Abstract: A light module comprising a means for supporting at least one collector of light rays in the vicinity of which there is a light guide suitable for guiding the rays emitted by a light source from an input face to at least two distinct and adjacent output faces. A distinction is made between a main output face, through which the rays pass in a first direction, and at least one additional output face which is oriented such that the light rays leaving the guide through this additional output face are directed toward the collector, in a second direction distinct from the first direction.

Abstract: A lighting unit including devices for emitting a luminous flux in the direction of a reflector featuring devices for optical deflection of the flux toward the outlet of the unit, the reflector including a support wall that is fastened to the optical deflection devices and is disposed across the optical deflection devices so as to be disposed between the optical deflection devices and the emission devices. The support wall includes a masking portion that is disposed facing the emission devices and a so-called cut-off edge of which is cut away so as to form a mask integral with the support wall adapted to allow to pass only a portion of the rays emitted by the emission devices. The invention also concerns a motor vehicle headlamp, notably in that it includes two lighting units disposed transversely side by side.

Abstract: An automated method for the production of cells and/or biomolecules such as protein or peptides includes culturing cells in at least one high cell density bioreactor, thereby fluidly connecting said bioreactor with a culture medium supply and a gas or gaseous mixture; fluidly connecting said bioreactor with a downstream unit; and growing cells to a density at least 50 million cells per ml. The total volume of the bioreactor is at least 10 liters. A system suitable for implementation of the automated method above is a small-scale and cupboard-sized system, which can be placed in a portable clean room.

Abstract: A lighting device for a motor vehicle, comprising a housing in which are arranged at least light-emitting means and optical-deflection means able to deflect the rays of light emitted toward an output face of the device, the device further comprising a main orifice formed in the housing for extracting the light-emitting means from the housing along a first axis. Fastening means are provided for fastening the emitting means in the device and the housing comprises an additional axis, distinct from the main orifice, for accessing the fastening means. The invention also relates to a motor vehicle headlamp equipped with at least one device of this type, and to a method of repositioning replacement means in a lighting device.

Abstract: A motor vehicle lighting and/or signaling assembly including: a lighting module and an adapter that can be placed and retained in position in a housing of support means of an optical collector, and separate means for pressing the adapter against the support means of the module in a first direction and for adjusting the adapter in the housing of the support means in a second direction other than the first direction, these pressing and adjustment means being carried by the module and/or by the adapter. The invention further concerns the associated adapter and the associated module in this lighting and/or signaling assembly.

Abstract: A lighting unit including devices for emitting a luminous flux in the direction of a reflector featuring devices for optical deflection of the flux toward the outlet of the unit, the reflector including a support wall that is fastened to the optical deflection devices and is disposed across the optical deflection devices so as to be disposed between the optical deflection devices and the emission devices. The support wall includes a masking portion that is disposed facing the emission devices and a so-called cut-off edge of which is cut away so as to form a mask integral with the support wall adapted to allow to pass only a portion of the rays emitted by the emission devices. The invention also concerns a motor vehicle headlamp, notably in that it includes two lighting units disposed transversely side by side.

Abstract: A light module comprising a means for supporting at least one collector of light rays in the vicinity of which there is a light guide suitable for guiding the rays emitted by a light source from an input face to at least two distinct and adjacent output faces. A distinction is made between a main output face, through which the rays pass in a first direction, and at least one additional output face which is oriented such that the light rays leaving the guide through this additional output face are directed toward the collector, in a second direction distinct from the first direction.

Abstract: A lock ring spreader is capable of being mounted to a lock ring having a first end and a second end. The lock ring spreader comprises a first mount that is mountable to the lock ring near the first end of the lock ring and a second mount that is mountable to the lock ring near the second end of the lock ring. A crank arm is pivotally coupled to the first mount and extends radially outward from the first mount relative to the lock ring. A link arm is pivotally coupled to the second mount and the crank arm, and extends radially outward from the second mount relative to the lock ring. Pivoting the crank arm radially inward relative to the lock ring pivots the link arm relative to the crank arm and expands the distance between the first mount and the second mount.

Abstract: The invention relates to a solid pharmaceutical composition comprising solid amorphous fulvestrant, said composition being formulated in combination with a solubilizing composition. The invention also relates to a method for preparing said composition and a kit including the composition.

Abstract: The present invention provides a catheter for the delivery of fluid medication across an anatomical region. In accordance with some embodiments, the catheter includes a tube having a plurality of exit holes in a side wall of the tube and an elongated member positioned within the tube. The exit holes combine to form a flow-restricting orifice of the catheter. Advantageously, fluid within the catheter flows through all of the exit holes, resulting in uniform distribution of fluid within an anatomical region.

Abstract: The invention relates to a solid pharmaceutical composition comprising solid amorphous fulvestrant, said composition being formulated in combination with a solubilizing composition. The invention also relates to a method for preparing said composition and a kit including the composition.

Abstract: The present invention relates to a cell culture device (1) comprising a disposable culture vessel comprising at least one external wall made of a material having a Young modulus E of less than 50 GPa, in which there is situated at least one cell culture zone and at least one cell-free medium transfer zone, allowing a flow of a culture medium between the cell culture zone and the transfer zone, and at least one sensor element of a cell-density sensor wherein said sensor element is situated in the cell culture zone of said vessel. The sensor element is an electrode arrangement of at least two and preferably at least four measuring electrodes arranged on the inner side of an external wall of the disposable culture vessel and directed towards the cell culture zone. The present invention further relates to a method of culturing cells.

Abstract: Mixing system comprising: a flexible bag (28) with a mixing device (1) comprising a magnetic impeller; and an alignment facilitation device adapted to facilitate alignment between the magnetic impeller and a magnetic driver (36) located external to the system. Specific flexible bag and hardware therefore.

Abstract: Flexible bag includes at least a first wall, a second wall facing the first wall when the flexible bag is folded and a functional part having at least a portion protruding from the first wall inside the bag. The second wall includes protective means intended to prevent damage to the flexible bag and/or to the functional part.

Abstract: The invention relates to a solid pharmaceutical composition comprising solid amorphous fulvestrant, said composition being formulated in combination with a solubilizing composition. The invention also relates to a method for preparing said composition and a kit including the composition.

Abstract: Catheters for uniform delivery of medication within an anatomical region. A catheter includes an elongated tube with a plurality of exit holes along an infusion section of the catheter, and an elongated flexible porous member residing within the tube and forming an annular space between the tube and the member. A catheter includes a tube having a plurality of exit holes in a side wall of the tube. The exit holes may combine to form a flow-restricting orifice of the catheter. A catheter includes an elongated tubular member made of a porous membrane. The porous membrane is configured so that a fluid introduced into an open end of the tubular member will flow through side walls of the tubular member at a substantially uniform rate along a length of the tubular member. A catheter includes an elongated “weeping” tubular coil spring attached to an end of, or enclosed within, a tube.

Abstract: An injectable pharmaceutical formulation of Melphalan comprising a solid composition of melphalan hydrochloride lyophilized with a content of impurities up to 1.3% (p/p)and a pH buffer solution; a process to prepare said solid composition. Also a reconstituted solution of melphalan comprising a solid composition of melphalan lyophilized reconstituted wherein said solution is aqueous, a perfusion free of organic solvent and a kit.

Abstract: The invention relates to the use of oxaloacetate in the treatment of ischaemia. The invention provides quantities that are therapeutically effective for the treatment of disorders associated with high levels of glutamate in brain tissue, such as, for example, cerebral ischaemia. In addition, the compositions of the invention are suitable for bolus-type delivery.

Abstract: Flexible bag comprising at least a first wall, a second wall facing the first wall when the flexible bag is folded and a functional part having at least a portion protruding from the first wall inside the bag, wherein the second wall comprises protective means intended to prevent damage to said flexible bag and/or to said functional part.