Abstract: The present invention provides an oral drug delivery system (“ODDS”) and methods of using and making the same. The ODDS comprises a tray fitted to at least some or all teeth of a patient's upper or lower arch for the application of medications to the patient in need of a medication. The tray is formed from a resilient elastomeric material molded to substantially conform to the teeth and gum tissue, the tray having at least one cavity formed to conform to the teeth, one or more raised ridges surrounding the cavity corresponding to a location along the patient's gum line, and one or more negative grooves configured to receive a medication by the raised ridges, and the negative grooves surrounding the cavity corresponding to an intersection of the teeth and gum line. A tooth structure medication can be included in the cavity apart from the one or more negative grooves.

Abstract: A computer analyzes blockchain ledger content. The computer receives a set of attributes associated with a predetermined entity and applies a one-way function to the attributes, generating an inquiry hash. The computer receives access to a blockchain ledger that includes a report with at least one report hash associated with an attribute of a report entity. The computer searches the report using the inquiry hash as a search key. The computer generates a list of candidate reports containing hashes that matches the inquiry hash. The computer assigns an entity matching confidence rating to candidate reports based, at least in part, on a predetermined identification utility value associated with each inquiry hash matched. The identification utility value indicates a likelihood that the report entity is the predetermined entity. The computer generates a list of high assurance reports having entity matching confidence ratings above a predetermined assurance threshold.

Abstract: A display device is disclosed. The display device comprises: a storage configured to store output brightness information for each gradation according to brightness information of an image; and a processor configured to acquire target brightness corresponding to brightness information of an input image on the basis of the information stored in the storage, acquire a target light amount on the basis of a light amount of the input image, acquire a plurality of correction effects corresponding to a plurality of correction images by applying a plurality of gradation adjustment curves to the input image, acquire a gradation adjustment curve corresponding to the maximum correction effect among the plurality of correction effects, and adjust and output a gradation for each pixel of the input image on the basis of the acquired gradation adjustment curve.

Abstract: Disclosed is an electronic device. The electronic device obtains a first histogram regarding a difference in gradation between adjacent pixels of an input image based on the first maximum output brightness, obtains a second histogram regarding a difference in gradation between the adjacent pixels of the input image based on the second maximum output brightness, obtains a third histogram regarding a difference in brightness between the adjacent pixels of the input image based on the first HVS recognition information, obtains a fourth histogram regarding a difference in brightness between the adjacent pixels of the input image based on the second HVS recognition information, and obtains a brightness value regarding the input image corresponding to the second maximum output brightness based on a difference between a first value obtained based on information on the first and third histograms and a second value obtained based on the second and fourth histograms.

Abstract: A cyber security threat tool may detect, analyze and alert of cyber security threats in, for example, a communication network of a service provider. For example, the tool may receive network connection data associated with a plurality of network connections between a plurality of computing devices, generate, based at least in part on the network connection data, a graphical database comprising a plurality of graph nodes corresponding to the plurality of computing devices and a plurality of graph edges corresponding to the plurality of network connections and performing a database query on the graphical database to generate query results, the database query including a connection pattern to be matched by the query results generated by the performing the database query. The cyber security threat tool may then render at least a portion of the query results in a graph view and cause the graph view to be output to a user.

Abstract: A thienopyridine derivative compound represented by Formula 1 or pharmaceutically acceptable salts thereof have an excellent inhibitory effect on protein kinase activity, and accordingly, pharmaceutical compositions containing the thienopyridine compound can be usefully used for the prevention or treatment of a disease associated with the activity of a protein kinase.

Abstract: Catalogs that describe respective offerings for fulfillment by respective applications, are aggregated to form an aggregate catalog. A request relating to at least one of the offerings is received based on content presented from the aggregate catalog. In response to the request, an orchestrated execution of an end-to-end process is performed to fulfill the request relating to the at least one offering, the executing of the end-to-end process comprising calling at least one of the applications.

Abstract: Embodiments are provided that relate to a computer system, a computer program product, and a machine-implemented method for improving performance of a dialog system employing an automated virtual dialog agent. Embodiments involve clustering traces of dialog conversation logs into sets, and search the traces for one or more contrastive temporal patterns between the sets.

Abstract: A display device is disclosed. The display device comprises: a storage configured to store output brightness information for each gradation according to brightness information of an image; and a processor configured to acquire target brightness corresponding to brightness information of an input image on the basis of the information stored in the storage, acquire a target light amount on the basis of a light amount of the input image, acquire a plurality of correction effects corresponding to a plurality of correction images by applying a plurality of gradation adjustment curves to the input image, acquire a gradation adjustment curve corresponding to the maximum correction effect among the plurality of correction effects, and adjust and output a gradation for each pixel of the input image on the basis of the acquired gradation adjustment curve.

Abstract: Provided herein are methods, kits, and compositions for the detection of an element of a biological sample using an antibody conjugated to a first oligonucleotide, which connects to a labelled oligonucleotide for detection via an oligonucleotide partially complementary to the first oligonucleotide and partially complementary to the second oligonucleotide.

Abstract: The present disclosure relates to C-glycoside derivatives having a fused phenyl ring or pharmaceutical acceptable salts thereof, a method for preparing the same, a pharmaceutical composition comprising the same, a use thereof and a method for dual inhibition of SGLT1 and SGLT2 using the same. A novel compound of the present disclosure has a dual inhibitory activity against SGLT1 and SGLT2, thus being valuably used as a diabetes therapeutic agent.

Abstract: A process and tool for reshaping and resizing grooves that were pre-formed in a pair of ferrules halves of an optical fiber ferrule. The pre-formed grooves are further subject to a separate, subsequent reshaping and resizing step using the tool and a gauge that may be a bare section of optical fiber or a pin. The ferrule halves are aligned, and using the pre-formed grooves as guides for the gauge optical fiber or gauge pin, the ferrule halves are compressed together with the gauge optical fiber or gauge pin therebetween, thereby reshaping and resizing the respective grooves on the ferrule halves. After reshaping and resizing, the resultant groove that is finally formed on each ferrule halve would be precisely shaped, sized and located with respect to the external alignment surface of each ferrule halve. The ferrule halves may be used to terminate an optical fiber cable.

Abstract: An image processing apparatus for minimizing a collective amount of power consumed by a plurality of display apparatuses of a multi-screen system to display an image of the multi-screen system, and for optimizing hue and luminance of the image of the multi-screen system.

Abstract: The present disclosure relates to novel imidazo[1,2-a]pyridine derivatives, and more particularly to imidazo[1,2-a]pyridine derivatives of Formula 1 wherein Y1, Y2 and Y3 are each independently H, halogen, a C1-C6 straight chain alkyl unsubstituted or substituted with R1, or hydroxy; R1 is hydroxy; Y4 is H, C1-C6 straight chain alkyl, or C1-C6 alkoxy; and X is H or halogen, and having an excellent activity of inhibiting gastric acid secretion, methods for preparing the same, and the use thereof. The imidazo[1,2-a]pyridine derivatives according to the present disclosure have gastric acid secretion inhibitory activity, and thus may be effectively used for the prevention or treatment of gastrointestinal inflammatory diseases or gastric acid-related diseases.

Abstract: An image processing apparatus for minimizing a collective amount of power consumed by a plurality of display apparatuses of a multi-screen system to display an image of the multi-screen system, and for optimizing hue and luminance of the image of the multi-screen system.

Abstract: The present disclosure relates to novel imidazo [1,2-?]pyridine derivatives, and more particularly to imidazo [1,2-?]pyridine derivatives having an excellent activity of inhibiting gastric acid secretion, methods for preparing the same, and the use thereof. The imidazo[1,2-?]pyridine derivatives according to the present disclosure have gastric acid secretion inhibitory activity, and thus may be effectively used for the prevention or treatment of gastrointestinal inflammatory diseases or gastric acid-related diseases.

Abstract: The present disclosure relates to C-glycoside derivatives having a fused phenyl ring or pharmaceutical acceptable salts thereof, a method for preparing the same, a pharmaceutical composition comprising the same, a use thereof and a method for dual inhibition of SGLT1 and SGLT2 using the same. A novel compound of the present disclosure has a dual inhibitory activity against SGLT1 and SGLT2, thus being valuably used as a diabetes therapeutic agent.