Abstract: An imaging system for performing a hybrid spiral scan pattern includes a scanner, a scanner controller in communication with the scanner to direct the scanner to perform a hybrid spiral scan pattern, wherein the hybrid spiral scan pattern includes a constant angular velocity (CAV) spiral scan pattern, a constant linear velocity (CLV) spiral scan pattern, and a transition spiral scan pattern. In some cases, the imaging system further includes a light source, and the scanner is positioned to receive light from the light source and direct the light to an object. In some cases, the imaging system further includes at least one position sensor for detecting actual positions of the scanner during the hybrid spiral scan pattern. In some cases, the imaging system further includes an image processor coupled to receive position data detected by the at least one position sensor and produce an image.

Abstract: Optical coherence tomography (OCT) imaging systems, handhold probes, and methods that use a field curvature to match a curved surface of tissue are disclosed. According to an aspect, an OCT imaging system includes optical elements to generate diverging light. The system also includes one or more mirrors and a lens system configured to scan the diverging light onto a curved surface of an object for imaging of the object.

Abstract: Peripheral retinal OCT can be used to generate peripheral retinal OCT images allowing for the peripheral retina to be viewed. A peripheral retinal vision system can determine that a set of fiducial markers is in a field-of-view of at least one camera and record positional data comprising a contact lens position and angle with respect to an OCT imaging system having OCT scanning mirrors in a first position. The system can determine whether a retinal layer is in an OCT scan captured while the set of fiducial markers is in the field-of-view of the at least one camera and the OCT scanning minors are in the first position; and for an OCT scan having he retinal layer and being captured while the set of fiducial markers is in the field-of-view of the at least one camera and the OCT scanning minors are in the first position, store that OCT scan.

Abstract: A method of fusing 2D and 3D imaging data includes receiving 3D imaging data and 2D color imaging data of a region of interest, segmenting the 3D imaging data to identify anatomical features in the region of interest, including surfaces of the anatomical features and a corresponding volume of the anatomical features, and generating an image by fusing the 2D color imaging data to the 3D imaging data according to the surfaces, the corresponding volumes, and identities of the anatomical features. In some cases, the 3D imaging data is captured via optical coherence tomography. In some cases, the 2D color imaging data is captured via color microscopy. In some cases, the method further includes rendering a final image at an output plane by casting a ray through the fused 3D imaging data for each pixel and viewpoint of the output image plane for the image.

Abstract: Systems and method for multiplexing and alternating light of different wavelengths in an ophthalmoscope are disclosed herein. According to an aspect, an imaging system includes an illumination system configured to generate and output light that alternates between at least two different wavelengths. The imaging system includes a multiplexer configured to receive the output light and to multiplex the light of different wavelengths onto a single optical channel. Further, the imaging system includes a scanning laser ophthalmoscope probe configured to operatively receive the multiplexed light, to apply the multiplexed light to a subject for imaging, and to receive light returning from the subject for generating an image of the subject.

Abstract: Systems and methods for providing surface contrast to display images for micro-surgical applications are disclosed. According to an aspect, an imaging system includes an OCT apparatus configured to capture OCT data of an eye. The OCT image data can include depth-resolved images of reflected light intensity over a period of time. The imaging system also includes a controller configured to determine movement of the eye relative to the OCT imaging field-of-view. The controller may also determine a location within the imaged portion of the eye which tracks with the eye movement. Further, the controller may apply a color gradient to render OCT images of the eye based on a position relative to the determined location of the eye tracking location. The controller may also control a display to display the OCT images with the applied color gradient.

Abstract: A method of mesoscopic photogrammetry can be carried out using a set of images captured from a camera on a mobile computing device. Upon receiving the set of images, the method generates a composite image, which can include applying homographic rectification to warp all images of the set of images onto a common plane; applying a rectification model to undo perspective distortion in each image of the set of images; and applying an undistortion model for adjusting for camera imperfections of a camera that captured each image of the set of images. A height map is generated co-registered with the composite image, for example, by using an untrained CNN whose weights/parameters are optimized in order to optimize the height map. The height map and the composite image can be output for display.

Abstract: Systems and methods for imaging based on multiple cross-sectional images acquired at different angles are disclosed. According to an aspect, multiple cross-sectional images of an object are acquired at different angles. The method also includes registering the acquired cross-sectional images. Further, the method includes reconstructing an enhanced resolution image of the object based on the registered images. As a result of registering the images, a distortion map is generated that is coregistered with the high-resolution image. The method also includes displaying an image of the object based on the enhanced resolution image and the distortion map.

Abstract: A method of imaging intraocular structures, includes capturing, via an optical coherence tomography (OCT) system, an image of features of an eye, determining geometric dimensions of elements within the eye from the image, creating an optical model of the eye with respect to the intraoperative OCT system using at least one of the determined geometric dimensions of the elements within the eye from the image and known dimensions of elements within the intraoperative OCT system, and applying the optical model to the image. An OCT system includes an optical system and a processing system coupled to the optical system. The processing system includes a processor, memory, and instructions stored on the memory that when executed by the processor, direct the intraoperative OCT system to perform the method of imaging intraocular structures including creating the optical model and applying the optical model to the image.

Abstract: Systems and methods for imaging a target feature of a subject based on the tracked positions of the subject and the target feature are disclosed. According to an aspect, a system includes a scanner configured to image a target feature of a subject. The system includes a mechanism configured to move the scanner. Further, the system includes a subject tracker configured to track positioning of the subject. The system includes a feature tracker configured to track positioning of the target feature. A controller is configured to control the mechanism to move the feature tracker to a position such that the feature tracker is operable to track a position of the target feature. The controller controls the mechanism to move the scanner to a position such that the scanner is operable to image the target feature based on the tracked position of the target feature by the feature tracker.

Abstract: Systems and methods for providing surface contrast to display images for microsurgical applications are disclosed. According to an aspect, an imaging system includes an OCT apparatus configured to capture OCT data of an eye. The OCT image data can include depth-resolved images of reflected light intensity over a period of time. The imaging system also includes a controller configured to determine movement of the eye relative to the OCT imaging field-of-view. The controller may also determine a location within the imaged portion of the eye which tracks with the eye movement. Further, the controller may apply a color gradient to render OCT images of the eye based on a position relative to the determined location of the eye tracking location. The controller may also control a display to display the OCT images with the applied color gradient.

Abstract: A 3D sensing depth camera involves a time-frequency multiplexed frequency-modulated continuous wave (FMCW) LiDAR technique. A sample arm of such a system for 3D depth sensing includes a scanner for beam scanning in a first axis and a diffractive optical element for spectrally encoded scanning along a second axis. The sample arm can further include beam shaping optics such as a collimator and a lens. Processing of an interferogram comprising depth information at a different position along the second axis for each frequency sweep of the light source involves applying a windowed spectral estimator at a particular spectral window size with zero-padding and according to a specified lateral sampling approach.

Abstract: Systems and methods for long working distance optical coherence tomography (OCT). According to an aspect, an OCT system includes a reference arm. Further, the OCT system includes a sample arm operably connected to the reference arm. The sample arm includes a scanner configured to scan an optical beam. The sample arm also includes an objective positioned a predetermined distance from the scanner, configured to receive the optical beam, and to direct the optical beam to an object positioned at about the predetermined distance from the scanner for imaging of the object.

Abstract: Systems and methods of optical coherence tomography stereoscopic imaging for microsurgery visualization are disclosed. In accordance with an aspect, a method includes capturing a plurality of cross-sectional images of a subject. The method includes generating a stereoscopic left image and right image of the subject based on the cross-sectional images. Further, the method includes displaying the stereoscopic left image and the right image in a display of a microscope system.

Abstract: Systems and methods for arbitrary viewpoint robotic manipulation and robotic surgical assistance are disclosed. According to an aspect, a system includes one or more controllers configured to receive an image dataset of an actual environment within which the robotic tool is positioned. The controller(s) are also configured to generate a virtual environment of the actual environment based on the image dataset. Further, the controller(s) can control display of the virtual environment including a virtual tool controllable by a user for use to control the robotic tool within the actual environment. The controller(s) can receive user input for altering a perspective view of display of the virtual environment from a first perspective view to a second perspective view. Further, the controller(s) can maintain orientation of display of the virtual tool with respect to the user during display of the first perspective view and the second perspective view of the virtual environment.

Abstract: Compact telescope configurations for light scanning systems and related methods are disclosed. According to an aspect, a system for imaging or relaying an image of an object includes a first optical element having a first focal length f1 for imaging or relaying an image of an object at the distance f1 from the first optical element. The system also includes a second optical element having a second focal length f2 for receiving an image of the object from the first optical element and for focusing an output of the image at the distance f2 from the second optical element on a side that opposes the first optical element. The first optical element and the second optical element are separated by a distance of approximately [Formula I], wherein r is the finite radius of curvature of the wavefront of light located at the object or image of the object.

Abstract: Systems and methods for imaging based on multiple cross-sectional images acquired at different angles are disclosed. According to an aspect, multiple cross-sectional images of an object are acquired at different angles. The method also includes registering the acquired cross-sectional images. Further, the method includes reconstructing an enhanced resolution image of the object based on the registered images. As a result of registering the images, a distortion map is generated that is coregistered with the high-resolution image. The method also includes displaying an image of the object based on the enhanced resolution image and the distortion map.

Abstract: Optical coherence tomography (OCT) imaging systems, handhold probes, and methods that use a field curvature to match a curved surface of tissue are disclosed. According to an aspect, an OCT imaging system includes optical elements to generate diverging light. The system also includes one or more mirrors and a lens system configured to scan the diverging light onto a curved surface of an object for imaging of the object.

Abstract: Whole eye optical coherence tomography (OCT) imaging systems and related methods are disclosed. According to an aspect, an OCT imaging system includes a source having an associated source arm path. Further, the OCT imaging system includes a reference arm coupled to the source arm. Further, the OCT imaging system includes a sample arm having an associated sample arm path and coupled to the source arm. The sample arm includes at least one optical component configured to simultaneously scan both an anterior and posterior portion of an eye of a subject.

Abstract: Systems and methods for eye tracking for motion corrected ophthalmic optical coherence tomography (OCT) are disclosed. According to an aspect, an imaging system includes an eye tracking device configured to determine movement of an eye. The imaging system also includes an OCT apparatus configured to generate OCT images of a retina of the eye. The OCT apparatus includes a scanner operable to be moved for relocating an OCT scan pivot at a pupil plane for image capture and during capture of the OCT images. The imaging system also includes a controller configured to control the scanner to relocate the OCT scan pivot at the pupil plane based on the determined movement of the eye.