Abstract: The invention provides certain 3,4-dihydroisoquinolin-2(1H)-yl compounds, particularly compounds of formula I, and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I to treat cognitive impairment associated with Parkinson's disease or schizophrenia.

Abstract: An apparatus comprises: a first chromatographic column fluidically coupled to a source of sample and a source of a first chromatographic mobile phase solvent; a second chromatographic column fluidically coupled to the first column; a source of a second mobile phase solvent fluidically coupled between the first and second columns; and a detector, the first chromatographic column being configurable to receive, in a trapping step, the first solvent and sample and to retain a first portion of a plurality of analytes therein and to pass a second portion of the plurality of analytes therethrough, the second chromatographic column being configurable, in the trapping step, to receive the second portion of the plurality of analytes and the first and second solvents and to retain the second portion of the plurality of analytes therein, the detector being arranged to receive the second and first portions in respective first and second elution steps.

Abstract: A coating system comprises a high gloss coating ink supply source, and a low gloss coating ink supply source. The system includes a coating module configured to receive the high gloss coating ink and the low gloss coating ink. The coating module includes a first and second group of nozzles configured to emit the high gloss and low gloss coating inks, respectively. The coating system has a controller that is configured to selectively actuate the first group and second group of inkjet nozzles to deposit the high gloss and low gloss coating inks onto the image receiving surface in accordance with a halftone pattern to form a gloss coating, the halftone pattern specifying a halftone density for the high gloss coating ink and for the low gloss coating ink, the halftone densities of the high and low gloss coating inks corresponding to a gloss level for the gloss coating.

Abstract: A printing apparatus has been developed that prints inkjet images on a continuous web with a configurable number of distinct ink colors.

Abstract: A printing system performs full printhead assembly width duplex printing operations on both sides of a continuous web of print media. The printing system includes an entrance roller configured to receive a print media and to direct the print media in a first direction or a second direction, an intermediate roller configured to receive the print media after the entrance roller directs the print media in the first direction, and to direct the print media in a third direction substantially opposite to the first direction, and an exit roller. An inverter apparatus inverts the print media after the entrance roller directs the print media in the first direction and before the exit roller receives the print media.

Abstract: Compounds and pharmaceutical compositions comprising compounds of the Formula as CB1 receptor inverse agonists useful for reducing body weight in mammals, treating cognitive impairment associated with schizophrenia, and mitigating treatment emergent weight gain observed during treatment with antipsychotics.

Abstract: A customer search terminal system may be configured to accept customer product searches and identify corresponding products and product information. A method for determining the efficacy of the customer search terminal may include receiving customer usage information including data related to customer usage of a customer search terminal and may also include receiving product sales information including data related to products sold at a point-of-sale terminal. The method may further include generating customer purchase behavior information by correlating the received customer search terminal usage information with the received product sales information when a product is sold at the point-of-sale terminal within a prescribed time period relative to a search for the product on the customer search terminal.

Abstract: A printing apparatus has been developed that prints inkjet images on a continuous web with a configurable number of distinct ink colors.

Abstract: A printing system has been developed that is capable of performing full printhead assembly width duplex printing operations on both sides of a continuous web of print media.

Abstract: A custom color printhead module comprises a mixing reservoir having a first opening and a second opening each configured to receive a first colored ink and a second colored ink and to mix the ink in the reservoir to form a custom colored ink. A first and a second reservoir supply valve are connected to the first and second opening, respectively, to open and close the first and second openings to enable and disable a flow of a first colored ink and a second colored ink into the mixing reservoir. A printhead is connected to the mixing reservoir to receive the custom colored ink from the mixing reservoir. A housing is configured to support the mixing reservoir and the printhead and configured for connection and removal from an imaging device.

Abstract: A coating system comprises a high gloss coating ink supply source, and a low gloss coating ink supply source. The system includes a coating module configured to receive the high gloss coating ink and the low gloss coating ink. The coating module includes a first group of nozzles configured to emit the high gloss coating ink, and a second group of nozzles configured to emit the low gloss coating ink. The coating module includes a mixing reservoir configured to receive the high gloss coating ink and the low gloss coating ink and to commingle the high gloss coating ink and the low gloss coating ink to form an intermediate gloss coating ink. The coating module includes a third group of inkjet nozzles configured to emit the intermediate gloss coating ink.

Abstract: A customer search terminal system may be configured to accept customer product searches and identify corresponding products and product information. A method for determining the efficacy of the customer search terminal may include receiving customer usage information including data related to customer usage of a customer search terminal and may also include receiving product sales information including data related to products sold at a point-of-sale terminal. The method may further include generating customer purchase behavior information by correlating the received customer search terminal usage information with the received product sales information when a product is sold at the point-of-sale terminal within a prescribed time period relative to a search for the product on the customer search terminal.

Abstract: A computer-implemental method of transacting a sealed bid competition has deadline-assurance process which in part upholds the integrity of the sealed bid competition. In a sealed bid competition, a buyer originates a “request for bid” communication that specifies bid items as well as includes a parameter of deadline. Participating vendors respond with “response” communications that contain substantive content presumptively responsive to the “request for bid” communication. The object of a sealed bid competition is to keep everyone, including especially the buyer, blind to the bid responses of everyone else until after the deadline. The deadline-integrity process has the buyer either precluded from access to the “response” communications until the deadline or else has the buyer's activity with accessing the “response” communications is logged so that such log record can thereafter disclose if the buyer voluntarily restrained itself from accessing the “response” communications until after the deadline.

Abstract: Compounds and pharmaceutical compositions of Formula (I) by blockade of the CB1 receptors via an inverse agonism mechanism which are useful for reducing body weight in mammals, cognitive impairment associated with schizophrenia, mitigating treatment emergent weight gain observed during treatment with antipsychotics and have increased bioavailability.

Abstract: A coating system comprises a high gloss coating ink supply source, and a low gloss coating ink supply source. The system includes a coating module configured to receive the high gloss coating ink and the low gloss coating ink. The coating module includes a first and second group of nozzles configured to emit the high gloss and low gloss coating inks, respectively. The coating system has a controller that is configured to selectively actuate the first group and second group of inkjet nozzles to deposit the high gloss and low gloss coating inks onto the image receiving surface in accordance with a halftone pattern to form a gloss coating, the halftone pattern specifying a halftone density for the high gloss coating ink and for the low gloss coating ink, the halftone densities of the high and low gloss coating inks corresponding to a gloss level for the gloss coating.

Abstract: A coating system comprises a high gloss coating ink supply source, and a low gloss coating ink supply source. The system includes a coating module configured to receive the high gloss coating ink and the low gloss coating ink. The coating module includes a first group of nozzles configured to emit the high gloss coating ink, and a second group of nozzles configured to emit the low gloss coating ink. The coating module includes a mixing reservoir configured to receive the high gloss coating ink and the low gloss coating ink and to commingle the high gloss coating ink and the low gloss coating ink to form an intermediate gloss coating ink. The coating module includes a third group of inkjet nozzles configured to emit the intermediate gloss coating ink.

Abstract: A custom color printhead module comprises a mixing reservoir having a first opening and a second opening each configured to receive a first colored ink and a second colored ink and to mix the ink in the reservoir to form a custom colored ink. A first and a second reservoir supply valve are connected to the first and second opening, respectively, to open and close the first and second openings to enable and disable a flow of a first colored ink and a second colored ink into the mixing reservoir. A printhead is connected to the mixing reservoir to receive the custom colored ink from the mixing reservoir. A housing is configured to support the mixing reservoir and the printhead and configured for connection and removal from an imaging device.

Abstract: The invention relates to a process for producing a polyolefin foam having a higher temperature resistance and comprising a polypropylene and/or polyethylene, which process comprises first mixing and melting one or more polyolefins having a melting range, measured by means of differential scanning calorimetry at a heating rate of 10° C./min, within the range of 95 to 170° C. and optionally other polyolefins and/or additives so as to form a homogeneous mixture having a melt temperature within the range of 120 to 160° C., melting said homogeneous mixture in an extruder, mixing said molten mixture with a physical foaming agent and subsequently cooling said mixture so that the molten mixture transfers from the liquid phase into a semi-crystalline phase, and expanding the cooled mixture into a foam. The invention further relates to an insulation foam produced with said process.

Abstract: A machine readable storage can include a set of instructions for load balancing. The storage can include a plug-in receptor of a load balancer. The plug-in receptor can be compliant with a known industry standard and can be is associated with a two or more load balancing algorithms. The load balancer can utilize selected ones of the load balancing algorithms to determine which of two or more voice servers are to handle incoming speech processing requests. Selected ones of the load balancing algorithms can include a speech utilization algorithm. The speech utilization algorithm can calculate a speech utilization score for at least one of the voice servers based upon speech processing specific factors.

Abstract: The present invention relates to compounds of formula I: which are antagonists of 5-HT6 receptor.