Abstract: The present invention relates to an air quality sensor-actuator device that monitors various physicochemical variables, controls up to two external devices and regulates by means of 0-10V control any machine that has this control input, communicates to the Internet via Wi-Fi with any 2.4 GHz router and has RS485 serial connectivity for integration thereof into open source ModBus. The device measures different variables concerning the air by means of a series of sensor means, in addition to carrying out a series of calculations using processing means and, depending on the data obtained, send command and actuation signals on external devices, and it also has a human-machine interface. The sensor means that the device subject matter of the invention has are: a temperature sensor, a relative humidity sensor, a particulate matter sensor that measures particle sizes of 1 micron, 2.5 microns and 10 microns, another sensor for measuring volatile organic compounds (VOC) and a fifth sensor for measuring CO2.

Abstract: A delivery apparatus for an expandable prosthetic heart valve can include a handle, a shaft having a proximal portion and a distal portion, the proximal portion being coupled to the handle, and a nosecone coupled to the distal portion of the shaft. The nosecone can include a proximal portion and a distal portion coupled to the proximal portion. The distal portion can be configured to flexibly curve relative to the proximal portion and the proximal portion is formed of a first material that is relatively harder than a second material forming the distal portion.

Abstract: In some embodiments, a vitrectomy probe may include an inner cutting tube reciprocating in an outer tube. The outer tube includes a side port and the inner tube includes a distal cutting port, and, in some embodiments, an additional side port. In some embodiments, the inner tube may also include a flat upper edge that cuts across the outer tube side port. In some embodiments, a diaphragm drives the inner tube and may have an open-stroke side with a lower hardness material than a closed-stroke side. In some embodiments, an aspiration tube coupled to the vitrectomy probe may include a first aspiration tubing and a second aspiration tubing with a lower hardness than the first aspiration tubing. In some embodiments, the vitrectomy probe may be coupled to pneumatic tubing that is stepped or tapered.

Abstract: Systems and methods for securely connecting a loading assembly to a delivery apparatus for loading a prosthetic medical device into the delivery apparatus are disclosed. As one example, a medical system can include a delivery apparatus for implanting a prosthetic medical device in a patient's body and a loading system. The delivery apparatus can comprise a flexible shaft, a coupling attached to a distal end of the flexible shaft, and a delivery capsule coupled to the coupling and extending distally from the coupling. The loading assembly can comprise a loading capsule comprising a plurality of axially extending flexible members configured to couple to an outer surface of the coupling and flex radially outward and a collar disposed around the loading capsule and configured to lock the plurality of flexible members in engagement with the coupling such that the plurality of flexible members cannot flex radially outward.

Abstract: A flexible delivery catheter comprising an outer jacket with a first portion and a second portion, a coil layer, and a coupler. The first portion and second portion of the outer jacket have a first inner diameter and a second inner diameter where the second inner diameter is greater than the first inner diameter. The change in diameter from the first inner diameter to the second inner diameter creates a shoulder. The coupler is coupled to the distal end of the outer jacket such that a cavity is formed by the coupler, the second portion of the outer jacket, and the shoulder of the outer jacket. A coil layer or hypotube is disposed within the cavity.

Abstract: The present invention provides a device for monitoring the application of a drug to a patient by means of a drug pen (100) of the type comprising a pushbutton (101) and a rotational dose selector (104). Said monitoring device (1) comprises: a coupling element (2) adapted for accommodating the pushbutton (101) and the selector (104) of the drug pen (100); and a core element (4) adapted for housing electronic components (400) comprising one or more sensors configured to monitor at least the dose delivered by the drug pen (100).

Abstract: The invention provides an automotive lighting device for an automotive vehicle. This device comprises a voltage regulator, a temperature sensor and a controlled light group. The controlled light group comprises a plurality of light sources and a light driver, the light driver comprising terminals and being configured to selectively activate or deactivate current flow in each terminal, in such a way that each light source is connected to one of the terminals. The controlled light group is fed by a voltage output value of the voltage regulator, the temperature sensor is arranged to sense a temperature in a zone of the lighting device and send information to the voltage regulator and the voltage regulator comprises a control driver to modify the voltage output value when receiving information from the temperature sensor.

Abstract: A flexible delivery catheter comprising an outer jacket, a coil layer, and a braided layer where the coil layer is disposed within the inner lumen of the braided layer, and the braided layer is disposed between the outer jacket and the coil layer. The coil layer is wound to resist axial compression and tension applied to the delivery catheter; the coil layer facilitates bending of the delivery catheter in a direction away from the longitudinal axis of the delivery catheter. The coil layer and the braided layer are provided along a distal tip portion of the delivery catheter, the distal tip portion extending along a length of the delivery catheter from a distal end of the delivery catheter toward the proximal end of the delivery catheter.

Abstract: In some embodiments, a vitrectomy probe may include an inner cutting tube reciprocating in an outer tube. The outer tube includes a side port and the inner tube includes a distal cutting port, and, in some embodiments, an additional side port. In some embodiments, the inner tube may also include a flat upper edge that cuts across the outer tube side port. In some embodiments, a diaphragm drives the inner tube and may have an open-stroke side with a lower hardness material than a closed-stroke side. In some embodiments, an aspiration tube coupled to the vitrectomy probe may include a first aspiration tubing and a second aspiration tubing with a lower hardness than the first aspiration tubing. In some embodiments, the vitrectomy probe may be coupled to pneumatic tubing that is stepped or tapered.

Abstract: In some embodiments, a vitrectomy probe may include an inner cutting tube reciprocating in an outer tube. The outer tube includes a side port and the inner tube includes a distal cutting port, and, in some embodiments, an additional side port. In some embodiments, the inner tube may also include a flat upper edge that cuts across the outer tube side port. In some embodiments, a diaphragm drives the inner tube and may have an open-stroke side with a lower hardness material than a closed-stroke side. In some embodiments, an aspiration tube coupled to the vitrectomy probe may include a first aspiration tubing and a second aspiration tubing with a lower hardness than the first aspiration tubing. In some embodiments, the vitrectomy probe may be coupled to pneumatic tubing that is stepped or tapered.

Abstract: The present invention relates to methods for increasing embryo implantation rate in a uterus, for preventing embryo implantation failure in a female subject suffering PCOS and for improving pregnancy rate comprising administering a composition comprising myo-inositol and D-chiro-Inositol in a weight ratio between 1:1 to 9:1 respectively to a female subject suffering PCOS. The invention also relates to a composition comprising myo-inositol and D-chiro-Inositol in a weight ratio between 1:1 to 9:1 respectively for use in the treatment or prevention of PCOS in a female subject, for use in the treatment or prevention of infertility in a female subject suffering polycystic ovary syndrome, or for use in preventing or reducing the risk of ovarian hyperstimulation syndrome in a female subject suffering polycystic ovary syndrome and subjected to ovary stimulation treatment.

Abstract: The invention provides an automotive lighting device for an automotive vehicle. This device comprises a voltage regulator, a temperature sensor and a controlled light group. The controlled light group comprises a plurality of light sources and a light driver, the light driver comprising terminals and being configured to selectively activate or deactivate current flow in each terminal, in such a way that each light source is connected to one of the terminals. The controlled light group is fed by a voltage output value of the voltage regulator, the temperature sensor is arranged to sense a temperature in a zone of the lighting device and send information to the voltage regulator and the voltage regulator comprises a control driver to modify the voltage output value when receiving information from the temperature sensor.

Abstract: The invention provides an automotive lighting device associated with vehicle electronics where the device includes light sources, a current sink device and a light driver. The current sink device is connected with the light sources so that each light source with a current sink device forms a light group. The light driver is configured to be electrically fed by a power source where the light driver includes terminals configured to selectively activate or deactivate current flow in each terminal, in such a way that each light group is connected. The light driver is arranged in series with the light groups relative to the power source, either located between the power source and the light groups or located between the light groups and the ground connection. The current sink device includes an input configured to receive an activation signal, in such a way that the current sink device can be selectively activated to consume power.

Abstract: Particular embodiments use the segmented bandwidth in downstream channels and upstream channels to manage a narrowcast service for subscribers. Particular embodiments include a channel manager that can process the signal from the headend to down-convert and filter narrowcast services that are sent in one or more of the downstream channels. Also, in the upstream direction, the channel manager can up-convert and stack narrowcast signals for sending to the headend. Further, in one embodiment, the narrowcast service may be provided using visible light communication (e.g., Li-Fi). Using visible light communication may overcome the last connection restrictions described in the background, such as end to end optical connections may be used. Further, using visible light communication may not interfere with other Wi-Fi links in the subscriber premises, such as existing MoCA connections, and may actually enhance the service at the subscriber premises.

Abstract: Particular embodiments use the segmented bandwidth in downstream channels and upstream channels to manage a narrowcast service for subscribers. Particular embodiments include a channel manager that can process the signal from the headend to down-convert and filter narrowcast services that are sent in one or more of the downstream channels. Also, in the upstream direction, the channel manager can up-convert and stack narrowcast signals for sending to the headend. Further, in one embodiment, the narrowcast service may be provided using visible light communication (e.g., Li-Fi). Using visible light communication may overcome the last connection restrictions described in the background, such as end to end optical connections may be used. Further, using visible light communication may not interfere with other Wi-Fi links in the subscriber premises, such as existing MoCA connections, and may actually enhance the service at the subscriber premises.

Abstract: The present invention provides a device for monitoring the application of a drug to a patient by means of a drug pen of the type comprising a pushbutton (101) and a rotational dose selector (104). Said monitoring device (1) comprises: a coupling element (2) adapted for accommodating the pushbutton (101) and the selector (104) of the drug pen (100); and a core element (4) adapted for housing electronic components (400) comprising one or more sensors configured to monitor at least the dose delivered by the drug pen (100).

Abstract: The present invention provides a device (1) for monitoring the application of a drug to a patient by means of a drug pen (100), whereby the drug pen comprises a front end provided with an injection needle and a rear end provided with an actuation pushbutton, the device comprising a body (2) which can be dismountably coupled to the pen; an injection detection means determining when a drug injection is carried out; and a processing means configured for storing the date and time of the injection when the injection detection means detects that a drug injection is carried out, whereby the body is configured to be coupled to the pushbutton of the pen such that the pushbutton is actuated by pushing directly on the body, whereby the injection detection means is implemented as actuation detector configured for detecting said pushing action.

Abstract: The present invention relates to methods for increasing embryo implantation rate in an uterus, for preventing embryo implantation failure in a female subject suffering PCOS and for improving pregnancy rate comprising administering a composition comprising myo-inositol and D-chiro-Inositol in a weight ratio between 1:1 to 9:1 respectively to a female subject suffering PCOS. The invention also relates to a composition comprising myo-inositol and D-chiro-Inositol in a weight ratio between 1:1 to 9: lrespectively for use in the treatment or prevention of PCOS in a female subject, for use in the treatment or prevention of infertility in a female subject suffering polycystic ovary syndrome, or for use in preventing or reducing the risk of ovarian hyperstimulation syndrome in a female subject suffering polycystic ovary syndrome and subjected to ovary stimulation treatment.

Abstract: In some embodiments, a vitrectomy probe may include an inner cutting tube reciprocating in an outer tube. The outer tube includes a side port and the inner tube includes a distal cutting port, and, in some embodiments, an additional side port. In some embodiments, the inner tube may also include a flat upper edge that cuts across the outer tube side port. In some embodiments, a diaphragm drives the inner tube and may have an open-stroke side with a lower hardness material than a closed-stroke side. In some embodiments, an aspiration tube coupled to the vitrectomy probe may include a first aspiration tubing and a second aspiration tubing with a lower hardness than the first aspiration tubing. In some embodiments, the vitrectomy probe may be coupled to pneumatic tubing that is stepped or tapered.

Abstract: In some embodiments, a vitrectomy probe may include an inner cutting tube reciprocating in an outer tube. The outer tube includes a side port and the inner tube includes a distal cutting port, and, in some embodiments, an additional side port. In some embodiments, the inner tube may also include a flat upper edge that cuts across the outer tube side port. In some embodiments, a diaphragm drives the inner tube and may have an open-stroke side with a lower hardness material than a closed-stroke side. In some embodiments, an aspiration tube coupled to the vitrectomy probe may include a first aspiration tubing and a second aspiration tubing with a lower hardness than the first aspiration tubing. In some embodiments, the vitrectomy probe may be coupled to pneumatic tubing that is stepped or tapered.