract: A location detection system identifies the locations of medical devices such as patient support apparatuses and/or patient care devices within a medical facility. The devices communicate via a wired connection to one or more medical facility systems (e.g. nurse call system, computer network, etc.), and/or via a wireless connection to such systems. The location detection system automatically determines location information of the devices and communicates the location information so that the recipient of any outgoing alerts and/or other information sent from the devices is apprised of the location of the particular device sending the alert or other information. Caregivers are thereby able to respond to the correct location of an alert, and software systems such as EMR systems, admission discharge and transfer (ADT) systems, etc. are able to correlate transmitted device data with the location and/or patient assigned to that location.

Abstract: Disclosed are methods, systems, and non-transitory computer-readable medium for optimizing user experience with respect to sequences of electronic messages to drive user engagement. For example, a method may include determining a set of messages including at least a first message and a second message; transmitting the first and second messages as an initial message to a first plurality of devices and a second plurality of devices, respectively; determining a first and second performance indicator at least based on one or more responses to the first and second messages transmitted as the initial message, respectively; comparing the first performance indicator and the second performance indicator; and sorting a sequence of the set of messages based on the comparison of the first performance indicator to the second performance indicator.

Abstract: A patient support apparatus is provided, such as a bed, cot, stretcher, or the like, that includes a sensor adapted to detect movement of the occupant while the occupant is supported on the support apparatus. A controller monitors outputs from the sensor in response to a mobility assessment control being activated. After monitoring the outputs for a period of time, the controller generates a mobility score based on the outputs from the sensor. In some embodiments, the controller use outputs from the sensor to determine which region of a defined surface area the patient has moved to. The controller records these visited regions over a time period and uses them to generate the mobility assessment. The mobility assessment provides an objective measure of an important factor used in predicting a patient's risk of developing pressure ulcers.

Abstract: Presented herein are methods and compositions for concatenating template strands during the bridge amplification process. The methods are useful for surface amplification at improved densities. The methods and compositions provided herein enable creation of clusters that are brighter, but at the same densities as currently achieved using standard cluster amplification.

Abstract: Disclosed are methods, systems, and non-transitory computer-readable medium for optimizing user experience with respect to email journeys. For example, a method may include determining a first development subset, a first quality assurance subset, and a first production subset of a first plurality of user identifiers; determining and transmitting a first development set of messages, a first quality assurance set of messages, and a first production set of message; determining a development performance indicator, a quality assurance performance indicator, and a production performance indicator based on one or more messages received in response to the transmitted first development set of messages, first quality assurance set of messages, and first production set of message, respectively.

Abstract: The present invention relates to compounds of Formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: A closed loop control system for controlling a plant comprises a controller includes an input arranged to receive a feedback signal from the plant. The controller is arranged to compare a value of the feedback signal to a set point value x(s) and to produce an error signal c(s) that is at least partially dependent on a difference between the value of the feedback signal and the set point value. The controller also includes an output arranged to supply the error signal c(s) to the plant. A monitor is arranged to compare a value of the error signal c(s) produced by the controller to a threshold value and to produce a warning signal when the value of the error signal c(s) exceeds the threshold value for a period of time greater than a predetermined period.

Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.

Abstract: Memory systems that include NAND flash memory and dynamic random access memory (DRAM) are configured to allow a considerably higher ratio of NAND to DRAM without a significant increase in write amplitude. The NAND includes a logical-to-physical (L2P) table. The DRAM includes a buffer divided into regions, an update table of recently written data and linked lists, one for each region of the buffer linking all items in the update table in that region, the DRAM maintaining a set of linked lists, each identifying all regions with the same number of updates in the update table.

Abstract: The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p, q, L, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.

Abstract: Systems and methods for rescheduling passengers are provided. One example aspect of the present disclosure is directed to a method for rescheduling passengers. The method includes receiving an indication that an event has disrupted a plurality of flights. The method includes identifying a plurality of itineraries. The method includes determining a plurality of sets for the itineraries. The method includes determining a plurality of operations plan alternatives based on the plurality of sets. The method includes determining one or more constraints from the plurality of sets of itineraries. The method includes applying the one or more constraints to the plurality of operations plan alternatives to determine an impact of the one or more constraints to the plurality of operations plan alternatives on the sets of itineraries. The method includes determining an operations plan comprising a schedule for the plurality of flights.