Abstract: A method of sealing an attachment face of a MST device to a mounting surface on a support member, the attachment face having an aperture connected to a first fluid conduit, the attachment face having a second aperture connected to a second conduit, the method comprising the steps of: applying a thermosetting adhesive to the mounting surface; aligning the first aperture with at least part of the second aperture; pressing the MST device and the mounting surface together; and, curing the thermosetting adhesive; wherein, the thermosetting adhesive has a viscosity of between 100 centiPoise and 10,000,000 centiPoise. Using a thermosetting adhesive instead of a thermoplastic adhesive provides a far more reliable seal. The bond between the thermoplastic adhesive and the MST device surface is prone to thermal fatigue and leakage or outright failure.

Abstract: A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates determined by subjecting to X-ray diffraction measurements a crystal comprising FIH. Such chemical entities may be used in the treatment of a condition associated with increased or decreased HIF levels or activity.

Abstract: An all-in-one combination layout tool is provided for marking center lines for spacing studs, marking rip lines, marking cut lines for roof rafters and staircase stringers, and other purposes. The tool comprises a rectangular base plate, an elongate locator bar with a rounded pivot corner, and two connectors to connect the locator bar to the base plate in a variety of configurations. The base plate includes multiple “pivot” points for pivotally connecting the locator bar, two strategically-placed arcuate slots for marking or making angle cuts, and two strategically placed parallel slots for configuring the tool to mark or make rip cuts. Angle markings are provided on two adjacent edges of the base plate, and 1/16-inch markings are provided on the opposite adjacent edges. The base plate is planar and has no enlarged flange or lip that would hinder its use in laying out staircase stringers.

Abstract: A method of attaching a MST device to a support member with an adhesive film, the MST device having an attachment face and a first fluid conduit connected to a first aperture in the attachment face; the support member having a mounting face and a second fluid conduit connected to a second aperture in the mounting face; and, the polymer film has an opening for fluid communication between the first aperture and the second aperture, the method comprising the steps of: forming the opening in the polymer film; aligning the opening with at least part of the second aperture; applying heat and pressure to attach the polymer film to the mounting face; and, positioning the MST device such that the opening is aligned with at east part of the first aperture. By pre-drilling the holes in the film, the attachment process is quicker and the resulting fluidic seal in more reliable.

Abstract: A method of maintaining an ink ejection face of a pagewidth printhead. The method includes the steps of: flooding the face with ink; positioning a transfer roller adjacent the face and without contacting the face; rotating the transfer roller and simultaneously transferring flooded ink from the ink ejection face onto the transfer roller; and removing ink from the transfer roller.

Abstract: A compound of formula (III): or a salt, solvate and chemically protected form thereof, wherein: R5 is an optionally substituted C5-20 aryl or C4-20alkyl group; L? is a single bond, —O— or —C(?O)—; A is selected from the group consisting of: formulae (i) (ii) (iii) wherein X and Y are selected from the group consisting of: O and CR3; S and CR3; NH and CR3; NH and N; O and N; S and N; N and S; and N and O, and where the dotted lines indicate a double bond in the appropriate location, and where Q is either N or CH; D is selected from: formulae (i) (ii) (iii) (iv) (v) (vii) (viii) (ix) B is selected from the group consisting of: formulae (A) (B) where RP6 is selected from fluoro and chloro; and R2 is either: (i) —CO2H; (ii) —CONH2; (iii) —CH2—OH; or (iv) tetrazol-5-yl.

Abstract: An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the status of the cell from the measured intracellular or extracellular signaling of the cell.

Abstract: An ink reservoir for a printer with an inkjet printhead includes a housing for storing a quantity of ink; an air inlet valve having a ball biased against an aperture of the air inlet valve for sealing an interior of the housing from atmosphere; an ink outlet valve having a circular valve seat and a ball for sealing against the valve seat; and a valve actuator having a sliding shaft extending between the ink outlet valve and the air inlet valve. The valve actuator opens the air inlet valve in response to the ink outlet valve opening to establish fluid communication with the inkjet printhead. The ball in the ink outlet valve is adapted to engage one end of the sliding shaft to slide the shaft towards the air inlet valve, whereat the other end of the shaft engages the ball of the air inlet valve against the bias applied thereon.

Abstract: A multi wheeled single track vehicle comprising of three or more wheels in a line, where two or more wheels are steered by an amount to enable the vehicle to follow a single track. Two or more wheels of the wheels are driven by a transmission comprising a chain and sprocket for drive from the engine to one wheel and another chain and sprocket for drive from one wheel to another. Suspension is provided for each wheel by a pair of equal, or near equal length of swinging arms, one above the other, (upper swinging arm and lower swinging arm) where both arms are positioned with the wheel end pivot axis above the wheel axle, and the motorcycle frame pivot axis above the final drive engine sprocket axis, with a spring damper (shock absorber) positioned between upper and lower swinging arms and a wheel axle support strut supporting the wheel axle.

Abstract: The present invention described and shown in the specification and drawings provides novel recombinant DT-based immunotoxins, and, more specifically anti-T cell immunotoxin fusion proteins. Also provided are immunotoxins that can be expressed in bacterial, yeast, or mammalian cells. The invention also provides means for expression of the immunotoxin fusion protein.

Abstract: A technique for identifying virtual machines (VMs) in a VM system includes determining a configuration file location on a data store for the VM. A VM manager (for the VM) and an associated VM identification assigned to the VM (by the VM manager) are determined. A unique VM identification is then created based on the configuration file location on the data store, the VM manager, and the associated VM identification.

Abstract: An all-in-one combination layout tool is provided for marking center lines for spacing studs, marking rip lines, marking cut lines for roof rafters and staircase stringers, and other purposes. The tool comprises a rectangular base plate, an elongate locator bar with a rounded pivot corner, and two connectors to connect the locator bar to the base plate in a variety of configurations. The base plate includes multiple “pivot” points for pivotally connecting the locator bar, two strategically-placed arcuate slots for marking or making angle cuts, and two strategically placed parallel slots for configuring the tool to mark or make rip cuts. Angle markings are provided on two adjacent edges of the base plate, and 1/16-inch markings are provided on the opposite adjacent edges. The base plate is planar and has no enlarged flange or lip that would hinder its use in laying out staircase stringers.

Abstract: An inkjet printer includes a printhead integrated circuit (IC) with an array of nozzles for ejecting ink on to print media; an ink supply reservoir for storing ink; an ink supply line defining a flow path from the ink supply reservoir to the printhead IC; a valve in the ink supply line proximate the printhead IC selectively closing the flow path to the printhead IC; an ink purge actuator for forcing a volume of ink out of the printhead under pressure; a printhead maintenance system having a collection roller for rotating such that the collection roller surface collects ink purged from the printhead and draws the ink away; and a pressure regulator provided in the ink supply reservoir downstream from the ink supply reservoir. The pressure regulator is normally biased shut, and operable to open upon a threshold pressure difference between ink upstream of the pressure regulator and ink downstream of the pressure regulator.

Abstract: A method of removing particulates from an ink ejection face of a printhead is provided. The method comprises the steps of: (a) flooding the face with ink from the printhead, thereby dispersing the particulates into the flooded ink; and (b) transferring the flooded ink, including the particulates, onto a transfer surface moving past the face. Damage to the face is avoided since the transfer surface does not contact the face.

Abstract: The invention relates to a method of preparing template constructs for solid-phase nucleic acid amplification and to use of the templates in methods of solid-phase nucleic acid amplification. The method involves carrying out two ligation reactions: (a) a ligation reaction in which the first end of one or more target polynucleotide molecules are ligated to surface-bound adaptor polynucleotide molecules, and (b) a ligation reaction in which solution-phase adaptor polynucleotide molecules are ligated to the second end of said target polynucleotide molecules, in order to produce one or more template constructs attached to a solid support.

Abstract: A compound of formula (I): or a salt, or chemically protected form thereof, wherein: R5 is an optionally substituted phenyl; A is ?wherein Q is N; R3 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl, and C5-7 aryl-C1-4 alkyl groups; R4 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl, and C5-7 aryl-C1-4 alkyl groups; R6 is selected from H, F, Cl, and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl, and C5-7 aryl-C1-4 alkyl groups; D is selected from: B is selected from the group consisting of: Where RN? is selected from H and C1-4 alkyl; where one of RP3 and RP4 is —Cm-alkylene-R2 and the other of RP3 and RP4 is H, m and n can be 0 or 1, and m+n=1 or 2; and additionally, when RP3 is —Cm-alkylene-R2, m can also be 2 or 3, and m+n=1, 2, 3 or 4, and when R2 is tetrazol-5-yl, m+n may be 0; or where one of RP3 and RP4 is —O—CH2—R2, and the other of RP3 and RP4 is H, n is 0; RN is H or optional

Abstract: The present invention provides methods for creating an array of features on a surface based on content transferred from a plurality of beads to the surface. Nucleic acid content can be transferred using a method including the steps of (a) providing a surface having one or more primer oligonucleotides attached to the surface; (b) providing a pool of beads, wherein beads in the pool have a plurality of templates attached thereto, the plurality comprising multiple copies of a single nucleic acid template sequence; (c) arraying the beads onto the surface by hybridizing the templates to the primer oligonucleotides; and (d) extending the primers to produce copies of the templates attached to the surface.

Abstract: An ink reservoir (2) for a printer with an inkjet printhead, having a housing (6) for storing a quantity of ink (42), an ink outlet valve (10), an air inlet valve (8); and, a valve actuator (52). The valve actuator opens the air inlet valve in response to the ink outlet valve opening to establish fluid communication with the inkjet printhead.

Abstract: A printhead purging system comprises an ink conduit for supplying ink to a printhead, a hammer head for hammering a wall of a compressible part of the conduit, a spring-loading mechanism for priming the hammer head, and a release mechanism for releasing the primed hammer head. Release of the primed hammer head compresses the ink conduit and results in purging of ink from the printhead.