Abstract: The disclosure provides a method for treating a subject afflicted with a tumor, e.g., lung cancer, having a high tumor mutation burden (TMB) status comprising administering to the subject an immunotherapy, e.g., an anti-PD-1 antibody or antigen-binding portion thereof. The present disclosure also provides a method for identifying a subject suitable for an immunotherapy, e.g., a treatment with an anti-PD-1 antibody or antigen-binding portion thereof, comprising measuring a TMB status of a biological sample of the subject. A high TMB status identifies the patient as suitable for treatment with an anti-PD-1 antibody or antigen-binding portion thereof. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.

Abstract: The disclosure provides a method for treating a subject afflicted with a tumor derived from a small cell lung cancer (SCLC) having a high tumor mutational burden (TMB) status comprising administering to the subject a monotherapy comprising an anti-PD-1 antibody or a combination therapy comprising an anti-PD-1 antibody and an anti-CTLA-4 antibody. The present disclosure also provides a method for identifying a subject suitable for treatment with an anti-PD-1 antibody or a combination therapy comprising an anti-PD-1 antibody and an anti-CTLA-4 antibody comprising measuring a TMB status of a biological sample of the subject. A high TMB status identifies the patient as suitable for treatment with an anti-PD-1 antibody or antigen-binding portion thereof. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.

Abstract: A projection dataset from a cone beam computed tomography (CBCT) can be input into a first set of one or more neural networks trained for at least one of saturation correction, truncation correction, and scatter correction. Reconstruction can then be performed on the output projection dataset to produce an image dataset. Thereafter, this image dataset can be input into a second set of one or more neural networks trained for at least one of noise reduction and artefact reduction, thereby generating a higher quality CBCT image.

Abstract: Voids are introduced in a copper shape to reduce warpage experienced by a printed circuit board during a reflow process. Copper shapes on an outer layer of a printed circuit board may be used to connect large packages that include ball grid arrays to the printed circuit board. The copper shapes may induce warpage in the printed circuit board during the reflow process. Routing a mesh pattern of voids in the copper shapes may reduce solder ball joint cracking and pad cratering during reflow and make solder joints more reliable. The voids may make the copper shapes less ridged and change the copper heat dissipation profile to remove sharp warpage forces that cause solder joints to experience pad cratering. The voids may be 8 mil x 8 mil cuts or indentations in the copper shape.

Abstract: Disclosed are apparatuses and methods of tuning a radio frequency circuit using stub tuners and photoconductive switches. In one aspect an electromagnetic stub tuner apparatus is disclosed. the apparatus includes a transmission line, and a photoconductive switch positioned along the length of the transmission line. The photoconductive switch is configured to turn on or turn off, wherein an impedance of the transmission line is changed when the photoconductive switch is turned on compared to when the photoconductive switch is turned off. In another aspect, a method of tuning a radio frequency circuit is disclosed. In yet another aspect, a method of producing a radio frequency tuning circuit is disclosed.

Abstract: A method for the computer-assisted implementation of radiology recommendations includes any or all of: receiving a set of inputs; determining and/or identifying a set of findings; determining a set of follow-up recommendations; and triggering a set of outputs and/or actions based on the set of follow-up recommendations. A system for the computer-assisted implementation of radiology recommendations preferably includes and/or interfaces a set of computing subsystems and/or processing subsystems, but can additionally include and/or interface with a set of devices (e.g., user devices), models, and/or any other components.

Abstract: A system and method for a virtual desktop system is disclosed. The system includes a master fabric region including resources for provisioning a desktop. The system includes an expansion fabric region including replicated resources for provisioning the desktop from the master fabric region. The system includes a control plane having a global pool. A client device application operated by a user associated with the global pool accesses a desktop from either the master fabric region or the expansion fabric region.

Abstract: Porous plugs for gas delivery in substrate supports and substrate supports and substrate processing chambers incorporating same are provided herein. In some embodiments, a porous plug for use in a substrate support includes: a porous central passageway; and a solid outer shell bonded to and surrounding the porous central passageway such that there is no continuous gap between the porous central passageway and the solid outer shell along an entire length of the porous plug, wherein the solid outer shell includes sealing surfaces disposed on ends of the solid outer shell to facilitate forming a seal along the sealing surface and surrounding the porous central passageway. In some embodiments, one or more o-ring retaining grooves can be formed about the outer surface of the solid outer shell.

Abstract: A system (100) includes an end point prediction engine (150) that predicts an end point (302) using a machine learning model (132) and one or more clinical report objects (152) for a patient, wherein the machine learning model inputs the one or more clinical report objects and outputs the predicted end point according to phrases or n-grams in the one or more clinical report objects. An end point visualization interface (160) visualizes the predicted end point (302) using a scorecard (162) or a timeline (164). An end point modeling engine (130) generates the machine learning model from training data that includes validated end points (122) and clinical report objects (116).

Abstract: A device, system, and method determines a reading environment by synthesizing downstream needs. The method at a workflow server includes receiving a request from a physician device utilized by a referring physician, the request directed to performing an imaging procedure. The method includes determining at least one normalized need from the request, the normalized need corresponding to the referring physician. The method includes generating information to be included in a reading environment based on the at least one normalized need, the information assisting an image interpreter in interpreting the imaging procedure.

Abstract: A three-dimensional printing system includes a print engine and a controller. The controller in turn includes a processor coupled to a non-transient memory. The non-transient memory stores software instructions that when executed by the processor cause the controller to operate the print engine to fabricate a body. The body includes a three-dimensional arrangement of 3D articles that are pairwise coupled together. An individual pair of the arrangement of 3D articles includes a first article and a second article. A curved body couples a first surface of the first article to the second article. The curved body intersects the first surface to define a closed intersection curve that bounds a break surface. Along the closed intersection curve a surface of the curved body subtends an acute angle with the first surface.

Abstract: A method and arrangement for determining measurements that need to be registered are disclosed. The method retrieves a plurality of clinical reports, detects a measurement in each of the plurality of clinical reports, and determines which of the detected measurements have been registered in a defined structured format. A method also identifies a plurality of patients with scheduled future clinical exam, determines if any of the plurality of patients have measurements that require registration and places the plurality of patients with the measurements requiring registration on a worklist. A further method retrieves data for a plurality of patients, determines whether each of the patients have new measurements, determines, for each of the patients, whether the new measurements have been registered, identifies a radiologist for each of the new measurements and generates a compliance scorecard for each of the radiologists.

Abstract: The present disclosure pertains to computer-assisted search of image slices. In some embodiments, an image slice having a detected finding (and representing a cross section of at least a portion of an individual) may be determined. A search space may be reduce to a subset of image slices respectively representing a cross section corresponding to the cross section represented by the determined image slice. The search space reduction may comprise filtering a set of image slices based on the cross section represented by the determined image slice. Image slice information related to the determined image slice and related one or more image slices (of the image slices subset) may be obtained based on the search space reduction. A determination of whether indications of the detected finding exist in the image slices (of the image slices subset) may be effectuated based on the image slice information.

Abstract: A substrate support device includes a blade and at least one pad provided on the blade to support a substrate. The pad includes a first fixed member, a second fixed member, and a bridge. The first fixed member is provided at an outer portion of the blade. The outer portion is located outside an outer circumference portion of the substrate when the substrate is supported on the pad. The second fixed member is provided at an inner portion of the blade. The inner portion is under the substrate when the substrate is supported on the pad. The bridge is flexible and connects the first fixed member and the second fixed member to support the outer circumference portion of the substrate. An upper surface of the bridge is inclined downward from the first fixed member toward the second fixed member when the substrate is not supported on the pad.

Abstract: A three-dimensional printing system includes a print engine and a controller. The controller in turn includes a processor coupled to a non-transient memory. The non- transient memory stores software instructions that when executed by the processor cause the controller to operate the print engine to fabricate a body. The body includes a three-dimensional arrangement of 3D articles that are pairwise coupled together. An individual pair of the arrangement of 3D articles includes a first article and a second article. A curved body couples a first surface of the first article to the second article. The curved body intersects the first surface to define a closed intersection curve that bounds a break surface. Along the closed intersection curve a surface of the curved body subtends an acute angle with the first surface.

Abstract: A system and method are provided for enabling a user to annotate a medical image. A collection of key-value pairs is provided, in which a key represents an image-observable quantity and a value represents the value of the image-observable quantity. A collection of structured finding objects is provided, wherein each structured finding object represents a set of key-value pairs, each set of key-value pairs representing a different annotation of the medical image. The user is enabled to select one or more of the collection of key-value pairs, thereby obtaining a user-selected structured finding object which represents a preliminary annotation of the medical image by the user. At least one recommended structured finding object is selected by using the user-selected structured finding object as input to a probabilistic recommendation algorithm. Feedback is provided to the user on the basis of the recommended structured finding object. The annotation is well suited for, e.g.

Abstract: A device, system, and method optimizes image acquisition workflows. The method performed at a workflow server includes receiving data associated with previous image acquisition procedures that have been performed, the image acquisition procedures having respective image orders, the image orders having respective contexts, each of the image acquisition procedures having used at least one sequence defining settings to capture an image. The method includes determining at least one metric associated with a use of a first one of the at least one sequence for a first one of the contexts. The method includes generating a rule indicative of whether the first sequence is to be included or excluded for a subsequent image acquisition procedure having the first context based on the at least one metric.

Abstract: A substrate support device includes a blade and at least one pad provided on the blade to support a substrate. The pad includes a first fixed member, a second fixed member, and a bridge. The first fixed member is provided at an outer portion of the blade. The outer portion is located outside an outer circumference portion of the substrate when the substrate is supported on the pad. The second fixed member is provided at an inner portion of the blade. The inner portion is under the substrate when the substrate is supported on the pad. The bridge is flexible and connects the first fixed member and the second fixed member to support the outer circumference portion of the substrate. An upper surface of the bridge is inclined downward from the first fixed member toward the second fixed member when the substrate is not supported on the pad.

Abstract: A device and method integrates a lesion stager in a reporting tool. The method includes receiving a user input. The user input is image data including at least one variable value. The variable value is indicative of a variable parameter of the image data. The method includes associating each of the at least one variable value with a corresponding variable parameter to generate at least one variable-value pair. The method includes determining a computed output value as a function of select ones of the at least one variable-value pair.

Abstract: The present disclosure pertains to computer-assisted search of image slices. In some embodiments, an image slice having a detected finding (and representing a cross section of at least a portion of an individual) may be determined. A search space may be reduce to a subset of image slices respectively representing a cross section corresponding to the cross section represented by the determined image slice. The search space reduction may comprise filtering a set of image slices based on the cross section represented by the determined image slice. Image slice information related to the determined image slice and related one or more image slices (of the image slices subset) may be obtained based on the search space reduction. A determination of whether indications of the detected finding exist in the image slices (of the image slices subset) may be effectuated based on the image slice information.