Abstract: Systems and methods are described for generating efficient iterative electronic recommendation structures. In various aspects, one or more processors aggregate a plurality of ratings vectors, where each ratings vector is associated with a vector type and contains one or more content ranking metrics associated with one or more users. The one or more processors generate similarity pairing values from the plurality of ratings vectors, where each similarity pairing value is based on a similarity mapping between a first ratings vector and a second ratings vector. The one or more processors further generate an electronic recommendation structure based on the similarity pairing values, where the electronic recommendation structure includes a bi-directional look-up interface that is configured to return a bi-directional recommendation value after receiving a lookup request for either the vector type of the first ratings vector or the vector type of the second ratings vector.

Abstract: Computing devices, systems, and methods for automatically prompting a foreign currency transaction by detecting a trip end condition associated with a registered user with respect to travel to a foreign location associated with a foreign currency. The methods and system may further determine that the registered user has a remaining foreign currency balance, and, as a result, may identify and send to the registered user's mobile device at least one option for using the remaining foreign currency balance. The at least one option may be a merchant offer from a merchant located in the area of the mobile device or may include an option to exchange the foreign currency for another currency. The trip end condition may be detected by determining that the registered user and/or user's mobile device is at an international departure location. The currency exchange may be with another registered user.

Abstract: An expandable intervertebral implant having an upper body portion, a lower body portion opposite the upper body portion. a wedge member connecting the upper body portion to the lower body portion, a nose member having a tapered distal end and a proximal end opposite the distal end, and an actuator disposed between the nose member and the wedge member, for translation of the wedge member along a longitudinal axis of the implant. A pin disposed in a center of the nose member connects to the actuator for centering the nose member with the actuator. Translation of the wedge member along the longitudinal axis of the implant displaces the upper body portion and the lower body portion away from each other, thereby expanding the intervertebral implant.

Abstract: In various embodiments, a targeting guide is disclosed. The targeting guide includes a handle defining a targeting hole and a targeting tower configured to be coupled to the handle. The targeting tower defines at least a first guide hole and a second guide hole. Each of the first and second guide holes are sized and configured to receive a respective first guide pin and second guide pin therethrough. The first and second guide pins are configured to indicate alignment of a k-wire inserted through the targeting hole defined by the handle. Methods of using a targeting guide are also disclosed.

Abstract: This invention relates to recombinant nucleic constructs comprising Type V CRISPR-Cas effector proteins, reverse transcriptases and extended guide nucleic acids and methods of use thereof for modifying nucleic acids in plants.

Abstract: A display system comprising a steerable display having a monocular field of view of at least 1 degree, positioned within a scannable field of view of at least 20 degrees, the steerable display positioned for a user. In one embodiment, the steerable display is positioned for the user's fovea.

Abstract: This invention relates to variants of Cas12a nucleases having altered protospacer adjacent motif recognition specificity. The invention further relates to methods of making CRISPR-CAS nuclease variants and methods of modifying nucleic acids using the variants.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: An expandable screw for orthopedic insertion and expansion between a collapsed state and an expanded state. The screw has an upper externally-threaded body segment, a lower externally-threaded body segment opposite the upper external thread segments, and an expansion member extending along a longitudinal axis thereof. The expansion member connecting the upper externally-threaded body segment to the lower externally-threaded body segment, and configured during the expansion between the collapsed state and the expanded state to separate the upper externally-threaded body segment from the lower externally-threaded body segment.

Abstract: An apparatus and a method for vehicle profiling. The apparatus includes at least a sensor, wherein the at least a sensor is configured to capture vehicle data of a vehicle, at least a processor and a memory communicatively connected to the at least processor, the memory contains instructions configuring the at least processor to receive the vehicle data from the at least a sensor, generate a graphic model of the vehicle as a function of the vehicle data, determine a vehicle status as a function of the vehicle data, classify the vehicle status and the vehicle data into one or more vehicle status groups and generate a vehicle report as a function of the one or more vehicle status groups.

Abstract: A textile fabric with a three-dimensional contour that blocks fluid penetration at the surface is created by attaching a solid liquid-blocking polymeric layer conforming to the contours of the surface to a fabric layer. The surface includes elevated areas, depressed areas, a plurality of surface fibers and gaps among the plurality the plurality of surface fibers. The liquid-blocking polymeric layer is forced to follow the contours of the surface fibers and gaps using vacuum, heat and forced air. The resulting textile fabric maintains a textile appearance.

Abstract: An expandable intervertebral implant having an upper body portion, a lower body portion opposite the upper body portion, a wedge member connecting the upper body portion to the lower body portion, a nose member having a tapered distal end and a proximal end opposite the distal end, and an actuator disposed between the nose member and the wedge member, for translation of the wedge member along a longitudinal axis of the implant. A pin connects to the actuator for positioning the nose member relative to the actuator. Translation of the wedge member along the longitudinal axis of the implant displaces the upper body portion and the lower body portion away from each other, thereby expanding the intervertebral implant.

Abstract: An apparatus and method for generating a vehicle maintenance activity, wherein the apparatus includes at least a processor and a memory communicatively connected to the at least a processor, the memory containing instructions configuring the at least a processor to receive image data, identify at least an indicator from the image data, receive vehicle data as a function of the indicator, classify the vehicle data to a plurality of vehicle data categories, and generate a vehicle maintenance activity as a function of the classified vehicle data.

Abstract: A system and method is disclosed for detecting anomalies in an additively manufactured part. An energy source generates a signal forming an optical beam for creating a melt pool in a layer of feedstock material being selectively fused to make a part in an additive manufacturing operation. A sensor is configured to receive a signal reflected from the melt pool. The reflected signal forms a thermal signal indicative of a temperature of the feedstock material at a known location on a layer of the feedstock material while the feedstock material is being fused at the known location. A controller receives and analyzes data relating to the received signal to determine if an anomaly exists at the known location.

Abstract: This invention relates to variants of Cas12a nucleases having altered protospacer adjacent motif recognition specificity. The invention further relates to methods of making CRISPR-CAS nuclease variants and methods of modifying nucleic acids using the variants.

Abstract: Systems, apparatuses, and methods for managing privacy of data are provided. The method includes providing at least one processor in communication with the at least one database, a memory device including readable instructions, and at least one of an agent device and a user device in communication with the at least one processor via a network connection; receiving at least one communication request related to user data; collecting usage data of the user data; and transmitting the communication containing the usage data to a user.

Abstract: Systems, apparatuses, and methods for managing privacy of data are provided. The method includes providing at least one database containing user data, at least one processor in communication with the at least one database, a memory device including readable instructions, and at least one user device in communication with the at least one processor via a network connection; receiving at least one preference related to the user data; storing the at least one preference in the at least one database; and using the at least one preference to selectively control at least one non-verbal interaction with the at least one user device.

Abstract: The invention relates to peptide linkers and fusion proteins comprising linkers designed for optimizing the activity of the proteins comprised therein, and methods for using the same. The invention further relates to newly designed Cas12a-based adenine base editors.

Abstract: Systems, apparatuses, and methods for managing privacy of data are provided. The method includes providing at least one database containing user data, at least one processor in communication with the at least one database, a memory device including readable instructions, and at least one user device in communication with the at least one processor via a network connection; receiving at least one preference related to the user data; storing the at least one preference in the at least one database; and using the at least one preference to prevent at least one interaction with the at least one user device.

Abstract: Systems, apparatuses, and methods for managing privacy of data are provided. The method includes providing at least one database containing user data, at least one processor in communication with the at least one database, a memory device including readable instructions, and at least one user device in communication with the at least one processor via a network connection; receiving at least one preference related to the user data; storing the at least one preference in the at least one database; and using the at least one preference to selectively control at least one verbal interaction with the at least one user device.