Abstract: The disclosure provides a method for treating a subject afflicted with a tumor derived from a non-small cell lung cancer (NSCLC) comprising administering to the subject a therapeutically effective amount of (a) an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof and (b) an anti-CTLA-4 antibody or an antigen binding portion thereof, wherein the tumor has a high tumor mutation burden (TMB) status. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.

Abstract: A system which comprises a series of native applications, suited to run on mobile devices, and a series of web-based applications for which functionality and processing are optimized. The native applications and the web-based applications are coordinated to optimize processes of acquiring, storing and disseminating data for speed, integrity and security.

Abstract: An automatic reversible arc assembly for a sprinkler includes a pair of primary stop members circumferentially spaced from each other by a first amount, and a pair of secondary stop members circumferentially spaced from each other by a second amount, different from the first amount. The primary stop members and the secondary stop members are coupled together and define a pivot assembly pivotable between a first position and a second position. A timer module cooperable with the pivot assembly is configured to hold the pivot assembly in the first position for a selectable period of time, after which the timer module enables the pivot assembly to pivot to the second position. The primary stop members are active in the first position, and the secondary stop members are active in the second position.

Abstract: Embodiments of welding work cells are disclosed. One embodiment includes a workpiece positioning system, a welding power source, and a welding job sequencer. The workpiece positioning system powers an elevating motion and a rotational motion of a workpiece mounted between a headstock and a tailstock to re-position the workpiece for a next weld to be performed. The welding power source generates welding output power based on a set of welding parameters of the power source. The welding job sequencer commands the workpiece positioning system to re-position the workpiece from a current position to a next position in accordance with a next step of a welding sequence of a welding schedule. The welding job sequencer also commands the welding power source to adjust a current set of welding parameters to a next set of welding parameters in accordance with the next step of the welding sequence of the welding schedule.

Abstract: Systems, methods and devices for a coaxial cable transmission system. A power supply receives a primary power signal from a power source. The power supply generates a switched direct current power signal from the primary power signal. A power gateway receives the switched direct current power signal over a coaxial cable from the power supply. The power gateway generates a secondary power signal from the switched direct current power signal. A load device receives the secondary power signal from the power gateway. In some implementations, the power supply generates the switched direct current power signal at a positive direct current voltage level for a first part of a time period and at a negative direct current voltage level for a second part of the time period.

Abstract: In an embodiment, the present invention provides a compound of the formula: or a pharmaceutically acceptable salt thereof, and methods of using this compound for treating type II diabetes mellitus.

Abstract: Disclosed is a system configured to receive a set of network snapshot segments from an output stream of a stream processing service, compile the set of network snapshot segments from the set of messages into a first network snapshot and a second network snapshot, and compare the first network snapshot and the second network snapshot to identify a difference between the first network snapshot and the second network snapshot.

Abstract: A method and system for internally determining, within a welding power supply, the energy input into a weld during a welding operation. The method includes determining a total energy input into the weld during a first time period, and determining a length of the weld made during the first time period.

Abstract: The spill proof bottle (10) disclosed comprises a container (22) suitable for holding a liquid and a lid (12) adapted to fasten to the container (22). The lid (12) has a base (16), a spinner (14), a twister (32) and a seal (20). The base (16) is configured with a channel (30) and a post (18). The post (18) has at least one outlet (28) for directing liquid out of the container (22). The spinner (14) has slots (62) and the twister (32) has complimentary tabs (60) adapted to convert rotational motion of the spinner(14) to vertical motion of the twister (32). The spinner (14) moves vertically from an open state to a closed state and then to a removable state. The seal (20) is fastened to the twister (32) and is adapted to cap the channel (30) preventing the flow of liquid out of the container (22) when in the closed state.

Abstract: Embodiments of systems and methods for supporting weld quality across a manufacturing environment are disclosed. One embodiment includes a manufacturing cell supporting welding of a sequence of welds to manufacture a workpiece. The manufacturing cell includes robotic welding equipment to make robotic welds as at least a portion of manufacturing a workpiece. The manufacturing cell also includes non-robotic welding equipment configured to allow a human operator to make non-robotic welds as at least a portion of manufacturing the workpiece. The manufacturing cell further includes a weld sequence controller configured to control timing associated with making the robotic welds and the non-robotic welds as a sequence of welds to manufacture the workpiece.

Abstract: Embodiments of welding work cells are disclosed. One embodiment includes a workpiece positioning system, a welding power source, and a welding job sequencer. The workpiece positioning system powers an elevating motion and a rotational motion of a workpiece mounted between a headstock and a tailstock to re-position the workpiece for a next weld to be performed. The welding power source generates welding output power based on a set of welding parameters of the power source. The welding job sequencer commands the workpiece positioning system to re-position the workpiece from a current position to a next position in accordance with a next step of a welding sequence of a welding schedule. The welding job sequencer also commands the welding power source to adjust a current set of welding parameters to a next set of welding parameters in accordance with the next step of the welding sequence of the welding schedule.

Abstract: Methods and systems of operating a gas turbine engine in a low-power condition are provided. In one embodiment, the method includes supplying fuel to a combustor by supplying fuel to a first fuel manifold and a second fuel manifold of the gas turbine engine. The method also includes, while supplying fuel to the combustor by supplying fuel to the first fuel manifold: stopping supplying fuel to the second fuel manifold; and supplying pressurized air to the second fuel manifold to flush fuel in the second fuel manifold into the combustor and hinder coking in the second fuel manifold and associated fuel nozzles.

Abstract: Methods and systems of operating a gas turbine engine in a low-power condition are provided. In one embodiment, the method includes supplying fuel to the combustor by supplying fuel to the first fuel manifold via a first flow divider valve and supplying fuel to the second fuel manifold via a second flow divider valve. While supplying fuel to the combustor by supplying fuel to the first fuel manifold, the method includes stopping supplying fuel to the second fuel manifold and supplying pressurized gas to the second fuel manifold via the second flow divider valve to flush fuel in the second fuel manifold into the combustor and hinder coking in the second fuel manifold and associated nozzles.

Abstract: The present disclosure is directed to a coupling assembly for a turbomachine. The coupling assembly includes a liner and a sleeve at least partially positioned circumferentially around the liner. A frame is positioned between the liner and the sleeve. The frame includes a first side wall, a second side wall, and a base wall extending from the first side wall to the second side wall. A block is positioned between the liner and the sleeve and is movable relative to the frame to permit the block to move toward and away from the base wall. Moving the block away from the base wall causes the block to exert an inward force on the liner and the base wall to exert an outward force on the sleeve.

Abstract: The present application provides a dispensing nozzle assembly for mixing a first fluid and a second fluid. The dispensing nozzle assembly may include a target assembly with a number of fins and a number of channels and a static mixer positioned about the fins.

Abstract: A storage system is provided in one example embodiment and may include a storage device that may include a plurality of outer walls; and a liner that covers one or more of the outer walls, wherein the liner comprises a woven material that is puncture-resistant. A storage device is provided in another example embodiment and may include a plurality of outer walls, wherein at least one of the outer walls comprises a woven material that is puncture-resistant. A vehicle is provided in another example embodiment and may include a fuel system that includes a fuel cell. The fuel cell may include a plurality of outer walls, and at least one of: a puncture-resistant liner covers one or more of the outer walls; and one or more of the outer walls comprises a woven material that is puncture resistant.

Abstract: A triangulation sensing system includes a projection axis configuration and an imaging axis configuration. The projection axis configuration includes a triangulation light source (e.g. an incoherent source) and a variable focus lens (VFL) that is controlled to rapidly periodically modulate a triangulation light focus position (TLFP) along a Z axis over a focus position scan range, to provide a corresponding triangulation light extended focus range (TLEFR) that supports accurate measurement throughout. In some implementations, the triangulation system may be configured to provide the best measurement accuracy for a workpiece region of interest (WROI) by exposing its triangulation image only when the scanned TLFP temporarily coincides with the WROI Z height. In some implementations, the triangulation system may be configured to limit various measurement operations to using only an operational pixel subset of a detector that receives image light from the WROI, in order to shorten the measurement time.

Abstract: Embodiments of systems and methods providing pattern recognition and data analysis in welding and cutting are disclosed. In one embodiment, a system includes a server computer and a data store connected to the server computer. The server computer receives welding data, including core welding data and non-core welding data, over a computer network from welding systems used to generate multiple welds to produce multiple instances of a same type of part. The server computer performs an analysis on the welding data to identify and group same individual welds of the multiple welds without relying on weld profile identification numbers as part of the analysis. A group of the same individual welds corresponds to a same weld location on the multiple instances of the same type of part. The data store receives the welding data from the server computer and digitally stores the welding data as identified and grouped.