Abstract: The present disclosure relates to a resin composition for vehicle parts, a vehicle part manufactured using the resin composition, and a method of manufacturing the vehicle part. Ultra-high molecular weight siloxane and an inorganic filler are mixed with an alloy resin of polyamide and polyethylene at an optimal rate in order to improve friction resistance and wear resistance while maintaining excellent impact resistance and low hygroscopicity. When a vehicle part is manufactured using the resin composition, it is possible to eliminate the application of silicone-based oil or to remarkably reduce the amount of silicone-based oil that is used, whereby it is possible to reduce manufacturing costs. Furthermore, ingredients that are harmful to human beings, such as POM, are not included, whereby it is possible to improve the quality of air in a vehicle.

Abstract: Compounds are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: Provided are methods and compositions for the treating a patient with a urea cycle disorder. Methods and compositions are also provided for modulating genes encoding enzymes that participate in the urea cycle by altering gene signaling networks.

Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable.

Abstract: A long-acting conjugate for brain targeting is disclosed. The long-acting conjugate includes a peptide for brain targeting and a physiologically active material. The long-acting conjugate contains a physiologically active material with improved durability and stability, which can pass through the blood-brain barrier (BBB) and comprises a physiologically active material. The long-acting conjugate for brain targeting including a peptide for brain targeting and a physiologically active material can pass through the blood-brain barrier, thus enabling the treatment of diseases associated with brain diseases, and additionally, can maintain the activity of a physiologically active material in vivo and increase its half-life in the blood.

Abstract: A fusion protein of a dimeric therapeutic enzyme and an immunoglobulin Fc region, a preparation method thereof, and a composition containing the fusion protein are disclosed.

Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable.

Abstract: The present patent application discloses at least the compounds according to Formula I? shown below, or pharmaceutically acceptable salts thereof, wherein ring D, ring A, ring E, JB, n, JD, J, X, Z, Z1, RC1, RC2, Y, R9, o and W are as defined herein.

Abstract: A virtual reality experience apparatus includes: a displaying device configured to provide an experiencing user with a virtual reality image; and a riding device configured to provide the experiencing user with a motion, wherein the riding device includes: a riding part providing the experiencing user with a ridable space, and a gyro mechanism generating a pitching motion and a rolling motion of the riding part, wherein the gyro mechanism includes: a base structure having a pair of support columns disposed apart from each other, a pitching mechanism rotatably mounted on the pair of support columns to be rotated with respect to a pitching axis extending between the pair of support columns, and a rolling mechanism rotatably mounted on the pitching mechanism to be rotated with respect to a rolling axis perpendicular to the pitching axis.

Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: A virtual reality experience apparatus includes: a displaying device configured to provide an experiencing user with a virtual reality image; and a riding device configured to provide the experiencing user with a motion, wherein the riding device includes: a riding part providing the experiencing user with a ridable space, and a gyro mechanism generating a pitching motion and a rolling motion of the riding part, wherein the gyro mechanism includes: a base structure having a pair of support columns disposed apart from each other, a pitching mechanism rotatably mounted on the pair of support columns to be rotated with respect to a pitching axis extending between the pair of support columns, and a rolling mechanism rotatably mounted on the pitching mechanism to be rotated with respect to a rolling axis perpendicular to the pitching axis.

Abstract: The present disclosure relates to a resin composition for vehicle parts, a vehicle part manufactured using the resin composition, and a method of manufacturing the vehicle part. Ultra-high molecular weight siloxane and an inorganic filler are mixed with an alloy resin of polyamide and polyethylene at an optimal rate in order to improve friction resistance and wear resistance while maintaining excellent impact resistance and low hygroscopicity. When a vehicle part is manufactured using the resin composition, it is possible to eliminate the application of silicone-based oil or to remarkably reduce the amount of silicone-based oil that is used, whereby it is possible to reduce manufacturing costs. Furthermore, ingredients that are harmful to human beings, such as POM, are not included, whereby it is possible to improve the quality of air in a vehicle.

Abstract: A display apparatus and a controlling method thereof are provided. The display apparatus may include: a display panel that displays a screen; a light source disposed at one side of the display panel; an audio input that receives an audio signal; and a processor that flickers the light source in response to the received audio signal.

Abstract: Provided herein is an eco-friendly artificial leather for an interior of an automobile and a manufacturing method thereof. The eco-friendly product is manufactured using a method that is compatible with various environmental regulations such as reduction of greenhouse gas emissions. The artificial leather includes a bio urethane-containing skin surface layer which uses biomass-derived components extracted from vegetable components, a solvent-free bio urethane adhesive layer, and a bio fiber base layer. The layers are sequentially stacked to minimize the use of organic solvents and components that are harmful to the human body.

Abstract: Inter-allotropic transformations of carbon are provided using moderate conditions including alternating voltage pulses and modest temperature elevation. By controlling the pulse magnitude, small-diameter single-walled carbon nanotubes are transformed into larger-diameter single-walled carbon nanotubes, multi-walled carbon nanotubes of different morphologies, and multi-layered graphene nanoribbons.

Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: A display apparatus and a controlling method thereof are provided. The display apparatus may include: a display panel that displays a screen; a light source disposed at one side of the display panel; an audio input that receives an audio signal; and a processor that flickers the light source in response to the received audio signal.

Abstract: A virtual reality experience apparatus includes an image apparatus providing an experiencing user with an image and a riding apparatus providing the experiencing user with a physical motion, wherein the riding apparatus includes a riding part providing the experiencing user with a ridable space; and a gyro mechanism generating at least one of a pitching motion, a yawing motion, a rolling motion, and a reciprocating motion in the riding part, such that a stimulus sensed by the experiencing user through a sense of sight and a stimulus sensed through a physical motion may coincide with each other.

Abstract: Ion-doped two-dimensional nanomaterials are made by inducing electronic carriers (electrons and holes) in a two-dimensional material using a captured ion layer at the surface of the material. The captured ion layer is stabilized using a capping layer. The induction of electronic carriers works in atomically-thin two-dimensional materials, where it induces high carrier density of at least 1014 carriers/cm2. A variety of novel ion-doped nanomaterials and p-n junction-based nanoelectronic devices are made possible by the method.

Abstract: The present invention relates to a virtual reality experience apparatus. The virtual reality experience apparatus includes the image apparatus providing an experiencing user with an image and the riding apparatus providing the experiencing user with a physical motion, and the riding apparatus may include a riding part providing the experiencing user with a ridable space; and a gyro mechanism generating at least one of a pitching motion, a yawing motion, a rolling motion, and a reciprocating motion in the riding part, such that a stimulus sensed by the experiencing user through a sense of sight and a stimulus sensed through a physical motion may coincide with each other. Accordingly, the experiencing user may be prevented from feeling a sense of displacement, and an immersion level may be improved, as a result, a sense of realism may be improved.