Abstract: Provided herein are compounds of Formula (I) and Formula (II) and stereoisomers, tautomers, and pharmaceutically acceptable salts or solvates thereof. Also provided are pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition by using the compounds and pharmaceutical compositions.

Abstract: Systems and methods capable for use in the development of high-speed, shape-transitioning, inward-turning inlets for air-breathing hypersonic vehicles, and inlets formed thereby. The systems and methods preferably provide for designing high-speed inlets for air-breathing hypersonic vehicles, wherein unique solutions are defined in each osculating plane of the inlet. Such systems and methods optionally provide an optimization process for tuning the post throat-shock Mach number of the inlet, and/or designs a shock-capture surface using a parallel-streamlines methodology, and/or a double cowl-lip geometry to allow flow to spill overboard.

Abstract: Systems and methods for operating a driveline disconnect clutch of a hybrid vehicle are presented. In one example, a driveline disconnect clutch liftoff pressure is estimated according to a derivative of a driveline disconnect clutch pressure when a driveline disconnect clutch is being de-stroked. The driveline disconnect clutch may be prepositioned in anticipation of driveline disconnect closing based on the estimated driveline disconnect clutch liftoff pressure.

Abstract: Embodiments of the present invention provide a concept for determining the relevance of a tag within a post. Responsive to receiving a post composed by a first user and containing a tag referring to a second user, a post context based on a topic of the post, a user context based on a record of the first user and a tag context based on a record of the second user are obtained. The post context and the user context are compared to the tag context, and it is determined whether the tag is relevant to the post and the first user based on comparing the post context and the user context to the tag context.

Abstract: Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium.

Abstract: A method of accumulating a personalized list of products viewed by a user on different website domains includes providing a first embedded code on a first website domain and a second embedded code on a second website domain in which the first website domain is different from said second website domain. Each of the embedded codes allows a specified third party server to communicate interactively with the user. The method further includes automatically accumulating a personalized list of products viewed by the user in a database on the specified third party server, wherein the personalized list includes at least a first product and a second product, wherein the first product is on the first website domain and the second product is on the second website domain.

Abstract: A structure for an III-V integrated circuit includes an integrated depletion and enhancement mode gallium nitride high electron mobility transistors (HEMTs). The structure includes a first, depletion mode HEMT having a first source, a first drain and a first fieldplate gate between the first source and the first drain, and a second, enhancement mode HEMT having a second source and a second drain. The second HEMT also includes a gallium nitride (GaN) gate and a second fieldplate gate between the second source and the second drain. The second fieldplate gate of the second HEMT may be closer to the second drain than the GaN gate. The structure provides a reliable, low leakage, high voltage depletion mode HEMT (e.g., with operating voltages of greater than 100V, but with a pinch-off voltage of less than 6 Volts) integrated with a gallium nitride (GaN) gate-based enhancement mode HEMT.

Abstract: Methods and systems are described herein for identifying the location and nature of any blur within one or more images received as a user communication and generating an appropriate correction. The system utilizes a first machine learning model, which is trained to identify blurred components of inputted images and determine whether the blurred components are located in portions of the inputted images comprising textual information. The system may apply a corrective action selected by the first machine learning model, which may comprise stitching blurred images together to a sharp product image and/or some other method appropriate for rectifying images received.

Abstract: The present disclosure pertains to a system for providing client-side physiological condition estimations during a live video session. In some embodiments, the system includes a first client computer system that is caused to: (i) store a neural network on one or more computer-readable storage media of the first client computer system, (ii) obtain a live video stream of an individual via a camera of the first client computer system during a video streaming session between the first client computer system and a second client computer system, (iii) provide, during the video streaming session, video data of the live video stream as input to the neural network to obtain physiological condition information from the neural network, and (iv) provide, during the video streaming session, the physiological condition information for presentation at the second client computer system.

Abstract: A gas-liquid separator system that can effectively and efficiently separate liquid from a streaming mixture having a liquid portion and a gas portion. The gas-liquid separator may be used in supercritical fluid chromatography application where an analyte is separated from a carrier gas, such as carbon dioxide. A streaming mixture is dispensed into a separation chamber formed by a spindle shaft configured inside of a shroud cavity. The shroud cavity has a plurality of concave channels along the inner surface and extend down to an outlet end. The concave channels create pressure variations that promote the liquid portion to condense onto the inner surface of the shroud and flow down to the exhaust port. A spherical collection portion is configured on the outlet of the shroud and the condensed liquid flows thereover and down along a cone portion and off the cone tip.

Abstract: Structures for a high-electron-mobility transistor and methods of forming a structure for a high-electron-mobility transistor. The high-electron-mobility transistor has a first semiconductor layer, a second semiconductor layer adjoining the first semiconductor layer along an interface, a gate electrode, and a source/drain region. An insulator region is provided in the first semiconductor layer and the second semiconductor layer. The insulator region extends through the interface at a location laterally between the gate electrode and the source/drain region.

Abstract: A system described herein may provide a technique for identifying User Equipment (“UEs”) associated with relevant users, such as “personal” UEs associated with first responders, based on the occurrence of an event, notifying the UEs of the event, and modifying radio access network (“RAN”) parameters such that the identified UEs are provided with priority access. Further, such modifications may be temporary (e.g., reverted after the event has occurred). In this manner, personal UEs associated with relevant users may be dynamically provided priority access in situations where such access may be beneficial, without needing to permanently provide the priority access to such UEs.

Abstract: A surgical light head and proximity detection method includes a housing, a plurality of light emitting elements arranged in the housing and configured to direct light at a target region of interest, and a plurality of distance sensors arranged in the housing. At least two of the distance sensors have field of views that overlap to define a common detection region of interest and the common detection region of interest at least partially overlaps with the target region of interest. The light head may have a plurality of integrally formed tilted seats that position the distance sensors relative to a center line of focus of the surgical light head. The distance sensors may be integrated in the housing via an optical component that is sealed relative to the housing and covers the distance sensor while enabling transmission and receipt of distance sensing signals therethrough.

Abstract: Described are systems, methods, and apparatus that detect keywords in one or more speech segments to authenticate that the speech is generated by the speaker as part of an intentional enrollment by the speaker into a service. For example, as a speech segment is received as part of an enrollment process, the speech segment may be converted into a log melspectrogram and the log melspectrogram may be processed using a machine learning model to determine if an expected keyword is represented by the log melspectrogram. If the keyword is detected, it may be determined that the speech output by the speaker is output as part of an intentional enrollment process.

Abstract: Structures for a laterally-diffused metal-oxide-semiconductor device and methods of forming a structure for a laterally-diffused metal-oxide-semiconductor device. The structure comprises a semiconductor substrate including a first well, a second well positioned within the first well, a source region positioned in the first well, and a drain region positioned in the second well. The first well has a first conductivity type, and the second well, the source region, and the drain region have a second conductivity type opposite to the first conductivity type. The structure further comprises a field plate over the semiconductor substrate and a contact connecting the field plate to the drain region. The field plate is positioned to overlap with the drain region and with a portion of the second well adjacent to the drain region. The contact and the field plate comprise the same metal.

Abstract: tion of heme oxygenase 1 (HO-1), in particular porphyrin, chlorin, bacteriochlorin or isobacteriochlorin compounds of formula I as defined herein having a tetrapyrrole or reduced tetrapyrrole backbone and a fluorophore. Such compounds can be used in the detection of HO-1 in vivo, ex vivo and in vitro, and can also be used in methods of diagnosis and as research reagents.

Abstract: A gas permeable cell culture device including a container body defining an interior volume, the container body having a semi-permeable membrane defining one end of the interior volume, a fitting defining an opposing end of the interior volume, and a cell transfer conduit. The cell transfer conduit having an open end positioned within the interior volume between the semi-permeable membrane and the fitting and a radial portion disposed within the interior volume and between the open end and opposing end of the container body.

Abstract: A map database stores data describing a set of connected roads each having one or more lanes, each having one or more lanes. The map database further stores data describing at an avoidance area comprising an area in the map database that an autonomous vehicle (AV) avoids traversing. A routability system determines at least one lane that can be accessed by the AV if the AV traverses the avoidance area, and generates a restored coverage area corresponding to the at least one lane. The restored coverage area corresponds to an area of restored coverage provided by the AV traversing the avoidance area. The routability system computes a score based on the restored coverage area, the score indicating an impact of restoring access by the AV to the avoidance area.

Abstract: Cleaning, maintaining, refurbishing, and/or diagnosing engine components including fuel system components, e.g., such as fuel-injectors. In one embodiment, a method of cleaning a fuel system component is provided. The method includes supplying a cleaning solution through the fuel system component, discontinuing the supplying of the cleaning solution, repeating the supplying of the cleaning solution and the discontinuing of the supplying of the cleaning solution a plurality of times, decoupling the source of cleaning solution, and connecting a source of fuel to the fuel system component, and supplying fuel through the fuel system component to re-establish fuel-based operation. In additional embodiments, a method of processing a fuel system component while it remains connected to an engine assembly, and a method of diagnosing a defective fuel system component, are provided.

Abstract: Some embodiments provide a system to facilitate transaction processing associated with an industrial asset supply chain having a first entity and a second entity. A first entity computer processor may retrieve, from a first entity database, information associated with pre-delivery data about the industrial asset. The first entity computer processor may then record pre-delivery data about the industrial asset via a secure, distributed transaction ledger. A second entity computer processor may retrieve, from a second entity database, information associated with a post-delivery event involving the industrial asset. The second entity computer processor may then record post-delivery event data about the industrial asset via a secure, distributed transaction ledger. The post-delivery event data might indicate, for example, that the industrial asset has been delivered, has been installed, is working properly, has been used, etc.