Abstract: The present invention relates to compounds of formula I: in which Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: The invention relates to a pulling machine for unloading and laying railway tracks, which moves by means of caterpillar tracks running next to the sleepers arranged on the setting bed, with the rail on the provisional supports arranged on the sleepers. The machine comprises a cabin and two caterpillar tracks and includes, in its rear tractor part, a pulling slide that comprises a tube with fastening elements, said tube sliding horizontally, actuated by a hydraulic cylinder comprising a piston connected to the tube, via three dismountable metal supports provided with teflon elements for facilitating the sliding, said metal supports being connected to steel elements acted upon by articulated arms generating the vertical movement by means of the action of another hydraulic cylinder, always maintaining the pulling direction. The machine pulls the rails without needing an auxillary track, maintaining the position of the track-laying train.

Abstract: An implant is provided with a main body (1) and with a double coating applied to at least one surface section of the main body (1), wherein the double coating comprises an adhesion promoter layer (2), applied directly to the at least one surface section of the main body, and of an osteointegrative layer (3) covering the adhesion promoter layer (2). The layers (2;3) consist of pure titanium, wherein the adhesion promoter layer (2) has a thickness of 2-6 ?m, in particular a thickness of 3-5 ?m, and the osteointegrative layer (3) has a thickness of 50-70 ?m, in particular of 55-65 ?m. Moreover, the osteointegrative layer (3) has a porosity of 70-90% and a roughness Rz of at least 45 ?m. A related method is also provided for producing such an implant.

Abstract: A control circuit for an energy saving contactor including at least one power contact is provided. The control circuit includes a power supply unit, an energy storage circuit coupled to the power supply unit, a first transducer coupled to the power supply unit and configured to switch the at least one power contact from an open armature position to a closed armature position, a latch system configured to maintain the at least one power contact in the closed armature position, a second transducer coupled to the power supply unit and configured to disengage the latch system to cause the at least one power contact to switch from the closed armature position to the open armature position, and a controller configured to control electrical power supplied from the power supply to the first and second transducers to selectively activate the first and second transducers based on monitored input voltage conditions.

Abstract: An implant is provided with a main body (1) and with a double coating applied to at least one surface section of the main body (1), wherein the double coating comprises an adhesion promoter layer (2), applied directly to the at least one surface section of the main body, and of an osteointegrative layer (3) covering the adhesion promoter layer (2). The layers (2;3) consist of pure titanium, wherein the adhesion promoter layer (2) has a thickness of 2-6 ?m, in particular a thickness of 3-5 ?m, and the osteointegrative layer (3) has a thickness of 50-70 ?m, in particular of 55-65 ?m. Moreover, the osteointegrative layer (3) has a porosity of 70-90% and a roughness Rz of at least 45 ?m. A related method is also provided for producing such an implant.

Abstract: A reactor system for producing polycarbonate includes a surface area in contact with a reaction mixture. The reaction mixture comprises a melt transesterification catalyst, a dihydroxy compound, a diaryl carbonate, and an phenolic byproduct. The surface area in contact with the reaction mixture contains one or more welds joining reactor system parts. All welds in contact with the reaction mixture join reactor system parts made from the same type of metal. If a filler metal is contained in the weld, the filler metal is made from the same type of metal as the metal parts joined by the weld.

Abstract: The disclosure relates to a composition comprising two or more immunogenic staphylococcal polypeptides and a multivalent vaccine composition comprising the immunogenic staphylococcal polypeptides.

Abstract: A reactor system for producing polycarbonate includes a surface area in contact with a reaction mixture. The reaction mixture comprises a melt transesterification catalyst, a dihydroxy compound, a diaryl carbonate, and an phenolic byproduct. The surface area in contact with the reaction mixture contains one or more welds joining reactor system parts. All welds in contact with the reaction mixture join reactor system parts made from the same type of metal. If a filler metal is contained in the weld, the filler metal is made from the same type of metal as the metal parts joined by the weld.

Abstract: The disclosure relates to a composition comprising two or more immunogenic staphylococcal polypeptides and a multivalent vaccine composition comprising the immunogenic staphylococcal polypeptides.

Abstract: A Spontaneous Area Network (SPAN) is formed by mobile and fixed nodes using wireless transmission links between nodes, usually in a nearby geographical area. Applications allow users to create, join, leave, and manage SPANs and groups in a SPAN. Automatic procedures allow nodes to join other SPANs. Transmission power of the wireless network interface is dynamic, varying depending on battery level, type of information to transmit, state and topology of the network. A delay tolerant object layer abstraction creates, modifies, deletes, publishes, and handles Delay Tolerant Distributed Objects (DTDOs). A Patient Transport Protocol (PTP) ensures a reliable transport of information through the network while avoiding congestion conditions. An aggressive and explosive network protocol (AGENET) has routing and forwarding capacities and uses datagrams to establish communication between different nodes of the SPAN.

Abstract: The invention relates to antigenic polypeptides expressed by pathogenic microbes, vaccines comprising said polypeptides; therapeutic antibodies directed to said polypeptides and methods to manufacture said polypeptides, vaccines and antibodies.

Abstract: The present invention provides a melt polymerization reactor system and method of producing polycarbonate using a late-addition catalyst formulation having a melt transesterification catalyst dispersed in a liquid carrier system which preferably includes less than 10 wt % water. The formulation also preferably includes a liquid carrier system having phenol and a cosolvent. The melt transesterification catalyst can be present in the formulation in a range of 50 ppm to 60,000 ppm.

Abstract: The invention relates to a pulling machine for unloading and laying railway tracks, which moves by means of caterpillar tracks running next to the sleepers arranged on the setting bed, with the rail on the provisional supports arranged on the sleepers. The machine comprises a cabin and two caterpillar tracks and includes, in its rear tractor part, a pulling slide that comprises a tube with fastening elements, said tube sliding horizontally, actuated by a hydraulic cylinder comprising a piston connected to the tube, via three dismountable metal supports provided with teflon elements for facilitating the sliding, said metal supports being connected to steel elements acted upon by articulated arms generating the vertical movement by means of the action of another hydraulic cylinder, always maintaining the pulling direction. The machine pulls the rails without needing an auxiliary track, maintaining the position of the track-laying train.

Abstract: The invention relates to a process for preparing 1-aryl-pyrazol-3-one intermediates, tautomers, and salts thereof, to novel intermediates, and to the use of the intermediates in the preparation of sigma receptor inhibitors.

Abstract: The disclosure relates to a composition comprising one, two or more immunogenic bacterial polypeptides and multi-valent and monovalent vaccine compositions comprising the immunogenic bacterial polypeptides.

Abstract: The disclosure relates to an apparatus and method of testing timing associated with the transmission and reception of a pulse signal. With regard to testing the transmission of the signal, a transmitter transmits a pulse within a selected hop offset subinterval of a hop interval. The receiver takes samples of the received signal for the entire duration of the hop interval. Successful timing operation is indicated when samples indicate a pulse received within the selected subinterval, and no pulses received within other subintervals of the hop interval. With regard to testing the reception of the signal, a transmitter transmits pulses within respective hop offset subintervals of a hop interval. The receiver is enabled only for the duration of a selected subinterval, but samples are taken for the entire duration of the hop interval. Successful timing operation is indicated when the samples indicate a pulse received within the selected subinterval, and no pulses received within other subintervals.

Abstract: Apparatus for generating a first signal (e.g., a pulse) including a current source adapted to generate a current based on a second signal that defines an amplitude of the current and a third signal that defines the timing of an amplitude change of the current, and an impedance element through which the current flows to generate the first signal. The impedance element may comprise a resonator having a resonant frequency approximate the center of the first signal frequency spectrum. An LO may be used to generate the third signal to control the timing of the amplitude change of the current. A detector may enable the current source in response to detecting a defined steady-state condition of the LO clock signal, and may disable the current source in response to the completion of the first signal. A controller may generate the second signal to control the current amplitude so as to perform power control and/or other functions.

Abstract: The present invention provides a melt polymerization reactor system and method of producing polycarbonate using a late-addition catalyst formulation having a melt transesterification catalyst dispersed in a liquid carrier system which preferably includes less than 10 wt % water. The formulation also preferably includes a liquid carrier system having phenol and a cosolvent. The melt transesterification catalyst can be present in the formulation in a range of 50 ppm to 60,000 ppm.

Abstract: An apparatus for supplying power to a load. The apparatus including a plurality of sources to provide charge, and a controller adapted to control a transfer of charge from the sources to the load at distinct times. The controller may control the transfer of charge based on variation of an ambient condition or a manufacturing process. The controller may control the transfer of charge to generate a defined voltage across the load. The apparatus may include a regulator adapted to regulate a voltage across the load. The regulator may regulate the voltage across the load in a defined timing relationship with the transfer of charge from the sources to the load.

Abstract: An apparatus for supplying power to a bursty or highly dynamic load. The apparatus includes a first circuit for supplying charge to the load at a first voltage, and a second circuit for replenishing the charge depleted from the first circuit, wherein the second circuit is charged at a second voltage greater than the first voltage in order to achieve a defined rate of charge replenishment. The apparatus may include a feedback network for controlling the voltage applied to the load in response to process and temperature variations. The feedback network may regulate the charge capacity of the second circuit, the resistance between the first and second circuits, the duration of the charge replenishment, or the second voltage in which the second circuit is charged.