Abstract: A system includes an outflow vent that has a cap releasably mounted to a panel within an internal cabin of a vehicle. The cap is elongated from a first end of the cap to a second end of the cap opposite the first end. The cap has a base wall that is overlaid on the panel and defines at least one slot therethrough. The cap receives an airflow generated by an airflow generator, and the at least one slot emits the airflow from the cap to form an air curtain within the internal cabin.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for training a neural network that includes one or more graph neural network layers. In one aspect, a method comprises: generating data defining a graph, comprising: generating a respective final feature representation for each node, wherein, for each of one or more of the nodes, the respective final feature representation is a modified feature representation that is generated from a respective feature representation for the node using respective noise; processing the data defining the graph using one or more of the graph neural network layers of the neural network to generate a respective updated node embedding of each node; and processing, for each of one or more of the nodes having modified feature representations, the updated node embedding of the node to generate a respective de-noising prediction for the node.

Abstract: A system comprising a client device and a server network, the client device configured to receive a query; transmit the query; receive a populated response; and display the populated response. The server network may be configured to receive the query; tokenize the query; generate an intent-match likelihood for each of a plurality of supported question intents; classify the query based on the intent-match likelihoods; evaluate each of the intent-match likelihoods to a confidence threshold; extract, via a Named Entity Recognition model, one or more entities from the query; determine one or more entity values for each of the one or more entities; query the at least one database to incorporate intent to the one or more entities and the one or more entity values; populate a response template with the one or more entity values and one or more specifics; and store the query and the populated response.

Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.

Abstract: Compounds and methods of using said compounds, alone or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

Abstract: Operating a gaseous fuel engine includes spark-igniting gaseous hydrogen fuel and air, and propagating combustion gases of the spark-ignited mixture outwardly from a spark gap. The propagating combustion gases are impinged upon a cone surface of a piston so as to limit a flame area of the propagating combustion gases. Additional gaseous hydrogen fuel and air is ignited in the combustion cylinder by way of the propagating combustion gases to urge a piston toward a bottom-dead-center position.

Abstract: An aircraft includes external structures, and one or more thermal emitters integrated with one or more of the external structures. The one or more thermal emitters are configured to generate heat to deice the one or more external structures. The one or more thermal emitters are configured to receive electrical power from one or more of an auxiliary power unit of the aircraft, a power distribution system of the aircraft, one or more engines of the aircraft, or an external power cart that is separate and distinct from the aircraft.

Abstract: Various embodiments of the present disclosure provide a scan-based architecture for register-transfer-level (RTL) or gate-level designs that improves the security of scan chain-based design-for-testability (DFT) structures. In various embodiments, the scan-based architecture includes invisible scan chains that are hidden in such a way that an attacker cannot easily identify or locate the invisible scan chains for exploitation and revealing internal secure information of the design. The invisible scan chains are dynamically configurable into a scan chain with select flip-flops, such that scan paths of the invisible scan chains may be different between different designs, chips, or testing operations. Various embodiments further employ key-based obfuscation by combining a scan control finite state machine with existing state machines within a design, which improves design security against unauthorized use and increases confidentiality.

Abstract: This invention is related to the field of PCSK9 biology and the composition and methods of use of small organic compounds as ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small organic compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small organic compound ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small organic compound ligands that can raise LDL levels.

Abstract: This invention is related to the field of PCSK9 biology and the composition and methods of use of small organic compounds as ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small organic compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small organic compound ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunctions; thus, there is also utility for small organic compound ligands and can raise LDL levels.

Abstract: In certain aspects, a computer-implemented method includes receiving, responsive to a managed device communicating with a reader, user data and access information of the managed device. The method includes identifying device information of the managed device associated with the user data and the access information. The method also includes determining at least one mobile device action to perform on the managed device based on the device information, the user data, and the access information. The method includes, responsive to determining the at least one mobile device action, transmitting a message to a push notification service, wherein the message initiates the managed device to communicate with a mobile device management server. The method includes, responsive to the managed device communicating with the mobile device management server, transmitting a management command to the managed device to perform the at least one mobile device action. Systems and media are also provided.

Abstract: In certain aspects of the present disclosure, a computer-implemented method includes receiving, at a mobile device management server in response to authentication being granted to an organization app on a mobile device, an API enable message from an organization service associated with the organization app. The API enable message includes instructions for the mobile device management server to retrieve device and user data from the mobile device. The method includes retrieving, responsive to receiving the API enable message, the device and user data from the mobile device. The method includes transmitting the device and user data to the automation service for requesting activation of an organization owned line of service ESIM on the mobile device. The method includes deploying a management app and security posture to the mobile device based on the organization owned line of service ESIM being activated on the mobile device.

Abstract: In certain aspects of the present disclosure, a computer-implemented method includes receiving, at a mobile device management (MDM) server from a carrier server, at least one activation code. The at least one activation code is associated with an inactive, organization owned cellular line of service. The method includes enrolling at least one personally owned device with the MDM server as an at least one personally owned, managed device. The method also includes, responsive to the at least one personally owned device being enrolled, transmitting a message to a push notification server, which initiates the at least one personally owned, managed device to communicate with the MDM server. The method includes transmitting, in response to the at least one personally owned, managed device communicating with the MDM server, one activation code of the at least one activation code to the at least one personally owned, managed device. Systems are also provided.

Abstract: A system and method for sensing an edge of a region includes at least one distance sensor configured to detect a plurality of distances of objects along a plurality of adjacent scan lines. A controller is in communication with the at least one distance sensor and is configured to determine a location of an edge of a region within the plurality of adjacent scan lines. The controller includes a comparator module configured to compare values corresponding to the detected plurality of distances, and an identification module configured to identify the location of the edge of the region according to the compared values. In one example, the values corresponding to the detected plurality of distances include couplets of standard deviations that are analyzed and selected to identify the location of the edge.

Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.

Abstract: An optical device includes a first electrode and a medium that includes ferroelectric liquid crystals and chiral dopants. The medium is located adjacent to the first electrode. The optical device may also include a second electrode distinct and separate from the first electrode. The optical device may be used as an optical dimming device, controlling an amount light passing through the optical device based on a voltage gradient provided to the optical device.

Abstract: An Internet of Things (IoT) device is deployed with embedded software that may comprise multiple components. After deployment, updated versions of one or more components of the embedded software may become available. The IoT device maintains a manifest of the installed components. Periodically, the IoT device requests an updated copy of the manifest from an upgrade server. The installed manifest and the updated manifest are compared to determine if updated versions of any components are available. If so, the IoT device requests only the components to be updated. Prior to beginning the copying of the upgraded components, an upgrade flag is set. The IoT device then begins copying the received components into memory, replaces the manifest with the updated manifest, and clears the upgrade flag.

Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

Abstract: This invention is related to the field of PCSK9 biology and the composition and methods of use of small organic compounds as ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small organic compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small organic compound ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small organic compound ligands that can raise LDL levels.

Abstract: An optical device includes a first set of one or more electrodes, a second set of one or more electrodes distinct and separate from the first set of one or more electrodes, and a solution containing transparent metal ions in a liquid or gel electrolyte. The solution is located between the first set of one or more electrodes and the second set of one or more electrodes. The optical device may operate as an optical dimming device, which may be used in head-mounted display devices or as dimmable windows or shutters.