Abstract: An inkjet printer with a printhead integrated circuit (IC) (28), an ink supply reservoir (6) for storing ink, an ink supply line (3) defining a flow path from the ink supply reservoir to the printhead IC, and a valve (22) in the ink supply line proximate the printhead IC selectively closing the flow path to the printhead IC.

Abstract: An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the status of the cell from the measured intracellular or extracellular signaling of the cell.

Abstract: The disclosure provides EP2 receptor agonist compounds and methods for using the compounds for treating conditions which can be alleviated by agonism of an EP2 receptor.

Abstract: The present invention is directed to methods of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprising contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate.

Abstract: An amperometric sensor suitable for determining the concentration of hydrogen peroxide in a sample, the sensor comprising a ferricyanide compound which, in reduced form, functions as a mediator specific to hydrogen peroxide.

Abstract: An ink supply system for an inkjet printhead is provided. The system including: (a) an ink reservoir for storing ink; (b) and ink conduit providing fluid communication between the ink reservoir and the printhead; and (c) a hammer mechanism for compressing part of the ink conduit.

Abstract: Piezoelectric vibration absorption system and method. In one embodiment, the invention provides a rider interface that includes a surface. A vibration dampening assembly is affixed to the surface. The vibration dampening assembly includes a piezoelectric element. A load element is electrically connected to the vibration dampening assembly such that the vibration dampening assembly dampens vibrations of the rider interface.

Abstract: A fill time and stabilize and measurement time are determined for a pneumatic testing procedure. The fill time is computed by identifying, in the filling of a sample unit, a time when a substantial portion of variations of a measured variable (due to stabilization) are completed. The stabilize and measurement time is determined by comparison of the measurement variable behavior when filling sample unit(s) that do not leak, to the measurement variable behaviors when filling a sample unit that is in communication with an orifice simulating a leak. A measurement performance factor may be computed from this data at each of several possible times after a unit is filled. A gauge repeatability factor may be computed based on variance of nonleaking units at each possible time, compared to the variable change made on a sample unit when coupled to a leak-simulating orifice. Either factor may be used to select a stabilize and measurement time.

Abstract: A method of fabricating a plurality of inkjet nozzles on a substrate. The method comprises the steps of: (a) providing a substrate having a plurality of trenches corresponding to ink inlets; (b) depositing sacrificial material so as fill the trenches and form a scaffold on the substrate; (c) defining openings in the sacrificial material; (d) depositing roof material over the sacrificial material to form nozzle chambers and filter structures simultaneously; (e) etching nozzle apertures through the roof material; and (f) removing the sacrificial material.

Abstract: A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is: (i) H or an optionally substituted C1-4 alkyl group; or (ii) an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 RN is H or optionally substituted C1-4 alkyl R3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.

Abstract: The invention provides a method for preparing and analysing a population of fragmented polynucleotide sequences having a substantially uniform size. The method can include steps of (a) binding at least some protection molecule to at least one polynucleotide sequence; (b) cleaving the at least one polynucleotide sequence to generate a plurality of polynucleotide fragment sequences of substantially uniform size; (c) amplifying the polynucleotide fragments; and (d) determining a sequence characteristic of a plurality of the polynucleotide fragments.

Abstract: The invention provides novel deazaxanthine and deazahypoxanthine compounds. The compounds may be useful in the therapy of diseases and conditions in which dipeptidylpeptidase-IV (DPP-IV) is implicated.

Abstract: A system and method for automatically upgrading/reverting of the software configurations in a storage system environment among a plurality of product release lines. A configuration upgrade/revert module of a storage system management module identifies a shortest path between an initial configuration and a desired end configuration using a transition table comprising of a plurality of transition functions. The upgrade/revert configuration module invokes the appropriate series of transition functions to modify the software configuration from the initial state to the desired end state.

Abstract: Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder mediated by CB1 receptors, such as obesity, wherein: R1 is aryl or heteroaryl; R2 is alkyl, aryl or heteroaryl; R3 is alkyl, aryl, heteroaryl, NR9R10, OR15, or NR16C(O)R17; Y is C?O, C?S, SO2, or (CR7R8)p; m=1 or 2; n=1 or 2; and p=1, 2, 3 or 4, R7 to R17 being as defined in the specification; wherein if —Y—R3 is C(O)NH(alkyl) then: R1 and/or R2 is selected from heteroaryl; and/or m and/or n is 2; and/or R11 and/or R12 is lower alkyl, or a pharmaceutically acceptable salt or prodrug thereof.

Abstract: A process for the preparation of a compound of formula R1—Y1—P(NR2R3)2 is provided. The process comprises reacting a compound of formula PX3 with a compound of formula HNR2R3 to form a compound of formula X—P(NR2R3)2; and reacting the compound of formula X—P(NR2R3)2 with a compound of formula R1—Y1—H in the presence of a hydrocarbon solvent to form the compound of formula R1—Y1—P(NR2R3)2. R1 represents a phosphorus protecting group; R2 and R3 each independently represent an alkyl, prefer-ably a C1-6alkyl, group, or R2 and R3 are joined, together with the N to which they are attached, to form a 5-7 membered ring; Y1 represents O or S, preferably O; and X represents a halogen, preferably Cl. The preferred solvent is toluene.

Abstract: Seismic data from towed marine streamers are sorted into two-dimensional common midpoint gathers of traces. The gathered traces are ordered by offset. The offset distribution of the ordered traces is regularized. The source and receiver coordinates of the regularized traces are adjusted to reflect the regularizing.

Abstract: A single integrator sensorless current mode control scheme for a switching power converter requires an amplifier circuit which produces an first current that varies with the difference Verror between a reference voltage and a voltage that varies proportionally with Vout, a circuit which produces a second current that varies with the voltage VL across the output inductor, a single integrating element connected to receive the first and second currents such that it integrates both Verror and VL, and a comparator which receives the integrated output at its first input and a substantially fixed voltage at its second input and produces an output that toggles when the voltage at its first input increases above and falls below the substantially fixed voltage. The comparator output is used to control the operation of the power converter's switching circuit and thereby regulate the output voltage.

Abstract: A method of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprises contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate. Preferably the substrate is a HIF polypeptide comprising HIF-1?, a fragment thereof comprising Asn 803 of HIF-1? or a peptide analogue of HIF-1? or fragment thereof comprising an asparagine equivalent to Asn 803 of HIF-1? and wherein hydroxylation of Asn 803 or of a said equivalent asparagine is determined.

Abstract: A measured quantity beverage dispenser that allows for numerous uses simply by replacing a disposable pouch or cartridge prefilled with a specific quantity of beverage. The measured quantity beverage dispenser efficiently and effectively delivers beverage to an end user by maintaining constant pressure within the disposable pouch. The measured quantity beverage dispenser further prevents accidental leaking or dispensing of beverage.