Abstract: The invention relates to an antigenic polypeptide referred to as DivIB and variants thereof, vaccines and immunogenic compositions comprising said polypeptide and the use of the vaccines and/or immunogenic compositions in the treatment and prevention of microbial infections.

Abstract: The invention relates to antigenic polypeptides expressed by pathogenic microbes, vaccines comprising said polypeptides; therapeutic antibodies directed to said polypeptides and methods to manufacture said polypeptides, vaccines and antibodies.

Abstract: The invention relates to an antigenic polypeptide referred to as DivlB and variants thereof, vaccines comprising said polypeptide and the use of the vaccine in protecting subjects from microbial infection.

Abstract: The disclosure relates to a composition comprising two or more immunogenic staphylococcal polypeptides and a multivalent vaccine composition comprising the immunogenic staphylococcal polypeptides.

Abstract: A cooking apparatus and method of assembling the same includes an outer shell including a base, a heating element positioned inside the outer shell, and a thermally conducting liner removably located inside the outer shell over the heating element. The liner includes an annular flange, and a first integral handle including a first latch. The apparatus and method further includes a lid configured to be placed over the liner, the lid including a sealing ring at an outer edge of the lid, and a top surface, wherein the first latch is configured to contact the top surface of the lid to secure the lid to the annular flange of the liner.

Abstract: The invention relates to antigenic polypeptides expressed by pathogenic microbes, vaccines comprising said polypeptides; therapeutic antibodies directed to said polypeptides and methods to manufacture said polypeptides, vaccines and antibodies.

Abstract: A continuous flow heater that mitigates the effect of altitude, characterized in that it consists of a combustion system with four mixers attached to a rectangular base into which the gas is injected and distributed through fifty small cavities is provided. The combustion system is attached to a heat transfer system. The continuous flow heater that mitigates the effect of altitude is suitable for altitudes greater than 2000 meters above the sea level without notable reductions in power or significant increases in polluting and toxic emissions. The combustion system has better air draft than conventional systems, enabling it to mitigate the reduction in the quantity of oxygen in the air at higher altitudes, improving the operation of the equipment compared to the operation of equipment already available on the market, and making a better use of non-renewable natural resources.

Abstract: A Spontaneous Area Network (SPAN) is formed by mobile and fixed nodes using wireless transmission links between nodes, usually in a nearby geographical area. Applications allow users to create, join, leave, and manage SPANs and groups in a SPAN. Automatic procedures allow nodes to join other SPANs. Transmission power of the wireless network interface is dynamic, varying depending on battery level, type of information to transmit, state and topology of the network. A delay tolerant object layer abstraction creates, modifies, deletes, publishes, and handles Delay Tolerant Distributed Objects (DTDOs). A Patient Transport Protocol (PTP) ensures a reliable transport of information through the network while avoiding congestion conditions. An aggressive and explosive network protocol (AGENET) has routing and forwarding capacities and uses datagrams to establish communication between different nodes of the SPAN.

Abstract: It comprises a preparation process of entecavir comprising: submitting a (1S,3R)-3-(tert-butyldimethylsilyloxy)-1-(oxiran-2-yl)pent-4-yn-1-ol (VIII) to a double esterification and to a radicalary cyclization, yielding a compound of formula (V), where either a compound of formula (VIII) is submitted to a first esterification reaction, then to a catalytic radicalary cyclization using titanocene dichloride as catalyst in the presence of Mn/2,4,6-collidine HCl or Zn/2,4,6-collidine/trimethylsilyl chloride, and finally to a second esterification reaction or, alternatively, the compound of formula (VIII) is submitted first to a catalytic radicalary cyclization, and then to an esterification reaction. Entecavir can be obtained by submitting compound (V) to a desilylation reaction to remove the TBS group and then to a Mitsunobu coupling with 2-amino-6-chloroguanine, followed by hydrolysis. It also relates to some new intermediates of the process.

Abstract: A Spontaneous Area Network (SPAN) is formed by mobile and fixed nodes using wireless transmission links between nodes, usually in a nearby geographical area. Applications allow users to create, join, leave, and manage SPANs and groups in a SPAN. Automatic procedures allow nodes to join other SPANs. Transmission power of the wireless network interface is dynamic, varying depending on battery level, type of information to transmit, state and topology of the network. A delay tolerant object layer abstraction creates, modifies, deletes, publishes, and handles Delay Tolerant Distributed Objects (DTDOs). A Patient Transport Protocol (PTP) ensures a reliable transport of information through the network while avoiding congestion conditions. An aggressive and explosive network protocol (AGENET) has routing and forwarding capacities and uses datagrams to establish communication between different nodes of the SPAN.

Abstract: An infant container cleaning apparatus is disclosed, comprising a stabilizer for holding one or more infant containers. The infant container cleaning apparatus also comprises a water application assembly for applying water, one or more cleaning agents, or a combination thereof to the one or more infant containers. Still further, the cleaning apparatus comprises at least one motion controller for varying the position, movement, speed, or a combination thereof of the stabilizer during the applying of the water, the one or more cleaning agents, or a combination thereof to the respective one or more infant containers by the water application assembly.

Abstract: A Spontaneous Area Network (SPAN) is formed by mobile and fixed nodes using wireless transmission links between nodes, usually in a nearby geographical area. Applications allow users to create, join, leave, and manage SPANs and groups in a SPAN. Automatic procedures allow nodes to join other SPANs. Transmission power of the wireless network interface is dynamic, varying depending on battery level, type of information to transmit, state and topology of the network. A delay tolerant object layer abstraction creates, modifies, deletes, publishes, and handles Delay Tolerant Distributed Objects (DTDOs). A Patient Transport Protocol (PTP) ensures a reliable transport of information through the network while avoiding congestion conditions. An aggressive and explosive network protocol (AGENET) has routing and forwarding capacities and uses datagrams to establish communication between different nodes of the SPAN.

Abstract: The invention relates to a process for preparing 1-aryl-pyrazol-3-one intermediates, tautomers, and salts thereof, to novel intermediates, and to the use of the intermediates in the preparation of sigma receptor inhibitors.

Abstract: An underground sprinkler system including a tank having an inner cavity adapted to hold chemicals, a distribution pipe fluidly connected to the inner cavity of the tank allowing chemicals to be added to the tank; a mixer connector pipe fluidly connected to the inner cavity of the tank and to a water source hose; a pump disposed in the tank for pumping the chemicals out of the inner cavity of the tank and into the water source hose via the mixer connector pipe; and a secondary connector pipe fluidly connected to the inner cavity of the tank and to the water source hose, the secondary connector pipe allows water from the water source hose to enter into the inner cavity of the tank.

Abstract: The disclosure relates to an apparatus and method of testing timing associated with the transmission and reception of a pulse signal. With regard to testing the transmission of the signal, a transmitter transmits a pulse within a selected hop offset subinterval of a hop interval. The receiver takes samples of the received signal for the entire duration of the hop interval. Successful timing operation is indicated when samples indicate a pulse received within the selected subinterval, and no pulses received within other subintervals of the hop interval. With regard to testing the reception of the signal, a transmitter transmits pulses within respective hop offset subintervals of a hop interval. The receiver is enabled only for the duration of a selected subinterval, but samples are taken for the entire duration of the hop interval. Successful timing operation is indicated when the samples indicate a pulse received within the selected subinterval, and no pulses received within other subintervals.

Abstract: This disclosure relates generally to methods for the manufacture of melt polymerized branched polycarbonates. The methods disclosure herein introduce branching agent into the melt process as a dissolved component in a solution comprised of a solvent and dissolved branching agent. Also disclosed are systems and apparatuses for performing the disclosed methods.

Abstract: An adjustable display board system comprises a display board, first and second grippers, first and second racks, and a handle. The first and second grippers are coupled to the display and include a plurality of teeth. The first and second racks are mounted to a rigid structure and include a plurality of teeth generally greater than the number of teeth of the first and second grippers. The teeth of the first and second grippers mesh with the teeth of the first and second racks to maintain the vertical position of the display board. The handle is pushed to disengage the grippers from the racks and allow vertical motion of the display board.

Abstract: The invention relates to an antigenic polypeptide referred to as DivlB and variants thereof, vaccines comprising said polypeptide and the use of the vaccine in protecting subjects from microbial infection.

Abstract: The invention relates to antigenic polypeptides expressed by pathogenic microbes, vaccines comprising said polypeptides; therapeutic antibodies directed to said polypeptides and methods to manufacture said polypeptides, vaccines and antibodies.

Abstract: An apparatus for generating an oscillating signal including an oscillator configured to generate the oscillating signal, a controller configured to generate a control signal that controls a characteristic (e.g., amplitude or frequency) of the oscillating signal, and a power supply configured to supply power to the oscillator as a function of the control signal. The power supply may be configured to supply power to the oscillator as a function of the amplitude or frequency of the oscillating signal to improve power efficiency.