Abstract: A direct injection fuel system is shown for injecting hydrogen fuel into a gas turbine combustor. The fuel injection system includes a plurality of fuel injector blocks. Each fuel injector block includes a fuel admission duct having an inlet for receiving hydrogen fuel from a fuel supply, an outlet for delivering hydrogen fuel into the combustor and a central axis extending from said inlet to said outlet. Each fuel injector block also includes an air admission duct located around the periphery of the fuel admission duct, having an inlet for receiving air from a diffuser and an outlet for delivering air into the combustor for mixing with the hydrogen fuel.

Abstract: A database system comprising a database comprising a plurality of data storage nodes, the plurality of data storage nodes including a primary storage node and a plurality of secondary storage nodes. The database system may also include at least one processor configured to: perform at least one write command to a secondary storage node of the plurality of secondary storage nodes; and perform at least one backup command, at least partially in parallel with the at least one write command being performed to the secondary storage node, of at least some data from a snapshot of data stored in the secondary storage node. A method for performing at least one backup command in a database at least partially in parallel with the at least one write command being performed.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.

Abstract: An intention detection mechanism detects a target user accessing an operational context and accesses sensor data collected by a plurality of sensors encoding signals describing one or more characteristics of the target user and surroundings of the target user. The intention detection mechanism converts the accessed sensor data into a multi-channel sensor data time series, where each channel represents a characteristic of the target user. The intention detection mechanism compares the sensor data time series to a multi-channel intentionality template to determine whether the sensor data time series contains the multi-channel intentionality template. The multi-channel intentionality template describes characteristics indicative of an intent of a target user accessing the operational context. If the sensor data time series contains the multi-channel intentionality template, the intention detection mechanism communicates a signal confirming that the target user intended to access to the operational context.

Abstract: Embodiments of an artificial meniscus are disclosed herein. An artificial meniscus includes at least one circumferential fiber bundle and the at least one non-circumferential fiber bundle embedded in a polymer material. The non-circumferential fiber bundles are fully encapsulated within the polymer material, and the circumferential fiber bundles extend out of anterior and posterior horns of the artificial meniscus to terminate in ends that are configured for fixation to bone. Methods of making and implanting artificial menisci are also disclosed herein. The methods of making include, but are not limited to, stepwise molding, layering, and curing of polymer material around the circumferential and non-circumferential fiber bundles. The methods of implanting include threading ends of the circumferential fiber bundles through first and second bone tunnels, then immobilizing the ends of the circumferential fiber bundles with respect to the bone of the subject.

Abstract: A system and method of producing a moulded article, e.g. a one-piece container, comprises delivering a fibre suspension to a porous mould and removing a suspending liquid (e.g. water) via pores of the porous mould. An inflatable bladder is inserted into the mould in a collapsed state and then inflated to apply pressure to internal walls of the article to remove water content. A wet embryonic form of the container is then transferred to a non-porous mould where an inflatable bladder applies internal pressure to compress the walls and remove further water content. The container is further dried by microwave and/or air drying and may be coated with a protective layer.

Abstract: This specification describes a simulation system that performs simulations of physical environments using a graph neural network. At each of one or more time steps in a sequence of time steps, the system can process a representation of a current state of the physical environment at the current time step using the graph neural network to generate a prediction of a next state of the physical environment at the next time step. Some implementations of the system are adapted for hardware GLOBAL acceleration. As well as performing simulations, the system can be used to predict physical quantities based on measured real-world data. Implementations of the system are differentiable and can also be used for design optimization, and for optimal control tasks.

Abstract: A device, system, and method perform an automatic change over for transport streams. The method is performed at an output server. The method includes selecting a first transport stream. The method includes generating a first portion of an output based on the first transport stream. The method includes selecting a second transport stream. The method includes determining a frametime to synchronize first packets of the first transport stream to second packets of the second transport stream. The frametime is based on a start time of a content item included in the first transport stream and the second transport stream and a completed progression of the content item using the first transport stream. The method includes determining a location in the second transport stream based on the frametime. The method includes generating a second portion of the output based on the second transport stream starting at the location.

Abstract: The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: The present disclosure relates to the field of molecular biology and more specifically to microarrays and methods.

Abstract: A method of characterizing candidate agents including steps of (a) providing a library of candidate agents attached to nucleic acid tags; (b) contacting the library with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed; (c) contacting the array with a screening agent, wherein one or more candidate agents in the array react with the screening agent; (d) detecting the array to determine that at least one candidate agent in the array reacts with the screening agent; (e) sequencing the nucleic acid tag to determine the tag sequences attached to candidate agents in the array; and (f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent.

Abstract: A tool, e.g. a downhole tool, utilizes at least one actuator which may be actuated rapidly between positions during operation of the tool. The actuator is moved via flow of an actuating fluid controlled by a main valve which, in turn, is controlled via a pilot valve. The pilot valve is operated to selectively control flow of the actuating fluid to the main valve so as to shift the main valve between desired operational positions.

Abstract: Techniques are described herein for concurrent voice assistants. A method includes: providing first and second automated assistants with access to one or more microphones; receiving, from the first automated assistant, an indication that the first automated assistant has initiated a first session, and in response: continuing providing, to the first automated assistant, access to the one or more microphones; discontinuing providing, to the second automated assistant, access to the one or more microphones; and preventing the second automated assistant from accessing one or more portions of an output audio data stream; receiving, from the first automated assistant, an indication that the first session has ended, and in response: continuing providing, to the first automated assistant, access to the one or more microphones; resuming providing, to the second automated assistant, access to the one or more microphones; and resuming providing, to the second automated assistant, the output audio data stream.

Abstract: The disclosure relates to gene edited wheat plants, seeds, and compositions, as well as improvements to wheat plant breeding and methods for creating modifications in wheat plant genomes.

Abstract: Methods for synthesizing chalcogenide perovskites and chalcogenide perovskites synthesized thereby. Such s method includes providing a precursor solution containing a metal precursor, depositing the precursor solution onto a substrate to form a precursor film, and heating the precursor film in the presence of a chalcogen source to form a chalcogenide perovskite. The precursor solution is oxygen-free, and the steps of depositing and heating are conducted in an inert atmosphere.

Abstract: In one embodiment, a method includes receiving a transaction authorization request associated with a transfer of resources to a receiving entity from a user, retrieving a transaction resource configuration of a virtual bank account (VBAN) associated with the receiving entity and the user, the transaction resource configuration being decoupled from an external resource account associated with the user and the VBAN, determining parameters of the transaction resource configuration are not satisfied, transmitting instructions for presenting a notification indicating a transaction authorization failure to a client device associated with the user, wherein the notification comprises an interactive prompt operable for receiving an input indicating whether the transaction authorization request should be authorized, and transmitting a transaction authorization response indicating whether the transaction is authorized, wherein the transaction being authorized causes a stored value balance of the external resource accoun

Abstract: A throttle-controlled intake system is disclosed that provides a driver of a vehicle with greater control over engine functions and vehicle performance. The throttle-controlled intake system includes a control module that is coupled with an aircharger air intake. The control module processes input signals from a throttle pedal of the vehicle and sends modified throttle position signals to a throttle body of the vehicle so as to increase throttle responsiveness of the vehicle. The throttle-controlled intake system further includes a wiring harness and a signal adjuster. The wiring harness electrically couples the control module with the throttle pedal and the throttle body. The control module sends signals directly to the throttle body of the engine, bypassing an electronic control unit of the vehicle. The signal adjuster includes a rheostat that enables manual adjustment of the throttle responsiveness of the vehicle.