Abstract: The present disclosure relates to novel imidazo [1,2-?]pyridine derivatives, and more particularly to imidazo [1,2-?]pyridine derivatives having an excellent activity of inhibiting gastric acid secretion, methods for preparing the same, and the use thereof. The imidazo[1,2-?]pyridine derivatives according to the present disclosure have gastric acid secretion inhibitory activity, and thus may be effectively used for the prevention or treatment of gastrointestinal inflammatory diseases or gastric acid-related diseases.

Abstract: The present disclosure relates to C-glycoside derivatives having a fused phenyl ring or pharmaceutical acceptable salts thereof, a method for preparing the same, a pharmaceutical composition comprising the same, a use thereof and a method for dual inhibition of SGLT1 and SGLT2 using the same. A novel compound of the present disclosure has a dual inhibitory activity against SGLT1 and SGLT2, thus being valuably used as a diabetes therapeutic agent.

Abstract: An attachment and securement system that allows an item to be secured onto a surface or a structure, and to be selectively positioned. The system consists of a first assembly with a magnet and an interface, and a second assembly with a screw actuated clamp and a post that terminates at a circular metal head. The first assembly is attached to an item such as a mobile communication device, a computing device, apparel, or an apparel accessory. The item with the attached first assembly is then placed in contact with and magnetically adhered to the second assembly, which is attached to a surface or structure. The magnet secures the item to the second assembly, and the circular design of the metal head allows the head to rotate about the magnet, allowing the item to be selectively positioned.

Abstract: A process and tool for reshaping and resizing grooves that were pre-formed in a pair of ferrules halves of an optical fiber ferrule. The pre-formed grooves are further subject to a separate, subsequent reshaping and resizing step using the tool and a gauge that may be a bare section of optical fiber or a pin. The ferrule halves are aligned, and using the pre-formed grooves as guides for the gauge optical fiber or gauge pin, the ferrule halves are compressed together with the gauge optical fiber or gauge pin therebetween, thereby reshaping and resizing the respective grooves on the ferrule halves. After reshaping and resizing, the resultant groove that is finally formed on each ferrule halve would be precisely shaped, sized and located with respect to the external alignment surface of each ferrule halve. The ferrule halves may be used to terminate an optical fiber cable.

Abstract: A toilet seat and toilet lid assembly is provided which prevents bodily waste from undesirably exiting flushing toilets and contaminating surrounding areas and surfaces. More particularly, the assembly comprises an annular toilet seat and a lid, hingedly attached to the seat. An underside of the lid is configured to closely mate with the opening formed in the seat. Prior to flushing a toilet, a user may pivotally close the assembly, which may be secured over a toilet bowl. When closed, a male protrusion in the lid may be closely mated with the opening in the seat to prevent contaminants within the toilet bowl from exiting such bowl when activating the toilet's flushing capability agitates water and waste contained therein.

Abstract: A connector assembly and system assembling an electric connector assembly are provided. The connector assembly includes a connector housing having a plurality of terminal cavities greater than the predetermined number of electric connections so as to define an empty terminal cavity and a filled terminal cavity. The connector housing further includes a blocking member. The blocking member is the blocking member disposed within each of the empty terminal cavities. Accordingly, the blocking member closes off each of the empty terminal cavities so as to prevent fluid transfer between the terminal positioning assurance member and the connector positioning assurance member so as to prevent fluid and debris transfer between the terminal positioning assurance member and the connector positioning assurance member, or stated in another way, prevents fluid and debris transfer between the first open end and the second open end.

Abstract: A connector assembly and system assembling an electric connector assembly are provided. The connector assembly includes a connector housing having a plurality of terminal cavities greater than the predetermined number of electric connections so as to define an empty terminal cavity and a filled terminal cavity. The connector housing further includes a blocking member. The blocking member is the blocking member disposed within each of the empty terminal cavities. Accordingly, the blocking member closes off each of the empty terminal cavities so as to prevent fluid transfer between the terminal positioning assurance member and the connector positioning assurance member so as to prevent fluid and debris transfer between the terminal positioning assurance member and the connector positioning assurance member, or stated in another way, prevents fluid and debris transfer between the first open end and the second open end.

Abstract: There is provided a method of registering advertisements for display on an electronic map through the use of an advertisement registration server. The advertisement registration server receives an access request from a terminal via the network. The server then searches a map information database for predetermined map information and transmits searched map information to the terminal. The predetermined map information is associated with center coordinates and a scale value. Further, the predetermined map information is structured into a lattice having a plurality of lattice units. From the terminal, the server receives an advertisement contents registration request having advertisement information identifying one or more of the plurality of lattice units. The server registers in an advertisement database the advertisement information in association with the one or more lattice units identified in the registration request, and the center coordinates and the scale value of the predetermined map information.

Abstract: The invention relates to compositions and methods for treating C. difficile associated disease (CDAD) through the administration to a subject in need thereof at least one nucleic acid encoding at least a portion of at least one of toxin A and toxin B.

Abstract: An orchestrator executes an end-to-end process across applications. The executing of the end-to-end process by the orchestrator comprises executing flow logic by the orchestrator, the flow logic according to a data model defining arguments to include in interactions between the orchestrator and each of the applications. A message broker exchanges information among the orchestrator and the applications.

Abstract: An orchestrator executes an end-to-end process across applications. The executing of the end-to-end process by the orchestrator comprises executing flow logic by the orchestrator, the flow logic according to a data model defining arguments to include in interactions between the orchestrator and each of the applications. A message broker exchanges information among the orchestrator and the applications.

Abstract: An orchestrator executes an end-to-end process across applications. An message broker exchanges information among the orchestrator and the processes of the applications. Adapters perform protocol and interface translations for information communicated between the message broker and the respective applications.

Abstract: An orchestrator executes an end-to-end process across applications. An message broker exchanges information among the orchestrator and the processes of the applications. Adapters perform protocol and interface translations for information communicated between the message broker and the respective applications.

Abstract: Catalogs that describe respective offerings for fulfillment by respective applications, are aggregated to form an aggregate catalog. A request relating to at least one of the offerings is received based on content presented from the aggregate catalog. In response to the request, an orchestrated execution of an end-to-end process is performed to fulfill the request relating to the at least one offering, the executing of the end-to-end process comprising calling at least one of the applications.

Abstract: A service exchange includes an orchestrator to execute a workflow that involves a plurality of applications and services of a plurality of data centers. A message broker is to exchange messages between the orchestrator and the applications. Adapters are to perform protocol and interface translations for information communicated between at least some of the applications and the message broker.

Abstract: The present invention is directed to methods of suppressing an immune response in a subject in need thereof comprising administering a therapeutically effective amount of a compound having the following formula: to the subject in need thereof, wherein R1-5 represents from one to five substituents independently selected from hydrogen, nitro, cyano, C1-C3-alkyl, halogen, carboxy, amino, trifluoromethyl, hydroxy, C1-C3-alkoxy groups, X is hydrogen, halo, N3, SH, ?O, ?CH2, an aromatic, preferably phenyl, ring optionally substituted by R1-5 groups as defined above, amino, mono- or disubstituted amino groups wherein the substituents are selected from C1-C4 alkyl, phenyl or benzyl groups optionally substituted by R1-5 groups as defined above Y is hydrogen, allyl C1-C4, amino, or a group of formula —(CH2)0-1A wherein A is an aromatic, preferably phenyl, ring optionally substituted by R1-5 groups as defined above with the proviso that when X and Y are hydrogen, R1-5 cannot represent a 4-hydroxy or 4-alkoxy groups

Abstract: A system and method for determining a location of a mobile object is provided. The system determines the location of the mobile object by determining distances between a plurality of sensors provided on a first and second movable parts of the mobile object. A stride length, heading, and separation distance between the first and second movable parts are computed based on the determined distances and the location of the mobile object is determined based on the computed stride length, heading, and separation distance.

Abstract: The invention relates to compositions and methods for treating C. difficile associated disease (CDAD) through the administration to a subject in need thereof at least one nucleic acid encoding at least a portion of at least one of toxin A and toxin B.

Abstract: The primary of a transformer is driven at low voltages to provide high-voltage dynamic drive from the secondary to a load. A high-current source is placed in series with both the transformer secondary and load. At least secondary inductance of the transformer, hence impedance, is controlled through core saturation to transition secondary output to the load between high-voltage dynamic drive inductively coupled from the primary, and high-current drive serially connected through the secondary. Switching between high voltage and high current output is accomplished through the transformer; no additional switching devices need exist in the high-voltage path. Broad voltage and current capabilities of the configuration inexpensively improve transient drive of highly reactive loads.

Abstract: A system and method for determining a location of a mobile object is provided. The system determines the location of the mobile object by determining distances between a plurality of sensors provided on a first and second movable parts of the mobile object. A stride length, heading, and separation distance between the first and second movable parts are computed based on the determined distances and the location of the mobile object is determined based on the computed stride length, heading, and separation distance.