Abstract: A recurrent neural network (RNN) method implemented on a computer system is used to produce summaries of unstructured text generated by multiple networks of individuals interacting over time by encoding the unstructured text into intermediate representations and decoding the intermediate representations into summaries of each network. Parameter data for the RNN is obtained by using multiple different versions of the same source texts to train the computer system. The method and computer system can be used to identify which of the networks match a query by determining which network generates the query with low or lowest cost.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: A fault detection system for detecting an electrical fault in a component includes an optical conductor with a first end and a second end, and configured to optically face the component. A first sensor and a second sensor can be operably coupled to the first end and the second end, respectively. The first sensor and the second sensor are each configured to detect electromagnetic radiation propagating through the optical conductor.

Abstract: An image fusion system provides a predicted alignment between images of different modalities and synchronization of the alignment, once acquired. A spatial tracker detects and tracks a position and orientation of an imaging device within an environment. A predicted pose of an anatomical feature can be determined, based on previously acquired image data, with respect to a desired position and orientation of the imaging device. When the imaging device is moved into the desired position and orientation, a relationship is established between the pose of the anatomical feature in the image data and the pose of the anatomical feature imaged by the imaging device. Based on tracking information provided by the spatial tracker, the relationship is maintained even when the imaging device moves to various positions during a procedure.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: The present disclosure generally relates to a multilayer extendable actuator. The actuator comprises: a first stiffening elastomeric layer; a second stiffening elastomeric layer; a set of middle layers disposed between the stiffening elastomeric layers, the middle layers comprising an elastic elastomeric layer that is more elastic than the stiffening elastomeric layers; and a set of grooves through one or more of the elastomeric layers, the grooves arranged such that a cross-section of the elastomeric layers comprises a wave profile around the grooves, wherein the actuator is extendable such that the elastomeric layers along the wave profile become alternatingly arranged along the extended actuator.

Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.

Abstract: A personal care product dispensing system with a body defining a cavity configured to retain a spreadable personal care product. A spreadable material is positioned within the cavity. A cover is mounted to the body. The cover defines a first aperture extending from a top surface of the cover to a bottom surface of the cover. A flexible applicator pad is mounted to the top surface of the cover with a valve positioned over the first aperture. The flexible applicator pad has a plurality of projections and each of the projections has a maximum cross sectional area of 0.20 mm2 to 0.60 mm2.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: The present disclosure relates to compounds of Formula I, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for treatment of viral infections, for example for treatment of paramyxoviridae, pneumoviridae, picornaviridae, flaviviridae, filoviridae, arenaviridae, orthomyxovirus, and coronaviridae infections.

Abstract: The present disclosure generally relates to compounds of Formula (1) and pharmaceutical compositions that may be used in methods of treating cancer.

Abstract: A personal care product dispensing system with a body defining a cavity configured to retain a spreadable personal care product. A spreadable material is positioned within the cavity. A cover is mounted to the body. The cover defines a first aperture extending from a top surface of the cover to a bottom surface of the cover. A flexible applicator pad is mounted to the top surface of the cover with a valve positioned over the first aperture. The flexible applicator pad has a plurality of projections and a projection density of 10 to 40 projections per square centimeter.

Abstract: This invention is related to the field of PCSK9 biology and the composition and methods of use of small organic compounds as ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small organic compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small organic compound ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small organic compound ligands that can raise LDL levels.

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: A pet water fountain is described comprising a bowl for holding an aqueous drinking fluid. The pet water fountain includes a housing configured to cover a portion of the bowl and have a fluid reservoir. The pet water fountain includes a rotatable cone positioned within the housing, the cone tapering outwardly from a bottom end to a top end, the bone bottom end having a fluid inlet to allow the passage of fluid from the bowl through the inlet and into the interior of the conde, the cone top end being in fluid communication with the housing fluid reservoir. The pet water fountain includes a filter ring coupled to the cone top end, the filter ring having an exterior housing and a filter media positioned within the exterior housing, and an electric motor coupled to the rotatable cone for rotatably driving the rotatable cone.

Abstract: An airform that can be inflated, for example, for facilitating construction of a structure is provided. The airform may include a first portion, a second portion, or multiple other portions, and reinforcement. The first portion may, for example, be configured to be disposed in a first orientation, such as vertically or in a radial profile, when the airform is inflated. The second portion transitioning from the first portion may be configured, for example, to assume an alternate shape and profile, such as a radial shape and profile, when the airform is inflated. The reinforcement may, for example, be provided at a portion of the airform that defines a transition from the first portion to the second portion.