Abstract: Systems, apparatus, computer-readable medium, and associated methods to monitor, analyze, and adjust at least one of a build and/or an additive manufacturing machine configuration are disclosed. An example apparatus includes memory circuitry, instructions, and processor circuitry to execute the instructions to implement at least a feature extractor, a variability analyzer, and an output generator. The feature extractor is to: i) group data for a plurality of builds associated with one or more additive manufacturing machines; and ii) extract features from the grouped data. The variability analyzer is to: i) process the grouped data with respect to the features to determine a measure of variability for each feature; and ii) compare the measure of variability for each feature to a respective allowable limit associated with the respective feature. The output generator is to provide actionable output to adjust at least a first additive manufacturing machine.

Abstract: A method, computer program product, and computer system are provided for testing drives in a redundant array of independent disks (RAID) array. The method includes: mirroring data from a selected drive to be tested in a RAID array to spare storage space in the RAID array; and, once the data is successfully mirrored, testing the selected drive to identify a preemptive failure of the selected drive. The RAID may be a traditional RAID (TRAID) array and the spare space may be a spare physical drive independent of array drive members. The RAID array may alternatively be a distributed RAID (DRAID) array and the spare space may be spare capacity spread through the array drive members.

Abstract: A pet water fountain is described comprising a bowl for holding an aqueous drinking fluid. The pet water fountain includes a housing configured to cover a portion of the bowl and have a fluid reservoir. The pet water fountain includes a rotatable cone positioned within the housing, the cone tapering outwardly from a bottom end to a top end, the bone bottom end having a fluid inlet to allow the passage of fluid from the bowl through the inlet and into the interior of the conde, the cone top end being in fluid communication with the housing fluid reservoir. The pet water fountain includes a filter ring coupled to the cone top end, the filter ring having an exterior housing and a filter media positioned within the exterior housing, and an electric motor coupled to the rotatable cone for rotatably driving the rotatable cone.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: An Internet of Things (IoT) device is deployed with embedded software. A debug client device stores an end-to-end encryption key that corresponds to an end-to-end encryption key stored on the IoT device. The debug client encrypts a debug instruction using the end-to-end encryption key and encrypts additional data using a point-to-point encryption key. The encrypted debug instruction and the encrypted additional data are sent to a debug server over a network. The debug server decrypts the additional data and identifies the IoT device from among multiple IoT devices. The debug server generates a message to the IoT device including the encrypted debug instruction, encrypts the message, and transmits the message to the IoT device. The IoT device decrypts the message using a first decryption key associated with the debug server, retrieves the encrypted message payload, and decrypts the message payload using the stored end-to-end encryption key.

Abstract: A recurrent neural network (RNN) method implemented on a computer system is used to produce summaries of unstructured text generated by multiple networks of individuals interacting over time by encoding the unstructured text into intermediate representations and decoding the intermediate representations into summaries of each network. Parameter data for the RNN is obtained by using multiple different versions of the same source texts to train the computer system. The method and computer system can be used to identify which of the networks match a query by determining which network generates the query with low or lowest cost.

Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

Abstract: A fault detection system for detecting an electrical fault in a component includes an optical conductor with a first end and a second end, and configured to optically face the component. A first sensor and a second sensor can be operably coupled to the first end and the second end, respectively. The first sensor and the second sensor are each configured to detect electromagnetic radiation propagating through the optical conductor.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: An image fusion system provides a predicted alignment between images of different modalities and synchronization of the alignment, once acquired. A spatial tracker detects and tracks a position and orientation of an imaging device within an environment. A predicted pose of an anatomical feature can be determined, based on previously acquired image data, with respect to a desired position and orientation of the imaging device. When the imaging device is moved into the desired position and orientation, a relationship is established between the pose of the anatomical feature in the image data and the pose of the anatomical feature imaged by the imaging device. Based on tracking information provided by the spatial tracker, the relationship is maintained even when the imaging device moves to various positions during a procedure.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: The present disclosure generally relates to a multilayer extendable actuator. The actuator comprises: a first stiffening elastomeric layer; a second stiffening elastomeric layer; a set of middle layers disposed between the stiffening elastomeric layers, the middle layers comprising an elastic elastomeric layer that is more elastic than the stiffening elastomeric layers; and a set of grooves through one or more of the elastomeric layers, the grooves arranged such that a cross-section of the elastomeric layers comprises a wave profile around the grooves, wherein the actuator is extendable such that the elastomeric layers along the wave profile become alternatingly arranged along the extended actuator.

Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.

Abstract: A personal care product dispensing system with a body defining a cavity configured to retain a spreadable personal care product. A spreadable material is positioned within the cavity. A cover is mounted to the body. The cover defines a first aperture extending from a top surface of the cover to a bottom surface of the cover. A flexible applicator pad is mounted to the top surface of the cover with a valve positioned over the first aperture. The flexible applicator pad has a plurality of projections and each of the projections has a maximum cross sectional area of 0.20 mm2 to 0.60 mm2.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: The present invention provides means and methods for the non-invasive diagnosis of intestinal infection in birds.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: The present disclosure relates to compounds of Formula I, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for treatment of viral infections, for example for treatment of paramyxoviridae, pneumoviridae, picornaviridae, flaviviridae, filoviridae, arenaviridae, orthomyxovirus, and coronaviridae infections.

Abstract: The present disclosure generally relates to compounds of Formula (1) and pharmaceutical compositions that may be used in methods of treating cancer.

Abstract: A personal care product dispensing system with a body defining a cavity configured to retain a spreadable personal care product. A spreadable material is positioned within the cavity. A cover is mounted to the body. The cover defines a first aperture extending from a top surface of the cover to a bottom surface of the cover. A flexible applicator pad is mounted to the top surface of the cover with a valve positioned over the first aperture. The flexible applicator pad has a plurality of projections and a projection density of 10 to 40 projections per square centimeter.