Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.

Abstract: An optical device includes a first electrode and a medium that includes ferroelectric liquid crystals and chiral dopants. The medium is located adjacent to the first electrode. The optical device may also include a second electrode distinct and separate from the first electrode. The optical device may be used as an optical dimming device, controlling an amount light passing through the optical device based on a voltage gradient provided to the optical device.

Abstract: An Internet of Things (IoT) device is deployed with embedded software that may comprise multiple components. After deployment, updated versions of one or more components of the embedded software may become available. The IoT device maintains a manifest of the installed components. Periodically, the IoT device requests an updated copy of the manifest from an upgrade server. The installed manifest and the updated manifest are compared to determine if updated versions of any components are available. If so, the IoT device requests only the components to be updated. Prior to beginning the copying of the upgraded components, an upgrade flag is set. The IoT device then begins copying the received components into memory, replaces the manifest with the updated manifest, and clears the upgrade flag.

Abstract: This invention is related to the field of PCSK9 biology and the composition and methods of use of small organic compounds as ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small organic compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small organic compound ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small organic compound ligands that can raise LDL levels.

Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

Abstract: A rate of change of current sensor includes two measurement coils, arranged on a substrate or printed circuit board. The coils form loops and progress substantially around a target measurement conductor. This ensures that the two measurement coils both receive the same electrostatic coupling from external conductors which are not the target of the measurement operation. Further, the two measurement coils are arranged such that the first coil and the second coil are, on average, the same distance to the current-carrying conductor of interest.

Abstract: The invention relates generally to antibodies that bind CD166, activatable antibodies that specifically bind to CD166 and methods of making and using these anti-CD166 antibodies and anti-CD166 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: An optical device includes a first set of one or more electrodes, a second set of one or more electrodes distinct and separate from the first set of one or more electrodes, and a solution containing transparent metal ions in a liquid or gel electrolyte. The solution is located between the first set of one or more electrodes and the second set of one or more electrodes. The optical device may operate as an optical dimming device, which may be used in head-mounted display devices or as dimmable windows or shutters.

Abstract: Devices, systems, and methods with behavioral one-time-passcode (OTP) generation. In one example, a server includes a memory and an electronic processor communicatively connected to the memory. The memory includes a behavioral one-time-passcode (OTP) program and a user profile repository. The electronic processor, when executing the behavioral OTP program, is configured to receive a one-time-passcode (OTP) request, generate a behavioral one-time-passcode (OTP) based on a user profile stored in the user profile repository in response to receiving the OTP request, and output the behavioral OTP that is generated.

Abstract: A joist assembly system that is structured for dynamic retrieval of components, dynamic and precise positioning and location of retrieved components, assembly of the components to form a joist, and delivery of the assembled joist. The joist assembly system has a plurality of material handling systems, a plurality of welding systems, and a rigging table system. The material handling systems are structured to load and position the components such as chords and webs onto the rigging table. The rigging table in turn supports the chords or webs. Subsequently, the plurality of welding systems weld the webs to the chords to form the joist.

Abstract: A method for delaying cylinder reactivation in a vehicle includes identifying, by a controller, a request to exit a cylinder deactivation state. The controller determines if the request is due to a transient condition. If the request is due to the transient condition, the controller analyzes at least one of the transient condition and a condition of the vehicle. The controller determines a first adjustment to the vehicle based on analyzing at least one of the transient condition and the condition of the vehicle. The first adjustment is configured to mitigate the transient condition. The controller implements the first adjustment.

Abstract: In certain aspects of the present disclosure, a computer-implemented includes generating a unique code for display on a managed device, and authorizing a manager device to selectively initiate at least one workflow on the managed device. The method includes, responsive to the manager device scanning the unique code, verifying the manager device is authorized. The method includes displaying on the manager device, based on verification that the manager device is authorized, an option corresponding to the at least one workflow. The method includes receiving, from the manager device, a selected workflow. The method includes, responsive to receiving the selected workflow, transmitting a message to a push notification server initiating the managed device to communicate with an MDM server. The method includes transmitting a command to the managed device causing performance of the selected workflow on the managed device. Systems and machine-readable media are also provided.

Abstract: Techniques for a privacy-based user data sharing protocol disclose a system that receives a request to consent to share user data with a subscriber device. The system identifies, based on the request, a smart contract associated with the subscriber device. The smart contract comprises one or more conditions for collecting and managing the user data. The system generates a token based on the smart contract, in which the token indicates consent by a user to share the user data with the subscriber device according to the one or more conditions. The system records the generated token to a blockchain.

Abstract: According to certain aspects of the present disclosure, a computer-implemented method is provided. The method includes receiving, at a manager device, data comprising at least one managed device. The method includes identifying, at the manager device, a website associated with the at least one managed device. The method also includes receiving, at a mobile device management server from the manager device, a first message to cause the mobile device management server to initiate transmission of a second message comprising a command that causes the at least one managed device to navigate to the website via a browser, restrict access to other websites other than the website, and enable a camera. Systems and machine-readable media are also provided.

Abstract: An image fusion system provides a predicted alignment between images of different modalities and synchronization of the alignment, once acquired. A spatial tracker detects and tracks a position and orientation of an imaging device within an environment. A predicted pose of an anatomical feature can be determined, based on previously acquired image data, with respect to a desired position and orientation of the imaging device. When the imaging device is moved into the desired position and orientation, a relationship is established between the pose of the anatomical feature in the image data and the pose of the anatomical feature imaged by the imaging device.

Abstract: The present disclosure relates to novel compounds, methods, and compositions capable of binding to PCSK9, thereby modulating PCSK9 proprotein convertase enzyme activity, for treatment of a disease or condition mediated, at least in part, by PCSK9. The compounds of the disclosure include compounds Formula (I).

Abstract: A fuel injector includes a nozzle assembly having a nozzle case, and a concentric check assembly within the nozzle case. Transfer passages are formed in an outer check of the check assembly, and spray orifices are formed in the nozzle case. A fuel volume is formed between the outer check and an inner check, and the inner check is movable to fluidly connect the transfer passages to the fuel volume. The outer check is rotatable between a first angular orientation and a second angular orientation to fluidly connect separate sets of the transfer passages to separate sets of the spray orifices. Spray ducts are in spray path alignment with at least one of the sets of spray orifices.

Abstract: A personal care product dispensing system with a body defining a cavity configured to retain a spreadable personal care product. A spreadable material is positioned within the cavity. A cover is mounted to the body. The cover defines a first aperture extending from a top surface of the cover to a bottom surface of the cover. A flexible applicator pad is mounted to the top surface of the cover with a valve positioned over the first aperture. The flexible applicator pad has a plurality of projections and a projection density of 10 to 40 projections per square centimeter.